SPHINGOLIPIDS
March 28, 2024MELANOCORTIN OBESITY
May 21, 2024- PPARα and dyslipidemia
- The role of PPARα in lipid metabolism and obesity: focusing on the effects of estrogen on PPARα actions
- PPARα in atherosclerosis and inflammation
- Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
- PPARα: energy combustion, hypolipidemia, inflammation and cancer
- Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human
- The PPARα–leukotriene B4 pathway to inflammation control
- PPARα is a key regulator of hepatic FGF21
- PPARα governs glycerol metabolism
- The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
- Identification of a physiologically relevant endogenous ligand for PPARα in liver
- PPARα gene variation and physical performance in Russian athletes
- PPARα: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
- The PPARα-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPARα
- A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation …
- trans-Activation of PPARα and Induction of PPARα Target Genes by Perfluorooctane-Based Chemicals
- Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
- Activation of PPARα and PPARγ by environmental phthalate monoesters
- Molecular scanning of the human PPARα gene: association of the L162V mutation with hyperapobetalipoproteinemia
- trans-Activation of PPARα and PPARγ by structurally diverse environmental chemicals
- Cannabinoid activation of PPARα; a novel neuroprotective mechanism
- Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure
- Role of PPARα in hepatic carbohydrate metabolism
- Genome-wide analysis of PPARα activation in murine small intestine
- PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
- Association between the PPARα-L162V polymorphism and components of the metabolic syndrome
- Effect of endurance training on lipid metabolism in women: a potential role for PPARα in the metabolic response to training
- Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
- PPARα activator effects on Ang II–induced vascular oxidative stress and inflammation
- “New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis
- Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
- Gene expression profiling in wild-type and PPARα-null mice exposed to perfluorooctane sulfonate reveals PPARα-independent effects
- Peroxisome proliferator-activated receptor α (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol …
- Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element
- Cannabinoids and PPARα signalling
- PPARα: an emerging therapeutic target in diabetic microvascular damage
- PPARα agonist-induced rodent tumors: modes of action and human relevance
- Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice
- Role of PPARα in mediating the effects of phthalates and metabolites in the liver
- Fibrates and future PPARα agonists in the treatment of cardiovascular disease
- PPARα in the pathogenesis of fatty liver disease
- Stimulation of PPARα promotes epidermal keratinocyte differentiation in vivo
- Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner
- Amelioration of high fructose-induced metabolic derangements by activation of PPARα
- Peroxisome proliferator-activated receptor-alpha (PPARα): at the crossroads of obesity, diabetes and cardiovascular disease
- PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice
- A role for PPARα in the control of SREBP activity and lipid synthesis in the liver
- Expression of peroxisome proliferator-activated receptor α (PPARα) in primary cultures of human vascular endothelial cells
- Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-α (PPARα)-regulated genes and is ameliorated by PPARα activation
- Chronic activation of PPARα is detrimental to cardiac recovery after ischemia
- A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
- Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
- Role of oxidative stress in cardiac dysfunction of PPARα−/− mice
- PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
- PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats
- Structure of the PPARα and-γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family
- L-FABP directly interacts with PPARα in cultured primary hepatocytes
- Cardiac hypertrophy is enhanced in PPARα−/− mice in response to chronic pressure overload
- III. Peroxisomal β-oxidation, PPARα, and steatohepatitis
- Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects
- Identification of a subtype selective human PPARα agonist through parallel-array synthesis
- Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
- PPARα agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
- Brain fatty acid synthase activates PPARα to maintain energy homeostasis
- PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome
- The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
- Recent update on the PPARα-null mouse
- Anticancer properties of PPARα-effects on cellular metabolism and inflammation
- DNA binding-independent induction of IκBα gene transcription by PPARα
- Administration of the potent PPARα agonist, Wy‐14,643, reverses nutritional fibrosis and steatohepatitis in mice
- Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice
- Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
- Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I
- PPARα deficiency in inflammatory cells suppresses tumor growth
- Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARα
- AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
- PPARα activators inhibit tissue factor expression and activity in human monocytes
- PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse
- Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARα
- Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis
- PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice
- Functional significance of the two ACOX1 isoforms and their crosstalks with PPARα and RXRα
- Nuclear receptor peroxisome proliferator-activated receptor α (PPARα) is expressed in resting murine lymphocytes: the PPARα in T and B lymphocytes is both …
- Fish oil feeding alters liver gene expressions to defend against PPARα activation and ROS production
- Activation of PPARα or γ reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
- PPARα in obesity: sex difference and estrogen involvement
- Different ways to regulate the PPARα stability
- PPARα agonists inhibit tissue factor expression in human monocytes and macrophages
- Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
- Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3‐L1 adipocytes and HepG2 hepatocytes
- The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism
- Dual activation of PPARα and PPARγ by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells
- Alterations of PPARα and its coactivator PGC-1 in cisplatin-induced acute renal failure
- Activation of PPARα lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2
- Novel aspects of PPARα‐mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study
- Peroxisome proliferator-activated receptor α (PPARα) influences substrate utilization for hepatic glucose production
- The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARα-dependent mechanisms
- Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARα
- PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice
- Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression [S]
- A role for peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased …
- Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators
- Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver
- Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes?
- PPARα and the regulation of cell division and apoptosis
- PPARα/γ ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
- Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARα, PPARγ, and LXR
- PPARα contributes to colonic protection in mice with DSS-induced colitis
- Isohumulones modulate blood lipid status through the activation of PPARα
- The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis
- Gene profiling in the livers of wild-type and PPARα-null mice exposed to perfluorooctanoic acid
- Effects of ovariectomy on PPARα, SREBP-1c, and SCD-1 gene expression in the rat liver
- Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
- PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
- PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1
- PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a
- Role of PPARα and its agonist in renal diseases
- A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity
- PPARα-and DEHP-induced cancers
- Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
- PPARα is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders
- Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
- Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARα, PPARγ and LXRα
- Peroxisome proliferator-activated receptor α (PPARα) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target …
- Less extrahepatic induction of fatty acid β-oxidation enzymes by PPARα
- Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development
- … activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes
- Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
- PPARα activators and fasting induce the expression of adipose differentiation-related protein in liver
- Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPARα and CAR
- PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle
- Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression
- Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro
- Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes
- PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways
- PPARα activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats
- Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in …
- … (PPAR) α activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARα, PPARγ, and their …
- Fenofibrate reduces intestinal cholesterol absorption via PPARα-dependent modulation of NPC1L1 expression in mouse
- Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA
- PPARα agonists reduce 11β-hydroxysteroid dehydrogenase type 1 in the liver
- Peroxisome proliferator-activated receptor α (PPARα) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart
- Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesion
- Fibrate and statin synergistically increase the transcriptional activities of PPARα/RXRα and decrease the transactivation of NFκB
- Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription
- Novel tricyclic-α-alkyloxyphenylpropionic acids: dual PPARα/γ agonists with hypolipidemic and antidiabetic activity
- The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
- PPARα ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity
- Role of peroxisome proliferator-activated receptor-α (PPARα) in bezafibrate-induced hepatocarcinogenesis and cholestasis
- Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice
- The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox …
- Statins activate human PPARα promoter and increase PPARα mRNA expression and activation in HepG2 cells
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARα/γ activation in 3T3-L1 cells
- Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) but not PPARα serves as a plasma free fatty acid sensor in liver
- Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation
- PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB
- Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
- Dietary isoflavone supplementation modulates lipid metabolism via PPARα-dependent and-independent mechanisms
- Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARα and uncoupling protein in diet-induced obese mice
- Differential responses of PPARα, PPARδ, and PPARγ reporter cell lines to selective PPAR synthetic ligands
- Cross-talk between statins and PPARα in cardiovascular diseases: clinical evidence and basic mechanisms
- Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of …
- Thermally oxidized dietary fat upregulates the expression of target genes of PPARα in rat liver
- Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse
- PPARα activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation
- Metabolic profiling of PPARα−/− mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
- Nrf2-and PPARα-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid
- Induction of hepatic ABC transporter expression is part of the PPARα–mediated fasting response in the mouse
- Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARα
- A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα
- PPARα and PPARδ activators inhibit cytokine-induced nuclear translocation of NF-κB and expression of VCAM-1 in EAhy926 endothelial cells
- Down regulation of hepatic PPARα function by AhR ligand
- Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation
- Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARα and PPARδ∗
- PPARα agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes
- The peroxisome proliferator-activated receptor α (PPARα): role in hepatocarcinogenesis
- PPARα controls the intracellular coenzyme A concentration via regulation of PANK1α gene expression1
- PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes
- Analysis of PPARα-dependent and PPARα-independent transcript regulation following fenofibrate treatment of human endothelial cells
- Activation of PPARα inhibits IGF‐I‐mediated growth and survival responses in medulloblastoma cell lines
- Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARα in high fat diet-induced obese mice
- PPARα agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine
- A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and-independent pathways
- PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents
- The PPARα/γ dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats
- PPARα activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes
- PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation
- PPARα ligands as antitumorigenic and antiangiogenic agents
- Human urinary metabolomic profile of PPARα induced fatty acid β-oxidation
- Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα) …
- Phytanic acid activates the peroxisome proliferator-activated receptor α (PPARα) in sterol carrier protein 2-/sterol carrier protein x-deficient mice
- The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα
- Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα
- Application of the dakin− west reaction for the synthesis of oxazole-containing dual PPARα/γ agonists
- Structure-based design of indole propionic acids as novel PPARα/γ co-agonists
- Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent …
- WY14, 643, a PPARα ligand, has profound effects on immune responses in vivo
- Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) α: PPARα fails to induce peroxisome …
- Farnesol stimulates differentiation in epidermal keratinocytes via PPARα
- … -STAT) and peroxisome proliferator-activated receptor-α (PPARα) signaling pathways: Growth hormone inhibition of PPARα transcriptional activity mediated …
- Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARα activators restores tissue homeostasis
- The PPARα agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation
- Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
- The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter
- An afferent vagal nerve pathway links hepatic PPARα activation to glucocorticoid-induced insulin resistance and hypertension
- Effects of green tea on insulin sensitivity, lipid profile and expression of PPARα and PPARγ and their target genes in obese dogs
- Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
- PPARα protects proximal tubular cells from acute fatty acid toxicity
- Beyond lipids, pharmacological PPARα activation has important effects on amino acid metabolism as studied in the rat
- Cardiac PPARα expression in patients with dilated cardiomyopathy
- ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα-mediated inhibition of glioma cell motility in vitro
- PPARα attenuates the proinflammatory response in activated mesangial cells
- Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARα and NF-κB
- Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARα-regulated gene expression in …
- Activation of PPARα and PPARγ reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1
- PPARα: its role in the human metabolic syndrome
- PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation
- PPARα L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity
- PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
- Effect of tesaglitazar, a dual PPARα/γ agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12‐week dose-ranging trial
- Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
- Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice
- Transcriptomic analysis of PPARα-dependent alterations during cardiac hypertrophy
- Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARα in nonproliferating species
- Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor α (PPARα)
- Coordinate induction of PPARα and SREBP2 in multifunctional protein 2 deficient mice
- Homocysteine-mediated PPARα, γ DNA methylation and its potential pathogenic mechanism in monocytes
- Role of the nuclear receptors HNF4α, PPARα, and LXRs in the TNFα-mediated inhibition of human apolipoprotein AI gene expression in HepG2 cells
- PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells
- PPARα deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins
- Nonclinical safety evaluation of muraglitazar, a novel PPARα/γ agonist
- Peroxisome proliferator-activated receptor α (PPARα) potentiates, whereas PPARγ attenuates, glucose-stimulated insulin secretion in pancreatic β-cells
- The PPARα/p16INK4a Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle–Dependent Telomerase Activation
- Hepatocyte-restricted constitutive activation of PPARα induces hepatoproliferation but not hepatocarcinogenesis
- Atorvastatin reverses age‐related reduction in rat hepatic PPARα and HNF‐4
- Design and synthesis of α-aryloxyphenylacetic acid derivatives: a novel class of PPARα/γ dual agonists with potent antihyperglycemic and lipid modulating activity
- Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α (PPARα) via a PPRE located in the first intron
- Design and biological evaluation of novel, balanced dual PPARα/γ agonists
- Human peroxisome proliferator-activated receptor α (PPARα) supports the induction of peroxisome proliferation in PPARα-deficient mouse liver
- … rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR
- Requirement of PPARα in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation
- Involvement of PPARα in the growth inhibitory effect of arachidonic acid on breast cancer cells
- PPARα and GR differentially down-regulate the expression of nuclear factor-κB-responsive genes in vascular endothelial cells
- PPARα agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity
- Fasting upregulates PPARα target genes in brain and influences pituitary hormone expression in a PPARα dependent manner
- Unlike PPARγ, PPARα or PPARβ/δ activation does not promote human monocyte differentiation toward alternative macrophages
- Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPARα/γ agonist: evidence for urolithiasis as the inciting event in the mode of …
- Genomic and non-genomic interactions of PPARα with xenobiotic-metabolizing enzymes
- PPARα agonists up-regulate organic cation transporters in rat liver cells
- Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18
- Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)
- Impaired Ras membrane association and activation in PPARα knockout mice after partial hepatectomy
- Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells
- WY14, 643, a peroxisome proliferator-activated receptor α (PPARα) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in …
- Iridoids from Fraxinus excelsior with Adipocyte Differentiation-Inhibitory and PPARα Activation Activity
- Alteration of a single amino acid in peroxisome proliferator-activated receptor-α (PPARα) generates a PPARδ phenotype
- The PPARα activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy
- Design of potent PPARα agonists
- Combination therapy with PPARγ and PPARα agonists increases glucose-stimulated insulin secretion in db/dbmice
- Multiple roles of PPARα in brown adipose tissue under constitutive and cold conditions
- Identification of novel peroxisome proliferator-activated receptor α (PPARα) target genes in mouse liver using cDNA microarray analysis
- Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs
- Fenofibrate increases homocystinemia through a PPARα-mediated mechanism
- Ragaglitazar: a novel PPARα & PPARγ agonist with potent lipid‐lowering and insulin‐sensitizing efficacy in animal models
- Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia
- Modulation of peroxisome proliferator-activated receptors (PPARs) by PPARα-and PPARγ-specific ligands and by 17β-estradiol in isolated zebrafish hepatocytes
- Activation of the rat scavenger receptor class B type I gene by PPARα
- Fibrate induction of the adrenoleukodystrophy‐related gene (ABCD2) Promoter analysis and role of the peroxisome proliferator‐activated receptor PPARα
- … subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARα …
- Characterization of Peroxisome Proliferator–Activated Receptor α—Independent Effects of PPARα Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate also …
- Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
- Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling
- Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα
- Reduced hepatic fatty acid oxidation in fasting PPARα null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression
- Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE
- PPARα Inhibits TGF-β–Induced β5 Integrin Transcription in Vascular Smooth Muscle Cells by Interacting With Smad4
- Oxidized omega-3 fatty acids inhibit NF-κB activation via a PPARα-dependent pathway
- Inhibition of cholesterol absorption associated with a PPARα-dependent increase in ABC binding cassette transporter A1 in mice
- Dual PPARα/γ activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats
- Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARα and TNFα
- Peroxisome proliferator-activated receptor (PPAR)-γ positively controls and PPARα negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a …
- Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARα, PPARγ, and PPARδ
- … -activated receptor-alpha (PPARα) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARα: implications for species …
- Inflammation, dyslipidaemia, diabetes and PPars: pharmacological interest of dual PPARα and PPARγ agonists
- A nuclear complex containing PPARα/RXRα is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function
- Effects of PPARγ and PPARα agonists on serum leptin levels in diet-induced obese rats
- High-density lipoprotein hydrolysis by endothelial lipase activates PPARα: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte …
- Effect of PPARα activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes
- Synthesis and dual PPARα/δ agonist effects of 1, 4-disubstituted 1, 2, 3-triazole analogues of GW 501516
- Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARα
- PPARα, but not PPARγ, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia
- The transcriptional coactivator peroxisome proliferator–activated receptor (PPAR) γ coactivator-1α and the nuclear receptor PPARα control the expression of glycerol …
- The human myeloperoxidase gene is regulated by LXR and PPARα ligands
- PPARα and PPARγ effectively protect against HIV‐induced inflammatory responses in brain endothelial cells
- Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ
- Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARα target genes in rat liver
- Relationships between the functional PPARα Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 …
- Feeding oxidized fat during pregnancy up-regulates expression of PPARα-responsive genes in the liver of rat fetuses
- Impairment of hepatic Stat‐3 activation and reduction of PPARα activity in fructose‐fed rats
- PPARα and PPARγ activators suppress the monocyte-macrophage apoB-48 receptor1
- PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
- RXR agonists activate PPARα-inducible genes, lower triglycerides, and raise HDL levels in vivo
- The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats
- Suppression of expression of muscle-associated proteins by PPARα in brown adipose tissue
- Novel 2, 3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARα agonists with potent hypolipidemic activity
- Fenofibrate, a ligand for PPARα, inhibits aromatase cytochrome P450 expression in the ovary of mouse
- Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARα-humanized mice
- PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and-3 and enzymes involved in hepatic carnitine synthesis
- Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart
- Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
- PPARα is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis
- Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARα
- Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana
- Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-α (PPARα) and PPARγ through MAPK-dependent COX-2 expression in …
- Auraptene, a citrus fruit compound, regulates gene expression as a PPARα agonist in HepG2 hepatocytes
- Relationship between PPARα activation and NO on proximal tubular Na+ transport in the rat
- PPARα agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS‐treated macrophages
- The dual PPARα/γ agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats
- Statins and PPARα agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment
- Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor α (PPARα) in HEK293 cells
- Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARα and PPARγ agonist activity
- Osthol regulates hepatic PPARα-mediated lipogenic gene expression in alcoholic fatty liver murine
- Association of PPARα gene polymorphisms and lipid serum levels in a Brazilian elderly population
- Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template
- PPARα is involved in photoentrainment of the circadian clock
- PPARα activation potentiates AhR-induced CYP1A1 expression
- Additivity of molecular fields: CoMFA study on dual activators of PPARα and PPARγ
- Fatty acids induce L-CPT I gene expression through a PPARα-independent mechanism in rat hepatoma cells
- Isoform specific changes in PPARα and β in colon and breast cancer with differentiation
- Energy balance: A new role for PPARα
- A Val227Ala polymorphism in the peroxisome proliferator activated receptor α (PPARα) gene is associated with variations in serum lipid levels
- Role of the peroxisome proliferator-activated receptor α (PPARα) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver
- Reduced fat mass in rats fed a high oleic acid–rich safflower oil diet is associated with changes in expression of hepatic PPARα and adipose SREBP-1c …
- Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
- PPARα activators may be good candidates as antiaging agents
- A Chemical Switch Regulates Fibrate Specificity for Peroxisome Proliferator-activated Receptor α (PPARα) VersusLiver X Receptor
- Molecular mechanism of allosteric communication in the human PPARα‐RXRα heterodimer
- Feeding of a deep-fried fat causes PPARα activation in the liver of pigs as a non-proliferating species
- Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor α (PPARα)
- PPARα/γ expression and activity in mouse and human melanocytes and melanoma cells
- C333H, a novel PPARα/γ dual agonist, has beneficial effects on insulin resistance and lipid metabolism
- Intestine-specific regulation of PPARα gene transcription by liver X receptors
- Administration of a PPARα agonist increases serum apolipoprotein AV levels and the apolipoprotein AV/apolipoprotein C-III ratio
- “Hypothesis of seven balances”: molecular mechanisms behind alcoholic liver diseases and association with PPARα
- Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARα-dependent manner
- Antihypertensive effect of ragaglitazar: A novel PPARα and γ dual activator
- Dual PPARα/γ agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE* 3Leiden mice
- … Receptor (PPAR) Activation Induces Tissue-Specific Effects on Fatty Acid Uptake and Metabolism in Vivo—A Study Using the Novel PPARα/γ Agonist Tesaglitazar
- Icariin promotes expression of PGC‐1α, PPARα, and NRF‐1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro1
- Effects and mechanisms of PPARα activator fenofibrate on myocardial remodelling in hypertension
- … of the critical structural determinant (s) of species-selective peroxisome proliferator-activated receptor alpha (PPARα)-activation by phenylpropanoic acid-type PPARα …
- Changes in liver PPARα mRNA expression in response to two levels of high-safflower-oil diets correlate with changes in adiposity and serum leptin in rats and mice
- Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARα agonists on urine pH
- Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4
- Relationship between peroxisome proliferator‐activated receptors (PPARα and PPARγ) and endothelium‐dependent relaxation in streptozotocin‐induced diabetic …
- Human skeletal muscle PPARα expression correlates with fat metabolism gene expression but not BMI or insulin sensitivity
- PPARα ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis
- PPARα-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation
- Association between the PPARα L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in …
- Potential utility of PPARα activation in the prevention of ischemic and drug-induced acute renal damage
- PPARα-dependent modulation of hepatic CYP1A by clofibric acid in rats
- A practical synthesis of the PPARα agonist,(R)-K-13675, starting from (S)-2-hydroxybutyrolactone
- Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists
- PPARα and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK‐HEP‐1
- Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARα in male and female mice
- Effects of PPARα, γ and δ haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein …
- L-FABP is exclusively expressed in alveolar macrophages within the myeloid lineage: evidence for a PPARα-independent expression
- Involvement of PPARγ co-activator-1, nuclear respiratory factors 1 and 2, and PPARα in the adaptive response to endurance exercise
- Regulation of phase I and phase II steroid metabolism enzymes by PPARα activators
- Alterations in skin and stratified epithelia by constitutively activated PPARα
- … levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial …
- Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARα-dependent stearoyl-coenzyme a desaturase
- Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants
- The effect of peroxisome proliferator-activated receptors α (PPARα) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity, and plasma …
- Mechanistic evaluation of PPARα-mediated hepatocarcinogenesis: Are we there yet?
- PPARα signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells
- Effects of high dietary fat and cholesterol on expression of PPARα, LXRα, and their responsive genes in the liver of apoE and LDLR double deficient mice
- PPARα activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans
- PPARα stimulation exerts a blood pressure lowering effect through different mechanisms in a time-dependent manner
- Evaluation of the therapeutic potential of PPARα agonists for X-linked adrenoleukodystrophy
- Thyroid hormone interacts with PPARα and PGC-1 during mitochondrial maturation in sheep heart
- Association of V227A PPARα polymorphism with altered serum biochemistry and alcohol drinking in Japanese men
- The dual PPARα/γ agonist tesaglitazar blocks progression of pre‐existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
- Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
- PPARα transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects
- The role of new technologies in defining a manufacturing process for PPARα agonist LY518674
- … of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor α (PPARα)
- Evaluation of the role of peroxisome proliferator-activated receptor α (PPARα in mouse liver tumor induction by trichloroethylene and metabolites
- Influences of the PPARα-L162V polymorphism on plasma HDL2-cholesterol response of abdominally obese men treated with gemfibrozil
- Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPARα and γ agonist in healthy subjects and patients with type 2 diabetes
- Hepatic PGC-1β overexpression induces combined hyperlipidemia and modulates the response to PPARα activation
- Stimulation of cardiac cardiolipin biosynthesis by PPARα activation
- Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARα and down-regulation of fatty acid synthase in …
- … (PFOS) toxicity in domestic chicken (Gallus gallus domesticus) embryos in the absence of effects on peroxisome proliferator activated receptor alpha (PPARα) …
- Evidence of differing genotypic effects of PPARα in women and men
- Selectivity of fatty acid ligands for PPARα which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells
- A novel PPARα agonist ameliorates insulin resistance in dogs fed a high-fat diet
- Peroxisome proliferator activated receptor δ (PPARδ) agonist but not PPARα corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells
- Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARα and PPARγ agonist activity
- Fibrates upregulate TRB3 in lymphocytes independent of PPARα by augmenting CCAAT/enhancer-binding proteinβ (C/EBPβ) expression
- PPARα-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy
- Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway
- Down-regulated expression of PPARα target genes, reduced fatty acid oxidation and altered fatty acid composition in the liver of mice transgenic for hTNFα
- PPARα-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells
- PPARα activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism
- Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts
- Modulation of PPARα expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion
- PPARα activator fenofibrate modulates angiotensin II-induced inflammatory responses in vascular smooth muscle cells via the TLR4-dependent signaling pathway
- Tesaglitazar, a dual PPARα/γ agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
- Evidence for peroxisome proliferator-activated receptor (PPAR) α-independent peroxisome proliferation: effects of PPARγ/δ-specific agonists in PPARα-null mice
- The dietary antioxidant resveratrol affects redox changes of PPARα activity
- … for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARα ligand-induced liver …
- Liver PPARα and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice
- Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists
- Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism
- Increase in weight induced by muraglitazar, a dual PPARα/γ agonist, in db/db mice: adipogenesis/or oedema?
- PPARγ but not PPARα ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells
- Reduction of all-trans-Retinal in the Mouse Liver Peroxisome Fraction by the Short-Chain Dehydrogenase/Reductase RRD: Induction by the PPARα Ligand …
- Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate …
- Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARα
- Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
- Time-course comparison of xenobiotic activators of CAR and PPARα in mouse liver
- Food entrainment of circadian gene expression altered in PPARα−/− brown fat and heart
- Irbesartan treatment up‐regulates hepatic expression of PPARα and its target genes in obese Koletsky (fak/fak) rats: a link to amelioration of hypertriglyceridaemia
- Dual regulation of mouse Δ5-and Δ6-desaturase gene expression by SREBP-1 and PPARα
- Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists
- RXR activators molecular signalling: involvement of a PPARα‐dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart
- Regulated expression by PPARα and unique localization of 17β‐hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver
- Peroxisome proliferator-activated receptor α (PPARα) down-regulation in cystic fibrosis lymphocytes
- Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor α (PPARα)
- (2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents
- Differential regulation of cytosolic and peroxisomal bile acid amidation by PPARα activation favors the formation of unconjugated bile acids
- Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor α (PPARα)-regulated peroxisomal acyl-CoA thioesterases
- Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARα with clofibrate
- Fatty acid oxidation inhibition with PPARα activation (FOXIB/PPARα) for normalizing gene expression in heart failure?
- PPARα mediates the effects of the pesticide methyl thiophanate on liver of the lizard Podarcis sicula
- Combined therapy with PPARα agonist and l-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency
- … ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11β-HSD1, PEPCK and DGAT2.: Comparison of PPARα, PPARγ, and liver x …
- Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARα
- Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II‐induced hypertension in rats
- Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic …
- Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARα
- Transcriptional activation of PPARα by phenobarbital in the absence of CAR and PXR
- Peroxisome proliferator-activated receptor alpha (PPARα) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes
- Effects of combined PPARγ and PPARα agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat
- Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARα activation
- The Effects of a PPARα agonist on myocardial damage in obese diabetic mice with heart failure
- … in enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver: Further support for the role of fatty acyl CoA oxidase in PPARα ligand …
- Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARα–RXR
- Ligand-and species-dependent activation of PPARα
- Mouse carnitine–acylcarnitine translocase (CACT) is transcriptionally regulated by PPARα and PPARδ in liver cells
- Lack of NF-κB1 (p105/p50) attenuates unloading-induced downregulation of PPARα and PPARα-regulated gene expression in rodent heart
- … , synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARα …
- PPARα and PPARγ are co‐expressed, functional and show positive interactions in the rat urinary bladder urothelium
- Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα)
- Effect of BM 17.0744, a PPARα ligand, on the metabolism of perfused hearts from control and diabetic mice
- The role of NF-κB in PPARα-mediated hepatocarcinogenesis
- Evidence for cross talk between PPARα and p38 MAP kinase
- … cooperatively with peroxisome proliferator-activated receptor gamma (PPARγ) coactivator 1α to coactivate nuclear receptors estrogen-related receptor α and PPARα
- Design and synthesis of potent and subtype-selective PPARα agonists
- The dominant negative thyroid hormone receptor β-mutant Δ337T alters PPARα signaling in heart
- Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARα-dependent pathway
- Overexpression of peroxisome proliferator-activated receptor-α (PPARα)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient …
- Fatty acid synthesis and PPARα hand in hand
- Altered mRNA expression of hepatic lipogenic enzyme and PPARα in rats fed dietary levan from Zymomonas mobilis
- Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARα in rat liver
- … domains from the human oestrogen receptor α (hERα) crystal structure, and the human peroxisome proliferator activated receptor α (PPARα) ligand binding domain …
- Substituted 2-[(4-aminomethyl) phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents
- The role of PPARα as a “lipostat” transcription factor
- Tesaglitazar, a PPARα/γ agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats
- Discovery of tertiary aminoacids as dual PPARα/γ agonists-I
- Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-κB and PPARα
- Induction of peroxisome proliferator-activated receptor alpha (PPARα)-related enzymes by di (2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not …
- Different sensitivity of PPARα gene expression to nutritional changes in liver of suckling and adult rats
- Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)
- PPARα mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse
- PPARα gene expression is up-regulated by LXR and PXR activators in the small intestine
- Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor α (PPARα)
- Discovery of a peroxisome proliferator activated receptor γ (PPARγ) modulator with balanced PPARα activity for the treatment of type 2 diabetes and dyslipidemia
- Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender‐specific manner
- Influence of pharmacological PPARα activators on carnitine homeostasis in proliferating and non-proliferating species
- PPARα and PPARγ regulation of liver and adipose proteins in obese and dyslipidemic rodents
- The Interleukin-1 receptor antagonist is a direct target gene of PPARα in liver
- Evidence for an association between the Leu162Val polymorphism of the PPARα gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
- Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor α (PPARα) agonist in human hepatoma cells
- PRIC295, a nuclear receptor coactivator, identified from PPARα-interacting cofactor complex
- Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor α (PPARα)
- Novel pirinixic acids as PPARα preferential dual PPARα/γ agonists
- Troglitazone reduces the expression of PPARγ while stimulating that of PPARα in mononuclear cells in obese subjects
- Oxidized frying oil up-regulates hepatic acyl-CoA oxidase and cytochrome P450 4 A1 genes in rats and activates PPARα
- DNA binding preferences of PPARα/RXRα heterodimers
- Enantioselective synthesis of the PPARα agonist (R)-K-13675 via (S)-2-hydroxybutyrolactone
- Differential action of 13-HPODE on PPARα downstream genes in rat Fao and human HepG2 hepatoma cell lines
- The peroxisome proliferator-activated receptor α (PPARα) regulates the plasma thiobarbituric acid-reactive substance (TBARS) level
- PPARα/γ-independent effects of PPARα/γ ligands on cysteinyl leukotriene production in mast cells
- Expression of the mRNA encoding truncated PPARα does not correlate with hepatic insensitivity to peroxisome proliferators
- Increased entropy production in diaphragm muscle of PPARα knockout mice
- PPARα does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte
- Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR
- PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver
- Time course investigation of PPARα-and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression
- Aleglitazar, a dual PPARα and PPARγ agonist for the potential oral treatment of type 2 diabetes mellitus.
- Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
- PPARα ligands and clinical trials: cardiovascular risk reduction with fibrates
- Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
- AZ 242, a novel PPARα/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
- … alterations in splenic iNOS regulation: influence of constitutively expressed IFN-γ and correction following supplementation with PPARα activators or vitamin E
- 7-Hydroxy-benzopyran-4-one derivatives: A novel pharmacophore of peroxisome proliferator-activated receptor α and-γ (PPARα and γ) dual agonists
- Reversal of high dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors
- Double gene deletion reveals the lack of cooperation between PPARα and PPARβ in skeletal muscle
- Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARα/γ dual agonists
- A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes
- Prevention of diet-induced obesity by safflower oil: insights at the levels of PPARα, Orexin, and Ghrelin gene expression of adipocytes in mice
- Modulación del PPARα por agentes farmacológicos y naturales y sus implicaciones metabólicas
- The characterization of PPARα ligand drug action in an in vivo model by comprehensive differential gene expression profiling
- Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists
- Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-α (PPARα) and PPARβ activity
- Expression of peroxisome proliferator-activated receptor α, and PPARα regulated genes in spontaneously developed hepatocellular carcinomas in fatty acyl-CoA …
- Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARα, promotes energy consumption and reduces visceral fat deposition in rats
- The Korean traditional medicine Gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARα actions in rat …
- A dual‐response partial least squares regression QSAR model and its application in design of dual activators of PPARα and PPARγ
- Pharmacological characterization of a human-specific peroxisome proliferater-activated receptor α (PPARα) agonist in dogs
- Effects of phthalate ester derivatives including oxidized metabolites on coactivator recruiting by PPARα and PPARγ
- Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα-dependent mechanism
- Fenofibrate induces a selective increase of protein-bound homocysteine in rodents: a PPARα-mediated effect
- Regulation of blood pressure, natriuresis and renal thiazide/amiloride sensitivity in PPARα null mice
- PPARα and AP-2α regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells
- Importance of PPARα for the effects of growth hormone on hepatic lipid and lipoprotein metabolism
- The PPARα ligand fenofibrate: meeting multiple targets in diabetic nephropathy
- PPARα activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase
- PPARα agonists stimulate progastrin production in human colorectal carcinoma cells
- The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARα-independent mechanism
- Induction of plasminogen activator inhibitor 1 by the PPARα ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway
- Involvement of ZIP/p62 in the regulation of PPARα transcriptional activity by p38-MAPK
- … , homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARα/γ …
- PPARα ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression
- Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARα/γ in fat milk-induced fatty liver rats
- A potent activator of PPARα and γ reduces the vascular cell recruitment and inhibits the intimal thickning in hypercholesterolemic rabbits
- HMG-CoA reductase inhibitors (statins) activate expression of PPARα/PPARγ and ABCA1 in cultured gallbladder epithelial cells
- Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
- Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARα agonists
- PPARα gene expression in the developing rat kidney: Role of glucocorticoids
- Combined effects of PPARγ2 P12A and PPARα L162V polymorphisms on glucose and insulin homeostasis: the Québec Family Study
- The effect of PPARα and PPARγ ligands on inflammation and ABCA1 expression in cultured gallbladder epithelial cells
- Peroxisome proliferator-activated receptorα (PPARα) agonists down-regulate α2-macroglobulin expression by a PPARα-dependent mechanism
- The PPARγ agonist pioglitazone represses inflammation in a PPARα-dependent manner in vitro and in vivo in mice
- Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARα
- Apoptosis of Endothelial Cells may be Mediated by Genes of Peroxisome Proliferator-activated Receptor γ1 (PPAR γ1) and PPARα Genes
- Effect of prenatal peroxisome proliferator-activated receptor α (PPARα) agonism on postnatal development
- PPARα activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic β-cell function in late pregnancy
- Tesaglitazar, a dual peroxisome proliferator-activated receptor agonist (PPARα/γ), improves metabolic abnormalities and reduces renal injury in obese Zucker rats
- Antagonism of COUP-TF and PPARα-RXRα on the Activation of the Malic Enzyme Gene Promoter: Modulation by 9-cis-RA
- HMG-CoA reductase and PPARα are involved in clofibrate-induced apoptosis in human keratinocytes
- Molecular Mechanism of Age-Specific Hepatic Lipid Accumulation in PPARα (+/−): LDLR (+/−) Mice, an Obese Mouse Model
- In vivo involvement of cytochrome P450 4A family in the oxidative metabolism of the lipid peroxidation product trans-4-hydroxy-2-nonenal, using PPARα …
- Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl) ethoxy] phenoxy} propionic acids: a new class of dual PPARα/γ agonists
- Design, synthesis, and evaluation of a new class of noncyclic 1, 3-dicarbonyl compounds as PPARα selective activators
- Effects of PPARα on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?
- Selective CETP inhibition and PPARα agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/Human CETP transgenic mice
- The clinical significance of PPARα and γ agonism
- PPARα activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism
- Downregulation of lactoferrin by PPARα ligands: Role in perturbation of hepatocyte proliferation and apoptosis
- Phosphatidylcholine and PPARα: A relevant connection in liver disease?
- Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver
- PPARα activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARγ-mediated increases …
- Molecular modelling of the peroxisome proliferator-activated receptor α (PPARα) from human, rat and mouse, based on homology with the human PPARγ crystal …
- Analysis of tissue-specific and PPARα-dependent induction of FABP gene expression in the mouse liver by an in vivo DNA electroporation method
- Differential transcriptional expression of PPARα, PPARγ1, and PPARγ2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice
- PPARα activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells
- Differences in the formation of PPARα-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration
- Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
- … , biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist …
- … isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor α (PPARα)
- Deficiency of PPARα disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose …
- A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARα−/− mice possibly through PGC-1 mediated PPARδ coactivation
- The peroxisome proliferator-activated receptor α (PPARα) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor …
- PPARα: Tempting fate with fat
- α-Lipoic Acid is a Weak Dual PPARα/γ Agonist: An Ester Derivative with Increased PPARα/γ Efficacy and Antioxidant Activity.
- PPARα-dependent alteration of GRP94 expression in mouse hepatocytes
- Four weeks one-leg training and high fat diet does not alter PPARα protein or mRNA expression in human skeletal muscle
- Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARα activation and oxidative stress
- Pleural mesothelial cells express both BLT2 and PPARα and mount an integrated response to pleural leukotriene B4
- Structure‐based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro1
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORα (PPARα) AGONIST, WY-14,643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN …
- Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARα/γ and TIMP gene expressions in ox-LDL-stimulated macrophages …
- Influence of peroxisome proliferator-activated receptor-alpha (PPARα) activity on adverse effects associated with amiodarone exposure in mice
- 4, 4-Dimethyl-1, 2, 3, 4-tetrahydroquinoline-based PPARα/γ agonists. Part I: Synthesis and pharmacological evaluation
- Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARα in human macrophages
- The pesticide adjuvant, Toximul™, alters hepatic metabolism through effects on downstream targets of PPARα
- PPARα stimulates the rat gastrin-producing cell
- PPARα-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells
- Conversion of human-selective PPARα agonists to human/mouse dual agonists: a molecular modeling analysis
- Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARα/γ and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages
- Cell cross-talk mediates PPARα null hepatocyte proliferation after peroxisome proliferator exposure
- Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARα selective
- WY-14 643, a selective PPARα agonist, induces proinflammatory and proangiogenic responses in human ocular cells
- PPARα Contributes to Tubular Protection
- PPARα ligand WY14643 reduced acute rejection after rat lung transplantation with the upregulation of IL-4, IL-10 and TGFβ mRNA expression
- PPARα agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells
- Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acids and vitamin A through PPARα in developing rats
- … ) phthalate induces both pro-and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARα
- PPARα and PPARδ transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2
- Structure-based design and synthesis of fluorescent PPARα/δ co-agonist and its application as a probe for fluorescent polarization assay of PPARδ ligands
- Inhibition of PPARα/RXRα‐mediated direct hyperplasia pathways during griseofulvin‐induced hepatocarcinogenesis
- Transcriptional modulations by RXR agonists are only partially subordinated to PPARα signaling and attest additional, organ-specific, molecular cross-talks
- Differential modulation of PPARα and γ target gene expression in the liver and kidney of rats treated with aspirin
- Interaction models of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids against PPARα and PPARγ: molecular modeling and comparative …
- Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor α (PPARα) stimulation
- The discovery of equipotent PPARα/γ dual activators
- Mode of action analysis and human relevance of liver tumors induced by PPARα activation
- PPARα-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator
- Expression of PPARα modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice
- Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists
- Synthesis and evaluation of N-acetyl-l-tyrosine based compounds as PPARα selective activators
- 4, 4-Dimethyl-1, 2, 3, 4-tetrahydroquinoline-based PPARα/γ agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural …
- Δ5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARα, in THP-1 cells
- Cardiovascular actions of the peroxisome proliferator‐activated receptor‐alpha (PPARα) agonist Wy14, 643
- Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARα in rodents
- PPARα: Savior or savage?
- Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARα L162V polymorphism
- Major role of soybean oil in preventing decrease in CYP4A1 mRNA content relative to PPARα mRNA down-regulation in infant rats
- PAR-5359, a well-balanced PPARα/γ dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo
- P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation
- PPARα activation during pregnancy severely impairs mammary lobuloalveolar development in mice
- Association between the FABP2 Ala54Thr, PPARα Leu162/Val, and PPARα intron7 polymorphisms and blood lipids ApoB and ApoCIII in hypertriglyceridemic subjects …
- Effects of cevoglitazar, a dual PPARα/γ agonist, on ectopic fat deposition in fatty Zucker rats
- Improvement of postprandial lipid handling and glucose tolerance in a non-diabetic population by the dual PPARα/γ agonist, tesaglitazar
- Molecular mechanics and molecular orbital simulations on specific interactions between peroxisome proliferator-activated receptor PPARα and plasticizer
- … coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PPARα and CAR, the …
- Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARα
- Identification of novel PPARα ligands by the structural modification of a PPARγ ligand
- Structure–activity studies on 1, 3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor α (PPARα) …
- Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARα agonists
- … response element (PPRE) present at positions− 681/− 669 in the rat liver 3-ketoacyl-CoA thiolase B gene functionally interacts differently with PPARα and HNF-4
- MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities
- Peroxisome Proliferator-Activated Receptor α (PPARα) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the …
- Molecular modeling study of species-selective peroxisome proliferator-activated receptor (PPAR) α agonist; possible mechanism (s) of human PPARα selectivity of an …
- A convergent kilogram-scale synthesis of the PPARα agonist LY518674: Discovery of a novel acid-mediated triazolone synthesis
- Combating atherosclerosis with LXRα and PPARα agonists: is rational multitargeted polypharmacy the future of therapeutics in complex diseases?
- Induction of the expression of the peroxisome proliferator‐activated receptor alpha (PPARα) by clofibrate in jerboa tissues
- The induction of atherogenic dyslipidaemia in poloxamer 407‐treated mice is not mediated through PPARα
- Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARα mRNA expression in rats fed a low or high corn oil diet
- Glycine amides as PPARα agonists
- Relationship between signal transduction and PPARα-regulated genes of lipid metabolism in rat hepatic-derived Fao cells
- Peroxisome proliferator-activated receptor α (PPARα) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents
- The possible therapeutic actions of peroxisome proliferator-activated receptor α (PPARα) agonists, PPARγ agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMG …
- Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists
- PPARα and PPARβ are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line
- Hepatic nuclear receptor PPARα in the koala (Phascolarctos cinereus): Cloning and molecular characterisation
- Activation of PPARα attenuates IFNγ and IL-1β-induced cell proliferation in astrocytes: involvement of IL-6 independent pathway
- PPARα and Effects of TCE
- Down-regulation of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARα
- PPARα: essential component to prevent myocardial oxidative stress?
- PPARα and PPARγ coactivation rapidly induces Egr-1 in the nuclei of the dorsal and ventral urinary bladder and kidney pelvis urothelium of rats
- PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy
- Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells
- Docosahexaenoic acid modulates the expression of T-bet and GATA-3 transcription factors, independently of PPARα, through suppression of MAP kinase activation
- Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARα and PPARγ ligands
- Baker’s yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARα ligands
- Effects of peroxisome proliferator-activated receptor α (PPARα) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells
- … of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators-PPARα and PPARγ selectivity …
- Activation of PPARα and PPARγ induce expression of the hepatic LDL receptor
- … terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARα) in the common …
- Synergistic effect of the human GLP‐1 analogue liraglutide and a dual PPARα/γ agonist on glycaemic control in Zucker diabetic fatty rats
- Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
- Haploinsufficiency in the PPARα and LDL receptor genes leads to gender-and age-specific obesity and hyperinsulinemia
- Ampk enhances the expression of pancreatic duodenal homeobox-1 via PPARα, but not PPARγ, in rat insulinoma cell line INS-1
- Liver PPARα and UCP2 are involved in the regulation of ovariectomy-induced adiposity and steatosis by swim training
- Cytochrome P450 eicosanoids regulate fatty acid metabolism via PPARα
- Antral G cells in rats during dosing with a PPARα agonist: a morphometric and immunocytochemical study
- Increased Proximal tubule PPARα in KAP2-PPARα Tg mice confers protection during acute kidney injury
- Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARα)
- Administration of ciprofibrate to lactating mothers induces PPARα-signaling pathway in the liver and kidney of suckling rats
- The conserved residue Phe273 (282) of PPARα (γ), beyond the ligand-binding site, functions in binding affinity through solvation effect
- Liquid chromatography-tandem mass spectrometry of a new PPARα/γ dual agonist PAR-5359 in rat plasma
- [14C] and [3H]‐labelling of Ragaglitazar: A dual acting PPARα and PPARγ agonist with hypolipidemic and anti‐diabetic activity
- The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver
- Preventing type 2 diabetes and cardiovascular disease in metabolic syndrome: the role of PPARα
- TNF and IL-1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
- Effects of 12 weeks of exercise on hepatic TNF-α and PPARα in an animal model of high-fat diet-induced nonalcoholic steatohepatitis
- The Peroxisome Proliferator-Activated Receptor α (PPARα) Ligand WY 14,643 Does Not Interfere with Leukotriene B4 Induced Adhesion of Neutrophils to Endothelial …
- PPARα deficiency does not modify age dependency but prevents high fat diet increase in plasma PAI-1 as well as insulin resistance
- PPARα, A key regulator of hepatic energy homeostasis in health and disease
- Differential antiatherogenic effects of PPARα versus PPARγ agonists: should we be surprised?
- (2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents
- Supramolecular Behavior of the Amphiphilic Drug (2R)-2-Ethylchromane-2-Carboxylic Acid Arginine Salt (a Novel PPARα/γ Dual Agonist)
- A selective PPARα agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys
- Synthesis of a 5-((Aryloxy) methyl)-3-(4-(trifluoromethyl) phenyl)[1, 2, 4] thiadiazole Derivative: A Promising PPARα, δ Agonist
- PPARβ/δ but not PPARα serves as plasma free fatty acid sensor in liver
- Reciprocal regulation of BMAL1 and PPARα defines a novel positive feedback loop in the rodent liver circadian clock
- Exploring the activation and function of PPARα and PPARβ/δ using genomics
- The PPARα activator fenofibrate fails to alter myocardial metabolism in healthy individuals despite marked peripheral effects
- Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
- WY14, 643, a PPARα ligand, attenuates expression of anti-glomerular basement membrane disease
- Partial resistance to PPARα agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism
- Fenugreek extract rich in 4-hydroxyisoleucine and trigonelline activates PPARα and inhibits LDL oxidation: Key mechanisms in controlling the metabolic syndrome
- Leukotriene B4: agonist for the fat regulator PPARα
- PPARα agonist fenofibrate inhibits IGF-I-mediated growth and DNA repair responses and sensitizes human glioblastoma cells to cisplatin
- Effects of Tribu Saponin from Tribulus terrestris on Gene Expression of ICAM-1, VCAM-1, PPARα and PPARγ in Artery Vessels of Atherosclerotic Rats.
- CoMFA, ADVANCE CoMFA AND CoMSIA STUDIES ON THE OXADIAZOLE SUBSTITUTED α-ISOPROPOXY PHENYLPROPIONIC ACIDS FOR PPARα AGONISTIC …
- PPARα activation and its consequences in humans
- Expression of the human UGT1 locus in transgenic mice by WY-14643 and implications on drug metabolism through PPARα activation
- PPARα activation: a drink from the fountain of youth?
- Regulation of arginine metabolism by dietary fatty acids: involvement of PPARα
- Rescue of cardiomyopathy in PPARα transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and PPARα activators
- Synthesis of urea acetates as potential PPARα/γ dual agonists
- Ab initio fragment molecular orbital calculations on the specific interactions between human, mouse and rat PPARα and GW409544
- The effect of soy isoflavones on the PPARα and PPARγ
- PPARα, Lipoprotein Metabolism, Metabolic Diseases, and Atherosclerosis
- Synthesis of tritium and carbon‐14 labelled NNC 61‐4655: a potent dual‐acting PPARα and PPARγ agonist
- Quantitative Structure Activity Analysis of 2-Alkoxydihydrocinnamates as PPARα/γ Dual Agonist
- Synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1, 3-oxazol-4-yl) ethoxy] pyridin-3-yl} propanoic acid, a dual PPARα/γ agonist
- Peroxisome Proliferator-Activated Receptor Alpha (PPARα): The Association with Pathogenesis of Fatty Liver Disease
- Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs
- Effect of aerobic exercise on the expression of PPARα, ABCA1 and ApoAI mRNA in high-fat diet rats muscles.
- Muscle ring finger‐1 (MuRF1) regulates cardiac fatty acid and glucose metabolism via its interaction with PPARα
- Polymorphisms of peroxisome proliferator-activated receptor a (PPARα)-exon 5 and its relationship with carcass and meat quality traits in cattle.
- Reduced LPA expression after peroxisome proliferator-activated receptor alpha (PPARα) activation in LPA-YAC transgenic mice
- Sustained formation of POBN radical adducts in mouse liver by peroxisome proliferators is dependent upon PPARα, but not NADPH oxidase
- Exploring the Activation and Function of PPARα and PPARß/δ Using Genomics
- Accelerated triacylglyceride dynamics induced by cardiac PPARα overexpression are potentiated by adrenergic stress to reveal increased reliance on endogenous …
- Tissue-specific Expression of Two Peroxisomal 3-ketoacyl-CoA Thiolase Genes in Wild and PPARα-null Mice and Induction by Fenofibrate
- The Effect of Rivoglitazone (Rivo) on Expression of Genes Targeted by PPARα and Those Implicated in Cardiac Function.
- (S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl) ethoxy) phenyl)-2-(piperazin-1-yl) propanoic acid compounds: Synthesis and biological evaluation of dual PPARα/γ …
- Muscle ring finger‐1 (MuRF1) inhibits spontaneous cardiac hypertrophy induced by the PPARα agonist fenofibrate in vivo
- Design and Synthesis of Novel 1, 3-Dioxane-2-carboxylic Acid Derivatives as PPARα/γ Dual Agonists
- PPARα and Atherosclerosis
- The Role of PPARα in Fatty Acid Metabolism and Hepatocarcinogenesis: Studies with PPARα-Null Mice
- A non-TZD PPARα/γ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice
- Cardiac Lipoprotein Lipase Deficiency Rescues Lipotoxic Cardiomyopathy and Identifies a Distinct Cellular PPARα Signaling Pathway
- Effect of PPARα ligand on TNFα-dependent expression of EGF receptor in human glioma cell line
- Transcriptional Regulation of Nutrient Metabolism by PPARα, γ and LXRα.
- Impaired Ras membrane-association and activation in PPARα knockout mice following partial hepatectomy
- Studies on the attenuation effects of intestinal PPARα
- PPARα and GR Differentially Down-Regulate the
- Statin reduces triglyceride level via activating PPARα and upregulating apolipoprotein A5 in hypertriglyceridemic rats
- Differential hepatic effects of perfluorobutyrate (PFBA) mediated by mouse and human PPARα
- KRP-101: A Potent PPARα Agonist Ameliolates Fat-Induced Insulin Resistance with Suppression of Adiposity in Dogs.
- PPARα-Regulated growth responses and their importance to hepatocarcinogenesis
- Role of Oxidative Stress in Cardiac Dysfunction of PPARα-/-Mice
- Identification of new PPARα target genes support its anti-inflammatory function in liver
- Regulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARα)
- RAGE dependent regulation of PPARα in bone metabolism
- PPARα controlling HDL metabolism and atherosclerosis
- Transcriptomic analysis of PPARα-dependent alterations during cardiac hypertrophy
- Research Article Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner
- PPARα regulates the expression of the amino acid degrading enzyme histidase
- Research Article Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects
- Probing the role of peroxisome proliferator-activated receptor alpha (PPARα) in the small intestine
- Poor match between genome wide in silico screening of PPARα targets and actual gene regulation in the mouse
- Perfluorohexanesulfonate and perfluorooctanesulfonate decrease plasma cholesterol and triglycerides in APOE* 3Leiden transgenic mice. Indication for a PPARα …
- Transcription coactivator PRIP is not essential for the function of nuclear receptors CAR and PPARα in liver
- Mannose binding lectin is a circulating mediator of hepatic PPARα activity in human
- Gly395Arg polymorphism of PPARα gene was not detected in japanese population of 729 individuals
- Peroxisome Proliferator-Activated Receptor (PPARα) Targeted Mutation Mouse Model
- The Krüppel like factors KLF11 and KLF10 are putative novel PPARα target genes in liver with a potential metabolic role
- Modulation of PPARα and PPARβ by ethanol in human breast cancer cell lines
- Fatty acid-dependent gene regulation of transporters and phase I/II metabolic enzymes by PPARα in murine small intestine
- PPARα is Essential for Cardiac Metabolic Adaptation to Chronic Hypoxia
- THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
- α-Lipoic Acid is a Weak Dual PPARα/γ Agonist
- The Dual PPARα/γ Agonist Tesaglitazar Reduces Atherosclerosis Development Beyond its Plasma Cholesterol-Lowering Effects in APOE* 3Leiden Transgenic …
- HEPATIC EXPRESSION OF PEROXISOME PROLIFERATORS ACTIVATED RECEPTORα (PPARα) IN PRIMARY BILIARY CIRRHOSIS: 1195
- Research Article Differences in Transcriptional Activation by the Two Allelic (L162V Polymorphic) Variants of PPARα after Omega-3 Fatty Acids Treatment
- Differences in transcriptional activation by the two allelic (L162V polymorphic) variants of PPARα after omega-3 fatty acids treatment
- Research Article PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex
- PPARα activation is essential for severe hepatic steatosis and hepatocellular carcinoma induced by HCV core protein
- The Role of Chronic PPARα Activation During Ischemia and Reperfusion Injury in the Female Rat Heart
- Treatment of obesity and type 2 diabetes with PPARα agonists–effects on myocardial metabolism, gene expression and ventricular function
- Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acids and vitamin A through PPARα in developing rats
- Human skeletal muscle PPARα expression correlates with expression of fat metabolism genes but not with BMI or insulin sensitivity
- Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling.
- Identification of a novel PPARα‐interacting protein
- PPARα and TCE: Keshava et al. Respond
- An epitope-tagging system for studying regulation of the peroxisome proliferator activated receptor alpha (PPARα)
- PPARα is a Key regulator of Hepatic FGF21 PPAR is a Key regulator of Hepatic FGF21
- Effect of maternal dietary restriction during pregnancy in rats on PPARα-regulated genes in the heart of the male offspring
- Effect of oleic acid on triglycerides (TG) accumulation and mRNA level of TNFα and PPARα in goose primary hepatocytes.
- In vivo PPARα activation attenuates cerebrovascular endothelial dysfunction via impeding NADPH oxidase-derived superoxide and augmenting …
- Repression of CYP4F1 gene by peroxisome proliferators is mediated by HNF4α and PPARα competition for PPRE sites in the CYP4F1 promoter
- PPARα Activation Reduced Remodelling And Improved Left Ventricular Function In Chronic Pressure/volume Overload Induced Heart Failure
- Thioredoxin-mediated negative autoregulation of peroxisome proliferator activated receptor α (PPARα) transcriptional activity
- Highly Sensitive and Potent Upregulation of Apolipoprotein A-IV/V by Novel PPARα Agonist, KRP-101, as Major PPARα-Regulated Genes in Human Hepatocytes.
- Acyl‐CoA Ligands of HNF‐4α and HNF‐4α/PPARα Interplay
- Partial resistance to PPARα agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism
- Glucagon Stimulates Fatty Acid Oxidation and Inhibits Triglyceride Synthesis in a PPARα-, p38 MAPK-and AMPK-Dependent Manner.
- Involvement of AMPK, p38 MAPK and PPARα in the regulation of avian uncoupling protein expression: regulation by isoproterenol and fatty acids in chick myoblasts
- Role of PPARα in control of torpor through FGF21-NPY pathway: From circadian clock genes to seasonal change and cardiovascular disease
- Activators of Nuclear Hormone Receptors, PPARα and FXR, Accelerate Maturation of the Epidermal Permeability Barrier In Utero• 321
- Statin induction of Liver Fatty Acid-Binding Protein (L-FABP) gene expression is PPARα-dependent.
- Protective Effect of KRP-101, Novel PPARα Agonist, on Fatty Liver Disease Through Induction of Lipid Oxidation & Suppression of Lipogenesis in Hamsters.
- The human multidrug resistance 3 (MDR3) transporter is a peroxisome proliferator-activated receptor α (PPARα) target gene
- PPARα AGONIST THERAPY AUGMENTS PARENCHYMAL REJECTION AND DOES NOT AMELIORATE TRANSPLANT-ASSOCIATED ARTERIOSCLEROSIS IN …
- Effect of berberine on PPARα/δ/γexpression in type 2 diabetic rat kidney
- PPARα agonists acutely dilate the mouse middle cerebral artery
- 3. PPARα AND FEMALE REPRODUCTION
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- SQUIRRELnovo: de novo design of a PPARα agonist by bioisosteric replacement
- Combined effects of PPARγ2 P12A and PPARα L162V polymorphisms on glucose and insulin homeostasis: the Québec Family Study
- PPARα L162V polymorphism alters the potential of N-3 fatty acids to increase lipoprotein lipase activity
- Proteomic profiling of salt‐induced changes in protein expression in PPARα null mice
- Neonatal leptin exposure induces altered expression of specific PPARα transcripts in adipose tissue of adult rats
- Effect of berberine on PPARα/δ/γ expression in type 2 diabetic rat kidney.
- Design and Synthesis of Naphthalimides as PPARα Agonists, Antihyperlipidemic, and Antiatherosclerotic Agents
- Activation of PPARα Is Positively Associated with the Upregulation of AMPKα Expression Impaired by Palmitate in INS-1 Beta Cells.
- PPARα Agonist Increases HDL Particle Size Through the Expression of Hepatic ABCG1 mRNA in the Zucker Diabetic Fatty Rat.
- Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009)
- Maternal diet alters expression of specific PPARα transcripts in the hearts of their female offspring
- Research Article Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα
- Bioassay-guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana.
- The PPARα/γ dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats.
- Short term consumption of lycopene and phytofluene decreases PPARα and PPARγ expression in selected rat tissues
- Effects of PPARα ligand on circadian rhythms and EEG delta power in mice
- Effect of berberine on PPARα/δ/γ expression in type 2 diabetic rat retinae.
- The involvement of PPARα in epoxide‐induced activation of adenosine receptors in angiogenesis
- Homocysteine-mediated PPARα, γ DNA methylation and its potential pathogenic mechanism in monocytes.
- PPARα Activation with Fenofibrate Attenuates Diabetic Nephropathy in Zucker Diabetic Fatty Rats
- Cardiomyocyte‐restricted PPARδ deletion in PPARα null mice leads to cardiac hypertrophy and heart failure
- Role of COX-2 in MCD Diet Induced Fibrosis and Its Corelation with PPARα
- Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARα/γ activation in 3T3-L1 cells.
- Changes in liver PPARα mRNA expression in response to two levels of high-safflower-oil diets correlate with changes in adiposity and serum leptin in rats and mice.
- Gender difference in PPARα regulation of inflammation and demyelination in EAE model of multiple sclerosis (50.1)
- Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs.
- A Novel Selective PPARα Agonist, CP900691, Improves Plasma Lipids, Lipoproteins, Glycemic Control and Reduces Body Weight in Diabetic Monkeys.
- Metabolic alterations beyond fatty acid oxidation defects in PPARα null mice hearts
- Phenotype of peroxisome proliferator-activated receptor-α (PPARα) deficient mice on mixed background fed high fat diet.
- The hepatic aquaporin 9 (AQP9) expression is regulated in response to castration and PPARα‐agonist treatment
- Effects of restraint on expression of PPARα, PPARβ and M-CPT-I mRNA in myocardium of rats.
- PPARα agonist protects against salt‐mediated increases in endogenous carbon monoxide production and blood pressure in Dahl salt‐sensitive rats
- Molecular mechanism of age-specific hepatic lipid accumulation in PPARα (+/-): LDLR (+/-) mice, an obese mouse model.
- Effects of high dietary fat and cholesterol on expression of PPARα, LXRα, and their responsive genes in the liver of apoE and LDLR double deficient mice.
- Combination Therapy with PPARα and Pparγ Agonists in Type 2 Diabetes Blunts the Reduction in Intra-Organ Triglyceride Content Seen with Pparγ Monotherapy.
- The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats.
- Arachidonic acid modulation of Ca2+-regulated exocytosis via PPARα/cGMP in gastric antral mucous cells of guinea pig
- Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver
- Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.).
- Coordinate regulation of the expression of the fatty acid transporter protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators
- The Korean traditional medicine Gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARα actions in rat …
- Altered mRNA expression of hepatic lipogenic enzyme and PPARα in rats fed dietary levan from Zymomonas mobilis.
- ACh‐stimulated exocytosis enhanced by arachidonic acid in guinea pig antral mucous cells: cGMP accumulation via PPARα
- Prevention of diet-induced obesity by safflower oil: insights at the levels of PPARα, Orexin, and Ghrelin gene expression of adipocytes in mice.
- Toxicogenomics/proteomics report: Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptorα (PPARα) stimulation
- Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARα L162V polymorphism
- The effects of Jiangzhiyigan Granules on the expression of Trx (thiordcoxin) and PPARα (peroxisome proliferator-activated receptor α) in liver tissues of rats with non …
- Omega‐3 fatty acids regulate gene expression levels differently in macrophages of men carrying the PPARα‐L162V polymorphism
- Reduced fat mass in rats fed a high oleic acid-rich safflower oil diet is associated with changes in expression of hepatic PPARα and adipose SREBP-1c-regulated …
- Effects of 12 weeks of exercise on hepatic TNF-α and PPARα in an animal model of high-fat diet-induced nonalcoholic steatohepatitis.
- P-442 DISCOVERY OF NOVEL PPARα LIGANDS BY THE MINOR STRUCTURAL MODIFICATIONS OF A PPARγ LIGAND
- Oxidized frying oil up-regulates hepatic acyl-CoA oxidase and cytochrome P450 4 A1 genes in rats and activates PPARα.
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α (PPARα) REGULATES ISCHEMIC LIVER INJURY: 209
- Integrated physiology and systems biology of PPARα
- The potential of natural products for targeting PPARα
- Regulation of ketone body metabolism and the role of PPARα
- Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
- Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
- Identification and characterization of PPARα ligands in the hippocampus
- PPARα is regulated by miR-21 and miR-27b in human liver
- Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models
- Bilirubin binding to PPARα inhibits lipid accumulation
- PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis
- Variation in the PPARα gene in Polish rowers
- PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver1–3
- PPARα as a therapeutic target in inflammation-associated diseases
- Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
- A map of the PPARα transcription regulatory network for primary human hepatocytes
- The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions
- PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling
- PPARα activation by culinary herbs and spices
- Protective and antioxidant effects of PPARα in the ischemic retina
- PPARα activation protects against cholestatic liver injury
- Insights into the role of hepatocyte PPARα activity in response to fasting
- PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway
- Interaction of PPARα with the canonic Wnt pathway in the regulation of renal fibrosis
- Human NPC1L1 expression is positively regulated by PPARα
- Impairment of PPARα and the fatty acid oxidation pathway aggravates renal fibrosis during aging
- MicroRNA‑518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus
- PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
- Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance
- Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease
- Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus)
- HMG-CoA reductase inhibitors bind to PPARα to upregulate neurotrophin expression in the brain and improve memory in mice
- CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα
- Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor α (PPARα)
- PPARα induces cell apoptosis by destructing Bcl2
- An ideal PPAR response element bound to and activated by PPARα
- The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway
- Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid‐lowering and insulin‐sensitizing effects in preclinical models
- Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 …
- Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
- The impact of PPARα activation on whole genome gene expression in human precision cut liver slices
- PPARα regulates tumor progression, foe or friend?
- Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis
- Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms
- Homeostatic PPARα signaling limits inflammatory responses to commensal microbiota in the intestine
- Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory
- Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα
- PPARα modulates gene expression profiles of mitochondrial energy metabolism in oral tumorigenesis
- Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer
- A specific ChREBP and PPARα cross-talk is required for the glucose-mediated FGF21 response
- PPARα signaling in the hippocampus: crosstalk between fat and memory
- PPARα is essential for retinal lipid metabolism and neuronal survival
- Palmitoleic acid improves metabolic functions in fatty liver by PPARα‐dependent AMPK activation
- Effects of the new dual PPARα/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose …
- Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling
- Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: structural basis for SPPARMα
- Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of …
- Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα
- On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
- Fatty acid chain length and saturation influences PPARα transcriptional activation and repression in HepG2 cells
- CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways
- Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
- Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia
- PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth
- Negatively regulating TLR4/NF-κB signaling via PPARα in endotoxin-induced uveitis
- Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα
- Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARα levels
- PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats
- Cloning, identification and accurate normalization expression analysis of PPARα gene by GeNorm in Megalobrama amblycephala
- PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
- Hippocampal PPARα is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice
- PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis
- AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
- PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis
- Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling
- PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation
- In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist
- Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway
- Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose–fed mice despite increased endoplasmic reticulum stress
- Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes
- Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
- Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis
- Mice with hyperbilirubinemia due to Gilbert’s syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα
- Effects of PPARα inhibition in head and neck paraganglioma cells
- PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats
- Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin
- Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium
- Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: from metabolomics to epigenetics
- Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis
- KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation
- The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and …
- PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors
- Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats
- The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ
- Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction
- Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes
- Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator–activated receptor alpha (PPARα)
- Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor?
- Aspirin induces lysosomal biogenesis and attenuates amyloid plaque pathology in a mouse model of Alzheimer’s disease via PPARα
- Ligand‐dependent nucleo‐cytoplasmic shuttling of peroxisome proliferator‐activated receptors, PPARα and PPARγ
- Perfluorooctanoic acid (PFOA)–induced liver lesions in two strains of mice following developmental exposures: PPARα is not required
- Aberrant miR199a-5p/caveolin1/PPARα axis in hepatic steatosis
- High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver
- Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide
- Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiation
- PPARα agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice
- Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia
- PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
- Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice
- The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
- Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice
- PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C
- Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: a randomized, double blind, active-and placebo-controlled, phase …
- Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells
- Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice
- The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway
- Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
- Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment
- Nuciferine ameliorates hepatic steatosis in high‐fat diet/streptozocin‐induced diabetic mice through a PPARα/PPARγ coactivator‐1α pathway
- Icariin attenuates cerebral ischemia–reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats
- Identification of picrasidine C as a subtype-selective PPARα agonist
- Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation
- Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
- Overfeeding dairy cattle during late-pregnancy alters hepatic PPARα-regulated pathways including hepatokines: Impact on metabolism and peripheral insulin …
- PARP1-mediated PPARα poly (ADP-ribosyl) ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease
- … –Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR
- Sleep deprivation induces dry eye through inhibition of PPARα expression in corneal epithelium
- The protective effect of the Cornus mas fruits (cornelian cherry) on hypertriglyceridemia and atherosclerosis through PPARα activation in hypercholesterolemic rabbits
- A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis
- Evaluation of PPARα activation by known blueberry constituents
- PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors
- Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells
- Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose
- Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells
- Fibrate-derived N-(methylsulfonyl) amides with antagonistic properties on PPARα
- Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and-independent pathways
- Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice
- PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis
- The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in …
- The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes
- The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides
- Peroxisome proliferator-activated receptor (PPAR) β/δ, a possible nexus of PPARα-and PPARγ-dependent molecular pathways in neurodegenerative diseases …
- Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPARα-regulated β-oxidative enzymes
- Fatty acid-specific alterations in leptin, PPARα, and CPT-1 gene expression in the rainbow trout
- The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats
- Effects of pemafibrate, a novel selective PPARα modulator, on lipid and glucose metabolism in patients with type 2 diabetes and hypertriglyceridemia: a randomized …
- Potent PPARα activator derived from tomato juice, 13-oxo-9, 11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice
- Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen …
- PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting
- … extract of diabetes-and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1
- Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist
- Stimulation of PPARα normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin
- Dose and effect thresholds for early key events in a PPARα-mediated mode of action
- Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
- Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism
- Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPARα in liver of mice fed high-fat diet
- Icariin is a PPARα activator inducing lipid metabolic gene expression in mice
- The peroxisome proliferator-activated receptor α (PPARα) agonist pemafibrate protects against diet-induced obesity in mice
- FGF21 is not a major mediator for bone homeostasis or metabolic actions of PPARα and PPARγ agonists
- New PPARα/γ/δ optimal activator rationally designed by computational methods
- Protective effects of adiponectin against renal ischemia‐reperfusion injury via prostacyclin‐PPARα‐heme oxygenase‐1 signaling pathway
- Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human …
- PPARα agonist, fenofibrate, ameliorates age-related renal injury
- Inhibition of JNK signalling mediates PPARα‐dependent protection against intrahepatic cholestasis by fenofibrate
- PPARα agonist stimulated angiogenesis by improving endothelial precursor cell function via a NLRP3 inflammasome pathway
- Hepatic PPARα function is controlled by polyubiquitination and proteasome‐mediated degradation through the coordinated actions of PAQR3 and HUWE1
- Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver
- Therapeutic effects of PPARα agonist on ocular neovascularization in models recapitulating neovascular age-related macular degeneration
- Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice
- The dietary isoflavone daidzein reduces expression of pro-inflammatory genes through PPARα/γ and JNK pathways in adipocyte and macrophage co-cultures
- Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity
- Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene …
- Liraglutide protects cardiac function in diabetic rats through the PPARα pathway
- PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
- Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα
- Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors
- Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart
- Differential effects on lung cancer cell proliferation by agonists of glucocorticoid and PPARα receptors
- PPARα mediates the hepatoprotective effects of nutmeg
- Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract
- Effect of cold stress on expression of AMPKα–PPARα pathway and inflammation genes
- PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis
- Benzothiazole-based N-(phenylsulfonyl) amides as a novel family of PPARα antagonists
- Oleoylethanolamide dose‐dependently attenuates cocaine‐induced behaviours through a PPARα receptor‐independent mechanism
- The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
- … of aqueous extract of syzigium cumini for its antihyperglycemic and antidyslipidemic properties in diabetic rats fed a high cholesterol diet—Role of PPARγ and PPARα
- Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro
- LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties
- High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α …
- The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism
- Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice
- Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs
- Free fatty acids increase intracellular lipid accumulation and oxidative stress by modulating PPARα and SREBP-1c in L-02 cells
- Sensitive bioassay for detection of PPARα potentially hazardous ligands with gold nanoparticle probe
- HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer
- Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway
- Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice
- A novel selective PPARα modulator (SPPARMα), K-877 (pemafibrate), attenuates postprandial hypertriglyceridemia in mice
- Transcriptome analysis of K-877 (a novel selective PPARα modulator (SPPARMα))-regulated genes in primary human hepatocytes and the mouse liver
- Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα
- Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice
- Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives
- Proline-and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor α (PPARα) activity
- Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα
- Activating PPARα Prevents Post–Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts
- DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells [S]
- PPARα in lysosomal biogenesis: a perspective
- Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate
- Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes
- Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis
- PPARα Regulates the Proliferation of Human Glioma Cells through miR-214 and E2F2
- A grape seed procyanidin extract inhibits HDAC activity leading to increased PPARα phosphorylation and target‐gene expression
- Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
- Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway
- … oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα
- Over-expression of PPARα in obese mice adipose tissue improves insulin sensitivity
- Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity
- PPARα agonist fenofibrate ameliorates learning and memory deficits in rats following global cerebral ischemia
- In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator‐activated receptor alpha (PPARα) at the blood–brain barrier
- Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome [S]
- PPARα promotes cancer cell Glut1 transcription repression
- Arctigenin inhibits liver cancer tumorigenesis by inhibiting gankyrin expression via C/EBPα and PPARα
- Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes
- Hypoxia-mediated down-regulation of OCTN2 and PPARα expression in human placentas and in BeWo cells
- PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2, 4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
- Therapeutic potential of panduratin A, LKB1‐dependent AMP‐activated protein kinase stimulator, with activation of PPARα/δ for the treatment of obesity
- Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARα in the associated hypertrophy
- The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation
- Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases
- CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site
- Hypoxia induces peroxisome proliferator‐activated receptor α (PPARα) and lipid metabolism peroxisomal enzymes in human glioblastoma cells
- In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?
- PPARα gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players
- GC-MS metabolomics on PPARα-dependent exacerbation of colitis
- MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARα pathway in HepG2 cells
- PPARα: A Master Regulator of Bilirubin Homeostasis
- Plasma mannose-binding lectin is stimulated by PPARα in humans
- Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer
- Regulation of Genes Involved in Carnitine Homeostasis by PPARα across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human)
- Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice
- Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity
- Protectin DX ameliorates palmitate-or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice
- Hepatic cerebroside sulfotransferase is induced by PPARα activation in mice
- A novel structural class of coumarin-chalcone fibrates as PPARα/γ agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular …
- New role of hispidulin in lipid metabolism: PPARα activator
- Association and Interaction of PPARα, δ, and γ Gene Polymorphisms with Low-Density Lipoprotein-Cholesterol in a Chinese Han Population
- Fenofibrate, a PPARα agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy
- PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4
- PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
- Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults
- PPARα antagonist AA452 triggers metabolic reprogramming and increases sensitivity to radiation therapy in human glioblastoma primary cells
- Hepatic-specific PPARα-FGF21 action in NAFLD
- PPARα–LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
- … PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to …
- Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes
- PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis
- PPARα regulates mobilization and homing of endothelial progenitor cells through the HIF-1α/SDF-1 pathway
- The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
- Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and …
- Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
- Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter …
- PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1
- AVE8134, a novel potent PPARα agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats
- Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
- MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARα in human hepatocellular carcinoma
- PPARα is necessary for radiation-induced activation of noncanonical TGFβ signaling in the heart
- PPARα activation alleviates damage to the cytoskeleton during acute myocardial ischemia/reperfusion in rats
- Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS
- Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues
- Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
- Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS
- Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα
- Activation of the nuclear receptor PPARα regulates lipid metabolism in foetal liver from diabetic rats: implications in diabetes‐induced foetal overgrowth
- p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα
- Adiponectin regulates AQP3 via PPARα in human hepatic stellate cells
- Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression
- High glucose potentiates L-FABP mediated fibrate induction of PPARα in mouse hepatocytes
- Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment
- Targeted metabolomics reveals a protective role for basal PPARα in cholestasis induced by α-naphthylisothiocyanate
- … regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARα/LPL and LDLR
- PPARα agonist suppresses inflammation after corneal alkali burn by suppressing proinflammatory cytokines, MCP-1, and nuclear translocation of NF-κB
- PPARα mediates the anti‐inflammatory effect of simvastatin in an experimental model of zymosan‐induced multiple organ failure
- Coordination among lipid droplets, peroxisomes, and mitochondria regulates energy expenditure through the CIDE-ATGL-PPARα pathway in adipocytes
- Effects of PPARα/PGC-1α on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice
- Scutellarin from Scutellaria baicalensis Suppresses Adipogenesis by Upregulating PPARα in 3T3-L1 Cells
- Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway
- Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP
- Targeting Nuclear Hormone Receptors: PPARα Agonists as Potential Disease-Modifying Drugs for Rheumatoid Arthritis
- … is independent from the presence of PPARα in the intestine and the nodose ganglion, while the impact of OEA on energy expenditure requires the presence of PPARα …
- Identification of the first PPARα/γ dual agonist able to bind to canonical and alternative sites of PPARγ and to inhibit its cdk5-mediated phosphorylation
- Bilobetin ameliorates insulin resistance by PKA‐mediated phosphorylation of PPARα in rats fed a high‐fat diet
- Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ
- Renoprotective effect of a novel selective PPARα modulator K-877 in db/db mice: a role of diacylglycerol-protein kinase C-NAD (P) H oxidase pathway
- PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH
- Phosphatidic acid (PA) can displace PPARα/LXRα binding to the EGFR promoter causing its transrepression in luminal cancer cells
- … cerebral hypoperfusion by inhibiting the amyloidogenic pathway: Involvement of BDNF/TrkB/CREB signaling and up-regulation of PPARα and PPARγ in rats
- Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor …
- Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells
- PPARα/HNF4α interplay on diversified responsive elements. Relevance in the regulation of liver peroxisomal fatty acid catabolism
- Energy metabolism in glioblastoma stem cells: PPARα a metabolic adaptor to intratumoral microenvironment
- Effects of MHY908, a new synthetic PPARα/γ dual agonist, on inflammatory responses and insulin resistance in aged rats
- … hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by …
- Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose
- Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
- Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPARα signaling and inhibiting the NF-κB and ERK1/2/AP-1 …
- Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease
- … Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways
- Transcriptional regulation of the human, porcine and bovine OCTN2 gene by PPARα via a conserved PPRE located in intron 1
- Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A
- Analysis on the association between PPARα/γ polymorphisms and lipoprotein (a) in a Chinese Han population
- PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice
- 5, 7‐Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB‐induced MMP expression in human skin fibroblast cells
- PPARα, a predictor of patient survival in glioma, inhibits cell growth through the E2F1/miR-19a feedback loop
- Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats
- Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
- PPARα-independent arterial smooth muscle relaxant effects of PPARα agonists
- The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH‐wildtype primary glioblastoma
- Effect of Berberine on PPARα/NO Activation in High Glucose- and Insulin-Induced Cardiomyocyte Hypertrophy
- PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
- Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces
- Resveratrol protects RPE cells from sodium iodate by modulating PPARα and PPARδ
- Environmental enrichment, age, and PPARα interact to regulate proliferation in neurogenic niches
- Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis
- MiR‐19a affects hepatocyte autophagy via regulating lncRNA NBR2 and AMPK/PPARα in D‐GalN/Lipopolysaccharide‐Stimulated hepatocytes
- L-carnitine protects against carboplatin-mediated renal injury: AMPK-and PPARα-dependent inactivation of NFAT3
- Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes
- Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR
- HMGB1 Is Involved in the Protective Effect of the PPARα Agonist Fenofibrate against Cardiac Hypertrophy
- Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice
- Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
- PPARα agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes
- Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver …
- Fenofibrate, a PPARα agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB
- Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism
- PPARα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system
- Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes
- Identification of dual PPARα/γ agonists and their effects on lipid metabolism
- PPARα and PPARγ regulate the nucleoside transporter hENT1
- Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8)[S]
- PPARα (peroxisome proliferator-activated receptor α) activation reduces hepatic CEACAM1 protein expression to regulate fatty acid oxidation during fasting …
- Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner
- Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα
- Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice
- Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV
- Upregulation of rat liver PPARα‐FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
- Effect of phase delay lighting rotation schedule on daily expression of per2, bmal1, rev-erbα, PPARα, and pdk4 genes in the heart and liver of Wistar rats
- Wogonin suppresses osteopontin expression in adipocytes by activating PPARα
- Transcriptomic signatures of peroxisome proliferator-activated receptor α (PPARα) in different mouse liver models identify novel aspects of its biology
- Activation of PPARα by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury
- Fenofibrate induces G0/G1 phase arrest by modulating the PPARα/FoxO1/p27kip pathway in human glioblastoma cells
- Reduced expression of 11β-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPARγ but increased PPARα expression
- PPARα polymorphisms as risk factors for dyslipidemia in a Brazilian population
- Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress
- The PPARα agonists fenofibrate and CP-778875 cause increased β-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat
- Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats
- Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging
- JAZF1 regulates visfatin expression in adipocytes via PPARα and PPARβ/δ signaling
- MAPK–PPARα/γ signal transduction pathways are involved in Chlamydia pneumoniae-induced macrophage-derived foam cell formation
- Opposing effects of PPARα agonism and antagonism on refractive development and form deprivation myopia in guinea pigs
- Gene–gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population
- A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα
- PPARα agonists based on stilbene and its bioisosteres: Biological evaluation and docking studies
- Is PPARα intron 7 G/C polymorphism associated with muscle strength characteristics in nonathletic young men?
- Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration
- PPARα protein expression was increased by four weeks of intermittent hypoxic training via AMPKα2-dependent manner in mouse skeletal muscle
- Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and-independent pathways
- Adiponectin ameliorates iron-overload cardiomyopathy through the PPARα–PGC-1–dependent signaling pathway
- PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis
- Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis
- Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8
- HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD
- Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in …
- Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARα-dependent protein stabilization but without …
- Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα signalling activation
- PPARα enhances cancer cell chemotherapy sensitivity by autophagy induction
- Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation
- Screening of medicinal plants for PPARα and PPARγ activation and evaluation of their effects on glucose uptake and 3T3-L1 adipogenesis
- Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects
- … endogenous apolipoprotein AI expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-κB, and nuclear receptors PPARα and …
- Scaffold-based pan-agonist design for the PPARα, PPARβ and PPARγ receptors
- PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron (Fe)-induced reduction in hepatic lipid deposition of javelin goby Synechogobius hasta
- Down-regulation of PPARα in the spinal cord contributes to augmented peripheral inflammation and inflammatory hyperalgesia in diet-induced obese rats
- Peroxisome proliferator-activated receptor α (PPARα) contributes to control of melanogenesis in B16 F10 melanoma cells
- … present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 …
- Peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARβ/δ) gene expression profile on ram spermatozoa and their relation to the sperm …
- Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice
- The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat
- The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation
- Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously …
- Activation of PPARα by fatty acid accumulation enhances fatty acid degradation and sulfatide synthesis
- Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPARα) in human hepatocarcinoma HepG2 cells by …
- Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation
- The relationship between KLF5 and PPARα in the heart: it’s complicated
- Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation
- PPARα is down-regulated following liver transplantation in mice
- PPARα ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats
- Increased expression of oxidative enzymes in adipose tissue following PPARα-activation
- … prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARα
- PPARα-L162V polymorphism is not associated with schizophrenia risk in a Croatian population
- Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα
- Swimming’s prevention of ovariectomy-induced obesity through activation of skeletal-muscle PPARα
- Differential regulation of stimulated glucose transport by free fatty acids and PPARα or-δ agonists in cardiac myocytes
- Hydrogen sulfide up-regulates the expression of ATP-binding cassette transporter A1 via promoting nuclear translocation of PPARα
- PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling
- Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein
- PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats
- Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
- 5‐Caffeoylquinic acid decreases diet‐induced obesity in rats by modulating PPARα and LXRα transcription
- Spectroscopic and molecular modeling approaches to investigate the interaction of bisphenol A, bisphenol F and their diglycidyl ethers with PPARα
- Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) …
- Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line
- Therapy with Astragalus polysaccharides rescues lipotoxic cardiomyopathy in MHC-PPARα mice
- Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
- Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced …
- … adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and …
- An association between the PPARα-L162V polymorphism and nicotine dependency among patients with schizophrenia
- DHEA administration activates transcription of muscular lipid metabolic enzymes via PPARα and PPARδ in obese rats
- Prostacyclin and PPARα agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms
- Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities
- Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice
- Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF‐1/PPARα and Ca2+/CaMKKβ/AMPK pathways
- Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway
- Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism …
- Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver
- SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300
- The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy
- Adiponectin deficiency-induced diabetes increases TNFα and FFA via downregulation of PPARα
- Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse …
- Pro-inflammatory effect of fibrinogen on vascular smooth muscle cells by regulating the expression of PPARα, PPARγ and MMP-9
- The PPARα agonist fenofibrate prevents formation of protein aggregates (Mallory-Denk bodies) in a murine model of steatohepatitis-like hepatotoxicity
- γ-Mangostin from Garcinia Mangostana Pericarps as a Dual Agonist That Activates Both PPARα and PPARδ
- PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury
- Xuezhikang contributes to greater triglyceride reduction than simvastatin in hypertriglyceridemia rats by up-regulating apolipoprotein A5 via the PPARα …
- Acyl-CoA thioesterase 1 (ACOT1) regulates PPARα to couple fatty acid flux with oxidative capacity during fasting
- The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits high-fat diet-induced hepatic steatosis via hepatic PPARα …
- Hyper-and hypo-nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis
- Direct effects of PPARα agonists on retinal inflammation and angiogenesis may explain how fenofibrate lowers risk of severe proliferative diabetic retinopathy
- Dietary alanyl-glutamine and vitamin E supplements could considerably promote the expression of GPx and PPARα genes, antioxidation, feed utilization, growth, and …
- Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of …
- … effects of Coreopsis tinctoria flowers phenolic extract against D-galactosamine/lipopolysaccharide-induced acute liver injury by up-regulation of Nrf2, PPARα, and …
- N-oleoylethanolamide suppresses intimal hyperplasia after balloon injury in rats through AMPK/PPARα pathway
- Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways
- Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARα agonist fenofibrate in a rat model
- The PPARα agonist fenofibrate improves the musculoskeletal effects of exercise in ovariectomized rats
- Caloric restriction in leptin deficiency does not correct myocardial steatosis: Failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling
- The effects of kefir, koumiss, yogurt and commercial probiotic formulations on PPARα and PPAR-β/δ expressions in mouse kidney
- Spinal cord injury induced changes of nuclear receptors PPARα and LXRβ and modulation with oleic acid/albumin treatment
- Discovery of potent dual PPARα agonists/CB1 ligands
- Aqueous extract of black maca prevents metabolism disorder via regulating the glycolysis/gluconeogenesis-TCA cycle and PPARα signaling activation in …
- … impair angiotensin II-induced arterial mononuclear cell adhesion through inhibition of Nox5 signaling pathways and increased RXR/PPARα and RXR/PPARγ …
- Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity
- Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design …
- Oleoylethanolamide alleviates macrophage formation via AMPK/PPARα/STAT3 pathway
- Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα
- Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of …
- … determinants for improved activity at PPARα: structure–activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα
- Inhibition of FAAH confers increased stem cell migration via PPARα
- IL-1β-induced downregulation of the multifunctional PDZ adaptor PDZK1 is attenuated by ERK inhibition, RXRα, or PPARα stimulation in enterocytes
- … well as the expression of sterol-regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator activated receptors α (PPARα) in diabetic rat
- Ubiquinol affects the expression of genes involved in PPARα signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of …
- Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice
- PPARα activation sensitizes cancer cells to epigallocatechin-3-gallate (EGCG) treatment via suppressing heme oxygenase-1
- Interleukin-6 affects aging-related changes of the PPARα-PGC-1α axis in the myocardium
- Naoxintong retards atherosclerosis by inhibiting foam cell formation through activating PPARα pathway
- Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory …
- Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα …
- Peroxisome proliferator-activated receptor α (PPARα) mRNA expression in human hepatocellular carcinoma tissue and non-cancerous liver tissue
- Dietary heme-mediated PPARα activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon
- Co‐treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis
- Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors (PPARα and PPARγ) gene …
- Pravastatin activates PPARα/PPARγ expression in the liver and gallbladder epithelium of hamsters
- Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-α (PPARα) in alcoholic cardiomyopathy
- PPARα activation attenuates amyloid-β-dependent neurodegeneration by modulating Endo G and AIF translocation
- Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
- Aleglitazar, a balanced dual PPARα and-γ agonist, protects the heart against ischemia-reperfusion injury
- Restoration of Endothelial Function in PPARα−/− Mice by Tempol
- Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
- A novel function of hepatic FOG2 in insulin sensitivity and lipid metabolism through PPARα
- The role of nuclear receptor PPARα in the sleep-wake cycle modulation. A tentative approach for treatment of sleep disorders
- PPARα agonists reduce alcohol drinking: do they act in the brain or in the liver?
- Role of AMPK and PPARα in the anti‐skin cancer effects of ursolic acid
- MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization
- Localization of peroxisome proliferator-activated receptor alpha (PPARα) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the …
- GW501516 acts as an efficient PPARα activator in the mouse liver
- Loss of PPARα perpetuates sex differences in stroke reflected by peripheral immune mechanisms
- Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPARα) agonist GW7647 or to …
- Naoxintong/PPARα Signaling Inhibits H9c2 Cell Apoptosis and Autophagy in Response to Oxidative Stress
- The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression
- Identification of the first potent, selective and bioavailable PPARα antagonist
- Monocarboxylate transporters 1 and 4: expression and regulation by PPARα in ovine ruminal epithelial cells
- Testing the PPAR hypothesis of tobacco use disorder in humans: A randomized trial of the impact of gemfibrozil (a partial PPARα agonist) in smokers
- Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors
- Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions
- Structure–activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
- Inhibition of PPARα attenuates vimentin phosphorylation on Ser-83 and collapse of vimentin filaments during exposure of rat Sertoli cells in vitro to DBP
- Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis
- Activation of PPARα by oral clofibrate increases renal fatty acid oxidation in developing pigs
- The 4′-hydroxyl group of resveratrol is functionally important for direct activation of PPARα
- Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5, 14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and …
- Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice
- … diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (PPARα)
- Δ9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells
- PPARα regulates endothelial progenitor cell maturation and myeloid lineage differentiation through a NADPH oxidase-dependent mechanism in mice
- Characterization of the binding between phthalate esters and mouse PPARα for the development of a fluorescence polarization-based competitive binding assay
- PPARα/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models
- RETRACTED ARTICLE: Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation
- Extracts of pomelo peels prevent high-fat diet-induced metabolic disorders in c57bl/6 mice through activating the PPARα and GLUT4 pathway
- Effects of dietary polyunsaturated fatty acids on DNA methylation and the expression of DNMT3b and PPARα genes in rats
- Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARα target gene in cardioprotection
- The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα
- PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons
- Synergetic neuroprotective effect of docosahexaenoic acid and aspirin in SH-Y5Y by inhibiting miR-21 and activating RXRα and PPARα
- A novel PPARα agonist propane-2-sulfonic acid octadec-9-enyl-amide inhibits inflammation in THP-1 cells
- Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα
- Effects of the PPARα agonist WY-14,643 on plasma lipids, enzymatic activities and mRNA expression of lipid metabolism genes in a marine flatfish, Scophthalmus …
- G0S2a1 (G0/G1 switch gene 2a1) is downregulated by TNF-α in grass carp (Ctenopharyngodon idellus) hepatocytes through PPARα inhibition
- 17β-estradiol inhibits PPARα of skeletal muscle
- Alleviation of toxicity caused by overactivation of PPARα through PPARα-inducible mir-181a2
- Peroxisome proliferator-activated receptor alpha (PPARα), a key regulator of lipid metabolism in Avians
- Rice Koji Extract Enhances Lipid Metabolism through Peroxisome Proliferator-Activated Receptor Alpha (PPARα) Activation in Mouse Liver
- … acid, a triterpenoid compound from Antrodia camphorata, by regulation of Akt phosphorylation, gluconeogenesis, and PPARα in streptozotocin-induced …
- … on peroxisome proliferator-activated receptor gamma coactivator-1α,(PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen related …
- Identification of novel PPARα/γ dual agonists by virtual screening, ADMET prediction and molecular dynamics simulations
- Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
- Donor PPARα gene polymorphisms influence the susceptibility to glucose and lipid disorders in liver transplant recipients: a strobe-compliant observational …
- IL-15 Mediates Mitochondrial Activity through a PPARδ-Dependent-PPARα-Independent Mechanism in Skeletal Muscle Cells
- Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice
- Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling
- 17-OxoDHA is a PPARα/γ dual covalent modifier and agonist
- 5, 7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation
- Computational and Biological Evaluation of N-octadecyl-N′-propylsulfamide, a Selective PPARα Agonist Structurally Related to N-acylethanolamines
- Retracted Article: Metabolomics reveals that PPARα activation protects against lithocholic acid-induced liver injury
- Activation of intestinal GR–FXR and PPARα–UGT signaling exacerbates ibuprofen-induced enteropathy in mice
- Molecular characterization and functional analysis of PPARα promoter in yellow catfish Pelteobagrus fulvidraco
- Hepatic fasting-induced PPARα activity does not depend on essential fatty acids
- Editor’s highlight: Clofibrate decreases bile acids in livers of male mice by increasing biliary bile acid excretion in a PPARα-dependent manner
- Evidence that activation of nuclear peroxisome proliferator-activated receptor alpha (PPARα) modulates sleep homeostasis in rats
- PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid …
- The PPARα pathway in Vγ9Vδ2 T cell anergy
- A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set …
- Acot1 is a sensitive indicator for PPARα activation after perfluorooctanoic acid exposure in primary hepatocytes of Sprague-Dawley rats
- Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats
- PPARα downregulates hepatic glutaminase expression in mice fed diets with different protein: carbohydrate ratios
- PPARα mediates sunitinib resistance via NF-κB activation in clear cell renal cell carcinoma
- Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice
- … -increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ
- Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes: Roles of AMPK and PPARα in the lipolytic effect of kinsenoside
- Virtual identification of novel PPARα/γ dual agonists by scaffold hopping of saroglitazar
- PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway
- Tissue-specific 5′ heterogeneity of PPARα transcripts and their differential regulation by leptin
- The combined strategy with PPARα agonism and AT1 receptor antagonism is not superior relative to their individual treatment approach in preventing the induction of …
- Mouse cardiac Pde1C is a direct transcriptional target of PPARα
- Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
- Reduced PPARα expression is associated with decreased survival and increased tissue bacterial load in sepsis
- PPARα attenuates palmitate-induced endoplasmic reticulum stress in human cardiac cells by enhancing AMPK activity
- Molecular cloning and tissue distribution of peroxisome proliferator-activated receptor-alpha (PPARα) and gamma (PPARγ) in the pigeon (Columba livia domestica)
- L-carnitine and PPARα-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells
- Artificial zinc-finger transcription factor of A20 suppresses restenosis in Sprague Dawley rats after carotid injury via the PPARα pathway
- Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents
- Relationship between PPARα mRNA expression and mitochondrial respiratory function and ultrastructure of the skeletal muscle of patients with COPD
- Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene …
- Protection of endothelial cells against Ang II-induced impairment: Involvement of both PPARα and PPARγ via PI3K/Akt pathway
- Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat
- OxLDL up-regulates Niemann–Pick type C1 expression through ERK1/2/COX-2/PPARα-signaling pathway in macrophages
- PPARα gene polymorphisms modulate the association between physical activity and cardiometabolic risk
- Binding interactions of halogenated bisphenol A with mouse PPARα: In vitro investigation and molecular dynamics simulation
- Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac lipotoxicity in mouse
- A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver
- 3D-QSAR study of tyrosine and propanoic acid derivatives as PPARα/γ dual agonists using CoMSIA
- PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca2+-regulated exocytosis
- Clofibrate induces heme oxygenase 1 expression through a PPARα-independent mechanism in human cancer cells
- Hepatic amino acid-degrading enzyme expression is downregulated by natural and synthetic ligands of PPARα in rats
- PPARα activation by fenofibrate protects against acute myocardial ischemia/reperfusion injury by inhibiting mitochondrial apoptosis
- Gemfibrozil not fenofibrate decreases systemic glucose level via PPARα
- The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα
- Effects of EPA supplementation on plasma fatty acids composition in hypertriglyceridemic subjects with FABP2 and PPARα genotypes
- PPARα-dependent induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
- The dipeptide H-Trp-Arg-OH (WR) is a PPARα agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells
- cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA Mixture Activates PPARα in HEK293 and Reduces Triacylglycerols in 3T3-L1 cells
- Osthol inhibits fatty acid synthesis and release via PPARα/γ-mediated pathways in 3T3-L1 adipocytes
- PPARα agonist Wy14643 suppresses cathepsin B in human endothelial cells via transcriptional, post-transcriptional and post-translational mechanisms
- Effect of polyene phosphatidyl choline on hepatocyte steatosis via PPARα/CPT-1A pathway
- … -AβPP 695 cells revealed mitochondrial dysfunction prior to amyloid-β pathology and potential therapeutic effects of both PPARγ and PPARα agonisms for Alzheimer’s …
- Abietic acid inhibits UVB‐induced MMP‐1 expression in human dermal fibroblast cells through PPARα/γ dual activation
- Red clover extract ameliorates dyslipidemia in streptozotocin‐induced diabetic C57BL/6 mice by activating hepatic PPARα
- Functional genetic variants of PPARγ and PPARα encoding peroxisome proliferator-activated receptors and susceptibility to ischemic stroke in Chinese Han …
- PPARα activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver
- Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
- Increased nitric oxide production and gender-dependent changes in PPARα expression and signaling in the fetal lung from diabetic rats
- Treatment of lactating sows with clofibrate as a synthetic agonist of PPARα does not influence milk fat content and gains of litters
- Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II
- A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats
- Development of a new class of benzoylpyrrole-based PPARα/γ activators
- Flow Cytometry Analysis of PPARα Receptors in Metabolic Syndrome/Studiul Receptorilor PPARα prin Metoda Citometriei în Flux în Sindromul Metabolic
- Synergistic mechanism of traditional Chinese medicine based on target combination of PepT1 and PPARα
- Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPARα/γ activity in microvascular endothelial cells
- Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine
- Circ5379-6, a circular form of tumor suppressor PPARα, participates in the inhibition of hepatocellular carcinoma tumorigenesis and metastasis
- Prediction of the PPARα agonism of fibrates by combined MM–docking approaches
- PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin–Angiotensin System
- PPARβ/δ Activation prevents hypertriglyceridemia caused by a high fat diet. Involvement of AMPK and PGC-1α-Lipin1-PPARα pathway
- Identification of novel PPARα/γ dual agonists by virtual screening of specs database
- β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ
- Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice
- The fatty acid profile in muscles and expression of PPARα, FADS2 and ME1 genes in liver of Chinese Wanxi White geese in fattening period.
- Aleglitazar, a balanced PPARα/γ agonist, has no clinically relevant pharmacokinetic interaction with high-dose atorvastatin or rosuvastatin
- MDG-1, a potential regulator of PPARα and PPARγ, ameliorates dyslipidemia in mice
- Association of PPAR𝜶 Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study
- Editor’s highlight: neonatal activation of the xenobiotic-sensors PXR and CAR results in acute and persistent down-regulation of PPARα-signaling in mouse liver
- Dual PPARα/γ ligand TZD18 improves myocardial metabolic remodeling after myocardial infarction in rats.
- PPARα ligands make memories
- Gene-Gene Interactions among PPARα/δ/γ Polymorphisms for Apolipoprotein (Apo) AI/Apob Ratio in Chinese Han Population
- Transcription factor GATA-6 recruits PPARα to cooperatively activate Glut4 gene expression
- The effect of PPARα gene polymorphism on some athletic performances of non-athletic 10-12 year-old boys of marand
- Discovery of cyclic amine-substituted benzoic acids as PPARα agonists
- Pretreatment with Proteasome Inhibitors Protects against Oxidative Injuries via PPARα-Dependent and-Independent Pathways in ARPE-19 Cells
- Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
- Role of PPARα in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes
- Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood
- PPARα autocrine regulation of Ca2+-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation
- A novel partial PPARα/γ dual agonist SN159 improves insulin sensitivity
- Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α (PPARα) activity of an ultraviolet absorber, 2-(2′-hydroxy-3′, 5′-di-tert …
- A novel PPARα/γ agonist, propane-2-sulfonic acid octadec-9-enyl-amide, ameliorates insulin resistance and gluconeogenesis in vivo and vitro
- Proliferative and Molecular Effects of the Dual PPARα/γ Agonist Tesaglitazar in Rat Adipose Tissues: Relevance for Induction of Fibrosarcoma
- Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition
- Lauric acid beneficially modulates apolipoprotein secretion and enhances fatty acid oxidation via PPARα-dependent pathways in cultured rat hepatocytes
- 4′,6-Dimethoxyisoflavone-7-O-β-d-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes
- Research Advance on PPARα Gene in Livestock and Poultry
- Peroxisome Proliferator-Activated Receptor Alpha (PPARα) in Redlip Mullet, Liza haematocheila:Molecular Cloning, Mrna Tissue Expression, and Response to …
- Inhibition of pulmonary β-carotene 15, 15′-oxygenase expression by glucocorticoid involves PPARα
- Expression of peroxisome proliferator-activated receptor alpha (PPARα) in non-somatotroph pituitary tumours and the effects of PPARα agonists on MMQ cells
- Discovery and preclinical evaluation of BMS-711939, an oxybenzylglycine based PPARα selective agonist
- The PPARα activator fenofibrate inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
- PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells
- Citral effect in male NMRI mice nonalcoholic steatosis model: assessing biochemical and histological parameters and PPARα gene expression
- Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPARα/TNFAIP3/TRAF6 axis after lipopolysaccharide …
- Effect of beta-3 adrenoceptor stimulation on the levels of ApoA-I, PPARα, and PPARγ in apolipoprotein E–deficient mice
- Synthesis and biological evaluation of gemfibrozil chiral analogues as potential PPARα agonists
- PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance
- Inhibitory effect of isorhamnetin on lipid accumulation in free fatty acid-induced steatotic hepatocytes through the PPARα pathway
- Abstract PR428: Association of PPARα Rs4253728 G> A Gene Polymorphisms with Cyp3A4 Enzyme Activity And Fentanyl Post-Operative Intravenous Analgesic Effect
- PPARα receptor expression in patients with metabolic syndrome
- Effects of perfluorooctanoic acid on oxidative stress and PPARα and its related CYP4A1 gene expression in rat liver
- Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver.
- Effects on lipid metabolism and expression of PPARα and FABP of Schizothorax prenanti by oxidized Konjac glucomannan
- Characterization of chemical constituents from Thymelaea hirsuta with PPARα/γ modulation activity
- Changes in gene expression in PBMCs profiles of PPARα target genes in obese and non-obese individuals during fasting
- Regulation of the expression of the avian uncoupling protein 3 by isoproterenol and fatty acids in chick myoblasts: possible involvement of AMPK and PPARα?
- Restore islet β-cells dysfunction and study the expression of PPARα and PPARγ in Stevia rebaudiana treated mice
- A Novel Selective PPARα Modulator
- The interaction of PPARα and CYP7B1 with ERα, β impacted the occurrence and development of intrahepatic cholestasis in pregnant Rats
- Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification
- … fed saturated fat/cholesterol have a blunted hypothalamic-pituitary-adrenal function, are insulin resistant and have decreased expression of IRS-1, PGC1α and PPARα
- C/EBP‐β Is Differentially Affected by PPARα Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A‐I Production During ER‐Stress and …
- KLF6 activates PPARα signalling in hepatic steatosis
- Association of functional genetic variants in PPARγ and PPARα encoding peroxisome proliferator-activated receptors with ischemic stroke in a unique Chinese …
- … , 4-oxadiazol-5-yl) ethyl) acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic …
- E2/ERβ Inhibits PPARα to Regulate Cell-Proliferation and Enhance Apoptosis in Hep3B-Hepatocellular Carcinoma
- … Aging and Other Inflammatory Disease States by Dehydroepian-drosterone-3ẞ-Sulfate, an Activator of the Peroxisome Proliferator-Activated Receptor Alpha (PPARα)
- MiR‐21 role in aspirin‐dependent PPARα and multidrug resistance protein 4 upregulation
- 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα
- A meta-analysis study of gene expression datasets in mouse liver under PPARα knockout
- Peroxisome Proliferator Activated Receptor Alpha (PPARα) Agonists: A Potential Tool for a Healthy Aging Brain
- Novel synthesis of butyl (S)-2-hydroxybutanoate, the key intermediate of PPARα agonist (R)-K-13675 from butyl (2S, 3R)-epoxybutanoate and butyl (S)-2, 3 …
- Influence of aerobic exercise on oxidative stress and PPARα in myocardium in metabolic syndrome rats
- PPARα-target gene expression requires TIS21/btg2 gene in liver of the C57Bl/6 mice under fasting condition
- Effect of genistein on the changes of PPARα expression and glycolipid level in oleic acid-induced steatosis in HepG2 cells.
- MK886 inhibits the pioglitazone-induced anti-invasion of MDA-MB-231 cells is associated with PPARα/γ, FGF4 and 5LOX
- Polymorphisms in the Egl nine homolog 3 (EGLN3) and Peroxisome proliferator activated receptor-alpha (PPARα) genes and their correlation with hypoxia …
- The involvement of the cd40-cd40l pathway in activated platelet-induced changes in huvec cox-2 and PPARα expression
- Proteomic Analysis of Salt-Induced Changes in Protein Expression in PPARα Null Mice
- Design, synthesis, and biological evaluation of resveratrol derivatives as PPARα agonists
- PPARα and PPARγ as main regulators of fatty acid metabolism.
- … of the Hepatic and Splenic Immune Status and Immunoglobulin Synthesis in Aged Male Mice Lacking the Peroxisome Proliferator‐Activated Receptor‐Alpha (PPARα)
- The application of comparative molecular field analysis for the design of α-anilino substituted-3-phenyl propanoic acids as novel PPARα/γ dual ligands
- Salvianolic acid B ameliorates cardiac hypertrophy in T2 DM mice by activating PPARα
- Hepatitis B virus upregulates host expression of α-1, 2-mannosidases via the PPARα pathway
- … statistical approach to compare transcriptomics data across experiments: a case study on the identification of candidate target genes of the transcription factor PPARα
- A moderate zinc deficiency does not impair gene expression of PPARα, PPARγ, and mitochondrial enoyl-CoA delta isomerase in the liver of growing rats
- Muscle Ring Finger‐1 (MuRF1), MuRF2, and MuRF3 Differentially Regulate the transcription factors PPARα, PPARγ, and PPARβ/δ, respectively, in vivo
- Analyzing PPARα/ligand interactions by chemical cross-linking and high-resolution mass spectrometry
- Research Progress on Pathogenesis of Obesity-Induced Insulin Resistance and Its Therapeutic Targets: PPARα/γ
- Fenofibrate, a specific peroxisome proliferator-actívated receptor alpha (PPARα) agonist, up-regulates MDR3/ABCB4 expression in human hepatocytes: 731
- Regulation of hypoxia inducible factor/prolyl hydroxylase binding domain proteins 1 by PPARα and high salt diet
- Odd-chain fatty acids predict insulin sensitivity in people with T2DM and protect HepG2 cells from palmitate-induced insulin resistance via PPARα
- QSAR STUDY OF INDANE-URIEDO-THIOISOBUTYRIC ACIDS AS A PPARα AGONISTS
- A HIGHLY SELECTIVE PPARα AGONIST K-877 SUPPRESSES NEOINTIMA FORMATION FOLLOWING CORONARY STENTING IN SWINE
- Correction to rice koji extract enhances lipid metabolism through peroxisome proliferator-activated receptor alpha (PPARα) activation in mouse liver
- PPARα Signaling is Activated by Cocoa in Mouse Liver
- Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil
- PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds
- Effects of Gubentongluo Formula on Oxidative Stress Reflected by Expressions of PPARα and L-FABP in Mice with IgA Nephropathy
- PPARα Association With Sirt1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart
- Identifying Changes in Punitive Transcriptional Factor Binding Sites Created by PPARα/δ/γ SNPs Associated with Disease
- CLINICAL EFFICIENCY AND SAFETY OF FENOFIBRATE, A PPARα AGONIST, IN THE PATIENTS WITH DIABETESASSOCIATED OSTEOARTHRITIS: A CROSS …
- PPARα Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil
- induction of peroxiSome proliferator-activated RecePToR α (PPARα)-mediated gene expreSSion by extractS of tomato
- Fenofibrate rescues diabetes-related impairment of ischaemia-mediated angiogenesis by a PPARα independent pathway
- A secretome analysis reveals that PPARα is upregulated by fractionated-dose γ-irradiation in three-dimensional keratinocyte cultures
- PPARα in diabetic keratopathy
- Reactivity of the Immune System and Activities of PPARα and PPARγ in the Liver under Conditions of LPS-Induced Acute Infl ammatory Response in Hypertensive …
- Effect of adiponectin on PPARα, ApoA5 and triglyceride in HepG2 cells and its mechanism
- The Intestinal-Liver Axis of FGF15-FGFR4-PPARα Signal Control Liver Ischemia Reperfusion Injury Through Regulating Autophagy
- Comparative analysis of the nuclear receptors CAR, PXR and PPARα in the regulation of hepatic energy homeostasis and xenobiotic metabolism
- Functional contribution by PPARα expression to emmetropization in mice
- PPARα Activation Induces N ε-Lys-Acetylation of Rat Liver Peroxisomal Multifunctional Enzyme Type 1
- … causes depression of the immune response and increases the sensitivity to endotoxin in association with low level of HDL and PPARα activity in hypertensive ISIAH …
- Non-hematopoietic PPARα protects against cardiac injury and enhances survival in experimental polymicrobial sepsis
- Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) …
- PPARα agonists and TGFβ inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors
- Nuclear receptor PPARα activation triggers hepatic cell death in Ikkβ-deficient mice
- Effects of Rhizoma Alismatis decoction on lipid metabolism and PPARα and ACO expression in rats with hyperlipemia
- Effects of Leonurus japonicus Houtt. and its N-containing constituents leonurine and stachydrine on the activity of PPARα, β/δ, and γ in a newly developed in vitro …
- CYP2C8 is a Novel Target of Peroxisome Proliferator-activated α (PPARα) In Human Liver
- Simulation of the PPARα regulome predicts PPARα activation exacerbates the development of hepatic steatosis
- PPAR𝛼 is required for PPAR𝛿 action in regulation of body weight and hepatic steatosis in mice
- Muscle Ring Finger‐1 (MuRF1) inhibits cardiac PPARα activity by directing its nuclear export and not its degradation
- Mechanisms of PPARα, sterol regulatory element binding proteins and AMP-activated protein kinase in alcoholic fatty liver diseases
- PPARα and PPARβ/δ Activation by Oat (Avena sativa) Oil Stimulates Keratinocyte Differentiation and Ceramide Synthesis
- PPARα gene variation and phisycal performance in italian soccer players
- The Relationship of miR‐21‐5p and PPARα in CKD‐Related NAFLD and Dyslipidemia
- The transcriptional co-regulation of hepatic lipid metabolism by GR and PPARα
- Design and Synthesis of 3-(2-Ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl] ethoxy} phenyl) propanoic Acid: A Novel Triple-acting PPARα,-γ, and-δ Agonist
- Characterization and modeling of acute effects of PPARα activation in rat liver cells
- PPARα is Essential for Retinal Neuronal Survival and Lipid Metabolism
- Integrative analysis and modeling of PPARα function in murine liver and small intestine
- Structural and Functional Alteration of Full Length PPARα and LXRα by Fatty Acids and their Thioesters
- PPARα activation in portal hypertension
- Structural Requirement of PPARα Agonist Through QSARs and Molecular Simulation Analyses
- Down-Regulation of PPARα through MicroRNA-Associated Mechanism in Diabetic Retinopathy
- Possible mechanism of PPARα/γ activator TZD18 in gastric cancer
- Neural plasticity: Role of PPARα activation
- Hepatoprotective effects of PPARα: molecular basis and pathophysiological role of PPARα in acute inflammation and non-alcoholic steatohepatitis
- PPARα Inhibition as a Novel Target for Renal Cell Carcinoma (RCC)
- QSAR STUDY OF INDANE-URIEDO-THIOISOBUTYRIC ACIDS AS A PPARα AGONISTS
- Cloning and bioinformatics analysis of PPARα gene in Tibetan chicken.
- Effects of medicinal plants of the genus Leonurus and seventeen of their isolated constituents on the activity of PPARα, β/δ, and γ in an in vitro luciferase reporter gene …
- Effects of PPARα Activation and the Role of HO‐1 in Acute SAH‐Induced Fall in Cerebral Blood Flow in Rat
- Dietary protein regulates gene expression of amino acid‐degrading enzymes through PPARα
- Studies on the attenuation effects of intestinal PPARα activation on postprandial hyperlipidemia
- Role of PPARα in the oxidative damage of rat liver cells BRL-3A induced by perfluorooctanoic acid
- Contribution of PPARα and Ketone Body to Sleep Homeostasis in Mice
- Fibrate Acids and Esters for the Treatment of Hyperlipidemia (PPARα Activators)
- PGC1α Activation Corrects Cardiac Dysfunction Caused by Anti-diabetic Dual-PPARα/γ Therapy
- Design, Synthesis And Biological Evaluation of New Analogs of The Dual PPARα/γ Agonist Lt175
- Identification of lead molecules capable of the simultaneous agonism of the PPARƴ and PPARα subtypes for the dual management of diabetes mellitus and …
- Identification of natural PPARα transactivating compounds and their effects on apolipoprotein AI transcription in HepG2 cells
- Demonstration of interaction of full‐length PPARα and LXRα
- Klf5 Mediates Glucose-driven Changes ofCcardiac PPARα in Diabetes
- The role of peroxisome proliferator activated receptor alpha (PPARα) in the effect of piroxicam on colon cancer
- Abstract P233: PPARα-Sirt1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- Therapeutic Effects of PPARα Agonist on Experimental Neovascular Age-Related Macular Degeneration
- PPARα expression in acs lymphocytes and its correlation with TNFα and hs-CRP in serum
- Estimation of the PPARα agonism of fibrates by a combined MM-docking approach
- PPARα agonist protects Aristolochic acid‐induced nephropathy by increasing mediated lipid metabolism (LB554)
- Biological Evaluation of New Fluorinated Analogues With PPARα and PPARγ Agonist Activity
- Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis
- Mogat1 is a fasting‐induced PPARα target gene that plays a role in coordinating the hepatic response to food deprivation
- Effect of eicosanoic acid on Ap generation of rat cortical neurons and intervention of activated-PPARα.
- Research Article Consequences of PPARα Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids
- GW26-e1825 Regulation of lipid metabolism and inflammation response by Danqi Pill through PPARα in coronary heart disease
- Bilirubin Induces the Burning of Fat via the Nuclear Receptor PPARα
- PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of…
- Exenatide Treatment Improves Nonalcoholic Fatty Liver Phenotype by Regulation of PPARα and ACOX1
- Anti-Diabetic Activity from a Marine Lipid Analogue-Analysis of a Potential New Therapeutic Agent Targeting the Nuclear Receptors PPARα and-γ
- Activation of PPARα During the Progressive Phase of Heart Failure Improved Myocardial Energetics and Function in Pressure Overload Heart Failure
- Abstract B7: Activation of PPARα suppresses HIF-1α signaling in human cancer cells.
- PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate
- Modulation of fatty acid and bile acid metabolism by PPARα protects against alcoholic liver disease
- Wy14643, an agonist for PPARα, down-regulates expression of TARC and RANTES in cultured human keratinocytes
- Nutritional regulation of the hepatokine FGF21 in the liver: interdependence of the transcription factors ChREBP and PPARα
- PPARα Activation Bypasses the Transcription Elongation Defect in Mutant tif1γ Erythroid Differentiation
- Elucidating novel role of bezafibrate, a PPARα agonist as potential anticancer agent in the treatment of renal cell carcinoma
- Effect of Compound Zhenzhu Tiaozhi Recipe on expressions of liver PPARα and its downstream genes in non-alcoholic fatty liver disease.
- Effect of EPA supplementation on body mass index in overweight hypertriglyceridemic subjects with different FABP2 and PPARα genotypes
- PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate 2
- The effects of PPARα and PPARγ agonists on proteinuria and oxidative stress in patients with type 2 diabetes mellitus.
- Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis 2
- Modulation of Inflammatory Signaling by PPARα and PPARγ in Acrolein-Treated gp91phox Knockout Mice
- PPARα activation promotes macrophage reverse cholesterol transport through an LXR-dependent pathway
- Modulation of PPARα Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice
- Effect of Danqi pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease.
- Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS☆
- Post-Translational Regulation of FAS-Mediated PPARα Activation
- Potential interest of InsR, CPT1A, SLC27A2, FASN and PPARα expression in blood cells as biomarkers of dyslipidemia in children
- Chronic Kidney Disease and Fibrosis: Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction
- PPARα/γ Agonist Tesaglitazar Reduces Inflammatory Macrophage Numbers And Induces Adipose Ucp-1 Expression In Diabetic Ob/ob Mice
- Research Article Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
- PPARγ2 gene Pro12Ala and PPARα gene Leu162Val SNPs interact with dietary intake of fat in determination of plasma lipid concentrations
- Regulatory interactions between the metabolic sensors SIRT1 and AMPK in modulating PPARα linked functions, in obesity-dependent type 2 diabetes mellitus
- Wy14643, a PPARα agonist, down-regulates expressions of TARC and RANTES and up-regulates those of filaggrin in cultured human keratinocytes
- Antagonism of Peroxisome Proliferator Activated Receptor Alpha (PPARα) by TPST-1120 Suppresses Tumor Growth and Stimulates Anti-Tumor Immunity
- PPARα and Nrf2 Govern Metabolic Deregulation and Oxidative Stress in a Murine Model for Nonalcoholic Steatohepatitis (NASH)
- The fatty acid profile in muscles and expression of PPARα, FADS2 and ME1 genes in liver of Chinese Wanxi White geese in fattening period.
- Deletion of Aryl Hydrocarbon Receptor Nuclear Translocator (HIF1-β) in the Heart Leads to Cardiomyopathy and Lipid Accumulation via PPARα
- PPARα signalling reduces subchondral bone thickening and inflammation, but does not prevent cartilage damage in STR/Ort mice
- PPARα/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: evaluation of a novel oleic acid conjugate in preclinical rat models
- GW9662, A PPAR γ-ANTAGONIST, INHIBITS TELMISARTAN-MEDIATED GENE MODULATION, AND ACTIVATED PPARα: PP. 18.98
- PPARα positively regulates human MDR3/ABCB4 transcription and increases biliary phosphatidylcholine secretion: 228
- … receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of …
- PPARα as Potential Therapeutic Target for Neurodegenerative Diseases
- Umbelliferone supplementation attenuates alcohol‐induced hepatic steatosis by regulating PPARα‐and SREBP‐1c pathway in rats (1116.2)
- Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells.
- Dietary alanyl-glutamine and vitamin E supplements could considerably promote the expression of GPx and PPARα genes, antioxidation, feed utilization, growth, and …
- The inhibitory effect of hydroalcoholic extract of black punica granatum pericarp on melanoma tumor angiogenesis through PPARα and PPARγ pathways in C57BL6 …
- Combination of SGLT2 Inhibitor and Novel Selective PPARα Modulator, Tofogliflozin (Tofo) and Pemafibrate (Pema), Improves Survival Rate in STAM Mice as a …
- Perfluorooctanoic Acid Reduces Viability and Decreases Expression of Peroxisome Proliferator‐Activated Receptor Alpha (PPARα) and Estrogen Receptor Alpha …
- … of aqueous extract of syzigium cumini for its antihyperglycemic and antidyslipidemic properties in diabetic rats fed a high cholesterol diet – role of PPARγ and PPARα.
- Beyond Peroxisome: ABCD2 Modifies PPARα Signaling and Identifies a Subclass of Peroxisomes in Mouse Adipose Tissue
- ABCD2 Alters PPARα Signaling in Vitro, but Does Not Impair Responses to Fenofibrate Therapy in a Mouse Model of Diet-induced Obesity
- Muscle Ring Finger‐1 (MuRF1) inhibits PPARα through mono‐ubiquitination of specific lysines adjacent to a novel nuclear export sequence (NES)
- Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα: a new potential class of therapeutic agents for …
- PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron (Fe)-induced reduction in hepatic lipid deposition of javelin goby Synechogobius hasta.
- Renoprotective effect of a novel selective PPARα modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD (P) H oxidase pathway
- Heme Oxygenase-PPARα Induction of FGF21 in Hepatocytes Recruits pAMPK/pAKT and Attenuates Insulin Resistance in Obese Mice
- Aqueous extract of black maca prevents metabolism disorder via regulating the glycolysis/gluconeogenesis-TCA cycle and PPARα signaling activation in golden …
- IL-15 Mediates Mitochondrial Activity through a PPAR𝛿-Dependent-PPAR𝛼-Independent Mechanism in Skeletal Muscle Cells
- Molecular research on a hypotensive herb formula and PPARα activation
- Fatty acids and their thioester derivatives as ligands for human PPARα–A comparison to murine PPARα
- Study on the tnf-α-stimulated nf-κb pathway regulating peroxisome proliferator-activated receptor alpha (PPARα) expression in hepg2 cells
- P04. 15LIGAND-ACTIVATED TRANSCRIPTION FACTORS PPARγ AND PPARα EXPRESSION IN HUMAN GLIOMA
- Protective effect of fasting in hearts and arteries of PPARα−/− mice
- GW501516 acts as an efficient PPARα activator in the mouse liver
- P63LIGAND-ACTIVATED TRANSCRIPTION FACTORS PPARγ AND PPARα EXPRESSION IN HUMAN GLIOMA
- High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α …
- Increased accumulation of 4-hydroxynonenal adducts in male GSTA4/PPARα double knockout mice enhances injury during early stages of alcoholic liver disease …
- T1-10 Oleoylethanolamide protects against ischemic stroke by modulating microglia M1/M2 polarization in PPARα-dependent manner
- Restoration of endothelial function in PPARα−/− mice by Tempol
- Comprehensive analysis of PPARα-induced gene expression in rat liver
- PPAR𝛼 Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction
- PPARα/β agonist MHY2013 attenuates age-associated renal fibrosis
- A selective PPARα modulator has preventive effects in murine models of retinopathy
- Effect of Donor Hepatic PPARα Gene Polymorphisms on Glucose and Lipid Disorders after Liver Transplantation.: Abstract# P-391
- Effects of Synthetic Ligands on Heterodimer Pairs Regarding PPARα, RXRα and LXRα
- Hepatocyte PI3Kα controls the PPARα-FGF21 axis and regulates whole body fatty acid homeostasis
- Interaction of PPARα, CD36 and Th17 in angiotensin II‐induced hypertension (1136.9)
- Amplification of PRDM16, BMP7, PPARα, COX II and PGC-1α Genes Tupaia belangeri
- High Fat Diet Upregulates Il-6 in the Heart Through PPARα
- Modeling PPARα activation of Benzoxazole-Phenoxyalkyl-Phenoxybutyric acids using diverse descriptors
- Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene …
- IDDF2018-ABS-0165 Circular RNA circ5379–6 performs functions in inhibiting tumorigenesis and metastasis of hepatocellular carcinoma via the regulation of PPARα
- Research Article PPAR𝛼 Is Required for PPAR𝛿 Action in Regulation of Body Weight and Hepatic Steatosis in Mice
- The impact of PPARα gene on the physiology, biochemistry of mouse
- GSK-3α Directly Regulates Lipid Metabolism Through Obesity-linked Phosphorylation of PPARα
- PPAR𝜶-Independent Arterial Smooth Muscle Relaxant Effects of PPAR𝜶 Agonists
- Research Article PPAR𝛼 Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury
- Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus).
- CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site
- PPARα agonists—an emerging concept in the management of neuropathic and visceral pain
- Cloning, identification and accurate normalization expression analysis of PPARα gene by GeNorm in Megalobrama amblycephala.
- HUMAN FABP1 T94A VARIANT IMPACTS FATTY ACID METABOLISM AND PPARα ACTIVATION IN 2 CULTURED HUMAN FEMALE HEPATOCYTES 3
- Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein.
- Abstract O-1: Klf5 Regulates Cardiac PPARα and Med13 and affects Cardiac Fatty Acid Metabolism And Obesity
- Sphingosine Kinase 1 is regulated by PPARα in response to free fatty acids and mediates skeletal muscle IL‐6 production and signaling in diet‐induced obesity
- Interactions of PPARα and Acid Sensing Ion Channels on Cerebral Perfusion in Mice
- Effect of cold stress on expression of AMPKα-PPARα pathway and inflammation genes.
- New role of hispidulin in lipid metabolism: PPARα activator.
- Constituents from Bupleurum chinense and their effects on PPARα and related nuclear receptors
- Mechanism-Based Inhibitory and PPARα-Dependent Modulating Effects of Silybin on Principle Hepatic Drug-Metabolizing Enzymes
- The study of novel PPARα agonist K-877 regulated genes in mouse liver and primary human hepatocytes
- Swimming’s prevention of ovariectomy-induced obesity through activation of skeletal-muscle PPARα.
- Homeostatic PPARα signaling limits inflammatory responses to commensal microbiota in the intestine.
- The whole genome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
- Retraction: 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα
- Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV.
- Application of PPARα Transgenic Mice in Drug Evaluation
- Depressed PPARα accelerates a vicious cycle between allergic inflammation and barrier dysfunction
- Effect of the PPARα-activator gemfibrozil on whole blood drug transporter gene expression in humans
- Therapeutic Effect of PPARα Agonist on Pericyte Loss in Diabetic Retinopathy
- Effect of eicosanoic acid on Ap generation of rat cortical neurons and intervention of activated-PPARα.
- PPARα-Independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis.
- L-carnitine protects against carboplatin-mediated renal injury: AMPK-and PPARα-dependent inactivation of NFAT3.
- A Novel Selective PPARα Modulator, Pemafibrate Promotes Ischemia-Induced Revascularization
- Caloric Restriction in Leptin Deficiency Does Not Correct Myocardial Steatosis: Failure to 1 Normalize PPARα/PGC1α and Thermogenic Glyecrolipid/Fatty Acid …
- PPARα Modulates Acrolein‐Induced Inflammatory Signaling in gp91phox Knock‐Out Mice
- Role of PPARα/PGC-1αin doxorubicin induced mouse dilated cardio-myopathy
- Effects of the Constituents of Terminalia Species on PPARα and PPARγ, Glucose Uptake and Adipogenesis
- PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
- miRNA-mediated anticancer properties of the PPARα-activator fenofibrate on glioblastoma cell growth and migration.
- Cloning of PPARα and PPARγ partial cDNA sequence and differential expression in tissues in grass carp (Ctenopharyngodon idella).
- Echinococcus granulosus stimulates high PPARα/γ expression and drives polarization of macrophages in vitro
- Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
- Transcriptional regulation of the human, porcine and bovine OCTN2 gene by PPARα via a conserved PPRE located in intron 1.
- The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.
- PW296 Fenofibrate Rescues Diabetes-related Impairment of Ischaemia-mediated Angiogenesis by PPARα Independent Modulation of Thioredoxin Interacting Protein
- The lipogenic transcription factors PPARα and Pparγ as possible linkage between lipid metabolism and Hedgehog-Signalling Pathway?
- Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells.
- Icariin is a PPARα activator inducing lipid metabolic gene expression in mice.
- Dietary procyanidins lower serum triglyceride levels via up‐regulation in PPARα and its downstream target gene expression
- Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway.
- Novel PPARα activators extracted from natural herbs suppress eczema lesion in oxazolone induced atopic dermatitis murine model
- Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice.
- Peroxisome proliferator-activated receptor alpha (PPARα) in redlip mullet, Liza Haematocheila: molecular cloning, mRNA tissue expression, and response to dietary …
- Wogonin suppresses osteopontin expression in adipocytes by activating PPARα.
- PPARα activation sensitizes cancer cells to epigallocatechin-3-gallate (EGCG) treatment via suppressing heme oxygenase-1.
- Identification of eupatilin from Artemisia argyi as a selective PPARα agonist using affinity selection ultrafiltration LC-MS.
- Effect of berberine on PPARα/NO activation in high glucose-and insulin-induced cardiomyocyte hypertrophy.
- Ablation of Aryl Hydrocarbon Nuclear Translocator (ARNT) in the Heart Leads to Diabetic Cardiomyopathy Phenotype Through PPARα Activity
- Effect of genistein on the changes of PPARα expression and glycolipid level in oleic acid-induced steatosis in HepG2 cells.
- Topical eupatilin as a PPARα activator is effective for atopic dermatitis
- GW29-e0256 Puerarin attenuates oxidized LDL-induced macrophage foam cell formation via PPARα signaling pathway
- Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats.
- Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population.
- The Lipid Droplet Associated Protein CIDEC/Fsp27 is Regulated by PPARα and Prevents Hepatic Triglyceride Utilization
- Naoxintong/PPARα signaling inhibits H9c2 cell apoptosis and autophagy in response to oxidative stress.
- Peroxisome proliferator activator receptor alpha (PPARα) activation using free fatty acid library; fatty acids compared
- Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats.
- Nuclear receptornuclear receptor CAR down-regulates hepatic PPARα-mediated expression of HMGCS2, a key enzyme of ketogenesis
- Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα.
- Potent PPARα activator derived from tomato juice, 13-oxo-9, 11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice.
- Biochanin A suppresses the secretion of proinflammatory cytokines from lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells via PPARα/γ …
- The dipeptide H-Trp-Arg-OH (WR) is a PPARα agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.
- Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARα levels.
- Improvement of synaptic plasticity by pharmacological activation of RXR nuclear receptors is PPARα dependent.
- Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver …
- Shugan Xiaozhi decoction attenuates nonalcoholic steatohepatitis by enhancing PPARα and L-FABP expressions in high-fat-fed rats.
- Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice.
- Free fatty acids increase intracellular lipid accumulation and oxidative stress by modulating PPARα and SREBP-1c in L-02 cells.
- Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation.
- Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice.
- INCREASED 4-HYDROXYNONENAL PROTEIN ADDUCTS IN MALE GSTA4-3 4/PPARα DOUBLE KNOCKOUT MICE ENHANCE INJURY DURING EARLY 4 …
- Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation.
- Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats.
- Effects of walnut on lipid profile and expression of SREBP-1c and PPARα in diabetic rat
- … NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)/NON-ALCOHOLIC STEATOHEPATITIS (NASH) BYCHICORY SEED EXTRACT VIA MODULATION OF PPARα …
- The hypolipidemic and hypoglycemic activities of fermented brown rice fibers by regulating PPARα and ChREBP in the livers of C57BL/6J mice.
- Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood.
- Peroxisome proliferator-activated receptor-alpha (PPARα) suppresses T helper 1 (Th1) cytokine production in male mice by inducing post-translational histone …
- Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.
- The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα.
- REMOVED: PPARα and PPARδ nuclear receptor regulation of body weight and hepatic steatosis
- The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits high-fat diet-induced hepatic steatosis via hepatic PPARα …
- P35 Treatment with oleic acid and a PPARα agonist increases fatty acid oxidation in beating human inducible pluripotent stem cell-derived cardiomyocytes
- … present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 …
- SUPPLEMENTAL DATA PPARα-INDEPENDENT ACTIVATION OF THE SREBP-2 PATHWAY IN NEWBORN PEROXISOME-DEFICIENT PEX2 KNOCK-OUT MICE
- Non‐peptide Agonist of the Receptor MAS, AVE 0991, Increases PPARα Expression in Muscle of Rats Fed Fructose‐Rich Diet
- … by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in …
- Hovenia dulcis extract reduces lipid accumulation in oleic acid-induced steatosis of Hep G2 cells via activation of AMPK and PPARα/CPT-1 pathway and in acute …
- … North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.
- Screening of 19 traditional Mexican medicinal plants for effects on the metabolic syndrome related targets PPARα, β/δ, and γ in an in vitro luciferase reporter gene …
- The Peroxisome proliferator-activated receptor alpha (PPARα) intron 7 G/C polymorphism is associated with muscle strength in a young-adult population.
- Synergetic neuroprotective effect of docosahexaenoic acid and aspirin in SH-Y5Y by inhibiting miR-21 and activating RXRα and PPARα.
- Effects of ERK1/2/PPARα/SCAD signal pathways on physiological car-diac hypertrophy and pathological cardiac hypertrophy
- Extracts of pomelo peels prevent high-fat diet-induced metabolic disorders in C57BL/6 mice through activating the PPARα and GLUT4 pathway.
- … Editors (2018) Retraction: 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα
- Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes: roles of AMPK and PPARα in the lipolytic effect of kinsenoside.
- 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα.
- Design and Synthesis of 3-(2-Ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl] ethoxy} phenyl) propanoic Acid: A Novel Triple-acting PPARα,-γ, and-δ Agonist
- Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα.
- … transcriptomics data across experiments: a case study on the identification of candidate target genes of the transcription factor PPARα. Bioinformatics and Biology …
- Effect of Gain-of-Function Mutations in NHR-49/PPARα on Longevity and Stress-Resistance
- PPARα: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases
- Targeting PPARα for the treatment and understanding of cardiovascular diseases
- The PPARα and PPARγ epigenetic landscape in cancer and immune and metabolic disorders
- Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach
- PPARα at the crossroad of metabolic–immune regulation in cancer
- Activation of PPARα enhances astroglial uptake and degradation of β-amyloid
- Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPARα
- Hepatic PPARα is critical in the metabolic adaptation to sepsis
- Hepatocyte-specific deletion of PPARα promotes NAFLD in the context of obesity
- PPARα: A potential therapeutic target of cholestasis
- PPARα signaling: A candidate target in psychiatric disorder management
- Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease
- Loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity
- SIRT6 promotes hepatic beta-oxidation via activation of PPARα
- Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
- PPARα agonist oral therapy in diabetic retinopathy
- Pemafibrate, a new selective PPARα modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases
- PPARα alleviates iron overload‐induced ferroptosis in mouse liver
- PPARγ and PPARα synergize to induce robust browning of white fat in vivo
- Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
- A protective effect of PPARα in endothelial progenitor cells through regulating metabolism
- PPARα modulation-based therapy in central nervous system diseases
- Neuroprotective effects of PPARα in retinopathy of type 1 diabetes
- A contemporary overview of PPARα/γ dual agonists for the management of diabetic dyslipidemia
- Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
- MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
- PPARα ligand-binding domain structures with endogenous fatty acids and fibrates
- Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network
- ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis
- ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway
- PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population
- Conjugated linoleic acid and brain metabolism: a possible anti-neuroinflammatory role mediated by PPARα activation
- Shared PPARα/γ target genes regulate brown adipocyte thermogenic function
- Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
- Functional and structural insights into the human PPARα/δ/γ targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor
- Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea
- PPARα inhibition overcomes tumor-derived exosomal lipid-induced dendritic cell dysfunction
- Treadmill exercise reduces α-synuclein spreading via PPARα
- PPARα− ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
- Intestinal PPARα protects against colon carcinogenesis via regulation of methyltransferases DNMT1 and PRMT6
- Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases
- Herpetrione, a new type of PPARα ligand as a therapeutic strategy against nonalcoholic steatohepatitis
- Chronic acidosis rewires cancer cell metabolism through PPARα signaling
- PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per-and polyfluoroalkyl substances: An integrated approach
- Clinical applications of a novel selective PPARα modulator, pemafibrate, in dyslipidemia and metabolic diseases
- A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)
- Activation of PPARα exhibits therapeutic efficacy in a mouse model of juvenile neuronal ceroid lipofuscinosis
- Hepatic lipid catabolism via PPARα-lysosomal crosstalk
- MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
- Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway
- Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy
- Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα
- Hypoxia via ERK signaling inhibits hepatic PPARα to promote fatty liver
- PPARα induces the expression of CAR that works as a negative regulator of PPARα functions in mouse livers
- Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders
- Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway
- The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through the AMPK/PPARα/CPT1b pathway
- … Differences between mouse and human PPARα in modulating the hepatocarcinogenic effects of perinatal exposure to a high-affinity human PPARα agonist in mice
- Feedback repression of PPARα signaling by Let-7 microRNA
- PPARα agonist fenofibrate enhances cancer vaccine efficacy
- LncRNA MEG8 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting PPARα
- Celastrol ameliorates acute liver injury through modulation of PPARα
- Canagliflozin ameliorates obesity by improving mitochondrial function and fatty acid oxidation via PPARα in vivo and in vitro
- A Photohormone for Light-Dependent Control of PPARα in Live Cells
- PPARα and NCOR/SMRT corepressor network in liver metabolic regulation
- Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis
- Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer’s disease mouse model
- GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways
- Lactobacillus plantarum FRT10 alleviated high-fat diet–induced obesity in mice through regulating the PPARα signal pathway and gut microbiota
- Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
- Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses
- ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
- CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway
- Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus
- Design, synthesis, and biological evaluation of triazolone derivatives as potent PPARα/δ dual agonists for the treatment of nonalcoholic steatohepatitis
- Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity
- Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance
- Fenofibrate induces PPARα and BMP2 expression to stimulate osteoblast differentiation
- PPARα is one of the key targets for dendrobine to improve hepatic steatosis in NAFLD
- Glyphosate-induced autophagy inhibition results in hepatic steatosis via mediating epigenetic reprogramming of PPARα in roosters
- Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet
- PPARα activation directly upregulates thrombomodulin in the diabetic retina
- STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation
- DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice
- The protective roles of PPARα activation in triptolide-induced liver injury
- Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White …
- PPARα suppresses Th17 cell differentiation through IL-6/STAT3/RORγt pathway in experimental autoimmune myocarditis
- Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
- Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
- Activation of PPARα ameliorates cardiac fibrosis in Dsg2-deficient arrhythmogenic cardiomyopathy
- PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α
- Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy
- NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease
- Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway
- Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences
- Atractylodin ameliorates colitis via PPARα agonism
- Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis
- Systems approach to discovery of therapeutic targets for vein graft disease: PPARα pivotally regulates metabolism, activation, and heterogeneity of macrophages and …
- … muciniphila are not associated with major changes in the circulating Endocannabinoidome but linked to higher Mono-Palmitoyl-Glycerol levels as new PPARα …
- Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury
- Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway
- Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway
- Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer’s disease
- Testicular toxicity of bisphenol compounds: Homeostasis disruption of cholesterol/testosterone via PPARα activation
- Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα
- Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway
- Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice
- PPARα serves as a new receptor of aspirin for neuroprotection
- Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα
- Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway
- Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure
- PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection
- PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression
- … integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα …
- mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis
- Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
- FABP3 deficiency exacerbates metabolic derangement in cardiac hypertrophy and heart failure via PPARα pathway
- … acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an …
- NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity
- PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway
- Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
- The PPARα regulation of the gut physiology in regard to interaction with microbiota, intestinal immunity, metabolism, and permeability
- Hederagenin improves Alzheimer’s disease through PPARα/TFEB-mediated autophagy
- Targeting HIF-1α in combination with PPARα activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived …
- PPARα/β activation alleviates age-associated renal fibrosis in Sprague Dawley rats
- Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2
- PPARα inhibits astrocyte inflammation activation by restoring autophagic flux after transient brain ischemia
- Aging‐induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation
- PPARα/γ-Targeting Amorfrutin Phytocannabinoids from Aerial Parts of Glycyrrhiza foetida
- Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways
- Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target
- Huangqin decoction ameliorates ulcerative colitis by regulating fatty acid metabolism to mediate macrophage polarization via activating ffar4-ampk-PPARα Pathway
- Metabolomics reveals gut microbiota contribute to PPARα deficiency-induced alcoholic liver injury
- Efficacy and safety of K-877 (pemafibrate), a selective PPARα modulator, in European patients on statin therapy
- Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway
- Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing …
- Therapeutic inhibition of PPARα-HIF1α-PGK1 signaling targets leukemia stem and progenitor cells in acute myeloid leukemia
- PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine-and cannabinoid-mediated behavior in mice
- PPARα in the Epigenetic Driver Seat of NAFLD: New Therapeutic Opportunities for Epigenetic Drugs?
- PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model
- Mangiferin Improved Palmitate-Induced-Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPARα: Mangiferin …
- … exposure induced greater hepatotoxicity than GenX mainly via activation of PPARα pathway while caused hepatomegaly in the absence of PPARα in female mice
- Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE−/− mice
- Maternal high-fructose corn syrup consumption causes insulin resistance and hyperlipidemia in offspring via DNA methylation of the PPARα promoter region
- Novel selective PPARα modulator pemafibrate for dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and atherosclerosis
- Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway
- … CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC: CPT1A inhibits ccRCC cell proliferation via PPARα …
- Oleoylethanolamide inhibits glial activation via moudulating PPARα and promotes motor function recovery after brain ischemia
- Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3
- Co‐option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA‐induced hepatic steatosis
- CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression
- Bempedoic acid as a PPARα activator: New perspectives for hepatic steatosis treatment in a female rat experimental model
- Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and …
- Terpenoids from Resina Commiphora Regulating Lipid Metabolism via Activating PPARα and CPT1 Expression
- Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity
- Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM
- Melatonin attenuates cisplatin-induced acute kidney injury in mice: Involvement of PPARα and fatty acid oxidation
- Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse …
- PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1
- Effects of legacy and emerging per-and polyfluoroalkyl substances on PPARα/β/γ regulation and osteogenic/adipogenic differentiation
- Xinshubao tablet ameliorates myocardial injury against heart failure via the DCN/PPARα/PGC-1α/P300 pathway
- Lycopene prevents DEHP-induced liver lipid metabolism disorder by inhibiting the HIF-1α-induced PPARα/PPARγ/FXR/LXR system
- Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease
- Lentinan protects against nonalcoholic fatty liver disease by reducing oxidative stress and apoptosis via the PPARα pathway
- … alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα
- Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats
- Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration—Probing the role of PPARα
- Phosphorus overload promotes hepatic lipolysis by suppressing GSK3β-dependent phosphorylation of PPARα at Ser84 and Thr265 in a freshwater teleost
- The marine‐derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα
- Fructose-1, 6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour …
- (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway
- Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk …
- Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues
- PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase
- Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway
- PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
- NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress
- Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver …
- Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease
- Gegen qinlian decoction coordinately regulates PPARγ and PPARα to improve glucose and lipid homeostasis in diabetic rats and insulin resistance 3T3-L1 …
- Secreted factors from adipose tissue reprogram tumor lipid metabolism and induce motility by modulating PPARα/ANGPTL4 and FAK
- Pathogenic role of PPARα downregulation in corneal nerve degeneration and impaired corneal sensitivity in diabetes
- The glitazars paradox: Cardiotoxicity of the metabolically beneficial dual PPARα and PPARγ activation
- Ncor2/PPARα-dependent upregulation of MCUb in the type 2 diabetic heart impacts cardiac metabolic flexibility and function
- … obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels
- PPARα-selective antagonist GW6471 inhibits cell growth in breast cancer stem cells inducing energy imbalance and metabolic stress
- TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter
- Lipidomic alterations and PPARα activation induced by resveratrol lead to reduction in lesion size in endometriosis models
- PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and …
- PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling
- … Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and Stabilization of PPARα
- PPARα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes
- Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation
- Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
- Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
- … Probiotic Lactobacillus plantarum FB003 Isolated from Salted-Fermented Shrimp and its Effect on Cholesterol Absorption by Regulation of NPC1L1 and PPARα
- Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway
- Regulation of monocyte activation by PPARα through interaction with the cGAS-STING pathway
- Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism
- The critical role of PPARα in the binary switch between life and death induced by endoplasmic reticulum stress
- PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis
- … -chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα)
- Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα
- Sex-regulated gene dosage effect of PPARα on synaptic plasticity
- Gemfibrozil protects dopaminergic neurons in a mouse model of Parkinson’s disease via PPARα-dependent astrocytic GDNF pathway
- PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
- Dihydrotrichodimerol Purified from the Marine Fungus Acremonium citrinum Prevents NAFLD by Targeting PPARα
- Functional and structural insights into human PPARα/δ/γ subtype selectivity of bezafibrate, fenofibric acid, and pemafibrate
- Lipid deposition in abalone Haliotis discus hannai affected by dietary lipid levels through AMPKα2/PPARα and JNK/mTOR/SREBP-1c pathway
- Echinacoside ameliorates alcohol-induced oxidative stress and hepatic steatosis by affecting SREBP1c/FASN pathway via PPARα
- Polycerasoidol, a natural prenylated benzopyran with a dual PPARα/PPARγ agonist activity and anti-inflammatory effect
- Elevated lipolysis in adipose tissue by doxorubicin via PPARα activation associated with hepatic steatosis and insulin resistance
- Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
- Selective PPARα modulator pemafibrate and sodium-glucose cotransporter 2 inhibitor tofogliflozin combination treatment improved histopathology in …
- Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin
- The protective role of microglial PPARα in diabetic retinal neurodegeneration and neurovascular dysfunction
- The role of Ap2a2 in PPARα‐mediated regulation of lipolysis in adipose tissue
- Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition
- Elucidation of molecular mechanism of a selective PPARα modulator, pemafibrate, through combinational approaches of X-ray crystallography …
- Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway
- Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells
- Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells
- Dietary fenofibrate attenuated high-fat-diet-induced lipid accumulation and inflammation response partly through regulation of PPARα and sirt1 in juvenile black …
- Exploring the pattern of metabolic alterations causing energy imbalance via PPARα dysregulation in cardiac muscle during doxorubicin treatment
- Neobavaisoflavone induces bilirubin metabolizing enzyme UGT1A1 via PPARα and PPARγ
- LncRNA MALAT1 promotes PPARα/CD36-mediated hepatic lipogenesis in nonalcoholic fatty liver disease by modulating miR-206/ARNT axis
- TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia
- Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism
- Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages
- Auraptene, a citrus peel-derived natural product, prevents myocardial infarction-induced heart failure by activating PPARα in rats
- PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection
- The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis
- Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart
- A 5: 2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
- Gastrin, via activation of PPARα, protects the kidney against hypertensive injury
- Role of PPARα in inflammatory response of C2C12 myotubes
- Pristimerin protects against pathological cardiac hypertrophy through improvement of PPARα pathway
- Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations
- … natural EPA-enriched phosphatidylcholine and phosphatidylethanolamine ameliorate lipid accumulation and insulin resistance via activation of PPARα/γ in mice
- Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS‐treated mouse chondrocytes and osteoarthritis model
- Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice
- Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway
- PPARα and PPARβ/δ Expression is Associated with Proinflammatory Markers in an Obese Pediatric Population
- PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice
- Atorvastatin restores PPARα inhibition of lipid metabolism disorders by downregulating miR-21 expression to improve mitochondrial function and alleviate …
- PPARα activation enhances the ability of nile tilapia (Oreochromis niloticus) to resist Aeromonas hydrophila infection
- PPARα agonist, MHY3200, alleviates renal inflammation during aging via regulating ROS/Akt/FoxO1 signaling
- Low-intensity exercise affects cardiac fatty acid oxidation by increasing the nuclear content of PPARα, foxo1, and lipin1 in fructose-fed rats
- The PPARα agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia
- PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice
- … oxide tetramer acid (HFPO-TeA)-induced developmental toxicities in chicken embryo: Peroxisome proliferator-activated receptor Alpha (PPARα) is involved
- Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and …
- Zi Shen Wan Fang regulates kynurenine metabolism to alleviate diabetes-associated cognitive impairment via activating the skeletal muscle PGC1α-PPARα signaling
- Enhancement of fear learning in PPARα knockout mice
- Gut‐specific inhibition of PPARα as a novel approach of NAFLD treatment
- Nanotized PPARα Overexpression Targeted to Hypertrophied Myocardium Improves Cardiac Function by Attenuating the p53-GSK3β-Mediated Mitochondrial Death …
- Torularhodin alleviates hepatic dyslipidemia and inflammations in high-fat diet-induced obese mice via PPARα signaling pathway
- Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling
- Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
- Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice
- CEPT1-mediated phospholipogenesis regulates endothelial cell function and ischemia-induced angiogenesis through PPARα
- Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway
- … barbarum polysaccharide combined with aerobic exercise ameliorates high-fat-induced nonalcoholic steatohepatitis via AMPK/PPARα/PGC-1α pathway
- Dietary Piperine Suppresses Obesity-Associated Breast Cancer Growth and Metastasis by Regulating the miR-181c-3p/PPARα Axis
- N‐glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD‐1
- Bilirubin: a ligand of the PPARα nuclear receptor
- Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway
- PPARα gene is a diagnostic and prognostic biomarker in clear cell renal cell carcinoma by integrated bioinformatics analysis
- Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure
- Fenofibrate rescues diabetes-related impairment of ischemia-mediated angiogenesis by PPARα-independent modulation of thioredoxin-interacting protein
- Activation of PPARα by fenofibrate attenuates the effect of local heart high dose irradiation on the mouse cardiac proteome
- Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway
- Diethyldithiocarbamate inhibits the activation of hepatic stellate cells via PPARα/FABP1 in mice with non-alcoholic steatohepatitis
- Synthesis and biological studies of “Polycerasoidol” and “trans-δ-Tocotrienolic acid” derivatives as PPARα and/or PPARγ agonists
- Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα …
- The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism
- Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis
- … extract prevents hepatic steatosis and liver damage in T2DM rats by hypoglycemic, insulin-sensitizing, antioxidant effects, and upregulation of PPARα
- Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes
- PPARα mediates night neon light-induced weight gain: role of lipid homeostasis
- … effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway
- Pemafibrate pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by modulating JAK2/STAT3β/PPARα pathway
- Polyphenols extracted from Shanxi‐aged vinegar exert hypolipidemic effects on OA‐induced HepG2 cells via the PPARα‐LXRα‐ABCA1 pathway
- Down-regulation of hepatic CLOCK by PPARα is involved in inhibition of NAFLD
- Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus
- … -rich extract from Sophora alopecuroides L. in HFD-and STZ-induced diabetic mice through PKC/GLUT4 pathway and regulating PPARα and PPARγ expression
- Xyloketal B reverses nutritional hepatic steatosis, steatohepatitis, and liver fibrosis through activation of the PPARα/PGC1α signaling pathway
- The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis
- PPARα Agonism Enhances Immune Response to Radiotherapy while Dietary Oleic Acid Results in Counteraction
- … -glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of …
- In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
- PPARα-dependent effects of palmitoylethanolamide against retinal neovascularization and fibrosis
- Eicosanoid-activated PPARα inhibits NFκB-dependent bacterial clearance during post-influenza superinfection
- Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling …
- Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes
- PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia
- Diallyl biphenyl-type neolignans have a pharmacophore of PPARα/γ dual modulators
- Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents
- Pharmacological blockade of PPARα exacerbates inflammatory pain-related impairment of spatial memory in rats
- PPARα/γ synergism activates UCP1-dependent and-independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice
- Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo
- Phenylsulfonimide PPARα Antagonists enhance nrf2 activation and promote oxidative stress-induced apoptosis/pyroptosis in MCF7 breast cancer cells
- Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPARα
- Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation
- Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2 …
- Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals
- Beta-caryophyllene inhibits cocaine addiction-related behavior by activation of PPARα and PPARγ: repurposing a FDA-approved food additive for cocaine use …
- Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro
- SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy
- NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression
- In vitro and in vivo study of the pathogenic role of PPARα in experimental periodontitis
- The effect of fenofibrate, a PPARα activator on toll-like receptor-4 signal transduction in melanoma both in vitro and in vivo
- Protective effects of bariatric surgery on kidney functions by inhibiting oxidative stress responses through activating PPARα in rats with diabetes
- SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice
- Concomitant PPARα and FXR activation as a putative mechanism of NASH improvement after gastric bypass surgery: a GEO datasets analysis
- Hepatocyte-secreted autotaxin exacerbates nonalcoholic fatty liver disease through autocrine inhibition of the PPARα/FGF21 axis
- Oleoylethanolamide stabilizes atherosclerotic plaque through regulating macrophage polarization via AMPK-PPARα pathway
- Luteolin mitigates diabetic dyslipidemia in rats by modulating ACAT-2, PPARα, SREBP-2 proteins, and oxidative stress
- Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway
- Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPARα/γ-AMPK-SIRT1 Pathway and Fatty Acid Metabolism
- CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway
- Exposure to short-chain chlorinated paraffins inhibited PPARα-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells
- PPARα alleviates inflammation via inhibiting NF-κB/Rel pathway in Vibrio splendidus challenged Apostichopus japonicus
- Early microRNA indicators of PPARα pathway activation in the liver
- The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα
- PPARα agonist WY-14,643 induces the PLA2/COX-2/ACOX1 pathway to enhance peroxisomal lipid metabolism and ameliorate alcoholic fatty liver in mice
- FOXO1 represses PPARα-mediated induction of FGF21 gene expression
- … , a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), lowers serum triglyceride levels by targeting hepatic PPARα in mice
- The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A …
- Profound modification of fatty acid profile and endocannabinoid-related mediators in PPARα agonist fenofibrate-treated mice
- Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway
- CAR and PPARα do not perform liquid-liquid phase separation in cells
- Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus
- … -to-subcutaneous fat ratio independently predicts the prognosis of locally advanced gastric cancer—–highlighting the role of adiponectin receptors and PPARα, β/δ, ɤ
- PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A
- Overexpression of salusin‑α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP‑1c pathway to inhibit lipid synthesis in HepG2 cells
- The anti-aging effect of velvet antler polypeptide is dependent on modulation of the gut microbiota and regulation of the PPARα/APOE4 pathway
- Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies
- Common Alterations in Parallel Metabolomic Profiling of Serum and Spinal Cord and Mechanistic Studies on Neuropathic Pain following PPARα Administration
- Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling
- A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms
- Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK/GLUT4/GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice
- Atherosclerosis plaque reduction by lycopene is mediated by increased energy expenditure through AMPK and PPARα in ApoE KO mice fed with a high fat …
- Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice
- Staphylococcus aureus oleate hydratase produces ligands that activate host PPARα
- Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway
- Hepatic Ago2 regulates PPARα for oxidative metabolism linked to glycemic control in obesity and post bariatric surgery
- Dapagliflozin mediates Plin5/PPARα signaling axis to attenuate cardiac hypertrophy
- Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway
- PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα
- Design and synthesis of novel quinazolinone‐based fibrates as PPARα agonists with antihyperlipidemic activity
- Downregulation of PPARα during experimental left ventricular hypertrophy is critically dependent on Nox2 NADPH oxidase signalling
- PPARα activation stimulates autophagic flux through lipid catabolism-independent route
- Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway
- PPARα/γ signaling pathways are involved in Chlamydia pneumoniae-induced foam cell formation via upregulation of SR-A1 and ACAT1 and downregulation of …
- PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet
- PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish
- Low-dose mono (2-ethylhexyl) phthalate promotes ovarian cancer development through PPARα-dependent PI3K/Akt/NF-κB pathway
- shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth
- The role of PPARα in autosomal dominant polycystic kidney disease
- PPARα Senses Bisphenol S to Trigger EP300-Mediated Autophagy Blockage and Hepatic Steatosis
- Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia
- TRPV1 activation inhibits phenotypic switching and oxidative stress in vascular smooth muscle cells by upregulating PPARα
- ABCC6 knockdown fuels cell proliferation by regulating PPARα in hepatocellular carcinoma
- Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1/FAS and PPARα/UCP2 …
- Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes
- Attenuation of high-fat diet-induced fatty liver through PPARα activation by stevioside
- The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function
- Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway
- NPRA promotes fatty acid metabolism and proliferation of gastric cancer cells by binding to PPARα
- The reversal of PXR or PPARα activation-induced hepatomegaly
- Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
- Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization
- Multi-omics analysis revealed NMBA induced esophageal carcinoma tumorigenesis via regulating PPARα signaling pathway
- Upregulation of miR-181a impairs lipid metabolism by targeting PPARα expression in nonalcoholic fatty liver disease
- LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis BX protein via Akt/mTOR signalling
- Gene expression profiling reveals that PXR activation inhibits hepatic PPARα activity and decreases FGF21 secretion in male C57BL6/J mice
- Highly selective PPARα (peroxisome proliferator‐activated receptor α) agonist Pemafibrate inhibits stent inflammation and restenosis assessed by multimodality …
- Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease
- Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis
- … of a phenolic-rich extract from Hypericum attenuatum Choisy in KK-Ay mice mediated through AMPK/PI3K/Akt/GSK3β signaling and GLUT4, PPARγ, and PPARα …
- Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
- PPARα agonist alleviates tumor growth and chemo-resistance associated with the inhibition of glucose metabolic pathway
- Melatonin Ameliorates Cisplatin-Induced Renal Tubular Epithelial Cell Damage through PPARα/FAO Regulation
- N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARα
- … the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARα/FoxO1 signaling pathway
- L-theanine regulates the immune function of SD rats fed high-protein diets through the FABP5/IL-6/STAT3/PPARα pathway
- Fenofibrate mediated activation of PPARα negatively regulates trophoblast invasion
- Clofibrate, a peroxisome proliferator–activated receptor-alpha (PPARα) agonist, and its molecular mechanisms of action against sodium fluoride–induced toxicity
- Effect of potential probiotic Leuconostoc mesenteroides FB111 in prevention of cholesterol absorption by modulating NPC1L1/PPARα/SREBP-2 pathways in …
- PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism
- Inhibition of PCSK9 prevents and alleviates cholesterol gallstones through PPARα-mediated CYP7A1 activation
- PPARα/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation
- Hepatic PPARα Is destabilized by SIRT1 deacetylase in undernourished male mice
- Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
- Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/PPARα pathway via targeting nicotinamide N-methyltransferase
- Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice
- … ‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα …
- Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells
- Retinoic Acid–PPARα Mediates β-Carotene Resistance to Placental Dysfunction Induced by Deoxynivalenol
- CXCL6 promotes the progression of NAFLD through regulation of PPARα
- Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic …
- PPARα and PPARγ signaling is enhanced in the brain of the naked mole-rat, a mammal that shows intrinsic neuroprotection from oxygen deprivation
- Oleic acid stimulates cell proliferation and BRD4–L-MYC-dependent glucose transporter transcription through PPARα activation in ovarian cancer cells
- Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent
- Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells
- Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies
- Distinct differences in lipoprotein particle number evaluation between GP-HPLC and NMR: Analysis in dyslipidemic patients administered a selective PPARα …
- Gentiopicroside improves non-alcoholic steatohepatitis by activating PPARα and suppressing HIF1
- … saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in vivo …
- The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology
- Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program
- PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
- PPARα is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF
- Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid
- Valproic acid-induced upregulation of multidrug efflux transporter ABCG2/BCRP via PPARα-dependent mechanism in human brain endothelial cells
- Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/PPARα-NF-κB/IR-S2 …
- The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
- Peroxisome proliferator–activated receptor α (PPARα)–dependent regulation of fibroblast growth factor 23 (FGF23)
- Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of …
- Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells
- PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells
- PPARα and γ activation effects of new nor-triterpenoidal saponins from the aerial parts of Anabasis articulata
- The lncRNA H19/miR-675 axis regulates myocardial ischemic and reperfusion injury by targeting PPARα
- Peroxisome Proliferator-Activated Receptor-α (PPARα) Expression in a Clinical Population of Pakistani Patients with Type 2 Diabetes and Dyslipidemia
- Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages
- Rosa rugosa flavonoids exhibited PPARα agonist-like effects on genetic severe hypertriglyceridemia of mice
- PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB
- Bile acid metabolism disorder mediates hepatotoxicity of Nafion by-product 2 and perfluorooctane sulfonate in male PPARα-KO mice
- Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists
- The effects of sodium butyrate supplementation on the expression levels of PGC-1α, PPARα, and UCP-1 genes, serum level of GLP-1, metabolic parameters …
- … Effect of γ-Oryzanol (OZ) and N-Acetylcysteine (NAC) against Experimentally Induced NAFLD in Rats Entails Hypoglycemic, Antioxidant, and PPARα …
- Ablation of Selenbp1 alters lipid metabolism via the PPARα pathway in mouse kidney
- In silico identification and experimental validation of (−)-muqubilin A, a marine norterpene peroxide, as PPARα/γ-RXRα agonist and RARα positive allosteric …
- An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment
- Therapeutic potential of PPARα agonist in ligature-induced experimental periodontitis
- … bile acids and activates hepatic farnesoid X receptor (FXR) but requires intact peroxisome proliferator activator receptor alpha (PPARα) signaling to significantly …
- Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner
- Hippocampal PPARα plays a role in the pharmacological mechanism of vortioxetine, a multimodal-acting antidepressant
- The KRAB Domain‐Containing Protein ZFP961 Represses Adipose Thermogenesis and Energy Expenditure through Interaction with PPARα
- RAE1 promotes nitrosamine-induced malignant transformation of human esophageal epithelial cells through PPARα-mediated lipid metabolism
- Discovery of novel peroxisome proliferator-activated receptor α (PPARα) agonists by virtual screening and biological evaluation
- Development of an analytical platform for the affinity screening of natural extracts by SEC-MS towards PPARα and PPARγ receptors
- Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse …
- LncRNA MALAT1 regulates proliferation and apoptosis of vascular smooth muscle cells by targeting miRNA-124-3p/PPARα axis.
- Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma
- High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis
- Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance
- The lack of PPARα exacerbated the progression of non-alcoholic steatohepatitis in mice with spleen deficiency syndrome by triggering an inflammatory …
- Paternal hyperglycemia induces transgenerational inheritance of susceptibility to hepatic steatosis in rats involving altered methylation on PPARα promoter
- Crosstalk between EP2 and PPARα modulates hypoxic signaling and myopia development in Guinea pigs
- Hippocampal PPARα is involved in the antidepressant-like effects of venlafaxine in mice
- VX-765 inhibits pyroptosis and reduces inflammation to prevent acute liver failure by upregulating PPARα expression
- SIRT6 activates PPARα to improve doxorubicin-induced myocardial cell aging and damage
- CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer
- WY14643 increases herpesvirus replication and inhibits IFNβ production independently of PPARα expression
- The tissue‐specific metabolic effects of the PPARα agonist ciprofibrate in insulin‐resistant male individuals: a double‐blind, randomized, placebo‐controlled crossover …
- Lemon balm extract ALS-L1023 regulates obesity and improves insulin sensitivity via activation of hepatic PPARα in high-fat diet-fed obese C57BL/6J mice
- Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway
- Computational investigation reveals Picrasidine C as selective PPARα lead: binding pattern, selectivity mechanism and ADME/tox profile
- PPARα activation by fenofibrate ameliorates radiation‐induced skin injury.
- Anti-Diabetic Effect of a Shihunine-Rich Extract of Dendrobium loddigesii on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK–GLUT4–PPARα
- Inflammation-induced nitric oxide suppresses PPARα expression and function via downregulation of Sp1 transcriptional activity in adipocytes
- The anti-hyperlipidemic effects of Poria cocos (Schw.) Wolf extract: Modulating cholesterol homeostasis in hepatocytes via PPARα pathway
- PPARα, PPARδ or both–that is the question!
- Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 …
- Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα
- Promoting the hippocampal PPARα expression participates in the antidepressant mechanism of reboxetine, a selective norepinephrine reuptake inhibitor
- Structurally Diverse Metabolites from the Ophiorrhiza japonica Bl. and Their Antioxidant Activities In Vitro and PPARα Agonistic Activities In Silico
- PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway
- … d alleviates high-fat-diet induced hepatic steatosis in hybrid grouper (Epinephelus lanceolatus♂× Epinephelus fuscoguttatus♀) by targeting AMPK/PPARα pathway
- The E3 ligase Trim63 promotes podocyte injury and proteinuria by targeting PPARα to inhibit fatty acid oxidation
- Novel dual PPARα/γ agonists protect against liver steatosis and improve insulin sensitivity while avoiding side effects
- Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease
- Klf4-Sirt3/PPARα-Lcad pathway contributes to high phosphate-induced lipid degradation
- Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells
- Long Noncoding RNA ZFAS1 Protects HK-2 Cells against Sepsis‐Induced Injury through Targeting the miR3723p/PPARα Axis
- PPARα polymorphisms association with total cholesterol and LDL-C levels in a Mexican population.
- Preventive effects of total flavonoid C-glycosides from Abrus mollis on nonalcoholic fatty liver disease through activating the PPARα signaling pathway
- Design, synthesis, and biological evaluation of deuterated indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ agonists
- ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK-PPARα-CPT1A axis
- Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA …
- Soyasapogenol C from Fermented Soybean (Glycine Max) Acting as a Novel AMPK/PPARα Dual Activator Ameliorates Hepatic Steatosis: A Novel SANDA …
- Stevia and Stevioside Attenuate Liver Steatosis through PPARα-Mediated Lipophagy in db/db Mice Hepatocytes
- … pericarp extract, suppresses tumor proliferation and angiogenesis in a mouse model of melanoma: possible involvement of PPARα and PPARγ pathways
- Overexpression of microRNA-21 mediates Ang II-induced renal fibrosis by activating the TGF-β1/Smad3 pathway via suppressing PPARα
- Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway
- Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design …
- LncRNA HOTAIR regulates the proliferation and apoptosis of vascular smooth muscle cells through targeting miRNA-130b-3p/PPARα axis.
- HypERlnc attenuates angiotensin II‐induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation‐mediated activation of PGC‐1α/PPARα pathway in AC16 …
- When Activator and Inhibitor of PPARα Do the Same: Consequence for Differentiation of Human Intestinal Cells
- Osteocalcin activates lipophagy via the ADPN-AMPK/PPARα-mTOR signaling pathway in chicken embryonic hepatocyte
- The PPARα agonist fenofibrate reduces the cytokine imbalance in a maternal immune activation model of schizophrenia
- The role of Huidouba in regulating skeletal muscle metabolic disorders in prediabetic mice through AMPK/PGC-1α/PPARα pathway
- Fenofibrate ameliorates letrozole-induced polycystic ovary in rats via modulation of PPARα and TNFα/CD95 pathway
- The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet
- MicroRNA-483-5p inhibits hepatocellular carcinoma cell proliferation, cell steatosis, and fibrosis by targeting PPARα and TIMP2
- Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease
- FMO1 Promotes Nonalcoholic Fatty Liver Disease Progression by Regulating PPARα Activation and Inducing Ferroptosis.
- Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation
- PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells
- Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation
- N-Palmitoylethanolamide exerts antidepressant-like effects in rats: involvement of PPARα pathway in the hippocampus
- Virtual identification of novel PPARα/γ dual agonists by 3D-QSAR, molecule docking and molecular dynamics studies
- Tripartite motif-containing 46 promotes viability and inhibits apoptosis of osteosarcoma cells by activating NF-κB signaling through ubiquitination of PPARα
- Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease
- ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα
- Oleoylethanolamide ameliorates motor dysfunction through PPARα‐mediates oligodendrocyte differentiation and white matter integrity after ischemic stroke
- Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway
- Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling
- Molecular modelling, synthesis, and biological evaluations of a 3, 5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist
- Basal PPARα inhibits bile acid metabolism adaptation in chronic cholestatic model induced by α-naphthylisothiocyanate
- Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei
- Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators
- Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography
- Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition
- HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis
- Uncoupling protein 1 knockout aggravates isoproterenol-induced acute myocardial ischemia via AMPK/mTOR/PPARα pathways in rats
- The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity
- … mechanisms underlying endoplasmic reticulum stress involvement in the development of gestational diabetes mellitus entail the CHOP-PPARα–NF–κB pathway
- Exenatide reduces cardiomyocyte apoptosis by stimulating adiponectin secretion and activating APPL1-AMPK-PPARα axis
- … upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 …
- Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity
- Endocannabinoids and endocannabinoid-like compounds modulate hypoxia-induced permeability in CaCo-2 cells via CB1, TRPV1, and PPARα
- Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function
- Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway
- Inhibition of PPARα target genes during cyclosporine A-induced nephrotoxicity and hepatotoxicity
- WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway
- Comparative study of the effect of 17 parabens on PXR-, CAR-and PPARα-mediated transcriptional activation
- Accumulation of lipid droplets in a novel Bietti crystalline dystrophy zebrafish model with impaired PPARα pathway
- Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys
- Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway
- Engineered Fenofibrate as Oxidation-Sensitive Nanoparticles with ROS Scavenging and PPARα-Activating Bioactivity to Ameliorate Nonalcoholic Fatty Liver Disease
- Alkaloids from the rhizomes of Acorus calamus and their PPARα, PPARγ, and glucokinase-activating activities
- Gardenia fruit and Eucommia leaves combination improves hyperlipidemia and hyperglycemia via pancreatic lipase and AMPK-PPARα and Keap-1-Nrf2-HO …
- The mRNA levels of PPARα, HIF-1α, and VEGF in the liver tissues of rats with alcoholic liver disease
- Dietary supplementation of vitamin E and citric acid could significantly promote the relative expression of PPARα and aconitase genes, concentration of …
- Phthalate Exposure, PPARα Variants, and Neurocognitive Development of Children at Two Years
- Icariside II exerts anti-type 2 diabetic effect by targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 signaling pathway
- Identification of phytochemicals as putative ligands for the targeted modulation of peroxisome proliferator‐activated receptor α (PPARα) in animals
- Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway
- PPARα-Mediated positive-feedback loop contributes to cold exposure memory
- Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway
- Exosomes derived from human dermal fibroblasts (HDFn‐Ex) alleviate DNCB‐induced atopic dermatitis (AD) via PPARα
- Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and …
- The IL-6/STAT signaling pathway and PPARα are involved in mediating the dose-dependent cardioprotective effects of fenofibrate in 5-fluorouracil-induced …
- Lonicerae Japonicae Flos extract and chlorogenic acid attenuates high-fat-diet-induced prediabetes via CTRPs-AdipoRs-AMPK/PPARα axes
- Bromide alleviates fatty acid‐induced lipid accumulation in mouse primary hepatocytes through the activation of PPARα signals
- Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model
- Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway
- Adiponectin stimulates apolipoprotein a-1 gene expression in Hepg2 cells Via ampk, PPARα, and lxrs signaling mechanisms
- Suppression of Hepatic PPARα in Primary Biliary Cholangitis Is Modulated by MiR-155
- … myocardial damage induced by lipopolysaccharide via the toll-like receptor 4 (TLR4)/Nuclear factor kappa B (NF-κB)/Proliferator-Activated receptor α (PPARα …
- Genistein and Sex Hormone Supplementation Modulated Hepatic PPARα, δ, and γ Subtypes and STAT1 Expressions in a NASH Rat Model with Bilateral …
- Fructose-1, 6-bisphosphatase 1 suppresses PPARα-mediated gene transcription and non-small-cell lung cancer progression
- Research progress of active components of traditional Chinese medicine in treatment of hyperlipidemia by activating PPARα pathway
- Potential natural dual agonist PPARα/γ-induced antidiabetic and antidyslipidemic properties of safrole-free nutmeg seed (Myristica fragrans Houtt) extract
- PrPC promotes endometriosis progression by reprogramming cholesterol metabolism and estrogen biosynthesis of endometrial stromal cells through PPARα …
- … alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα …
- Autophagy-dependent increased ADAM10 mature protein induced by TFEB overexpression is mediated through PPARα
- Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria
- Structural Basis for PPARα Activation by 1H-pyrazolo-[3, 4-b] pyridine Derivatives
- Molecular cloning and structural characterization of PPARα gene from turbot (Scophthalmus maximus) and functional exploration of lipid metabolism in response to …
- … (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα
- Transcriptional profiling of drug-induced liver injury biomarkers: Association of hepatic Srebf1/PPARα signaling and crosstalk of thrombin, alcohol dehydrogenase …
- PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
- PPARα/γ, adiponectin, and GLUT4 overexpression induced by moronic acid methyl ester influenced glucose and triglyceride levels of experimental diabetic mice
- Telmisartan is the most effective ARB to increase adiponectin via PPARα in adipocytes
- Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion
- In silico identification of microRNAs targeting the PPARα/γ: promising therapeutics for SARS-CoV‑2 infection
- Evolution of a 4-benzyloxy-benzylamino chemotype to provide efficacious, potent, and isoform selective PPARα agonists as leads for retinal disorders
- Cyanidin Increases the Expression of Mg2+ Transport Carriers Mediated by the Activation of PPARα in Colonic Epithelial MCE301 Cells
- Crataegus aronia prevents high‐fat diet‐induced hepatic steatosis in rats by activating AMPK‐induced suppression of SREBP1 and activation of PPARα
- Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured …
- Garcinia biflavonoid 1 improves lipid metabolism in HepG2 cells via regulating PPARα
- Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPARα/HO-1-Mediated Attenuation of Inflammation
- Functional analysis of Epinephelus coioides peroxisome proliferative–activated receptor α (PPARα): Involvement in response to viral infection
- Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting …
- Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway
- MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression
- Nitric oxide synthesis stimulated by arachidonic acid accumulation via PPARα in acetylcholine‐stimulated gastric mucous cells
- The 5-lipoxygenase inhibitor zileuton protects pressure overload-induced cardiac remodeling via activating PPARα
- Effects of a selective PPARα modulator, sodium-glucose cotransporter 2 inhibitor, and statin on the myocardial morphology of medaka nonalcoholic fatty liver disease …
- Effects of benzotriazole ultraviolet stabilizers on rat PXR, CAR and PPARα transcriptional activities
- 3, 3′, 5-triiodo-l-thyronine inhibits drug-induced liver injury through activation of PPARα as revealed by network pharmacology and biological experimental …
- Amoxicillin modulates ApoA-I transcription and secretion, predominantly via PPARα transactivation inhibition
- Amelioration of oxidative stress and neuroinflammation by Saroglitazar, a dual PPARα/γ agonist in MES induced epileptic rats
- Mulberry fruit repairs alcoholic liver injury by modulating lipid metabolism and the expression of miR-155 and PPARα in rats
- Selective activation of PPARα maintains thermogenic capacity of beige adipocytes
- Rutaecarpin reduces lipids by DGKθ‐dependent activation of PPARα
- Macrophage angiotensin-converting enzyme (ACE) reduces atherosclerosis by increasing PPARα and fundamentally changing lipid metabolism
- Study on the Mechanism of Estrogen Regulating Endometrial Fibrosis After Mechanical Injury Via MIR-21-5P/PPARα/FAO Axis
- Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss
- The key molecular mechanisms of sini decoction plus ginseng soup to rescue acute liver failure: Regulating PPARα to reduce hepatocyte necroptosis?
- Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
- FABP regulates fatty acid metabolism and oxidative response via PPARα/RXR signaling in Litopenaeus vannamei following environmental exposure of clofibric acid
- Docosahexaenoic acid inhibits TNFα-induced ICAM-1 expression by activating PPARα and autophagy in human endothelial cells
- MicroRNA-144-3p Inhibits Host Lipid Catabolism and Autophagy by Targeting PPARα and ABCA1 During Mycobacterium Tuberculosis Infection
- Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression
- Synthesis of DHA (omega-3 fatty acid): FADS2 gene polymorphisms and regulation by PPARα
- Exploring dual agonists for PPARα/γ receptors using pharmacophore modeling, docking analysis and molecule dynamics simulation
- Synthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner–Wadsworth–Emmons Olefination with PPARα/γ Agonist Activity
- Molecular characterization and tissue distribution of SREBP-1 and PPARα in Onychostoma macrolepis and their mRNA expressions in response to thermal exposure
- Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways
- Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARα
- PDE9 inhibition activates PPARα to stimulate mitochondrial fat metabolism and reduce cardiometabolic syndrome
- C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation …
- Studies on novel regulators of the fibroblast growth factor 23 (FGF23) synthesis in bone cells: the impact of p38MAPK, PPARα, and myostatin [kumulative Dissertation]
- Tilianin alleviates lipid deposition and fibrosis in mice with nonalcoholic steatohepatitis by activating the PPARα/Nnat axis
- Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4
- Downregulation of CPT1A exerts a protective effect in dextran sulfate sodium‐induced ulcerative colitis partially by inhibiting PPARα signaling pathway
- Cheonggukjang-specific component 1, 3-diphenyl-2-propanone as a novel PPARα/γ dual agonist: An in vitro and in silico study
- Identification of a novel regulatory pathway for PPARα by RNA-seq characterization of the endothelial cell lipid peroxidative injury transcriptome
- Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka …
- … -47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty …
- Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity
- Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes
- Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, attenuates molecular pathological alterations in learning memory in AD mice
- FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARα/HO-1 in ApoE−/− Mice
- Effects of Individual Amino Acids on PPARα Transactivation, mTORC1 Activation, ApoA-I Transcription and pro-ApoA-I Secretion
- Periostin Acts as a Bridge between Gestational Diabetes Mellitus (GDM) and Chronic Inflammation to Modulate Insulin Resistance by Modulating PPARα/NF-κB/TNF-α …
- Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated …
- The hsa-miR-214-3p/ATGL axis regulates aberrant lipolysis to promote acute myeloid leukemia progression via PPARα in vitro
- Gemfibrozil reduces lipid accumulation in SMMC‑7721 cells via the involvement of PPARα and SREBP1
- Association of placental PPARα/γ and miR-27b expression with macrosomia in healthy pregnancy
- Two faces of PPARα/NFκB signaling pathway in inflammatory responses to adipocytes lipolysis in grass carp Ctenopharyngodon idella
- Chrysin attenuates estradiol-induced endometrial hyperplasia in rats via enhancing PPARα activity
- PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1
- Association of POR and PPARα polymorphisms with risk of anti-tuberculosis drug-induced liver injury in Western Chinese Han population
- Effects of aerobic exercise on PPARα signaling in diabetes rats and its association with PPARγ
- Activation or inhibition of PPARα-mediated fatty acid β-oxidation does not active cardiomyocyte proliferation in normal or infarcted adult mice
- Lipid Messenger Phosphatidylinositol-4, 5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation
- Structural development of 1H-pyrazolo-[3, 4-b] pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective …
- Cucurbita ficifolia Bouché Regulates the Metabolism of Carbohydrates and Lipids in Liver by Activation of PPARα without Affectation on PPARγ in Vivo and in …
- Combining fecal 16 S rRNA sequencing and spinal cord metabolomics analysis to explain the modulatory effect of PPARα on neuropathic pain
- The mechanism behind BAF60c in myocardial metabolism in rats with heart failure is through the PGC1α-PPARα-mTOR signaling pathway
- Moderate aerobic exercise-induced cytokines changes are disturbed in PPARα knockout mice
- Ror1 promotes PPARα‐mediated fatty acid metabolism in astrocytes
- Atractylenolide II-ameliorated hyperlipidemia in mice by regulating AMPK/PPARα/SREBP-1C signaling pathway
- Dietary lipid supplementation could significantly affect the growth, fatty acid profiles, and expression of PPARα, leptin, and adiponectin genes in juvenile genetically …
- Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2, 2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease …
- Aspirin up‐regulates suppressor of cytokine signaling 3 in glial cells via PPARα
- Sphingosine 1‐phosphate combining with S1PR4 promotes regulatory T cell differentiation related to FAO through Nrf2/PPARα
- Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis
- Enantioselective Synthesis of 7(S)-Hydroxydocosahexaenoic Acid, a Possible Endogenous Ligand for PPARα
- First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors
- A novel microRNA boosts hyper-β-oxidation of fatty acids in liver by impeding CEP350-mediated sequestration of PPARα and thus restricts chronic hepatitis C
- The role of synthetic ligand of PPARα in regulation of transcription of genes related to mitochondria biogenesis and dynamic in an animal model of Alzheimer’s …
- Electroacupuncture improves glucose and lipid metabolism by regulating APN/AMPK/PPARα signaling of skeletal muscle in Zucker diabetic obese rats
- Identification of 3H-benzo[b] [1,4] diazepine derivatives as PPARα agonists by in silico studies and biochemical evaluation
- PFOA/PFOS Facilitated Intestinal Fatty Acid Absorption by Activating the PPARα Pathway: Insights from Organoids Model
- Gut microbial sodium butyrate alleviates renal ischemia-reperfusion injury by regulating HES1/PPARα
- PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
- Effect of Buyang Huanwu Tang on myocardial mitochondrial energy metabolism and AMPK/PPARα signaling pathway in rats with diastolic heart failure
- Effects of sodium arsenite on the expression of lipid metabolism related genes SREBP-1c, PPARα and FAS in L-02 cells
- Molecular Docking of Anthocyanin Compound as Anti-Hyperlipidemia Against PPARα, HMG-CoA Reductase and ACAT Proteins
- Dibutylstannanediyl (2Z, 2′ Z)-bis (4-(benzylamino)-4-oxobut-2-enoate inhibits prostate cancer progression by activating p38 MAPK/PPARα/SMAD4 signaling
- PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice
- Tanshinone IIA Alleviates Atherosclerosis Through Inhibition of NF-κB and PPARα/ABCA1 Signaling Pathways
- WY14643 Increases Herpesvirus Replication Independently of PPARα Expression and Inhibits IFNβ Production
- Silencing of PPARαBb mRNA in brown trout primary hepatocytes: Effects on molecular and morphological targets under the influence of an estrogen and a PPARα …
- 2, 4-Dihydroxyphenyl-benzo [d] thiazole (MHY553), a synthetic PPARα agonist, decreases age-associated inflammatory responses through PPARα activation and RS …
- Commentary: Dapagliflozin Mediates Plin5/PPARα Signaling Axis to Attenuate Cardiac Hypertrophy
- The Effect of Turmeric and Mangosteen Peel Extract on PPARα Gene Expression in the Retina of HFD-Induced Rat Model
- Rutin forestalls dysregulated cardiac bioenergetics in bisphenol A and dibutyl phthalate-exposed rats through PPARα and AMPK modulation
- Selective PPARα agonist pemafibrate inhibits TNF-α-induced S100A7 upregulation in keratinocytes
- Peroxisome proliferator-activated receptor alpha (PPARα) rs4253778 polymorphism in a Turkish soccer player cohort
- PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese
- Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis
- PPARα ablation suppresses T cell responses and anti-tumor immunity by compromising the antigen-presenting properties of tumor-associated Macrophages
- WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC
- Lithocholic acid decreases mRNA stability of nuclear receptor PPARα by upregulating miR-21 expression in hepatoma HepG2 cells
- Potential Role of PPARα in Ameliorating Neuropathic Pain by Gut Microbiota Alteration
- Effect of Bezafibrate, a PPARα Activator, on Acute and Subacute Inflammation in Male Wistar Rats
- Selective Activation of PPARα Mitigates Peritoneal Inflammation and Fibrosis through NLRP3 Inflammasome Suppression and Inflammation Modulation
- Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARα-Dependent and Independent Pathways
- Energy metabolism in cellular regenerative processes: focus on PPARα
- The PPARα Agonist Fenofibrate Reduces the Levels of Proinflammatory Cytokines in a Maternal Immune Activation Model of Schizophrenia
- Scintillation Proximity Assay (SPA)-Based Radioligand Binding for PPARα, PPARγ, and PPARδ Receptors
- Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
- Adiponectin improves endometrial receptivity in rats with polycystic ovary syndrome by upregulating the PPARα/HOXA10 pathway
- Immunohistochemistry of PPARα, PPARγ and IFNγ in kidney tissues of african catfish (clarias gariepinus) at different seasons
- PPARα suppresses low-intensity-noise-induced body weight gain in mice: the aggravation of fatty liver is covered up
- Daidzein protects endothelial cells against high glucose-induced injury through the dual-activation of PPARα and PPARγ.
- The mechanism of BAF60c in myocardial metabolism through the PGC1α/PPARα/mTOR signaling pathway in rats with heart failure
- PPARα-Ligand Binding Modes Revealed by X-ray Crystallography
- Hydroxycitric acid inhibits oxalate nephropathies formation through crystallization regulation and activation of the PPARα pathway
- Keratocytes promote corneal neovascularization through MMP13 induced by PPARα-inhibition
- WY14643, a agonist of PPARα, attenuates HFD-induced AIH by regulating hepatocyte lipid metabolism, necrosis and apoptosis via inhibiting JNK signaling pathway
- 17-OR: efficacy and safety of chiglitazar, a novel PPARα/γ/d pan-agonist, in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 …
- PPARα agonist exerts protective effects in podocyte injury via inhibition of the ANGPTL3 pathway
- The contribution of the AGT, GNB3, MTHFR, MTRR, ApoE, and PPARα polymorphisms to the development of masked arterial hypertension in patients with low …
- … with early-stage diabetic nephropathy evaluated by the MR mDixon-Quant technique: association with the expression of SREBP-1 and PPARα in renal tissue
- The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet
- Construction of a PPARα reporter assay system with drug-metabolizing capability
- Formononetin improves heart failure with preserved ejection fraction in mice by activating the PPARα/PGC-1 pathway
- Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s
- Computer‐Assisted Selective Optimization of Side‐Activities—from Cinalukast to a PPARα Modulator
- Corrigendum: Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
- Blockade of the PPARα metabolic checkpoint with TPST-1120 suppresses tumor growth and stimulates anti-tumor immunity
- Genetic variation characteristics and tissue expression analysis of PPARα gene in Tibetan sheep.
- Study of the effect of CHOP signaling molecule in PPARα activation and inhibition with response to inflammation in mice with acute liver failure
- Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα
- Mori Folium Improves Glucose and Lipid Metabolism Disorders in Rats with Type 2 Diabetes Mellitus by Regulating PI3K/Akt/PPARα/CPT-1 Pathway
- PPARα and fatty acid oxidation coordinate hepatic transcriptional architecture
- Roles of PPARα in Liver Health and Diseases
- Effects of PPARα pathway on hepatic lipid metabolism in non-alcoholic fatty liver disease rat model
- … of eight weeks of high-intensity intermittent training (HIIT) and low-intensity endurance training (LIET) with a high-fat diet on the expression of PPARα and PLIN5 of …
- Aerobic exercise improves hepatic steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway
- In vivo brain levels of acetylcholine and 5‐hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagement
- Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin
- The loss of hepatic PPARα prompts fatty liver disease-induced hypertension and cardiovascular disease
- The anti-inflammatory and anti-apoptotic role of crocin against expression of MMp-9, TIMP-1, MCP-1, caspase-3, PPARα in heart tissue, and metamorphoses of …
- Functional Bioassays Lithograph Ligand Reflections in the PPARα Sphere
- Effect of Fenofibrate as PPARα Agonist in Suppressing the Development of Oxaliplatin-Induced Peripheral Neuropathy via TRPA1 Modulation.
- The Role of Endothelial PPARα and TBK1 in Vascular Inflammation and Atherogenesis
- Restoring cellular NAD (P) H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency
- Research progress on the biological characteristics of PPARα and its role in cerebral infarction
- PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women
- … of Secondary Metabolites in Flower-Petal Annona muricata as Agonists for Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) for Liver Function
- Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Cofactor Recruitment Assay for PPARα and PPARγ
- Berberine attenuates angiotensin Ⅳ-induced cardiomyocyte hypertrophy via activation of PPARα/NO signaling pathway
- Phase 1/1b multicenter trial of TPST-1120, a peroxisome proliferator-activated receptor alpha (PPARα) antagonist as a single agent (SA) or in combination in patients …
- Ketogenic diet improves low temperature tolerance in mice by up-regulating PPARα in the liver and brown adipose tissue
- The new epigenetic driver role of PPARα and mitochondria in metabolic dysfunction associated liver disease (MASLD), paving the way towards new therapeutics and …
- The Effect Of Intense Periodic Training And Consumption Of Black Grape Seed Extract On PPARα And PparΓ Gene Expression In Pancreatic Tissue Of Male Rats With …
- PPARα‐targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host‐microbe intersection during SIV infection
- MiR-455-3p mediates PPARα through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells
- Carnitine Status and Fatty Acid Oxidation in the Small Intestines of Nursing Piglets under PPARα Activation
- PPARα regulates the development and inflammation of vein graft lesions
- Arid1a protects against hepatic steatosis and insulin resistance via PPARα-mediated fatty acid oxidation
- Effects of combined FGF15 overexpression and PPARα activation on mash development in mice
- Gualou Xiebai Banxia Decoction treats type 2 diabetes mellitus combined with acute myocardial infarction via chemerin/CMKLR1/PPARα signaling pathway
- Mechanisms of tanshinone Ⅱ_A in reducing 4-HNE-induced hepatocyte damage by activating PPARα
- Evaluation of the Relationship between Peroxisome Proliferator Receptors (PPARα, PPARγ, and PPARδ) Expression and Carcinoembryonic Antigen (CEA) in …
- The exogenous natural phospholipids, EPA-PC and EPA-PE, contributes to ameliorate lipid accumulation and inflammation via activation of PPARα/γ
- AI-guided use of balanced PPARα/γ dual agonist finetunes macrophage responses in inflammatory bowel disease
- PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview
- Eight Weeks of Swimming Training and CBD Oil Consumption Downregulates the Expression of MAPK and PPARα Genes in the Heart Tissue of Myocardial …
- Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, reverses neuroinflammation in lipopolysaccharide-induced mice
- Structure-based virtual screening of plant-derived natural compounds as potential PPARα agonists for the treatment of dyslipidemia
- The Role of PPARα in Liver Progenitor Cell-Mediated Liver Regeneration
- Function of PPARα signaling in the retinal microvasculature.
- Effect of Modified Gegen Qinliantang on FXR/SHP/PPARα Signaling Pathway in Type 2 Diabetic db/db Mice
- Contribution of Polymorphism in PPARα Untranslated Region to The Development of Axial Spondyloarthritis
- Abstract 1514 FK506-Binding Protein 51 (FKBP51), a New Regulator of Insulin Receptor Alternative Splicing and PPARα Activation That May Control Metabolic …
- Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and …
- Peroxisome Proliferator-Activated Receptor-α (PPARα) Regulates Mitochondrial Metabolism and Wound Healing in the Cornea
- PPARα in Ocular Neuronal Degeneration
- Probing the role of the PPARα regulated gene TMED5
- Effects of PPARα on metabolic syndrome and its mechanism in mice.
- PPARα regulates monocyte activation through interaction with the cGAS-STING pathway
- Bilirubin is a Metabolic Hormone that Reshapes the PPARα Coregulator Profile in Adipocytes
- Curcumin promotes progression of AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
- IL6/STAT Signaling Pathway and PPARα are Involved in Mediating the dose Dependent Cardioprotective Effect of Fenofibrate in 5-fluorouracil induced Cardiotoxicity
- PPARα loss-of-function-induced microglial polarization contributes to diabetic retinal neurodegeneration and neurovascular dysfunction
- 180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells
- HEK293A Cells Memorize a Brief Cold Exposure via a PPARα-Mediated Positive-Feedback Mechanism
- Differential effects of individual amino acids on PPARα transactivation, ApoA-I transcription and (pro)-ApoA-I secretion
- The Effects of Sodium Butyrate Supplementation on the Expression Levels of PGC-1α, PPARα, and UCP-1 Genes, Serum Level of GLP-1, Metabolic Parameters, and …
- PPARα Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress. Biomedicines 2021, 9 …
- Targeting PPARα/γ by icariside Ⅱ to rescue acute liver injury via coactivating SIRT6
- Study on mechanism of protective effect in nonalcoholic fatty liver rats by TiaoganQuzhi Formula based on miR-34a/SIRT1/PPARα signaling pathway
- Hepatic JNK-mediated bile acid homeostasis regulates liver cancer through PPARα
- QSAR rationales for the PPARα/γ agonistic activity of 4, 4-Dimethyl-1, 2, 3, 4-tetrahydroquinoline derivatives
- Pueraria Flos Alleviates Alcoholic Liver Injury Via Regulation of PPARα and MAOA: Deciphering the Effective Forms and Potential Mechanism Based on a …
- FABP3 deficiency exacerbates metabolic derangement in cardiac hypertrophy via PPARα pathway
- Persistent Emerging Contaminants at Trace Levels Dysregulates Biomolecules in Different Organs in Mice: Role of PPARα
- Abstract MP25: Differential Expression Of PPARα In Peripheral Arterial Segments Of Patients With Advanced Atherosclerosis
- Activation of PPARα stimulates hippocampal neurogenesis
- The Protective Role of PPAR𝛼 in Cardiac Metabolism Under Metabolic Stress
- High-intensity interval training (HIIT) induces hepatic ketone body production possibly through altering expression of mTORC1, PPARα and FGF21 in mice
- In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists
- PPARα inhibition impairs the reconsolidation of fear memories in mice
- Effects of Metformin on Attenuating Renal Dysfunction Through the Modulation of AMPK/PPARα Dependent Pathways in Obese Rats
- The Loss of PPARα in Adipocytes Induces Lipogenesis via the PASK‐SREBP1 Signaling Axis
- Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J …
- USP7/PGC1β/PPARα Axis Promotes Cardiometabolic Disorders and Mitochondrial Homeostasis Dysfunction in Diabetic Mice
- microRNA-18a upregulates the regulatory immune function in patients with chronic hepatitis B through the PPARα/γ signaling pathway
- Effects of sodium arsenite on the expression of lipid metabolism related genes SIZEBP-1c, PPARα and FAS in L-02 cells.
- Diabetes-induced down-regulation of PPARα plays a key role in the deficiency of endothelial progenitor cells and mitochondrial function
- Targeting Microglial PPARα Ameliorates the Outcome of Ischaemic Stroke by Enhancing Interaction with Infiltrating Peripheral Monocytes/Macrophages
- Fenofibrate induced‐hepatomegaly and liver regeneration is PPARα dependent and partially related to the activation of YAP pathway
- Liver and Biliary Tract Physiology/Pathophysiology: High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis …
- Comparative Efficacy of Sweated and Non-Sweated Salvia Miltiorrhiza Bge. Extracts on Acute Myocardial Ischemia Via Regulating the PPARα/RXRα/NF-κB Signaling …
- Novel Dual PPARα/δ Agonist F3SM Increased Oxidative Muscle Fiber and Ameliorated Metabolic Disorders in Non‐trained Mice
- Involvement of AKT/FOXO Genes in the Interactions of PPARα and PHD in DOCA‐Induced Pathology
- The nuclear receptor PPARα (peroxisome proliferator-activated receptor α) as a novel therapeutic target for schizophrenia
- ADMET Prediction of Dual PPARα/γ Agonists for Identification of Potential Anti-diabetic Agents
- Potential Natural Dual Agonist PPARα/γ-induced Antidiabetic and Anti-dyslipidemic Properties of Safrole-Free Nutmeg Seed (Myristica fragrans Houtt) Extract
- [Retracted] Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway
- Biomarkers of one-carbon metabolism and B-vitamin status: Targeted metabolomics in rats and humans exploring the effects of PPARα-activation and dietary …
- Maternal Feeding of a Synthetic PPARα Agonist Alters Renal Development of Fatty Acid Metabolism in the Neonatal Piglet
- The regulation of cGAS-STING signaling by PPARα-mediated autophagy in ischemic retinopathy
- Icariside II, a Novel Dual PPARα/γ Agonist, Confers Protection Against D-GalN/LPS-Induced Acute Liver Injury: Involvement of SIRT6/NF-κB/Pyroptosis Axis
- Effects of PPARα pathway on hepatic lipid metabolism in non-alcoholic fatty liver disease rat model
- Expression of PPARα and PGC1α proteins in cardiac tissue of male rats with type 2 diabetes after high intensity interval training
- Aspirin Modulates Hippocampal Plasticity and Protects Memory via PPARα
- Dapagliflozin Attenuates Aorta Smooth Muscle Aging and Atherosclerosis via Inhibiting the PPARα Pathway
- PPARα agonist suppresses inflammation after corneal alkali burn by suppressing proinflammatory cytokines, MCP-1, and nuclear translocation of NF-B
- Prenatal PPARα Activation Moved Forward Transient Browning of WAT at Neonates and Increased HFD-Induced UCP1 Expression in WAT of Male Mice at Adulthood
- Chlorogenic Acid Relieves Hfd-Induced Non-Alcoholic Fatty Liver Disease Via Microbiota and Enhancing Foxo1/PPARα Pathway
- Cyclophilin D Sequesters PPARα in Mitochondria to Impair Fatty Acid Oxidation in Cisplatin‐induced Acute Kidney Injury
- PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat.
- Abstract C109: Tumor derived exosomal lipids-induced dendritic cell immunosuppression by PPARα
- PPARα interacts with PHD proteins on Renal Fibrosis in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease
- Oleuropein-induced acceleration of CYP-catalyzed drug metabolism: central role for nuclear receptor PPARα
- Correlations of PPARα and PPARγ expressions with 1H-MRS quantified hepatic fat content in pups of rats that experienced intrauterine growth restriction
- Erratum: In vitro and in vivo study of the pathogenic role of PPARα in experimental periodontitis
- MiR-33a-5p Promotes M1 Macrophage Polarization and Inflammatory Accumulation in Long-Term Stored Blood Through Regulation of the PPARα/ACC2/AMPK/CPT …
- Corrigendum to” Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2, 2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile …
- … well as a reduction in chocolate and caloric intake at post-weaning periods in the feeding tests. Their liver showed a decreased gene expression of Cnr1, PPARα
- Retraction: Metabolomics reveals that PPARα activation protects against lithocholic acid-induced liver injury
- PPARα-deficiency exacerbates ethanol-induced chronic injury of gastric mucosa in mice
- PPARα and γ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata
- Expression of PPARα and PGC1α proteins in cardiac tissue of male Wistar rats with type 2 diabetes after 8 weeks of high intensity interval training
- Deletion of Telomere‐Rap1 aggravates cardiac aging by impairing fatty acid oxidation via PPARα signaling
- EARLY PPARα ACTIVATION PROTECT AGAINST HEPATIC MICROSTEATOSIS INDUCED BY POST-NATAL OVERFEEDING
- Effects of PPARα on metabolic syndrome and its mechanism in mice.
- Synthesis of PPARα Agonist GW641597X
- GLP-1-mediated delivery of the PPAR𝛼/𝛾 dual-agonist Tesaglitazar improves obesity and glucose metabolism in mice
- Loss of Repressor Activator Protein 1 Precipitates Cardiac Aging in Mice via p53/PPARα Signaling
- PPARα in Osteocytes Regulates Marrow Fat
- Correction to: Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling
- Limonin inhibits apoptosis, promotes autophagy and improves non-alcoholic fatty liver disease by promoting oxidative metabolism of fatty acids through PPARα
- BDE-47 Promotes Non-Alcoholic Fatty Liver Disease Through CD36-Mediated Increased Fatty Acid Uptake and PPARα-Induced Abnormal Fatty Acid Oxidation
- Carnitine Status and Fatty Acid Oxidation in the Intestines of Nursing Piglets under PPARα Activation
- PPARα antagonists as cytotoxic agents in gliomas and pancreatic, colorectal, and renal cancer
- PPARα-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory
- Irisin/PPARα improves the ox-LDL-induced endothelial cell pyroptosis and inflammatory response
- Research data supporting” PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia”
- … Analyses and Computational Modeling Reveal That Fatty Acid Transport Protein 2 (FATP2) Impacts the Transcriptional Activity of PPARα Thus Altering the …
- PPARα Agonist Fenofibrate Attenuates Iron Induced Liver Injury in Mice by Modulating 1 the Sirt3 and β-catenin Signaling 2
- Effects of methamphetamine on KI-67, PPARα, PPARγ and Bax genes on human SH-SY5Y cell proliferation, differentiation and apoptosis.
- Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes.
- Attenuation of high-fat diet-induced fatty liver through PPARα activation by stevioside.
- Expression of Concern on “Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα”
- Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression
- Retracted: Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats
- HM-chromanone Attenuates Hepatic Steatosis by Activating AMPK and PPARα Pathway in HepG2 Cells
- Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway
- Efficacy of Zhibai Dihuang Decoction on energy metabolism of spermatogenic cells in Ureaplasma urealyticum-infected rats: A study based on AMPK and PPARα …
- Fine particles cause the abnormality of cardiac ATP levels via PPARα-mediated utilization of fatty acid and glucose using in vivo and in vitro models.
- … -chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα).
- … -glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of …
- Preventive effects of total flavonoid C-glycosides from Abrus mollis on nonalcoholic fatty liver disease through activating the PPARα signaling pathway.
- Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways
- … of a phenolic-rich extract from Hypericum attenuatum Choisy in KK-Ay mice mediated through AMPK/PI3K/Akt/GSK3β signaling and GLUT4, PPARγ, and PPARα …
- Synthesis of DHA (omega-3 fatty acid): FADS2 gene polymorphisms and regulation by PPARα
- Anti-diabetic effect of a shihunine-rich extract of Dendrobium loddigesii on 3T3-L1 cells and db/db mice by up-regulating AMPK-GLUT4-PPARα.
- NHR-49/PPARα regulates HLH-30/TFEB-mediated innate immune response via a flavincontaining monooxygenase in C. elegans
- Transcription factors NHR-49/PPARα and HLH-30/TFEB promote host defense in C. elegans via a flavin-containing monooxygenase
- 1894-P: HIF-2α Induced by Hypoxia Exacerbates Nonalcoholic Fatty Liver Disease Progression via Suppressing PPARα
- Retraction Note: Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation
