TERPENOIDS
December 8, 2023THIAZOLIDINEDIONES
December 8, 2023- Molecular physiology of amylin
- The role of amylin in the control of energy homeostasis
- Amylin: history and overview
- Dose-response for glucagonostatic effect of amylin in rats
- Polymorphic fibrillar assembly of human amylin
- Amylin: a novel action in the brain to reduce body weight
- Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin
- Amylin decreases meal size in rats
- Clinical implications of amylin and amylin deficiency
- Amylin agonists: a novel approach in the treatment of diabetes
- Missense mutation of amylin gene (S20G) in Japanese NIDDM patients
- Amylin, food intake, and obesity
- Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin
- Degradation of amylin by insulin-degrading enzyme
- In vitro autoradiographic localization of amylin binding sites in rat brain
- The role of amylin in the physiology of glycemic control
- Anorexia following the intrahypothalamic administration of amylin
- Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans
- S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin
- Permeability of the blood-brain barrier to amylin
- Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus
- Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
- High affinity amylin binding sites in rat brain.
- Stable and metastable states of human amylin in solution
- Mechanisms of amylin/leptin synergy in rodent models
- Roles of amylin in diabetes and in regulation of nutrient load.
- Expression of the rat amylin (IAPP/DAP) gene.
- Preclinical pharmacology of pramlintide in the rat: comparisons with human and rat amylin
- Structure and biology of amylin
- Full-length rat amylin forms fibrils following substitution of single residues from human amylin
- Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
- The physiology of amylin and insulin
- Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (∗)
- Atomic structure of the cross‐β spine of islet amyloid polypeptide (amylin)
- Amylin decreases food intake in mice
- Central amylin expression and its induction in rat dams
- Pancreatic amylin as a centrally acting satiating hormone
- The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin
- Amyloid fibril formation from full-length and fragments of amylin
- Dynamic α-helix structure of micelle-bound human amylin
- Reduction of food intake in rats by intraperitoneal injection of low doses of amylin
- Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans
- Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment.
- Amylin receptors: molecular composition and pharmacology
- Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease
- Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight
- Differential permeability of the blood–brain barrier to two pancreatic peptides: insulin and amylin
- Pancreatic signals controlling food intake; insulin, glucagon and amylin
- Amylin deposition in the kidney of patients with diabetic nephropathy
- An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell …
- Copper (II) inhibits the formation of amylin amyloid in vitro
- Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR
- Tissue expression and secretion of amylin
- Induction of insulin resistance in vivo by amylin and calcitonin gene–related peptide
- Inhibition of central amylin signaling increases food intake and body adiposity in rats
- Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro
- The human amylin analog, pramlintide, corrects postprandial hyperglucagonemia in patients with type 1 diabetes
- Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
- The aggregation potential of human amylin determines its cytotoxicity towards islet β‐cells
- Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
- Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies
- Insights into amylin–leptin synergy
- Development of sensitive immunoassays to detect amylin and amylin-like peptides in unextracted plasma
- Central amylin acts as an adiposity signal to control body weight and energy expenditure
- Brainstem mechanisms of amylin-induced anorexia
- Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms
- Comparison of the effects of calcitonin gene‐related peptide and amylin on osteoblasts
- Amylin and bone metabolism in streptozotocin‐induced diabetic rats
- An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or-3
- Synergy between amylin and cholecystokinin for inhibition of food intake in mice
- The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus
- Amylin receptors mediate the anorectic action of salmon calcitonin (sCT)
- Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction
- Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats
- Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development
- Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
- Emerging therapies mimicking the effects of amylin and glucagon-like peptide 1
- The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis
- Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle.
- Amylin receptor blockade stimulates food intake in rats
- Amylin
- Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily
- Effects of amylin on glucose metabolism and glycogenolysis in vivo and in vitro.
- A” is for amylin and amyloid in type 2 diabetes mellitus
- Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus
- Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats
- Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic …
- S20G mutation of the amylin gene is associated with Type II diabetes in Japanese
- Modulation of food intake by peripherally administered amylin
- Role of aromatic interactions in amyloid formation by peptides derived from human amylin
- Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid-and human amylin-induced toxicity
- Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state
- Evidence for a partially structured state of the amylin monomer
- Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin
- The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats
- International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
- Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin
- Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide
- Pramlintide, an amylin analog, selectively delays gastric emptying: potential role of vagal inhibition
- Amylin replacement with pramlintide as an adjunct to insulin therapy improves long‐term glycaemic and weight control in Type 1 diabetes mellitus: a 1‐year …
- Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin)
- Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight
- Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation
- Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose …
- Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat
- Control of food intake and energy expenditure by amylin—therapeutic implications
- Cosecretion of amylin and insulin from isolated rat pancreas
- Amylin stimulates osteoblast proliferation and increases mineralized bone volume in adult mice
- Islet amyloid polypeptide (amylin) is expressed in sensory neurons
- Molecular basis for the recognition and cleavages of IGF-II, TGF-α, and amylin by human insulin-degrading enzyme
- Interaction of leptin and amylin in the long‐term maintenance of weight loss in diet‐induced obese rats
- Solution structures of rat amylin peptide: simulation, theory, and experiment
- Antiobesity effects of the β-cell hormone amylin in diet-induced obese rats: effects on food intake, body weight, composition, energy expenditure, and gene expression
- In vivo and in vitro effects of amylin and amylin-amide on calcium metabolism in the rat and rabbit
- Solution state structures of human pancreatic amylin and pramlintide
- Amylin regulation of carbohydrate metabolism.
- Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors
- Rat amylin: cloning and tissue-specific expression in pancreatic islets.
- Fatty acids induce amylin expression and secretion by pancreatic β-cells
- Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes
- Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures
- Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus
- Plasma islet amyloid polypeptide (Amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients
- In vivo central actions of rat amylin
- Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP
- Actions of amylin on subfornical organ neurons and on drinking behavior in rats
- Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats
- Pharmacology of receptors for calcitonin gene-related peptide and amylin
- Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid
- Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.
- Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM
- Direct plasma radioimmunoassay for rat amylin-(1-37): concentrations with acquired and genetic obesity
- Human aging is associated with parallel reductions in insulin and amylin release
- Adjunctive therapy with the amylin analogue pramlintide leads to a combined improvement in glycemic and weight control in insulin-treated subjects with type 2 …
- Amyloid β and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP‐1 cells and murine microglia
- Fibrillogenic amylin evokes islet β-cell apoptosis through linked activation of a caspase cascade and JNK1
- Amylin in the periphery II: an updated mini-review
- Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk
- Co-secretion of amylin and insulin from cultured islet β-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents
- Amylin and its relation to insulin and lipids in obese children before and after weight loss
- Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK
- Stimulation of both aerobic glycolysis and Na+-K+-ATPase activity in skeletal muscle by epinephrine or amylin
- In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain
- Syntheses, structures and anorectic effects of human and rat amylin
- Amylin replacement with pramlintide in type 1 and type 2 diabetes: a physiological approach to overcome barriers with insulin therapy
- Amylin-induced in vivo insulin resistance in conscious rats: the liver is more sensitive to amylin than peripheral tissues
- Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes
- Amylin: physiology and pharmacology
- Antiulcer effects of amylin: a review
- Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer’s Disease Amyloid‐β Neurotoxicity
- Tests of adipsia and conditioned taste aversion following the intrahypothalamic injection of amylin
- Heparin-binding properties of the amyloidogenic peptides Aβ and amylin: dependence on aggregation state and inhibition by Congo red
- Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan’s enhancement of islet amyloid polypeptide (amylin) fibril formation.
- Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas
- Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187
- Amylin inhibits glucose-induced insulin secretion in a dose-dependent manner. Study in the perfused rat pancreas
- Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats
- Amylin/islet amyloid polypeptide: biochemistry, physiology, patho-physiology.
- Does neuropeptide Y contribute to the anorectic action of amylin?
- The role of neuropeptide Y, orexins, cocaine and amphetamine-related transcript, cholecystokinin, amylin and leptin in the regulation of feeding in fish
- Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice
- The acute effect of amylin and salmon calcitonin on energy expenditure
- Thiol reducing compounds prevent human amylin‐evoked cytotoxicity
- Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host …
- Identification of central projections from amylin-activated neurons to the lateral hypothalamus
- Amylin and the gastrointestinal tract
- Role of amylin in nutrient intake–animal studies
- Amylin stimulates plasma renin concentration in humans
- Alzheimer’s β-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic …
- Area postrema and the anorectic actions of dexfenfluramine and amylin
- Pancreatic cancer cells selectively stimulate islet β cells to secrete amylin
- Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications
- Amylin and glucose co-activate area postrema neurons of the rat
- Amylin fasting plasma levels are decreased in patients with osteoporosis
- The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit.
- Pramlintide, a synthetic analog of human amylin, improves the metabolic profile of patients with type 2 diabetes using insulin
- Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
- Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior
- Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin
- Amylin–its physiological role in humans
- Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats
- Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions
- Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice
- Amylin inhibits bone resorption by a direct effect on the motility of rat osteoclasts
- Anorexia following the systemic injection of amylin
- Shared pathways of osteoblast mitogenesis induced by amylin, adrenomedullin, and IGF-1
- Human amylin induces “apoptotic” pattern of gene expression concomitant with cortical neuronal apoptosis
- Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation
- Effects of calcitonin gene-related peptide and amylin on human osteoblast-like cells proliferation
- Effects of amylin on feeding of goldfish: interactions with CCK
- Amylin and food intake in mice: effects on motivation to eat and mechanism of action
- Distribution and kinetics of amylin in humans
- Amylin and insulin interact to reduce food intake in rats
- Dissociation of the effects of amylin on osteoblast proliferation and bone resorption
- Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas
- Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes
- Nano‐Scale Imaging and Dynamics of Amylin‐Membrane Interactions and Its Implication in Type II Diabetes Mellitus
- Amylin is associated with delayed gastric emptying in critically ill children
- In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle
- Mechanism of action of amylin in bone
- Behavioral effects of amylin injected intracerebroventricularly in the rat
- Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet β‐cells
- Effects of amylin and the amylin agonist pramlintide on glucose metabolism
- Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status
- Amylin and adrenomedullin: novel regulators of bone growth
- The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes
- Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats
- Effects of amylin on appetite regulation and memory
- Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat
- Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences
- Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats
- Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin
- The amylin analog pramlintide improves glycemic control and reduces postprandial glucagon concentrations in patients with type 1 diabetes mellitus
- Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa
- Role of amylin in insulin secretion and action in humans: antagonist studies across the spectrum of insulin sensitivity
- Immunohistochemical localization of amylin in rat brainstem☆,☆☆
- Amylin and the integrated control of nutrient influx
- Reduction of postprandial hyperglycemia in subjects with IDDM by intravenous infusion of AC137, a human amylin analogue
- The role of amylin and related peptides in osteoporosis
- Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet β-cells
- Design and study of peptide-based inhibitors of amylin cytotoxicity
- Central and peripheral administration of amylin induces energy expenditure in anesthetized rats
- Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia
- Effects of pramlintide, an analog of human amylin, on plasma glucose profiles in patients with IDDM: results of a multicenter trial
- Combination therapy with amylin and peptide YY [3–36] in obese rodents: anorexigenic synergy and weight loss additivity
- Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat
- Amylin-based pharmacotherapy-past, present & future
- Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice
- Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat: evidence for a metabolic role of endogenous amylin
- Effect of the disulfide bond on the monomeric structure of human amylin studied by combined Hamiltonian and temperature replica exchange molecular dynamics …
- Amylin injection causes elevated plasma lactate and glucose in the rat
- Central amylin signaling and the regulation of energy homeostasis
- Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus
- Processing of synthetic pro‐islet amyloid polypeptide (proIAPP) ‘amylin’ by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro
- Effects of amylin and adrenomedullin on the skeleton
- Amylin‐amide: a new bone‐conserving peptide from the pancreas
- Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets
- Systemic administration of a novel octapeptide, amylin-(1—8), increases bone volume in male mice
- Inhibition of Amyloid Fibril Formation of Human Amylin by N‐Alkylated Amino Acid and α‐Hydroxy Acid Residue Containing Peptides
- Effects of adrenomedullin, calcitonin gene-related peptide, and amylin on cerebral circulation in dogs
- Autoradiographic distribution and receptor binding profile of [125I] Bolton Hunter-rat amylin binding sites in the rat brain.
- Endogenous amylin contributes to the anorectic effects of cholecystokinin and bombesin
- Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic β-cells
- Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study
- Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers
- Amylin and amylin-amide lack an acute effect on blood glucose and insulin
- Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons
- Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat
- Effects of amylin on human osteoblast-like cells
- Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function
- Roles of amylin in satiation, adiposity and brain development
- Pharmacological characterisation of amylin-related peptides activating subfornical organ neurones
- Amylin in bone conservation current evidence and hypothetical considerations
- Hypertrophic effects of calcitonin gene-related peptide (CGRP) and amylin on adult mammalian ventricular cardiomyocytes
- Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers
- Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney
- Changes in Amylin and Amylin-Like Peptide Concentrations ana (β-Cell Function in Response to Sulfonylurea or Insulin Therapy in NIDDM
- In vitro effects of amylin on carbohydrate metabolism in liver cells
- Age-related changes in amylin secretion
- Induction of apoptosis by human amylin in RINm5F islet β-cells is associated with enhanced expression of p53 and p21WAF1/CIP1
- Amylin release during oral glucose tolerance test
- Anti-inflammatory activity of amylin and CGRP in different experimental models of inflammation
- Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance
- The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: evidence for associations with type 2 diabetes and cholesterol levels
- Structural diversity of the soluble trimers of the human amylin (20–29) peptide revealed by molecular dynamics simulations
- Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin
- Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice
- Fas-associated death receptor signaling evoked by human amylin in islet β-cells
- Altered islet amyloid polypeptide (amylin) gene expression in rat models of diabetes
- Amylin given by central and peripheral routes inhibits acid gastric secretion
- Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling.
- Amylin reduces food intake more potently than calcitonin gene-related peptide (CGRP) when injected into the lateral brain ventricle in rats
- Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product
- Response to intravenous injections of amylin and glucagon in fasted, fed, and hypoglycemic rats
- It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development
- Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet β-cells
- Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked …
- Anti-insulin effects of amylin and calcitonin-gene-related peptide on hepatic glycogen metabolism
- Extra-pancreatic expression of the rat islet amyloid polypeptide (amylin) gene
- Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases
- Deletions of genes encoding calcitonin/a-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors …
- Amylin influences insulin-stimulated glucose metabolism by two independent mechanisms
- Coordinate regulation of amylin and insulin expression in response to hypoglycemia and fasting
- Anorectic effects of amylin in rats over the life span
- Amylin and gastrointestinal activity
- Amylin tonally regulates arginine-stimulated insulin secretion in rats
- Circulating amylin in human essential hypertension: heritability and early increase in individuals at genetic risk
- Islet amyloid polypeptide (IAPP; amylin) influences the endocrine but not the exocrine rat pancreas
- Amylin in the periphery
- Islet amyloid polypeptide (amylin)-deficient mice develop a more severe form of alloxan-induced diabetes
- Effect of race and hypertension on plasma amylin concentrations
- The effects of amylin on carbohydrate metabolism in skeletal muscle in vitro and in vivo
- Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats
- Amylin regulation of fuel metabolism
- Proteoglycans synthesized and secreted by pancreatic islet β-cells bind amylin
- High-frequency oscillations in circulating amylin concentrations in healthy humans
- Promotion of β-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine
- Exenatide. Amylin/Eli Lilly.
- Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism
- Glucoregulatory endocrine responses to intermittent exercise of different intensities: Plasma changes in a pancreatic [beta]-cell peptide, amylin
- Lack of acute effect of amylin (islet associated polypeptide) on insulin sensitivity during hyperinsulinaemic euglycaemic clamp in humans
- Effects of centrally injected amylin on sexual behavior of male rats
- The regulation of amylin and insulin gene expression and secretion
- The specificity of amylin for the diagnosis of pancreatic adenocarcinoma
- Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance
- Pramlintide: A human amylin analogue reduced postprandial plasma glucose, insulin, and C‐peptide concentrations in patients with type 2 diabetes
- Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin
- Amylin causes anorexigenic effects via the hypothalamus and brain stem in chicks
- In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer
- Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rat islets following dexamethasone treatment
- Optimizing diabetes treatment using an amylin analogue
- Amylin secretion from the perfused pancreas: dissociation from insulin and abnormal elevation in insulin-resistant diabetic rats
- Activation of amylin gene transcription by LIM domain homeobox gene isl-1.
- Amylin and insulin in rat soleus muscle: dose responses for cosecreted noncompetitive antagonists
- Synthesis and structural investigations of N-alkylated β-peptidosulfonamide–peptide hybrids of the amyloidogenic amylin (20–29) sequence: implications of …
- Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin
- Inverse relation between amylin and glucagon secretion in healthy and diabetic human subjects
- Failure to establish islet amyloid polypeptide (amylin) as a circulating beta cell inhibiting hormone in man
- Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats
- Amylin as a growth factor during fetal and postnatal development of the rat kidney
- Amylin inhibits ovariectomy-induced bone loss in rats
- Amylin and severe acute pancreatitis
- Effects of rat amylin on renal function in the rat
- Amylin and insulin co-replacement therapy for insulin-dependent (type I) diabetes mellitus
- Differential effects of amylin on memory processing using peripheral and central routes of administration
- Aspirin and diabetes: inhibition of amylin aggregation by nonsteroidal anti-inflammatory drugs
- Prevention and promotion effects of apolipoprotein E4 on amylin aggregation
- Increased levels of plasma amylin in advanced renal failure.
- Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity
- Effects of amylin deficiency on trabecular bone in young mice are sex-dependent
- Transformation of the amyloidogenic peptide amylin (20–29) into its corresponding peptoid and retropeptoid: Access to both an amyloid inhibitor and template for self …
- Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene-related peptide-I (CGRPα) …
- The threshold of amylin-induced anorexia is lower in chicks selected for low compared to high juvenile body weight
- Amylin and diabetes.
- Amylin peptide is increased in preterm neonates with feed intolerance
- Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse
- Acute effects of the human amylin analog AC137 on basal and insulin-stimulated euglycemic and hypoglycemic fuel metabolism in patients with insulin-dependent …
- The effect of pramlintide (amylin analogue) treatment on bone metabolism and bone density in patients with type 1 diabetes mellitus
- Amylin and CGRP induce insulin resistance via a receptor distinct from cAMP-coupled CGRP receptor
- The role of amylin in the insulin resistance of non-insulin-dependent diabetes mellitus
- Vasodilator responses to calcitonin gene-related peptide (CGRP) and amylin in the rat isolated perfused kidney are mediated via CGRP1 receptors.
- Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation
- Amylin increases bone volume but cannot ameliorate diabetic osteopenia
- Interaction of the renal amylin and renin-angiotensin systems in animal models of diabetes and hypertension
- Involvement of multiple receptors in the biological effects of calcitonin gene‐related peptide and amylin in rat and guinea‐pig preparations
- Nephrectomy decreases amylin and pramlintide clearance in rats
- Skeletal effects of amylin and related peptides
- Investigation on the mechanisms involved in the central protective effect of amylin on gastric ulcers in rats
- Amylin and Hypertension: Association of an Amylin− G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats
- Special report regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved
- Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori
- Human amylin stimulates inflammatory cytokine secretion from human glioma cells
- Plasma amylin and insulin concentrations in normoglycemic and hyperglycemic cats.
- Amylin: physiological roles in the kidney and a hypothesis for its role in hypertension
- Amylin (1–8) is devoid of anabolic activity in bone
- Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats
- β-Structure in human amylin and 2 designer β-peptides: CD and NMR spectroscopic comparisons suggest soluble β-oligomers and the absence of significant …
- Rapid publication: Hypocalcemic actions of amylin amide in humans
- Self‐Assembly of Amylin (20–29) Amide‐Bond Derivatives into Helical Ribbons and Peptide Nanotubes rather than Fibrils
- Differential expression of islet amyloid polypeptide (amylin) and insulin in experimental diabetes in rodents
- Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin
- Amylin/insulin secretory ratios in morbidly obese man: inverse relationship with glucose disappearance rate
- Protective effects of amylin on reserpine-induced gastric damage in the rat
- Aspects of secretion and actions of amylin: interplay between amylin and other hormones.
- Characterization of amylin and calcitonin receptor binding in the mouse α-thyroid-stimulating hormone thyrotroph cell line
- Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats
- Amylin-mediated inhibition of insulin-stimulated glucose transport in skeletal muscle
- Amylin increases transport of tyrosine and tryptophan into the brain
- Effects of glucagon, insulin, amylin and CGRP on feeding
- Neuroendocrine actions of amylin
- Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins
- Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans
- Presence of liver CGRP/amylin receptors in only nonparenchymal cells and absence of direct regulation of rat liver glucose metabolism by CGRP/amylin
- Amylin and syndrome‐X
- Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin
- Diet-derived nutrients modulate the effects of amylin on c-Fos expression in the area postrema and on food intake
- Effect of amylin in various experimental models of gastric ulcer
- Daily amylin replacement reverses hepatic glycogen depletion in insulin‐treated streptozotocin diabetic rats
- Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 type 2 (non-insulin-dependent) diabetic patients
- The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role …
- Amylin-induced relaxation of the perfused mesenteric arterial bed: meditation by calcitonin gene-related peptide receptors
- Distribution of amylin-immunoreactive neurons in the monkey hypothalamus and their relationships with the histaminergic system
- Differential responses of circulating amylin to high‐fat vs. high‐carbohydrate meal in healthy men
- Basal plasma levels of insulin, leptin, ghrelin, and amylin do not signal adiposity in rats recovering from forced overweight
- Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat
- Cross-reactivity of amylin with calcitonin-gene-related peptide binding sites in rat liver and skeletal muscle membranes
- Differential calcitonin gene‐related peptide (CGRP) and amylin binding sites in nucleus accumbens and lung: potential models for studying CGRP/amylin receptor …
- Amylin-immunoreactivity is co-stored in a serotonin cell subpopulation of the vertebrate stomach and duodenum
- Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats
- Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN‐5F cells
- Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic β cells
- Understanding Amylin Receptors
- Calcitonin gene-related peptide (CGRP) and amylin and the endocrine pancreas
- IAPP/amylin gene transcriptional control region: evidence for negative regulation
- Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: a sign of impaired β-cell function?
- Amylin and glycaemic regulation: a possible role for the human amylin analogue pramlintide
- Atomic force microscopy study of human amylin (20-29) fibrils
- Positive inotropic, positive chronotropic and coronary vasodilatory effects of rat amylin: mechanisms of amylin-induced positive inotropy
- Vasorelaxant effect of glucagon-like peptide-(7-36) amide and amylin on the pulmonary circulation of the rat
- Amylin replacement therapy in patients with type 1 diabetes
- Effects of amylin on the release of insulin and glucagon from the perfused rat pancreas
- Amylin compared with calcitonin: competitive binding studies in rat brain and antinociceptive activity
- Arcuate neurons of overweight rats differ in their responses to amylin from controls
- Release of amylin from perfused rat pancreas in response to glucose, arginine, β-hydroxybutyrate, and gliclazide
- Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice
- Amylin increases cyclic AMP formation in L6 myocytes through calcitonin gene-related peptide receptors
- Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumors.
- Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus
- Inhibition of insulin release by amylin is not mediated by changes in somatostatin output
- Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment
- Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus
- Effect of insulin, proinsulin, and amylin on renin release from perfused rat kidney
- Molecular forms of islet amyloid polypeptide (IAPP/amylin) in four mammals
- Amylin analogue as an antidiabetic agent
- Rat amylin-(8—37) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats
- Amylin or CGRP (8–37) fragments reverse amylin-induced inhibition of 14C-glycogen accumulation
- Amylin, amyloid and age-related disease
- Increased density of renal amylin binding sites in experimental hypertension
- Amylin mobilizes [Ca2+] i and stimulates the release of pancreatic digestive enzymes from rat acinar AR42J cells: evidence for an exclusive receptor system of amylin
- Attenuation of the anorectic effects of cholecystokinin and bombesin by the specific amylin antagonist AC 253
- The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors
- CGRP receptors mediating CGRP‐, adrenomedullin‐and amylin‐induced relaxation in porcine coronary arteries. Characterization with ‘Compound 1′(WO98/11128), a …
- Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney
- Attenuation of the anorectic effects of glucagon, cholecystokinin, and bombesin by the amylin receptor antagonist CGRP (8–37)
- Behaviorally specific inhibition of sham feeding by amylin
- Chronic infusion of the amylin antagonist AC 187 increases feeding in Zucker fa/fa rats but not in lean controls
- Effect of 14 days’ subcutaneous administration of the human amylin analogue, pramlintide (AC137), on an intravenous insulin challenge and response to a standard …
- Interaction of amylin with calcitonin gene‐related peptide receptors in the microvasculature of the hamster cheek pouch in vivo
- Pharmacokinetics and pharmacodynamics of AC137 (25, 28, 29 tripro‐amylin, human) after intravenous bolus and infusion doses in patients with insulin‐dependent …
- Gastric amylin expression: cellular identity and lack of requirement for the homeobox protein PDX-1. A study in normal and PDX-1-deficient animals with a cautionary …
- Biotinyl analogues of amylin as biologically active probes for amylin/CGRP receptor recognition
- Preliminary report Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7–36) NH2, amylin, cholecystokinin, and other …
- Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects
- Structural insights into the polymorphism of amyloid-like fibrils formed by region 20− 29 of amylin revealed by solid-state NMR and X-ray fiber diffraction
- Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors
- Molecular model-building of amylin and α-calcitonin gene-related polypeptide hormones using a combination of knowledge sources
- Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelin
- Increased secretion of amylin in women with polycystic ovary syndrome
- Amylin in pancreatic islets and pancreatic endocrine neoplasms
- Inhibitory effect of amylin on basal and parathyroid hormone-stimulated bone resorption in cultured neonatal mouse calvaria
- Plasma amylin immunoreactivity and insulin resistance in insulin resistant relatives of patients with non-insulin-dependent diabetes mellitus
- Islet amyloid polypeptide (amylin) modulates chylomicron metabolism in rats
- Stimulation of adenylate cyclase by amylin in CHO-K1 cells.
- Amylin immunoreactivity in the rat trachea and characterization of the interaction of amylin and somatostatin on airway mucus secretion
- In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer
- The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm
- Molecular characterization of calcitonin gene-related peptide (CGRP) related peptides (CGRP, amylin, adrenomedullin and adrenomedullin-2/intermedin) in goldfish …
- S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients
- Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial …
- Amylin is an agonist of the renal porcine calcitonin receptor
- The amylin superfamily: A novel grouping of biologically active polypeptides related to the insulin A-chain
- Immunohistochemical localization of amylin in human pancreas, thyroid, pituitary and their tumors
- Activity of amylin at CGRP1-preferring receptors coupled to positive contractile response in rat ventricular cardiomyocytes
- Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin
- Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens.
- Comparison of Fos induced in rat brain by GLP-1 and amylin
- Amylin release from perfused rat pancreas in response to glucose and arginine
- Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.
- Islet amyloid polypeptide (IAPP/amylin) causes insulin resistance in perfused rat hindlimb muscle
- S20G mutation of the amylin gene in Japanese patients with type 2 diabetes
- Control of glycogen synthase and phosphorylase by amylin in rat skeletal muscle. Hormonal effects on the phosphorylation of phosphorylase and on the …
- Unresolved Challenges with Insulin Therapy in Type 1 and Type 2 Diabetes: Potential Benefit of Replacing Amylin, a Second β-Cell Hormone
- Positive inotropy of calcitonin gene-related peptide and amylin on porcine isolated myocardium
- Pramlintide (Amylin).
- … rat hindlimb is increased after glucose-administration and is suppressed by a selective amylin antagonist: evidence for action of endogenous amylin in skeletal muscle
- Delayed fibril formation of amylin (20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis
- Circadian anorectic effects of peripherally administered amylin in rats.
- Effects of islet amyloid polypeptide (amylin) and calcitonin gene-related peptide (CGRP) on glucose metabolism in the rat
- Pancreatic amylin content in human diabetic subjects and its relation to diabetes
- Stimulatory effects of islet amyloid polypeptide (amylin) on exocrine pancreas and gastrin release in conscious rats
- Effects of amylin and other peptide hormones on Na+–K+ transport and contractility in rat skeletal muscle
- Islet amyloid polypeptide/amylin contents in pancreas change with increasing age in genetically obese and diabetic mice
- Plasma amylin concentration is related to the severity of intestinal ischemic injury in rats
- Reduction of islet amylin expression and basal secretion by adenovirus-mediated delivery of amylin antisense cDNA
- Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure
- Evidence for release of free glucose from muscle during amylin-induced glycogenolysis in rats
- Influence of glucose concentration on the inhibitory effect of amylin on insulin secretion. Study in the perfused rat pancreas
- Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation
- The physiology of calcitonin gene-related peptide in the islet compared with that of islet amyloid polypeptide (amylin).
- Amylin evokes phosphorylation of P20 in rat skeletal muscle
- Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system
- Acute application of human amylin, unlike β-amyloid peptides, kills undifferentiated PC12 cells by apoptosis
- Effects of the amylin analogue pramlintide on hepatic glucagon responses and intermediary metabolism in type 1 diabetic subjects
- Adrenomedullin increases cyclic AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes
- The effect of islet amyloid polypeptide (amylin) and calcitonin gene-related peptide on glucose removal in the anaesthetized rat and on insulin secretion from rat …
- Effects of 4 weeks’ administration of pramlintide, a human amylin analogue, on glycaemia control in patients with IDDM: effects on plasma glucose profiles and serum …
- Characterization of amylin binding sites in a human hepatoblastoma cell line
- Amylin S20G mutation in Mexican population
- Amylin-induced suppression of ANP secretion through receptors for CGRP1 and salmon calcitonin
- Inhibitory effect of amylin (islet amyloid polypeptide) on insulin response to non-glucose stimuli. Study in perfused rat pancreas.
- … hydroxyphenyl) methyl]-2-oxoethyl]-4-(1, 4-dihydro-2-oxo-3 (2H)-quinazolinyl)(BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors—the role …
- Effect of amylin on the tone of rat aorta ring preparation
- Developmental Regulation of Amylin and Insulin-Gene Expression in Lean (Fa/Fa) and obese (fa/fa) Zucker rats
- Differential changes in islet amyloid polypeptide (amylin) and insulin mRNA expression after high-fat diet-induced insulin resistance in C57BL/6J mice
- Metabolic effects of amylin in lactating goats
- Effects of amylin on bone development and egg production in hens
- The effects of amylin on motivated behavior in rats
- Effects of amylin and salmon calcitonin on feeding and drinking behavior in pygmy goats
- Different influence of CGRP (8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats
- Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter
- Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
- Aggregation of liposomes induced by the toxic peptides Alzheimer’s Aβs, human amylin and prion (106–126): facilitation by membrane-bound GM1 ganglioside
- Dose-dependent elevation of cyclic AMP, activation of glycogen phosphorylase, and release of lactate by amylin in rat skeletal muscle
- The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat …
- Amylin in human pancreatic islets
- Comparison of the in vitro and in vivo pharmacology of adrenomedullin, calcitonin gene-related peptide and amylin in rats
- Amylin is more potent and more effective than glucagon in raising plasma glucose concentration in fasted, anesthetized rats
- Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin
- The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils
- Hypersecretion of amylin from the perfused pancreas of genetically obese (fafa) rats and its alteration with aging
- Biological action of pancreatic amylin: relationship with glucose metabolism, diabetes, obesity and calcium metabolism.
- Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle
- The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat
- Amylin inhibits insulin-stimulated glucose uptake in C2C12 muscle cell line through a cholera-toxin-sensitive mechanism
- Amylin, calcitonin gene-related peptide, and adrenomedullin: effects on thiazide receptor and calcium
- GABAA receptor antagonists prevent abnormalities in leptin, insulin and amylin actions on paraventricular hypothalamic neurons of overweight rats
- Amylin reduces plasma glucagon concentration in cats
- Lack of effect of calcitonin gene-related peptide and amylin on major markers of glucose metabolism in hepatocytes
- The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes
- Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats
- Impaired phasic insulin and amylin secretion in diabetic rats
- Optimizing treatment success with an amylin analogue
- Circulating levels of incretin hormones and amylin in the fasting state and after oral glucose in GH-deficient patients before and after GH replacement: a placebo …
- Islet amyloid polypeptide/amylin in pancreatic β-cell line derived from transgenic mouse insulinoma
- Reversal of the inhibitory effects of calcitonin gene-related peptide (CGRP) and amylin on insulin secretion by the 8–37 fragment of human CGRP
- Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation
- Amylin analogue in the treatment of obesity
- Amylin replacement therapy in patients with insulin-requiring type 2 diabetes
- Post-partum evaluation of amylin in lean patients with gestational diabetes mellitus
- Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site
- Biologically active human islet amyloid polypeptide/amylin in transgenic mice
- Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas
- S15261 antagonises amylin-induced impaired glucose tolerance
- Plasma amylin concentrations in fasted and fed rats quantified by a monoclonal immunoenzymometric assay
- Responsiveness to Leptin Restored by Amylin in Diet Induced Obese (DIO) Rats: Magnitude and Mechanisms of Synergy.
- Sex steroids do not prevent amylin-induced apoptosis in human cells
- Amylin induces natriuresis by a central angiotensin-dependent mechanism
- Role of amylin in glucose homeostasis and its perspective use in diabetes management
- Islet amyloid polypeptide (amylin) increases the renal excretion of calcium in the conscious dog
- A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor
- Amylin and hypertension: the status of the current debate
- 8–37hCGRP, an amylin receptor antagonist, enhances the insulin response and perturbs the glucose response to infused arginine in anesthetized rats
- Insulin treatment improves relative hypersecretion of amylin to insulin in rats with non-insulin-dependent diabetes mellitus induced by neonatal streptozocin injection
- Amylin-mediated reduction in insulin sensitivity corresponds to reduced insulin receptor kinase activity in the rat in vivo
- Regulation of amylin release from cultured rabbit gastric fundic mucosal cells
- Islet amyloid polypeptide/amylin contents in pancreata increase in genetically obese and diabetic mice
- Non-competitive antagonism of amylin on CGRP1-receptors in rat coronary small arteries
- Analysis of rat amylin amide from commercial sources: Identification of a mercury complex.
- Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY
- AMYLIN-CONTAINING CELLS IN THE GASTRO-ENTERO-PANCREATIC (GEP) ENDOCRINE SYSTEM OF THE RAT AND HUMANS AN IMMUNOHISTOCHEMICAL …
- Effects of exogenous somatostatin and insulin on islet amyloid polypeptide (amylin) release from perfused rat pancreas
- … adenylate cyclase by amylin and CGRP: A single receptor displaying apparent negative cooperativity towards CGRP and simple saturation kinetics for amylin, a …
- Insulin-like growth factor-I inhibits insulin and amylin secretion in conscious rats
- Amylin as a neuroendocrine hormone
- … for 125I-labelled human alpha calcitonin gene related peptide ([125I] hCGRP alpha) and 125I-labelled Bolton-Hunter rat amylin ([125I] BHrAMY) specific binding sites …
- … or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor
- The stimulatory effect of amylin on mucus secretion in isolated rat trachea
- Unimpaired effect of insulin on glucokinase gene expression in hepatocytes challenged with amylin
- Section Review Oncologic, Endocrine & Metabolic: The amylin, CGRP and calcitonin family of peptides
- Gestational diabetes mellitus is associated with an increase in the total concentration of amylin molecules
- GSK3 involvement in amylin signaling in isolated rat soleus muscle
- Increased secretion and expression of amylin in spontaneously diabetic Goto-Kakizaki rats treated with rhGLP-1 (7–36)
- Pancreatic hormone amylin and integrity of the gastric mucosa
- Induction of acute hyperglycemia, hyperlactemia and hypocalcemia in fed and fasted BALB/c mice by intravenous amylin injection
- Mercury in a commercial preparation of rat amylin.
- Amylin alters the biological action of the incretin hormone GLP-1 (7-36) amide
- Leapin’lizards: Amylin targets diabetes and obesity via incretins
- 8–37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo
- Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic β‐cells
- Chapter viii calcitonin gene-related peptide (cgrp), amylin and adrenomedullin: anatomical localization and biological functions in the mammalian and human brains
- Amylin prevents TRAIL-mediated apoptotic effects of reserpine in the rat gastric mucosa
- Development and characterization of monoclonal antibodies specific for amylin
- Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin
- Intestinal ischaemia-reperfusion increases plasma amylin concentration in rats
- Effects of amylin and salmon calcitonin on β-endorphin-induced growth hormone and prolactin secretion in the rat
- Human amylin mimicks amyloid β protein-induced reactive gliosis and inhibition of cellular redox activity in cultured astrocytes
- Nucleotide sequence of a cDNA for canine amylin
- Amylin peptide levels are raised in infants of diabetic mothers
- INVOLVEMENT OF DA1AND DA2RECEPTORS IN THE GASTROPROTECTIVE ACTIVITY OF AMYLIN IN THE RAT
- Lack of islet amyloid polypeptide/amylin-immunoreactivity in urine collected from healthy volunteers after ingestion of a carbohydrate-rich meal
- Cardiac consequences of increased amylin secretion in diabetics
- Synthesis of biologically active tritiated amylin and salmon calcitonin analogues
- Histamine H1-receptors differentially mediate the action of amylin on hypothalamic neurons in control and in overweight rats
- Fibrillogenic amylin evokes the apoptosis of human mesangial cells
- What makes an amylin receptor?
- Strong Promoter Activity of Human and Rat Islet Amyloid Polypeptide/Amylin Gene Constructs in Mouse Beta Cells (βTC 3)
- Amylin as an additional possible pathogenic factor in NIDDM and the insulin resistance syndrome
- The CGRP family: calcitonin gene-related peptide (CGRP), amylin and adrenomedullin
- Examination of somatostatin involvement in the inhibitory action of GIP, GLP-1, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist …
- Effect of amylin on prolactin release
- Alpha2-adrenoceptors and the regulation of glucose, insulin and amylin levels in diabetic rats
- The ability of amylin to reduce eating depends on the protein content of the diet
- … for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes: linkage studies of the islet amyloid polypeptide/amylin and liver glycogen …
- Islet amyloid polypeptide (amylin) does not seem to be directly involved in the development of gestational diabetes mellitus
- Integrated neurohormonal approach to the treatment of obesity: the amylin agonist pramlintide and its interactions with leptin and PYY signaling pathways
- Transient increase of rat gastric amylin in the neonatal period and in experimental ulcers
- Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats
- Renal amylin binding in normotensive and hypertensive rats: effects of angiotensin converting enzyme inhibition with perindopril
- Amylin/IAPP (islet amyloid polypeptide)–physiology and clinical significance
- Amylin, the kidney and hypertension
- Backbone‐modified amylin derivatives: implications for amyloid inhibitor design and as template for self‐assembling bionanomaterials
- Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin (20–29)
- Effect of (8–32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat
- High plasma amylin/islet amyloid polypeptide levels in patients with residual medullary thyroid carcinoma after total thyroidectomy
- β-cell tropin-and glucose-induced hypersecretion of insulin and amylin from perfused fatty rat pancreas
- Calcitonin gene-related peptide-induced suppression of atrial natriuretic peptide release through receptors for CGRP1 but not for calcitonin and amylin
- Amylin/islet amyloid polypeptide expression in medullary carcinoma of the thyroid: correlation with the expression of the related calcitonin/CGRP genes
- Administration of human amylin increases plasma renin activity and plasma aldosterone in man.
- Direct inhibitory effect of adrenomedullin, calcitonin gene-related peptide, calcitonin, and amylin on cholecystokinin-induced contraction of guinea-pig isolated caecal …
- Interaction of Human Amylin with Phosphatidylcholine and Phosphatidylserine Membranes
- The vasorelaxant effect of adrenomedullin, proadrenomedullin N‐terminal 20 peptide and amylin in human skin
- Amylin Expression in the Pancreatic β-Cell
- Inhibitory effect of amylin on growth hormone responsiveness to growth-hormone-releasing hormone in the rat
- Amylin impairment of insulin effects on glycogen synthesis and phosphoenolpyruvate carboxykinase gene expression in rat primary cultured hepatocytes
- Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells
- Effect of synthetic human amylin on glycogen synthesis in skeletal muscle in vivo
- Release of amylin from perfused rat pancreas in response to glucose and glucagon
- Molecular form of islet amyloid polypeptide (amylin) released from isolated rat islets of Langerhans
- Determinants of BIBN4096BS affinity for CGRP and amylin receptors; the role of RAMP1
- Effect of amylin on islet cell secretion
- Mercury contamination of rat amylin mimics vasoactivity and cytotoxic effects
- Pramlintide (human amylin analogue) as an adjunct to insulin therapy in patients with type 1 diabetes improved glycemic control over 2 years
- Effect of amylin on mast cell secretion as a possible mechanism increasing gastric mucosa resistance
- Amylin does not suppress hypoglycemia-induced secretion of glucagon in rats
- Amylin-immunoreactivity in monkey hypothalamus
- Effects of pancreatic polypeptide amylin on ulceration and acid gastric Secretion
- Calcitonin gene-related peptide (CGRP), adrenomedullin (AM), amylin, and calcitonin (CT) receptors and overlapping biological actions
- The selective amylin antagonist, AC413, prevents sucrose-induced increases in mean arterial pressure in rats.
- Compared to wild-type human amylin, S20G mutant amylin exhibits increased cytotoxicity in transfected COS-1 cells and increased amyloidogenicity in vitro
- An amylin antagonist has opposite effects to amylin on basal lipids and counteracts insulin resistance in high fat fed rats
- Therapeutic potential of human amylin analogues in diabetes mellitus
- Amylin evokes protein p20 phosphorylation and insulin resistance in rat skeletal muscle extensor digitorum longus
- Diabetes II and amylin: a modern perspective
- Amylin and calcitonin gene-related peptide
- The effects of systemic administration of amylin on the tibia of laying hens
- Hepatocyte nuclear factor 1 negatively regulates amylin gene expression
- 5. New Type of Amyloidosis b) Islet Amyloid Polypeptide (IAPP/Amylin) in Non-Insulin-Dependent Diabetes Mellitus
- Role of amylin in the pathogenesis of type II diabetes mellitus
- Effect of islet amyloid polypeptide (IAPP/amylin) on 2-deoxyglucose uptake in mouse pancreatic acini
- –To: Poa NR, Cooper GJS, Edgar PF: Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori. Diabetologia 46: 574–578
- Additive effect of islet amyloid polypeptide (IAPP/amylin) and insulin on 2-deoxyglucose uptake in mouse pancreatic acini
- Amylin and Incretin Enhancers for Diabetes Type 2
- Amylin: its potential role in the etiopathogenicity of diabetes mellitus
- Amylin hormone, leptin and other metabolic hormones in preterm babies
- Advance of the relation in amylin and insulin resistance
- Construction of transgenic mouse system expressing human islet amyloid polypeptide (IAPP)/amylin
- Amylin competes for binding sites of CGRP in the chamber angle and uvea of monkey, cat, and pig eye
- Amylin and Calcitonin Gene-Related Peptide
- β‐Amyloid peptides 1–40βA and 25–35βA suppress human amylin‐mediated death of RINm5F islet β‐cells with distinct actions on fibril formation
- Amyloidogenic peptides such as beta-amyloid, amylin and calcitonin strongly enhance the susceptibility of rat hippocampal neurons to excitatory amino acids in vivo
- Protective action of amylin on ulcer model of pylorus ligation
- Postpartum evaluation of amylin secretion in gestational diabetes mellitus
- Effect of amylin on insulin secretion in rat pancreatic islets and its mechanism
- Sustained Glucose-Lowering and Gastric-Emptying Effects of Amylin Agonism in Rats
- Effects of Pramlintide (Amylin Agonist) in Type 1 Diabetes are not mediated by GLP-1 (7-36) amide
- Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin transgenic mice
- Amylin, 8. L protein Introduction
- The effect of different glucose endovenous administrations on amylin and insulin blood concentration in healthy subjects.
- Protective antiulcer and analgetic actions of amylin-islet pancreatic polypeptide
- Serum amylin correlates with delayed gastric emptying in critically ill children
- If You Poison Us Do We Not Die-A Critical Analysis of the Legality of Poison Puts in the Wake of San Antonio Fire & Police Pension Fund v. Amylin, Inc.
- The Roles of Amylin in the Periphery
- Pharmacology of amylin action
- Good news for Amylin
- Zirkadiane anorektische Effekte von peripher verabreichtem Amylin bei Ratten
- Amylin and its role in metabolic control
- Functional study of amylin and regulation of amylin receptor
- Environmental effects on conformational diseases. Reactive oxygen species and membrane interactions with prion, amylin and their peptide fragments
- mRNA profiling of pancreatic islets isolated from persistent hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) reveals low amylin gene expression
- Aspirations for amylin-will they be realised?
- Peptide and protein structure in aqueous hexafluoroisopropanol:(I) Monomeric and beta-aggregate forms of human amylin.(II) Cold denaturation of alpha …
- The Effect of Amylin on Insulin Action in Cultured Cells
- Amylin peptides
- Study of serum amylin level among Egyptian obese patients
- Role of amylin in the regulation of energy metabolism in health and disease
- Effect of Ensure® overfeeding on the anorectic effect of amylin
- Acute pancreatitis: epidemiology and relationship to amylin
- Characterisation of human amylin transgenic mice
- Amyloidogenesis in type II diabetes: aggregation and stability of human amylin
- Molecular mechanism of human amylin-mediated cytotoxicity
- AMYLIN: A PEPTIDE REGULATING FAT STORES?
- Variability of Amylin Gene in Korean Subjects
- Ser2001y Mutation of Amylin in Essential Hypertensives
- Amylin is a Substrate for Insulin-Degrading Enzyme (IDE)
- Treatment of diabetes mellitus with amylin agonists
- Treatment of diabetes mellitus with amylin agonists
- The effect of amylin on glucose metabolism in skeletal muscle
- Spectroscopic Characterization of PEG-Amylin Derivatives
- Amylin Pharmaceuticals, Inc., San Diego, CA
- Amylin Pharmaceuticals: Diabetes and Beyond
- Amylin–a partner hormone to insulin
- Studies of the amylin signalling pathway in skeletal muscle with respect to carbohydrate metabolism
- Central modulation of the feeding response to amylin by leptin and insulin.
- Amylin: Another beta-cell killer.
- Amyloid formation by human amylin
- Transcription of the amylin gene in newborn dogs
- Amylin Detection on a Miniature Optical Fiber Sensor
- IN VITRO zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA AUTORADIOGRAPHIC LOCALIZATION OF AMYLIN BINDING SITES IN RAT …
- Clinical Characteristics of S20G Mutation of Amylin Gene in Korean Type 2 Diabetic Patients.
- Structural analysis of amylin and its analogs by NMR spectroscopy
- Spontaneous Diabetes in Hemizygous Human-amylin Transgenic Mice without Islet Amyloid Formation
- Augmenting With Amylin: Hormone slows bone breakdown
- Immunocytochemical Expression of Amylin in Pancreatic Islets of Man, Rabbit and Guinea Pig
- Amylin and insulin resistance in diabetic patients with liver cirrhosis
- Central amylin causes more potent anorexigenic effects in chicks selected for low rather than high body weight
- Amylin stimulates plasma renin activity by a mechanism distinct from that of CGRP.
- Polymorphism and assembly dynamics of amylin fibrils
- Ya Huang, Amylin Pharmaceuticals, Inc., San Diego, CA
- Experimental study of amylin-induced functional damage to rat pancreatic islet cells in vitro
- Influence of amylin on apoptosis of human pancreatic islet?-cells and its molecular mechanism
- The influence of amylin on glucose metabolism in mouse hepatocytes is independent of cAMP
- Study of serum amylin in liver cirrhosis with diabetes mellitus
- The effects of human amylin over-expression in a transgenic model of diabetes mellitus
- Effect of islet amyloid polypeptide (Amylin) on glucose metabolism and secretion of insulin in the rats
- Effects of amylin on bone development and egg production in hens
- Activation of ghrelin and amylin in the subfornical organ in rat slice preparations
- Islet human amylin oligomer formation is differentially correlated with β-cell death and diabetes onset between homozygous and hemizygous human amylin …
- Amylin sensitivity and secretion following diet-induced obesity in rats
- Characterisation of calcitonin generelated peptide (CGRP) and amylin receptors
- Islet amyloid polypeptide (IAPP, amylin) in dexamethasone treated rats
- Human IAPP/amylin overproducing transgenic mice: Characterization of an animal model to study the role of IAPP in the pathogenesis of Type 2 diabetes
- calcitonin-gene-related peptide and amylin
- Amylin Levels Decrease 1 Month After Roux–en-Y Gastric Bypass Surgery in Patients with Type 2 Diabetes.
- Study of factors affecting amylin fibril formation and the characterization of a protein which prevents amyloidogenesis
- Identification and Characterization of an Insulin Based Inhibitor of Amylin and Aβ40 Amyloid Formation
- Lack of Association between the S20G Missense Mutation of Amylin Gene and Essential Hypertension in Korean Population
- Calcitonin/Amylin Receptors and Ramps
- Calcitonin, amylin, CGRP and adrenomedullinbph_501_14 30.. 31
- Human and Rat Amylin: Syntheses, Structures and Binding Sites
- Central amylin decreases appetite and total food transit rate in 4‐day post hatch chicks
- Amylin and Neuromedin U-Two Novel Regulatory Peptides of the Gastroenteropancreatic System
- Combination therapy with amylin and PYY (3–36) in diet-induced obese rats: A response surface analysis.
- Effect of amylin on biomechanical properties of the femur in glucocorticoid-induced osteoporosis rats
- No Association of the S20g Mutation of Amylin Gene with Insulin Secretion, Insulin Sensitivity, and Diabetes Mellitus in Taiwanese
- Amylin Gene Sequence of the Amyloidogenic Region in the Velvet Monkey (Chlorocebus aethiops).
- Selection and preliminary identification of human Fab fragement antibody against amylin from phage antibody library.
- Calcitonin, amylin, CGRP and adrenomedullin
- Receptors for adrenomedullin, amylin, and parathyroid hormone: identification, pharmacological characterization and cellular mechanisms
- The mechanism of death evoked by human amylin in pancreatic islet B cells
- Effects of oral glucose ingestion on plasma amylin concentration in diabetic and nondiabetic humans.
- Collapse Of Rat And Human Amylin From Nanosecond-resolved Intramolecular Contact Formation
- New regulatory peptides in rat stomach secretion (amylin, PGP, semax)
- Calcitonin gene-related peptide (CGRP), amylin
- Involvement of amylin and leptin in early developmental programming of brain pathways controlling energy balance and body weight
- Bombesin but not amylin blocks the orexigenic effect of peripheral ghrelin
- Effects of amylin on bone minernal density and structure parameters of bone tissue in glucocorticoid-induced osteoporosis rats
- Dark-Cycle Feeding and Meal Pattern Analysis in Rats Following Peripheral Administration of the Novel Amylin-Mimetic Peptide Davalintide
- … Mobilizes [Ca2+]i and Stimulates the Release of Pancreatic Digestive Enzymes From Rat Acinar AR42J Cells: Evidence for an Exclusive Receptor System of Amylin
- Role of Amylin and Calcitonin-Gene-Related Peptide (CGRP) in the Control of Food Intake
- Alain D. Baron has joined Amylin Pharmaceuticals (San Diego, CA) as vice president, clinical research. Dr. Baron joins the company from Indiana University School of …
- Amylin Enhances Glucose Stimulated Insulin Release From Neonatal Rat Pancreatic Islets.
- The effects of amylin on the islet beta-cells voltage-gated L-calcium channels in rats
- Acute Experimental Pancreatitis in Rats Is Ameliorated by Treatment with Pramlintide, a Synthetic Analogue of the β-Cell Hormone Amylin: 189
- Neurotrophic effects of amylin during development of brainstem projections involved in energy homeostasis
- Cardiovascular and metabolic responses to peripheral leptin infusion in rats: Role of amylin in leptin sensitivity
- Fas-associated death receptor signaling evoked by human amylin in islet β-cellsd
- Co-secretion of amylin and insulin from a clonal mouse β-cell line: modulation by nutrient secretagogues, somatostatin and a somatostatin analogue
- Aggregation of Amylin in type II diabetes: Molecular recognition elements in islet amyloid assembly and functional inhibition
- Potent combination of amylin and leptin reduces food intake, blood pressure, and orexigenic neuropeptides in obese FBNF1 rats
- Amylin excites a subset of proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) via enhancing the excitatory glutamatergic synaptic inputs
- Solid state NMR investigations of lipid bilayers and biomembrane binding molecules: Dendrimers and amylin
- Fas-associated Death Receptor Signalling Evoked by Human Amylin in Islet B-cells
- Human Amylin-induced Apoptosis of RINm5F Islet β-cells is Associated with Increased Reactive Oxygen Species, but not Nitric Oxide or Zinc Ion
- Peptide fragments from amylin, calcitonin, and alpha-lactalbumin as models of protein aggregation and protein folding
- 3P-047 Kinetic association of amylin fibrils and lipid vesicles (The 46th Annual Meeting of the Biophysical Society of Japan)
- … K, Aroda V, Chen K, Halseth A, Kesty NC, Burns C, Lush CW, Weyer C: Progressive reduction in body weight after treatment with the amylin analog pramlintide in …
- … chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP supress misfolding and formation of beta-sheet-containing aggregates by human amylin: apotential role for …
- … -1 LOWERS mRNA LEVEL OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (PEPCK) GENE, BUT DOES NOT SUPPRESS AMYLIN GENE EXPRESSION IN …
- Characterization of the amyloidogenic subunits Aβ 1-4 0, Aβ 1-4 2, Aβ 1-4 0 (Dutch) and amylin: heparin-binding properties and multiple effects of Congo red.
- Changes Occurring in the Concentration of Insulin-like Growth Factor-1, Amylin and in Insulin in Relation to Diabetes Melltius
- Amylin: pharmacology, physiology, and clinical potential
- Creating the amylin story
- Control of energy homeostasis by amylin
- pH dependence of amylin fibrillization
- Amylin deposition in the brain: a second amyloid in Alzheimer disease?
- Amylin structure–function relationships and receptor pharmacology: implications for amylin mimetic drug development
- Primer on pramlintide, an amylin analog
- Amyloidogenesis of the amylin analogue pramlintide
- Role of amylin in type 1 and type 2 diabetes
- Development of cagrilintide, a long-acting amylin analogue
- Amylin brain circuitry
- Mechanism of amylin fibrillization enhancement by heparin
- A structural basis for amylin receptor phenotype
- Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes
- Amylin–Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity
- Role and cytotoxicity of amylin and protection of pancreatic islet β-cells from amylin cytotoxicity
- Amylin at the interface between metabolic and neurodegenerative disorders
- Amylin as a potential link between type 2 diabetes and alzheimer disease
- Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin
- Copper (II)–human amylin complex protects pancreatic cells from amylin toxicity
- Neuroprotective effects of the amylin analogue pramlintide on Alzheimer’s disease pathogenesis and cognition
- Amylin as a future obesity treatment
- The interaction of amylin with other hormones in the control of eating
- Neuroendocrine hormone amylin in diabetes
- Amylin modulates the mesolimbic dopamine system to control energy balance
- Interaction of amylin species with transition metals and membranes
- Amylin and its analogs: a friend or foe for the treatment of Alzheimer’s disease?
- The role of copper(ii) in the aggregation of human amylin
- Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress
- Amylin analog pramlintide induces migraine‐like attacks in patients
- Amylin uncovered: a review on the polypeptide responsible for type II diabetes
- Activity of Pramlintide, Rat and Human Amylin but not Aβ1–42 at Human Amylin Receptors
- Effects of amylin on eating and adiposity
- 2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure
- Copper (II) and amylin analogues: A complicated relationship
- Actions of β-amyloid protein on human neurons are expressed through the amylin receptor
- Amylin-mediated control of glycemia, energy balance, and cognition
- Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
- Amylin acts in the central nervous system to increase sympathetic nerve activity
- Hypothalamic amylin acts in concert with leptin to regulate food intake
- Amylin is a novel neuropeptide with potential maternal functions in the rat
- Mechanistic perspective and functional activity of insulin in amylin aggregation
- Amylin: what might be its role in Alzheimer’s disease and how could this affect therapy?
- Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies
- Amylin activates distributed CNS nuclei to control energy balance
- β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor
- Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin
- Human amylin: from pathology to physiology and pharmacology
- Amylin receptor ligands reduce the pathological cascade of Alzheimer’s disease
- Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly
- Monoconjugation of human amylin with methylpolyethyleneglycol
- Long-acting amylin analogues for the management of obesity
- Molecular signature for receptor engagement in the metabolic peptide hormone amylin
- Interictal amylin levels in chronic migraine patients: A case-control study
- The association of circulating amylin with β‐amyloid in familial Alzheimer’s disease
- Mediators of amylin action in metabolic control
- Amylin signaling in diabetes and Alzheimer’s disease: therapy or pathology?
- Peripheral insulin and amylin levels in Parkinson’s disease
- Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
- Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling
- Secondary structure of rat and human amylin across force fields
- Effect of proline mutations on the monomer conformations of amylin
- Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells
- Amylin alters human brain pericyte viability and NG2 expression
- Lessons from two prevalent amyloidoses—what amylin and Aβ have in common
- d-Retro Inverso Amylin and the Stability of Amylin Fibrils
- Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol
- Deamidation accelerates amyloid formation and alters amylin fiber structure
- Ion mobility spectrometry–mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors
- Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice
- Amylin receptor: a common pathophysiological target in Alzheimer’s disease and diabetes mellitus
- Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of …
- Preparation and characterization of PEGylated amylin
- Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice
- Amylin and leptin: co-regulators of energy homeostasis and neuronal development
- Regulation of the assembly and amyloid aggregation of murine amylin by zinc
- CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?
- Amylin receptor components and the leptin receptor are co‐expressed in single rat area postrema neurons
- Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior
- Molecular mechanisms of amylin turnover, misfolding and toxicity in the pancreas
- On the structure of the copper–amylin complex
- Rodent models of leptin receptor deficiency are less sensitive to amylin
- In Silico Cross Seeding of Aβ and Amylin Fibril-like Oligomers
- Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways
- Amylin in Alzheimer’s disease: Pathological peptide or potential treatment?
- Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor
- A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation
- Conformational distribution and α-helix to β-sheet transition of human amylin fragment dimer
- Protein aggregates and proteostasis in aging: Amylin and β-cell function
- Circulating differentially methylated amylin DNA as a biomarker of β-cell loss in type 1 diabetes
- Combined Amylin/GLP-1 pharmacotherapy to promote and sustain long-lasting weight loss
- Probing ion channel activity of human islet amyloid polypeptide (amylin)
- Amylin receptor: a potential therapeutic target for Alzheimer’s disease
- Ionic strength effects on amyloid formation by amylin are a complicated interplay among Debye screening, ion selectivity, and Hofmeister effects
- IAPP/amylin and β-cell failure: Implication of the risk factors of type 2 diabetes
- CGRP, amylin, immunology, and headache medicine
- Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose
- Amylin amyloid inhibition by flavonoid baicalein: key roles of its vicinal dihydroxyl groups of the catechol moiety
- Molecular insights into the oligomerization dynamics and conformations of amyloidogenic and non-amyloidogenic amylin from discrete molecular dynamics …
- Amylin–Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer’s disease
- Inhibition of human amylin aggregation and cellular toxicity by lipoic acid and ascorbic acid
- Structure and thermodynamics of amylin dimer studied by Hamiltonian-temperature replica exchange molecular dynamics simulations
- Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model
- Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans
- Long-acting amylin analogue for weight reduction
- Genistein: a dual inhibitor of both amyloid β and human islet amylin peptides
- The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping
- Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
- Receptor-mediated toxicity of human amylin fragment aggregated by short-and long-term incubations with copper ions
- Amylin treatment reduces neuroinflammation and ameliorates abnormal patterns of gene expression in the cerebral cortex of an Alzheimer’s disease mouse model
- Orientations of residues along the β-arch of self-assembled amylin fibril-like structures lead to polymorphism
- Identification of key interactions in the initial self-assembly of amylin in a membrane environment
- Fractal self-assembly and aggregation of human amylin
- Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
- Molecular simulations indicate marked differences in the structure of amylin mutants, correlated with known aggregation propensity
- Amyloidogenicity, cytotoxicity, and receptor activity of bovine amylin: implications for xenobiotic transplantation and the design of nontoxic amylin variants
- Activation of amylin receptors attenuates alcohol‐mediated behaviours in rodents
- Intraneuronal amylin deposition, peroxidative membrane injury and increased IL-1β synthesis in brains of Alzheimer’s disease patients with type-2 diabetes and in …
- Polymeric particles for the controlled release of human amylin
- GLP‐1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities
- TNF-α acutely upregulates amylin expression in murine pancreatic beta cells
- Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacology
- Association of plasma amylin concentration with Alzheimer disease and brain structure in older adults
- α-helix to β-hairpin transition of human amylin monomer
- Amylin selectively signals onto POMC neurons in the arcuate nucleus of the hypothalamus
- Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease
- Heme bound amylin: spectroscopic characterization, reactivity, and relevance to type 2 diabetes
- Amylin and calcitonin: potential therapeutic strategies to reduce body weight and liver fat
- Human Amylin in the Presence of SARS-COV-2 Protein Fragments
- Amylin as a potential link between type 2 diabetes and Alzheimer disease
- Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake
- Effect of amylin on memory and central insulin resistance in a rat model of Alzheimer’s disease
- Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer’s disease
- Active-site environment of copper-bound human amylin relevant to type 2 diabetes
- Distributed amylin receptor signaling and its influence on motivated behavior
- Heterogeneous amylin fibril growth mechanisms imaged by total internal reflection fluorescence microscopy
- The impact of exposure profile on the efficacy of dual amylin and calcitonin receptor agonist therapy
- Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases
- Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signaling
- Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese
- Benzbromarone, quercetin, and folic acid inhibit amylin aggregation
- Amylin receptor signaling in the nucleus accumbens negatively modulates μ-opioid-driven feeding
- Positive association between plasma amylin and cognition in a homebound elderly population
- Change of plasma amylin after bariatric surgery challenged by oral glucose is associated with remission of type 2 diabetes mellitus
- A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
- A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats
- Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases
- An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder
- An amylin analog used as a challenge test for Alzheimer’s disease
- An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain
- Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells
- Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates
- Systemic and central amylin, amylin receptor signaling, and their physiological and pathophysiological roles in metabolism
- Neuroprotective effects of the amylin analog, pramlintide, on Alzheimer’s disease are associated with oxidative stress regulation mechanisms
- The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells
- Amylin Dyshomeostasis Hypothesis: Small Vessel–Type Ischemic Stroke in the Setting of Type-2 Diabetes
- Does receptor balance matter?–Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic …
- Amylin and GLP-1 target different populations of area postrema neurons that are both modulated by nutrient stimuli
- Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines
- Inhibition of human amylin fibril formation by insulin-mimetic vanadium complexes
- Calcitonin and amylin receptor peptide interaction mechanisms: insights into peptide-binding modes and allosteric modulation of the calcitonin receptor by …
- Hypothalamic anorexigenic signaling pathways (leptin, amylin, and proopiomelanocortin) are semaglutide (GLP-1 analog) targets in obesity control in mice
- Rosmarinic acid potently detoxifies amylin amyloid and ameliorates diabetic pathology in a transgenic rat model of type 2 diabetes
- Disaggregation of amylin aggregate by novel conformationally restricted aminobenzoic acid containing α/β and α/γ hybrid peptidomimetics
- Characterizing the assembly behaviors of human amylin: a perspective derived from C-terminal variants
- Copper (II) complexes of rat amylin fragments
- Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity
- Amylin, bariatric surgery, and type 2 diabetes mellitus
- Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries
- High-fat diet increases amylin accumulation in the hippocampus and accelerates brain aging in hIAPP transgenic mice
- Rapid assessment of human amylin aggregation and its inhibition by copper (II) ions by laser ablation electrospray ionization mass spectrometry with ion mobility …
- Analysis of amylin consensus sequences suggests that human amylin is not optimized to minimize amyloid formation and provides clues to factors that modulate …
- Date palm (Phoenix dactylifera L.) fruit’s polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes
- Olive component oleuropein promotes β-cell insulin secretion and protects β-cells from amylin amyloid-induced cytotoxicity
- Neuroprotective effects of amylin analogues on Alzheimer’s disease pathogenesis and cognition
- Anti-aggregation effect of carbon quantum dots on diabetogenic and beta-cell cytotoxic amylin and beta amyloid heterocomplexes
- Insight into a new binding site of zinc ions in fibrillar amylin
- Mutations and seeding of amylin fibril-like oligomers
- α-CGRP disrupts amylin fibrillization and regulates insulin secretion: Implications on diabetes and migraine
- Amyloidogenesis of feline amylin and plasma levels in cats with diabetes mellitus or pancreatitis
- Thermodynamic surprises of Cu (II)–amylin analogue complexes in membrane mimicking solutions
- High-speed atomic force microscopy reveals the structural dynamics of the amyloid-β and amylin aggregation pathways
- Varicella-zoster virus infection of primary human spinal astrocytes produces intracellular amylin, amyloid-β, and an amyloidogenic extracellular environment
- Glycosylation of pramlintide: synthetic glycopeptides that display in vitro and in vivo activities as amylin receptor agonists
- Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication
- Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models
- Undercover toxic ménage à trois of Amylin, Copper (II) and Metformin in human embryonic kidney cells
- IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation
- The calcitonin receptor plays a major role in glucose regulation as a function of dual amylin and calcitonin receptor agonist therapy
- Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure–activity relationships for amylin receptor agonism
- Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels
- The role of leptin in the sporadic form of Alzheimer’s disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin
- Molecular mechanisms of the bindings between non-amyloid β component oligomers and amylin oligomers
- Amylin/Calcitonin receptor–mediated signaling in POMC neurons influences energy balance and locomotor activity in chow-fed male mice
- Effects of forcefield and sampling method in all-atom simulations of inherently disordered proteins: Application to conformational preferences of human amylin
- Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes
- Amylin and amylin receptors in Alzheimer’s disease
- ADO09, a co‐formulation of the amylin analogue pramlintide and the insulin analogue A21G, lowers postprandial blood glucose versus insulin lispro in type 1 …
- A novel dual amylin and calcitonin receptor agonist, KBP‐089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference
- The dual amylin and calcitonin receptor agonist KBP-088 induces weight loss and improves insulin sensitivity superior to chronic amylin therapy
- KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats
- Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene–related peptide and amylin-induced pain in mice
- The removal of disulfide bonds in amylin oligomers leads to the conformational change of the ‘native’amylin oligomers
- A single pseudoproline and microwave solid phase peptide synthesis facilitates an efficient synthesis of human amylin 1–37
- Amylin induces hypoglycemia in mice
- Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis
- Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide
- Stepwise oligomerization of murine amylin and assembly of amyloid fibrils
- Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR
- Amylin enhances amyloid-β peptide brain to blood efflux across the blood-brain barrier
- Genetic depletion of amylin/calcitonin receptors improves memory and learning in transgenic Alzheimer’s disease mouse models
- Hypoglycemia attenuates acute amylin-induced reduction of food intake in male rats
- Effect of Zn 2+ ions on the assembly of amylin oligomers: insight into the molecular mechanisms
- Pramlintide antagonizes beta amyloid (Aβ)-and human amylin-induced depression of hippocampal long-term potentiation
- Inhibition of human amylin aggregation by Flavonoid Chrysin: An in-silico and in-vitro approach
- Amylin and diabetic cardiomyopathy–amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium
- Charge-based inhibitors of amylin fibrillization and toxicity
- The dual amylin‐and calcitonin‐receptor agonist KBP‐042 increases insulin sensitivity and induces weight loss in rats with obesity
- Amylin pharmacology in Alzheimer’s disease pathogenesis and treatment
- Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer’s disease
- THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin–physiology and pharmacology
- The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
- Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele
- Charge effects at nano-bio interfaces: a model of charged gold nanoclusters on amylin fibrillation
- Amylin and leptin interaction: role during pregnancy, lactation and neonatal development
- Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives
- The role of two natural flavonoids on human amylin aggregation
- Gut hormones such as amylin and GLP-1 in the control of eating and energy expenditure
- Feasibility of amylin imaging in pancreatic islets with β-amyloid imaging probes
- Optimization of tolerability and efficacy of the novel dual amylin and calcitonin receptor agonist KBP-089 through dose escalation and combination with a GLP-1 …
- Molecular dynamics simulation study on the molecular structures of the amylin fibril models
- Slow internal dynamics and charge expansion in the disordered protein CGRP: A comparison with amylin
- Structural modulation of human amylin protofilaments by naturally occurring mutations
- Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines
- Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain
- Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway
- Activation of the amylin pathway modulates cocaine-induced activation of the mesolimbic dopamine system in male mice
- Involvement of amylin and leptin in the development of projections from the area postrema to the nucleus of the solitary tract
- Suppl 2: amylin analogues in the treatment of diabetes mellitus: medicinal chemistry and structural basis of its function
- Role of cholesterol and phospholipids in amylin misfolding, aggregation and etiology of islet amyloidosis
- Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and …
- Assembly behavior of amylin fragment hIAPP19-37 regulated by Au (III) complexes
- Amylin exerts osteogenic actions with different efficacy depending on the diabetic status
- Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes
- Chiral effect at nano-bio interface: a model of chiral gold nanoparticle on amylin fibrillation
- Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice
- Amylin may offer (more) help to treat postmenopausal obesity
- Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat
- Rapid, scalable assay of amylin-β amyloid co-aggregation in brain tissue and blood
- Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice
- Improved metabolic efficacy of a dual amylin and calcitonin receptor agonist when combined with semaglutide or empagliflozin
- Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice
- Role of mass spectrometry in the study of interactions between amylin and metal ions
- Whole‐brain mapping of amylin‐induced neuronal activity in receptor activity–modifying protein 1/3 knockout mice
- Sequence specificity of amylin-insulin interaction: a fragment-based insulin fibrillation inhibition study
- Amylin Protein Expression in the Rat Brain and Neuro-2a Cells
- The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and …
- Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced …
- Aggregation of amylin: Spectroscopic investigation
- Salmon calcitonin exerts an antidepressant effect by activating amylin receptors
- Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state
- Delayed response of amylin levels after an oral glucose challenge in children with Prader-Willi syndrome
- Effects of a selective long‐acting amylin receptor agonist on alcohol consumption, food intake and body weight in male and female rats
- Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization
- Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons
- Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists
- Sub-toxic human amylin fragment concentrations promote the survival and proliferation of SH-SY5Y cells via the release of VEGF and HSPB5 from endothelial RBE4 …
- Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts
- Influence of human amylin on the membrane stability of rat primary hippocampal neurons
- Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
- Heterogeneous triangular structures of human islet amyloid polypeptide (amylin) with internal hydrophobic cavity and external wrapping morphology reveal the …
- Amylin conjugation with methoxyl polyethyleneglycol
- Proteasome regulates turnover of toxic human amylin in pancreatic cells
- Combined amylin–leptin treatment lowers blood pressure and adiposity in lean and obese rats
- How to blast osteoblasts? Novel dicarba analogues of amylin-(1–8) to treat osteoporosis
- Zinc Interactions with a Soluble Mutated Rat Amylin to Mimic Whole Human Amylin: An Experimental and Simulation Approach to Understand Stoichiometry …
- Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice
- Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic
- Amylin–leptin coadministration stimulates central histaminergic signaling in rats
- Active-site environment of Cu bound amyloid β and amylin peptides
- Physico-chemical stability of co-formulation of PEGylated human amylin with insulin
- Monitoring oligomer formation from self-aggregating amylin peptides using ESI-IMS-MS
- … on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 …
- A selective role for receptor activity‐modifying proteins in subchronic action of the amylin selective receptor agonist NN1213 compared with salmon calcitonin on body …
- Quantification of protein aggregation rates and quenching effects of amylin–inhibitor complexes
- Incretins, amylin and other gut‐brain axis hormones in children with coeliac disease
- The long-acting amylin/calcitonin receptor agonist ZP5461 suppresses food intake and body weight in male rats
- MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2
- Endogenous amylin and glucagon‐like peptide‐1 concentrations are not associated with gastric emptying in critical illness
- Human islet amyloid polypeptide overexpression in INS-1E cells influences amylin oligomerization under ER stress and oxidative stress
- Amylin in the insulin resistance of patients with rheumatoid arthritis
- Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome
- The dual amylin-and calcitonin-receptor agonist KBP-042 works as adjunct to metformin on fasting hyperglycemia and HbA1c in a rat model of type 2 diabetes
- Effect of two herbal polyphenol compounds on human amylin amyloid formation and destabilization
- Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin)
- Amylin blunts hyperphagia and reduces weight and fat gain during recovery in socially stressed rats
- Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore
- Amylin stimulates fatty acid esterification in 3T3-L1 adipocytes
- Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in …
- Dose frequency optimization of the dual amylin and calcitonin receptor agonist KBP-088: long-lasting improvement in food preference and body weight loss
- The link between type 2 diabetes and neurodegeneration: roles for amyloid-β, amylin, and tau proteins
- Pramlintide: an amylin analogue protects endothelial cells against oxidative stress through regulating oxidative markers and NF-κb expression
- Bloodborne Pancreatic Amylin, a Therapeutic Target for Alzheimer’s Disease
- Effect of agitation on the peptide fibrillization: Alzheimer’s amyloid‐β peptide 1‐42 but not amylin and insulin fibrils can grow under quiescent conditions
- Heme bound amylin self-assembled monolayers on an Au electrode: an efficient bio-electrode for O 2 reduction to H 2 O
- Be positive: optimizing pramlintide from microcanonical analysis of amylin isoforms
- Novel amylin analogues reduce amyloid-β cross-seeding aggregation and neurotoxicity
- Valsartan inhibits amylin-induced podocyte damage
- Amylin, Aβ42, and amyloid in varicella Zoster virus vasculopathy cerebrospinal fluid and infected vascular cells
- Plasma amylin and cognition in diabetes in the absence and the presence of insulin treatment
- Dual amylin and calcitonin receptor agonist treatment improves insulin sensitivity and increases muscle-specific glucose uptake independent of weight loss
- A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model
- Serum preptin and amylin levels with respect to body mass index in polycystic ovary syndrome patients
- Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction‐induced weight loss in rats
- Relation between serum amylin level and epilepsy
- BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats
- Amperometric immunoassay for the obesity biomarker amylin using a screen printed carbon electrode functionalized with an electropolymerized carboxylated …
- Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry
- Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model
- Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin …
- Noncompetitive affinity assays of glucagon and amylin using mirror-image aptamers as affinity probes
- Mouse Microglial Calcitonin Receptor Knockout Impairs Hypothalamic Amylin Neuronal pSTAT3 Signaling but Lacks Major Metabolic Consequences
- Effects of amylin on food intake and body weight via sympathetic innervation of the interscapular brown adipose tissue
- The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia
- Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats
- First-phase insulin and amylin after bariatric surgery: a prospective randomized trial on patients with insulin resistance or diabetes after gastric bypass or …
- Amylin level and gastric emptying in obese children: before and after weight loss
- Comment on Yoo et al. Amylin Protein Expression in the Rat Brain and Neuro-2a Cells. Int. J. Mol. Sci. 2022, 23, 4348
- Inhibition of human amylin amyloidogenesis by human amylin-fragment peptides: Exploring the effects of serine residues and oligomerization upon inhibitory potency
- Full length amylin oligomer aggregation: insights from molecular dynamics simulations and implications for design of aggregation inhibitors
- Complete characterization of the mutation landscape reveals the effect on amylin stability and amyloidogenicity
- Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells
- Identification, tissue distribution, and anorexigenic effect of amylin in Siberian sturgeon (Acipenser baeri)
- Serum preptin and amylin values in psoriasis vulgaris and Behçet’s patients
- Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression
- Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer’s Disease in a Mouse Model
- The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formation
- The dual amylin and calcitonin receptor agonist, KBP-066, induces an equally potent weight loss across a broad dose range while higher doses may further improve …
- Cyclic N-terminal loop of amylin forms non amyloid fibers
- The increase in the number of amylin neurons in the medial preoptic area throughout the lactational period and its relationship with melanin-concentrating hormone
- The central anorexigenic mechanism of amylin in Japanese quail (Coturnix japonica) involves pro-opiomelanocortin, calcitonin receptor, and the arcuate nucleus of …
- Silibinin protects rat pancreatic β‐cell through up‐regulation of estrogen receptors’ signaling against amylin‐ or Aβ1–42‐induced reactive oxygen species/reactive …
- Glycomacropeptide Impacts Amylin-Mediated Satiety, Postprandial Markers of Glucose Homeostasis, and the Fecal Microbiome in Obese Postmenopausal …
- Peptide conjugates of benzene carboxylic acids as agonists and antagonists of amylin aggregation
- In silico comparative study of human and porcine amylin
- PEGylated prodrugs of antidiabetic peptides amylin and GLP-1
- Palatable food access impacts expression of amylin receptor components in the mesocorticolimbic system
- Amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice
- Amylin serum levels are upregulated in patients with systemic lupus erythematosus.
- Evolutionary adaptation and amyloid formation: does the reduced amyloidogenicity and cytotoxicity of ursine amylin contribute to the metabolic adaption of bears and …
- … of amyloid aggregates stabilized by main chain H-bond instead of the steric zipper: molecular dynamics study of the amyloidogenic segment of amylin wild-type and …
- Amylin in vasodilation, energy expenditure and inflammation
- The dye SYPRO orange binds to amylin amyloid fibrils but not pre‐fibrillar intermediates
- Quantitative, high-throughput assays for proteolytic degradation of amylin
- Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells
- Human amylin induces CD4+ Foxp3+ regulatory T cells in the protection from autoimmune diabetes
- Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity
- Understanding the mechanism of amylin aggregation: From identifying crucial segments to tracing dominant sequential events to modeling potential aggregation …
- Analysis of prairie vole amylin reveals the importance of the N-terminus and residue 22 in amyloidogenicity and cytotoxicity
- Development of 99mTc-Labeled Pyridyl Benzofuran Derivatives To Detect Pancreatic Amylin in Islet Amyloid Model Mice
- Patatin-like phospholipase domain containing 3-gene (adiponutrin), preptin, kisspeptin and amylin regulates oocyte developmental capacity in PCOS
- Synthesis and evaluation of novel two-photon fluorescence probes for in vivo imaging of amylin aggregates in the pancreas
- Diabetes-related amylin dyshomeostasis: a contributing factor to cerebrovascular pathology and dementia
- Effects of amylin on egg quality traits of hens during the early laying period
- Binding orientations and lipid interactions of human amylin at zwitterionic and anionic lipid bilayers
- Intrathecal amylin and salmon calcitonin affect formalin induced c-fos expression in the spinal cord of rats
- Effects of amylin against amyloid-β-induced tauopathy and synapse loss in primary neurons
- Structural and thermodynamical properties of early human amylin oligomers using replica exchange molecular dynamics: mutation effect of three key residues F15 …
- Treatment sequencing using the dual amylin and calcitonin receptor agonist KBP-336 and semaglutide results in durable weight loss
- Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
- Simultaneous quantification of davalintide, a novel amylin-mimetic peptide, and its active metabolite in beagle and rat plasma by online SPE and LC–MS/MS
- Complex formation of nickel (ii) and zinc (ii) ions with peptide fragments of rat amylin
- An inducible model of human amylin overexpression reveals diverse transcriptional changes
- Amylin modulates the formalin‐induced tonic pain behaviours in rats
- The BDNF protein and its cognate mRNAs in the rat spinal cord during amylin-induced reversal of morphine tolerance
- Role of glucagon-like peptide-1 analogue versus amylin as an adjuvant therapy in type 1 diabetes in a closed loop setting with ePID algorithm
- Inhibition of amylin fibril formation and protection of islet β-cells by medicinal plants
- Insight into the role of the gut-brain axis in alcohol-related responses: Emphasis on GLP-1, amylin, and ghrelin
- Amylin ve glukoz homeostazisi üzerine etkileri
- Potentiometric and spectroscopic studies on the copper (II) complexes of rat amylin fragments. The anchoring ability of specific non-coordinating side chains
- The toxic nature of murine amylin and the immune responsivity of pancreatic islet to conformational antibody in mice
- Role of amylin and its receptors in neurodegeneration
- Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats
- Coordination of Zn 2+ and Cu 2+ to the membrane disrupting fragment of amylin
- Amylin analogs for the treatment of diabetes mellitus
- … dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with …
- Molecular confinement of human amylin in lipidic nanoparticles
- Computational and Experimental Approaches to Design Inhibitors of Amylin Aggregation
- Medicinal plants support the amylin-suppressed viability of islet β-cells
- Structural effects driven by rare point mutations in amylin hormone, the type II diabetes-associated peptide
- GLP-1 and amylin in the treatment of obesity
- Conformational tuning of Amylin by charged styrene-maleic-acid copolymers
- Ion‐Transfer Electrochemistry of Rat Amylin at the Water–Organogel Microinterface Array and Its Selective Detection in a Protein Mixture
- Effects of intrathecal amylin on formalin-induced nociception and on cAMP accumulation in the rat embryonic spinal cells
- Asn‐linked N–acetylglucosamine of the amylin receptor 2 extracellular domain enhances peptide ligand affinity
- Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in …
- Structural Insights into the Polymorphism of Self‐Assembled Amylin Oligomers
- Melanocortin 4 receptor–mediated effects of amylin on thermogenesis and regulation of food intake
- Peripherally administered amylin inhibits stress-like behaviors and enhances cognitive performance
- The Fluorescent Dye 1, 6-Diphenyl-1, 3, 5-hexatriene Binds to Amyloid Fibrils Formed by Human Amylin and Provides a New Probe of Amylin Amyloid Kinetics
- Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro
- Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro
- Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development
- The influence of amylin on the bile acid spectrum in rats
- Preliminary examination of insulin and amylin levels in women with purging disorder
- Inhibition of amyloid formation of amyloid β (1–42), amylin and insulin by 1, 5-diazacyclooctanes, a spermine-acrolein conjugate
- Development of novel PET imaging probes for detection of amylin aggregates in the pancreas
- Heterotropic modulation of amylin fibrillation by small molecules: Implications for formulative designs
- Plasma levels of ghrelin and GLP-1, but not leptin or amylin, respond to a psychosocial stressor in women and men
- The importance of understanding amylin signaling mechanisms for therapeutic development in the treatment of Alzheimer’s disease
- A review of the efficacy and cardiovascular safety of amylin analogues
- Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin
- Firing up brown fat with brain amylin
- Amyloidogenicity and cytotoxicity of des-Lys-1 human amylin provides insight into amylin self-assembly and highlights the difficulties of defining amyloidogenicity
- The correlation between amylin and insulin by treatment with 2-deoxy-D-glucose and/or mannose in rat insulinoma ins-1E cells
- Preparation of uniformly 13C, 15N-labeled recombinant human amylin for solid-state NMR investigation
- Neuroprotective Mechanisms of Amylin Receptor Activation, Not Antagonism, in the APP/PS1 Mouse Model of Alzheimer’s Disease
- Development of peptide-based inhibitors of amylin aggregation employing aromatic and electrostatic repulsion
- Investigation of the Effect of Pyrogallol on the Formation of Amylin Amyloid Fibrils as a Strategy for the Treatment of Type 2 Diabetic Patients: A Theoretical and …
- Establishment of an Adult Medaka Fatty Liver Model by Administration of a Gubra-Amylin-Nonalcoholic Steatohepatitis Diet Containing High Levels of Palmitic Acid …
- Modeling energy intake and body weight effects of a long-acting amylin analogue
- … effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin levels in the …
- Type‐2 Diabetes, Pancreatic Amylin, and Neuronal Metabolic Remodeling in Alzheimer’s Disease
- The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism …
- Amylin: new insight into pathogenesis, diagnosis, and prognosis of non-insulin-dependent diabetes-mellitus-related cardiomyopathy
- Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells
- The effect of pramlintide, an antidiabetic amylin analogue, on angiogenesis-related markers in vitro
- Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy
- Novel radiogallium-labeled pyridyl benzofuran derivative for detection of amylin aggregates in pancreas
- Synergistic long-range effects of mutations underlie aggregation propensities of amylin analogues
- Correlations between endogen amylin hormone and some hormonal, biochemical and bone parameters in pullets
- Brain Distribution and Sexually Dimorphic Expression of Amylin in Different Reproductive Stages of the Zebra Finch (Taeniopygia guttata) Suggest Roles of …
- Intermittent High‐Fat Diet Intake Reduces Sensitivity to Intragastric Nutrient Infusion and Exogenous Amylin in Female Rats
- … cytotoxicity assays of “aggregation‐prone” IAPP8–16 and its non‐amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin
- Effects of heparin on amylin fibrillization
- Functional coupling reactions of human amylin receptor and nicotinic acetylcholine receptors in rat brain neurons.
- Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata
- Expression of Amylin and Preptinin Iraqi Patients with Type 2 Diabetes Mellitus
- Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin
- Incretins and amylin in pediatric diabetes: new tools for management of diabetes in youth
- Amylin perturbs the organization of collagen network
- Effect of eight weeks high-fat diet with endurance training on plasma levels of Amylin in male Wistar rats
- Unambiguous characterization of PEGylation site on human amylin by two‐dimensional nuclear magnetic resonance spectroscopy
- An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis
- Microcanonical insights into the physicochemical stability of the coformulation of insulin with amylin analogues
- Characterization of Novel 18F-Labeled Phenoxymethylpyridine Derivatives as Amylin Imaging Probes
- Catechol-Containing Compounds are a Broad Class of Protein Aggregation Inhibitors: II. Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic …
- Preclinical Efficacy of NN1213, an Amylin Receptor Selective Analogue, in Animal Models of Obesity
- Conformational tuning of amylin by charged SMA copolymers
- Free energy simulations of amylin I26P mutation in a lipid bilayer
- Characterising the signalling profiles of the calcitonin and amylin receptors
- A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ 1–42, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing …
- Involvement of amylin BH2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia–reperfusion-induced myocardial injury in diabetic rats
- Ghrelin, amylin, gastric inhibitory peptide and cognition in middle-aged HIV-infected and uninfected women: the women’s interagency HIV study
- Computational re-engineering of Amylin sequence with reduced amyloidogenic potential
- Molecular Insights into the Role of Water in Early-stage Human Amylin Aggregation
- Effects of Extract and Phenol Glycoside from Rose Petals on the Amylin Fibrils
- Pramlintide: profile of an amylin analog
- Author Correction: Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts
- Skin Capillary Amylin Deposition Resembles Brain Amylin Vasculopathy (S33. 003)
- Amyloidogenic amylin deposits on red blood cells of stroke patients
- Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
- Novel insights into amylin aggregation
- Unique inversion events of residues around the backbone in the turn domain of β-arches in amylin fibrils
- Altered metabolic gene expression in the brain of a triprolyl-human amylin transgenic mouse model of type 2 diabetes
- Study of ZN (II) effect on amylin aggregation
- A case control study demonstrates an increase in plasma amylin associated with chronic migraine
- Amyloid‐β removal from the brain is blocked by circulating amyloid‐forming amylin secreted by the pancreas
- Correction to: IAPP/amylin and β‑cell failure: implication of the risk factors of type 2 diabetes
- Anti-obesity effects of the novel long-acting amylin analogue ZP4982 in high-fat diet fed rats
- Co-aggregation of alpha-synuclein with amylin (HIAPP) leads to an increased risk in type II diabetes patients for developing Parkinson’s disease
- In vivo efficacy of human-derived anti-amylin antibodies in a transgenic mouse model of diabetes mellitus
- Amylin oligomers stabilize membrane rafts
- A direct fluorescence‐based technique for cellular localization of amylin
- Non‐Aggregating Amylin Fragments as an Inhibitors of the Aggregation Process of Susceptible to Aggregation Fragments 18–22, 23–27, and 33–37 of Hormone
- An electrospray ionization study on complexes of amylin with Cu (II) and Cu (I)
- 092 Brain amylin accumulation in Parkinson’s disease is not driven by type 2 diabetes mellitus
- Treatment with a dual amylin and calcitonin receptor agonist improves metabolic health in an old, obese, and ovariectomized rat model
- Female mice exhibit a more sensitive automated squint response to pain induced by CGRP and amylin
- Exploring expression of amylin and CGRP receptors in the rat brain
- Molecular determinants of amylin receptor agonism
- Amylin receptor agonism protects against metabolic side effects of acute olanzapine
- Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus
- Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists
- Serum preptin and amylin levels in acne vulgaris patients
- Thermodynamic Surprises of Cu (II)-Amylin Complexes in Membrane Mimicking Solutions
- Combined GLP-1 Receptor Agonist and Amylin Analogue Pharmacotherapy to Treat Obesity Comorbid With Type 1 Diabetes
- Association of amylin in the development of impaired fasting glucose and impaired glucose tolerance
- Correlation of leptin, neuropeptide Y and amylin in childhood obesity
- The Islet Amyloid Polypeptide hormone Amylin: Its function, effects and uses in medicine
- Structural stability of diabetes-related amylin protofilaments: Applications to fibril design
- Determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation
- Cyclic N terminal fragment of amylin forms non amyloid fibers: implications for intra-and inter-molecular interactions in amylin
- The molecular mechanisms of Stress-Induced Amylin turnover in pancreatic Beta cell
- Amylin
- … Composition and Raft Domain Formation on the IAPP-Membrane Interaction: The Role of Cholesterol on the Inhibition of IAPP (Amylin) Fibrilization and the …
- Correlation of helical propensity in amylin sequences with known aggregation propensity
- Investigation of amylin level changes among obese patients at different glucose metabolic states and effects of rosiglitazone intervention
- Human amylin transgenic mice show elevated core body temperature and increased energy expenditure
- Effects of The Anti-glucagon Treatment (Amylin) on Isolated Hearts Performance in Experimentally Induced Type II Diabetes in Rats
- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin)
- Serum amylin level in Behçet’s disease and relation to parameters of metabolic syndrome and disease activity
- Amylin under examination. Fibrillogenic polypeptide hormone of the pancreas
- Effect of Vernonia amygdalina on the Serum Amylin and Insulin Levels of Alloxan-Induced Diabetic Rats
- Ginger essential oil and citral ameliorate atherosclerosis via modulating TMAO and gut microbiota in ApoE−/− mice fed on Gubra amylin NASH diet with ʟ-carnitine
- Plasma amylin concentration in suckling goat neonates and its relationship with C-reactive protein, selected biochemical and hormonal indicators
- IDF21-0191 Plumbagin and Plumbagin amino acid ester conjugates inhibit amylin priori and post-priori
- Dual Amylin and Calcitonin Receptor Agonists: A Novel Treatment for Obesity and Related Co-Morbidities
- BZ043, a Novel Amylin Analog, in a Fixed Combination with Insulin Glargine—Nonclinical Results
- In Silico cross seeding of A# and amylin fibril-like oligomers
- Inhibition of human amylin aggregation: in silico and in vitro studies
- Rosmarinic acid, a catechol‐containing natural product, potently inhibits amylin amyloidosis
- Relation between serum amylin level and epilepsy
- Hsp70 Delays Amyloid Aggregation of Amylin by Inhibiting Primary Nucleation
- Analogues of amylin, alpha-glucosidase inhibitors and the digestive system in homeostasis regulation
- Localization of amylin‐like immunoreactivity in the striped velvet gecko pancreas
- Leptin and Amylin Influence the Excitability of Area Postrema Neurons, Possibly via cAMP‐Mediated Mechanisms
- Effect Of Aqueous Alcoholic Extract Of Devil’s Claw On The Serum Levels Of Adiponectin, Agouti, Omentin, Amylin, Orexin A, Resistin, Chemerin, Ghrelin, Leptin, NPY …
- Defining Sequence Determinants of Amylin Amyloid Formation Through Complementary Approaches
- Early Events in the Onset of Type II Diabetes: Effects of Aggregated Amylin (IAPP) on the Islet Proteome and Metabolic Pathways
- Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model
- Acute Phase Proteins, Immunoglobulins and Cytokines Responses to Amylin Injection in Wister Rats*“Mohamed Mohamed Soliman,“AffDesoky Abdel-Magied’ …
- Dissecting the Role of Amylin Receptor in Alzheimer’s Disease
- AMYLIN RECEPTOR EXPRESSION IN THE MESOCORTICOLIMBIC SYSTEM
- Human Amylin in the Presence of SARS-COV-2 Protein Fragments (preprint)
- Therapeutic potential of an old friend-the dichotomy of amylin in physiology and pathophysiology
- pH Dependence of Amylin Fibrillization
- The role of amylin receptor components in body weight and food intake control in obese knockout mouse models
- Baseline blood amylin levels predict longitudinal cognitive decline in participants at risk for or with mild cognitive impairment and dementia
- The pH-Dependence of Amylin Fibrillization
- 92-LB: Safety, Tolerability, and Clinical Effects of ZP8396, a Novel Long-Acting Amylin Analog—A Single Ascending Dose Trial
- Role of Amylin in Obesity
- San Diego survives Amylin shock
- Characterization of the oligomeric forms of human amylin
- Intrinsically disordered proteins (IDP) and metal ions: the case of amylin (HiAPP)
- Amylin, CGRP and the AMY1 receptor: Localisation in the trigeminal ganglia and receptor regulation
- Amylin and its effects on glucose homeostasis.
- In Vivo Downregulation Of Pancreatic Amylin In Diabetic Mice Improves Recognition Memory
- DURAL AMYLIN AND CGRP LEAD TO DIFFERENTIAL SEX-SPECIFIC RESPONSES CONTINGENT ON OVARIAN HORMONES IN RODENT MIGRAINE …
- Amylin under examination. Fibrillogenic potential of the troublesome molecule
- The role of amylin in type 2 diabetes
- The gut-brain axis and alcohol-mediated behaviours: the amylin story
- Synthesis and aggregation dynamics of amylin.
- The role of amylin in Alzheimer’s disease
- Determining the effect of trace elements (Lead and Zinc) on amylin Amyloidogenesis in vitro
- Cerebrovascular accumulation of amyloid‐forming amylin secreted from the pancreas induces brain hypoxia
- Survey of CNS Expression of the Amylin Receptor in Health and Metabolic Disease: Potential Relevance to Alzheimer’s Disease
- … , protofibrils, lipoproteins, and transmembrane channels formed by amyloid beta (Alzheimer’s disease), synucleins (Parkinson’s disease), and amylin (type 2 diabetes)
- Abstract WP247: Amylin, A Diabetes-associated Amyloid-forming Peptide, Accumulates In Thrombi And On Red Blood Cells-A New Biomarker For Stroke?
- Aggregation kinetics of amylin and its optical and electrochemical properties
- Amylin (hIAPP) Aggregates on the Membrane
- Correlation of Serum Amylin Level to Polycystic Ovarian Syndrome.
- In vivo downregulation of pancreatic amylin improves brain function and reduces brain β amyloid pathology in APP/PS1 mice
- Amylin-mediated regulation of LRP1 by miR-103/107 induces cerebral microvascular dysfunction and impairs β-amyloid efflux
- Amylin Inhibits the Feeding of the Siberian Sturgeon
- Characterization of the Amyloidogenic Peptides Amylin & PAP248-286
- ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES
- Amylin‐mediated regulation of LRP1 by miR‐103/107 impairs β‐amyloid efflux
- Computational modelling of graphene oxide and amyloidogenic protein amylin
- Phenotypic characterisation of human amylin transgenic mice: altered hormone signalling in the brain underlying obesity and insulin resistance
- Insight into the Metal Binding Sites in Amylin Aggregates
- Mechanisms of Metabolic Hormone Amylin Action on Alzheimer’s Disease Pathogenesis
- Research Article Charge-Based Inhibitors of Amylin Fibrillization and Toxicity
- Identification of Key Interactions in the Initial Self-Assembly of Amylin in a Membrane Environment
- Amylin challenge test and its correlation with brain imaging for Alzheimer’s disease
- Observation of Structural Growth of Fibrils of Amylin Protein
- Serum Amylin Indicates Hypertriglyceridemia in Pre-diabetics
- Evaluating the folding variations in human amylin peptid in the presence of Lead and Selenium
- Affinity Enhancers for Peptide Ligand Binding to the Extracellular Domain of the Amylin Receptor 2
- The role of amylin in the development of diabetic osteopathy
- Combined GLP1 Agonist and Amylin Analogue for Severe Obesity in a Patient with Type 1 DM
- Amylin Interacts with Aβ and May Accelerate the Development of Dementia
- Early Detection of Amylin Aggregation with a Miniature Optical-Fiber Based Sensor
- Copper (II) complexes of rat amylin fragments (360 views)
- Molecular Switches Regulating Assembly Transitions of Biological Molecules: Tubulin, Amylin and Lipids.
- Biophysical perspectives of amyloid-β and amylin induced modulations in its optical and electrical properties
- Presence of UCP2 and Amylin in human Alzheimer’s disease brains
- The effects of systemic administration of amylin on the pancreas of laying hens
- The effects of systemic administration of amylin on the pancreas of laying hens.
- Amylin Detection with a Miniature Optical-Fiber Based Sensor
- Investigating the Phenotype of Amylin Receptor-expressing Cells in the Ventral Tegmental Area
- The Pathophysiological Mechanisms of Human Amylin Induced Stress in Pancreatic Cells
- Elucidating the Mechanism of Human Amylin Trafficking in the Pancreatic β Cells
- Amylin’s Role in Nociception: Study in Amylin KO Mice
- Molecular Dynamics of Amylin Amyloid Single Beta-Sheet
- GM‐CSF reduces amylin amyloid and prevents pancreatic cell death in the hIAPP mouse model of Type 2 diabetes mellitus, a known risk factor for Alzheimer’s …
- Of Mice and Men: Translational Research on Amylin Agonism
- Structure-function analysis of calcitonin and amylin receptors
- Novel, Selective Amylin Agonists as Therapeutic Tools to Treat Diabetes
- Molecular Dynamics Simulation Study on the Molecular Structures of the Amylin Fibril Models
- Molecular Structure, Cytotoxicity and Inhibitive Factors of Human Amylin
- Amylin Structure, Aggregation and Pancreatic β Cell Toxicity
- Identifying a new migraine-relevant receptor: potential paracrine interaction between calcitonin gene-related peptide and the amylin 1 receptor in the parabrachial …
- Construction of human phage antibody library and screening for human monoclonal antibodies of amylin
- INVESTIGATING EFFECTS OF HUMAN AMYLIN AND H202 ON AMYLOID PRECURSOR PEPTIDE (APP) PROCESSING
- Effect of amylin on the expression of steroidogenic acute regulatory protein in mouse brain.
- Effect of Eighteen Weeks Endurance Training and High-Fat Diet on Amylin Plasma Levels of Male Wistar Rats
- Description and potential role in rodents’ maternal care of amylin expressed in the central nervous system
- Unraveling the Molecular Mechanisms of Human Amylin Binding, Turnover and Toxicity in Pancreatic Cells
- Chronic central administration of amylin decreases fat mass but does not modify body weight
- Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
- Mutations and Seeding of Amylin Fibril-Like Oligomers
- Investigating the Interactions between Aβ and Amylin: Insight into the Link between Alzheimer’s and Type II Diabetes
- Inhibition of Human Amylin Amyloidogenesis by Human Amylin-Fragment Peptides: Exploring the Effects of Serine Residues and Oligomerization upon Inhibitory …
- Orientations of Residues along the β-Arch of Self-Assembled Amylin Fibril-Like Structures Lead to Polymorphism
- Supplementary Information for ‘Characterizing the Assembly Behaviors of Human Amylin: A Perspective Derived from C-terminal Variants’
- Insights into amylin aggregation by 2D IR spectroscopy
- Correction to “The Fluorescent Dye 1, 6-Diphenyl-1, 3, 5-hexatriene Binds to Amyloid Fibrils Formed by Human Amylin and Provides a New Probe of Amylin Amyloid …
- The effects of vitamin D supplementation on endogen amylin hormone, hormonal and biochemical parameters, and insulin resistance in type-2 diabetic patients with …
- Homology models of the extracellular domains of the calcitonin and amylin receptors, with or without bound amylin and CGRP
- Molecular Mechanisms of the Bindings between Non-Amyloid β Component Oligomers and Amylin Oligomers
- Amylin under examination. Fibrillogenic polypeptide of pancreatic amyloid
- 1993-P: Deconstruction of the Role of the Amylin and Calcitonin Receptors in the Regulation of Body Weight and Glucose Tolerance
- Over-expression of human amylin in transgenic mice as a model for the pathogenesis of gestational diabetes
- Regulation of amyloid‐beta pathology by CNS amylin receptors in APP/PS1 mice: Development of new models and analysis methods/amyloid/Abeta
- Effect of Peptide Conjugates of Carboxylic Acids to the Aggregation of Amylin
- Microhemorrhages in Myocardium and Kidneys Provoked by Amylin-Loaded Erythrocytes
- Aggregation Induced Conformation Changes Determine Amylin Membrane Affinity
- EQUILIBRIUM INVESTIGATIONS OF METAL ION COMPLEXES OF AMYLIN HORMONE FRAGMENTS AND ITS MUTANTS
- Impact of the inhibition of UCP2 on the activity and presence of Amylin in RIN‐5F cells
- Low blood amylin delays Alzheimer’s pathology by modulating brain hypoxia and amyloid composition: A study in humans and rats: Biomarkers (non‐neuroimaging) …
- Lipid membrane disruption by amylin in type II diabetes mellitus: Effect of head group loss
- Exploration of Non-Specific Peptide Inhibitors of Amylin Aggregation in Type-2 Diabetes
- Metabolic and neurogenic effects of amylin in the rodent Area postrema
- 211-OR: Dual Amylin and Calcitonin Receptor Agonists Increase Mitochondrial Respiratory Capacity in Adipose Tissues of Obese Rat
- Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
- Molecular Simulations Indicate Marked Differences in the Structure of Amylin Mutants, Correlated with Known Aggregation Propensity
- Probing Ion Channel Activity of Human Islet Amyloid Polypeptide (Amylin)
- ThT and Capillary Electrophoresis to Monitor the Effects of Solutions Conditions on Amylin Aggregation
- Intrathecal amylin and salmon calcitonin affect formalin induced c-fos expression in the spinal cord of rats
- Structural Insights to Toxic Amylin Oligomers from 2D IR Spectroscopy
- In Silico Molecular Docking of Fisetin with the Amyloidogenic Peptides Human Amylin and Aβ42
- Characterising Interactions Between Amyloid-beta 42 and Amylin Peptide Heterodimers: A Molecular Simulation Approach
- Investigating the role of de novo designed peptides in ameliorating amylin aggregation and β-cell toxicity in Type 2 Diabetes (T2D)
- Amylin mediates brainstem control of heart rate in the diving reflex
- Amylin and pramlintide modulate γ-secretase activity and APP processing in lipid rafts
- The effects of amylin on the clearance and aggregation of amyloid beta in BV-2 microglia cell culture
- Abstract W P252: Amylin Vasculopathy, a Novel Mechanism of Cerebrovascular Injury and Neurologic Deficits in Diabetes
- High-Resolution Imaging of Amylin Aggregation and Internalization in Pancreatic Cells: Implications in Health and Disease
- Involvement of the histaminergic system in amylin and leptin action-a study with H1rKO mice
- The effects of astragalus combined with metformin on insulin resistance and plasma amylin level in newly diagnosed type 2 diabetic patients
- In silico folding and aggregation study of human amylin, an amyloidosis protein
- Amylin under examination. Fibrillation–cytotoxic pancreatic polypeptide aggregation
- Amylin-induced microglial IL-6 production enhances ventromedial hypothalamic leptin signaling
- Deamidation Accelerates Amyloid Formation and Alters Amylin Fiber Structure
- Correction: Complex formation of nickel (ii) and zinc (ii) ions with peptide fragments of rat amylin
- Pre-Diabetes Promotes Buildup of Amylin in the Heart That Alters Cardiac Function by Remodeling the Myocytes
- A Single Pseudoproline and Microwave Solid Phase Peptide Synthesis Facilitates an Efficient Synthesis of Human Amylin 1â [euro]” 37
- Increased toxicity of amylin (Islet Amyloid Polypeptide) in beta cells induced by photochemical internalization
- Amylin Peptide: An Association with Feed Intolerance in Preterm Neonates and Infants of Diabetic Mothers
- 840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats
- 861-P: The Effect of Dual Amylin and Calcitonin Receptor Agonist Treatment on Spatial Memory in Rat Models of Metabolic Syndrome
- Computational Study of Human-Amylin Induced Calcium Dysregulation in Cardiac Myocytes Characteristic of Pre-Diabetes
- Comparing Solution Structures of Amylin and CGRP by Nanosecond Laser-Pump Spectroscopy and Atomistic Simulations
- Amylin dual action: a second gluco regulatory β-cell hormone, treatment and cause for the diabetes
- Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety
- Amyloid Accelerators: Small Molecules that Accelerate Amyloid Formation by Amylin
- Expression and characterization of the human amylin receptor AMY3 in the mammalian cell-line RK13 (rabbit kidney cells) as a cellular model for Amyloid beta …
- Diet-derived protein and amino acids attenuate the responsiveness of the area postrema to the anorectic hormone amylin in male rats
- The study of the formation of oligomers and amyloid plaques from Amylin by capillary electrophoresis and fluorescent microchip electrophoresis
- 213-OR: Antidiabetic Potential of Novel, Long-Acting Amylin Analogue ZP8396 in ZDF Rats
- Circulating Amylin Amyloid Oligomers Accumulate in the Heart and Induce Cardiomyocyte Dysfunction in a Rat Model of Type-2 Diabetes
- Targeting a metabolic OA in vivo model by a novel dual amylin calcitonin receptor agonist, KBP-056
- A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ1–42, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing …
- Back Picture: Ion‐Transfer Electrochemistry of Rat Amylin at the Water–Organogel Microinterface Array and Its Selective Detection in a Protein Mixture (Chem. Asian J …
- 1406-P: ZP8396, a Novel Amylin Analogue, Induces Weight Loss in DIO Rats with a Formulation Space at Physiological pH
- Ginger Essential Oil and Citral Ameliorate Atherosclerosis Via Modulating TMAO and Gut Microbiota in ApoE −/− Mice Fed on Gubra Amylin NASH Diet with ʟ …
- Early postnatal amylin treatment enhances hypothalamic leptin signaling and 1 neural development in the selectively bred diet-induced obese rat. 2
- Modulation of Prepulse Inhibition and Ingestive Behavior by Nucleus Accumbens AMY1 Amylin Receptors
- Influence Of Specific Hsc70 Domains On Fibril Formation Of Human Amylin Involved In Type 2 Diabetes: Importance Of The C-terminal Lid
- Over-expression of Human Amylin Leads to Oligomerization and beta-cell Dysfunction Associated with Mitochondrial Uncoupling, Activation of c-Jun and Decrease …
- Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl …
- 1393: AN AMYLOIDOGENIC HEXAPEPTIDE, AMYLIN, ATTENUATES INFLAMMATION AND ACUTE LUNG INJURY IN MURINE SEPSIS
- Healthy pancreatic b-cells secrete the hormones insulin and amylin in a fixed ratio. Both hormones are lacking in type 1 diabetes, and postprandial glucose …
- Amylin and preptin regulate glucose homeostasis in infertile women with polycystic ovary syndrome and poor responders undergoing IVF/ICSI
- 1829-P: Aggravating Liver Lipid Accumulation and Fibrosis in Nonalcoholic Steatohepatitis Model of MS-NASH Mice by a Modified Amylin Diet
- 1306-P: In Vivo Downregulation of Pancreatic Amylin in Diabetic Mice Improves Recognition Memory
- P3-091 PLASMA AMYLIN LEVELS ARE ASSOCIATED WITH BRAIN STRUCTURE AMONG INDIVIDUALS WITH TYPE-2 DIABETES
- 823-P: The Long-Acting Dual Amylin and Calcitonin Receptor Agonist KBP Has Increased Efficacy on Weight Loss and Glucose Control Compared with Cagrilintide in …
- 824-P: Dual Amylin and Calcitonin Receptor Agonists Improve Insulin Sensitivity and Increase Tissue-Specific Glucose Uptake Independent of Weight Loss
- PS 0121; Cardiology: Is Serum Amylin Level Associated with Myocardial Function in Type 2 Diabetes Mellitus Patient without Cardiac Diseases?
- Plasma Ghrelin and GLP-1, but not Leptin or Amylin, Respond to a Psychosocial Stressor in Humans
- 2035-P: Treatment with a Dual Amylin and Calcitonin Receptor Agonist Improves Metabolic Health in a Rat Model of Elderly Menopausal Women
- 750: ENDOGENOUS GHRELIN, AMYLIN AND GLUCAGON-LIKE PEPTIDE-1 AND THEIR ASSOCIATIONS WITH GASTRIC EMPTYING IN THE CRITICALLY ILL
- Design, synthesis and testing of a novel fluorescent probe for the staining of amyloid fibrils of Aβ1-42 peptide, α-synuclein and amylin and for the detection of amyloid …
