INSULIN & AGING
February 5, 2021EXCITOXICITY & THE BRAIN
February 8, 2021- mTor‐dependent stimulation of the association of eIF4G and eIF3 by insulin
- insulin signalling to mTor mediated by the Akt/PKB substrate PRAS40
- The role of mammalian target of rapamycin (mTor) in insulin signaling
- Amino acid and insulin signaling via the mTor/p70 S6 kinase pathway: a negative feedback mechanism leading to insulin resistance in skeletal muscle cells
- The cardioprotection of the insulin-mediated PI3K/Akt/mTor signaling pathway
- Down‐regulation of placental mTor, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon
- Judicious toggling of mTor activity to combat insulin resistance and cancer: current evidence and perspectives
- Akt/mTor role in human foetoplacental vascular insulin resistance in diseases of pregnancy
- Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTor in isolated rat hepatocytes
- Activation of mammalian target of rapamycin (mTor) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTor complex 1
- Stimulation of the insulin/mTor pathway delays cone death in a mouse model of retinitis pigmentosa
- insulin activation of Rheb, a mediator of mTor/S6K/4E-BP signaling, is inhibited by TSC1 and 2
- MAP kinases and mTor mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632
- insulin and amino-acid regulation of mTor signaling and kinase activity through the Rheb GTPase
- Glycerolipid signals alter mTor complex 2 (mTorC2) to diminish insulin signaling
- Acute mTor inhibition induces insulin resistance and alters substrate utilization in vivo
- IKKβ suppression of TSC1 function links the mTor pathway with insulin resistance
- Chronic mTor inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
- insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTor-NFκB-Opa-1 signaling pathway
- insulin-and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTor signaling cascade
- Long‐chain omega‐3 fatty acids regulate bovine whole‐body protein metabolism by promoting muscle insulin signalling to the Akt–mTor–S6K1 pathway and insulin …
- Inappropriate activation of the TSC/Rheb/mTor/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
- Distinct signaling events downstream of mTor cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
- insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTor and Rac1 signaling pathways
- Glucose phosphorylation is required for insulin-dependent mTor signalling in the heart
- Quantification of the effect of amino acids on an integrated mTor and insulin signaling pathway
- … 3-kinase/Akt/mTor pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
- Adipocyte-specific deletion of mTor inhibits adipose tissue development and causes insulin resistance in mice
- Mammalian target of rapamycin (mTor) is involved in the neuronal differentiation of neural progenitors induced by insulin
- mTorC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTor
- Activation of mTor/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation
- Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTor activation
- Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTor/S6K1 and AMPK pathways
- The PI3K/Akt/mTor signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
- Longevity pathways (mTor, SIRT, insulin/IGF-1) as key modulatory targets on aging and neurodegeneration
- The TSC-mTor pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor-or rictor-independent manner
- Amino acids are necessary for the insulin-induced activation of mTor/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle
- Genetically reducing mTor signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease
- The insulin-like growth factor-I–mTor signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth
- mTor complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
- insulin-like growth factor II targets the mTor pathway to reverse autism-like phenotypes in mice
- mTor inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
- Hepatitis C virus activates the mTor/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
- Activation of placental insulin and mTor signaling in a mouse model of maternal obesity associated with fetal overgrowth
- Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTor-mediated insulin receptor substrate 1 phosphorylation
- mTor and neuronal cell cycle reentry: how impaired brain insulin signaling promotes Alzheimer’s disease
- Zinc stimulates the activity of the insulin-and nutrient-regulated protein kinase mTor
- insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with refractory Ewing’s sarcoma family …
- Exercise training reduces insulin resistance and upregulates the mTor/p70S6k pathway in cardiac muscle of diet‐induced obesity rats
- insulin-and lipopolysaccharide-mediated signaling in adipose tissue macrophages regulates postprandial glycemia through akt-mTor activation
- Maternal protein restriction in the rat inhibits placental insulin, mTor, and STAT3 signaling and down-regulates placental amino acid transporters
- Glucose induces mouse β-cell proliferation via IRS2, mTor, and cyclin D2 but not the insulin receptor
- hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTor signaling
- Effects of insulin and pathway inhibitors on the PI3K-Akt-mTor phosphorylation profile in acute myeloid leukemia cells
- Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTor
- Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTor complex 1 inhibition
- Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTor pathway
- Overexpression of kinase-dead mTor impairs glucose homeostasis by regulating insulin secretion and not β-cell mass
- Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTor/p70 S6K pathway
- insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with metastatic adrenocortical …
- Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
- Inhibition of the mTor/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake
- insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTor-p70S6K signaling without increased Akt phosphorylation
- Mammalian target of rapamycin (mTor) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
- A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTor pathway
- Mechanistic target of rapamycin (mTor): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer …
- insulin promotes glucose consumption via regulation of miR-99a/mTor/PKM2 pathway
- Salmonella enterica Typhimurium infection causes metabolic changes in chicken muscle involving AMPK, fatty acid and insulin/mTor signaling
- Systematic Screen for Drosophila Transcriptional Regulators Phosphorylated in Response to insulin/mTor Pathway
- insulin and mTor pathway regulate HDAC3-mediated deacetylation and activation of PGK1
- The role of AMPK/mTor/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 …
- The regulation of lipid deposition by insulin in goose liver cells is mediated by the PI3K-AKT-mTor signaling pathway
- Amino acids and leucine allow insulin activation of the PKB/mTor pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
- Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTor …
- Both Wnt and mTor signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells
- Palmitate induced insulin resistance by PKCtheta-dependent activation of mTor/S6K pathway in C2C12 myotubes
- insulin-like peptides and the mTor-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death
- PKCζ is essential for pancreatic β-cell replication during insulin resistance by regulating mTor and cyclin-D2
- Akt/mTor Counteract the Antitumor Activities of Cixutumumab, an Anti-insulin–like Growth Factor I Receptor Monoclonal Antibody
- insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K …
- mTor-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1
- Leucine activates pancreatic translational machinery in rats and mice through mTor independently of CCK and insulin
- insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTor kinase axis in a RBM20-dependent manner
- insulin fails to enhance mTor phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
- insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTor)-induced negative feedback down-regulates …
- Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTor signaling pathway
- insulin-induced de novo lipid synthesis occurs mainly via mTor-dependent regulation of proteostasis of SREBP-1c
- Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTor and rictor
- … a model describing regulation of casein synthesis by the mammalian target of rapamycin (mTor) signaling pathway in response to insulin, amino acids, and …
- … hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTor) and c-Jun N-terminal kinase/insulin receptor substrate 1 …
- Antiproliferation of cardamonin is involved in mTor on aortic smooth muscle cells in high fructose-induced insulin resistance rats
- THE ROLE OF AMPK AND mTor IN THE DEVELOPMENTOF insulin RESISTANCE AND TYPE 2 DIABETES. THE MECHANISM OF METFORMIN ACTION …
- Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTor and TNF-α modulations
- insulin stimulates goose liver cell growth by activating PI3K-AKT-mTor signal pathway
- insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTor signaling …
- Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt–GLUT4, GSK3β and mTor–S6K1
- Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTor (mammalian target of rapamycin …
- Activation of the PI3K/Akt/mTor/p70S6K1 signaling cascade in the mononuclear cells of peripheral blood: association with insulin and insulin-like growth factor levels …
- Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTor signaling: Role of Lepidium sativum seed extracts
- 17β-estradiol regulates glucose metabolism and insulin secretion in rat islet β cells through GPER and Akt/mTor/GLUT2 pathway
- Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTor expression, as a novel component, in a rat model of Polycystic …
- Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTor and signal pathway
- Inhibiting insulin and mTor signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma
- Implication of RICTOR in the mTor inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 …
- Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTor pathway
- … of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: roles of Akt, mTor, GSK3β, and PTEN
- insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTor: studies on the function of Ser675 and Ser907
- Pectic bee pollen polysaccharide from Rosa rugosa alleviates diet-induced hepatic steatosis and insulin resistance via induction of AMPK/mTor-mediated autophagy
- Evodiamine inhibits insulin-stimulated mTor-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese …
- … improves vascular endothelial dysfunction by inducing autophagy via AMPK/mTor signaling activation in a rat model of type 2 diabetes mellitus with insulin …
- The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTor) complex 1 and its contribution to mTor complex 1 …
- … a low-protein diet in utero demonstrate changes in mTor signaling in pancreatic islets of langerhans, associated with altered glucagon and insulin expression and a …
- insulin-induced stimulation of JNK and the PI 3-kinase/mTor pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
- insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTor) pathway
- Galangin and pinocembrin from propolis ameliorate insulin resistance in HepG2 cells via regulating Akt/mTor signaling
- insulin Potentiates Ca2+ Signaling and Phosphatidylinositol 4,5-Bisphosphate Hydrolysis Induced by Gq Protein-Coupled Receptor Agonists through an mTor …
- Hexanoic, octanoic and decanoic acids promote basal and insulin-induced phosphorylation of the Akt-mTor axis and a balanced lipid metabolism in the HepG2 …
- … lychee fruit extract alleviates diet‐induced insulin resistance via suppressing mTor/SREBP‐1 mediated lipogenesis in liver and restoring insulin signaling in skeletal …
- insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3β and PI3K/Akt/mTor-dependent …
- Amino acid-and insulin-induced activation of mTorC1 in neonatal piglet skeletal muscle involves Sestrin2-GATOR2, Rag A/C-mTor, and RHEB-mTor complex …
- The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTor inhibitor-mediated antitumor efficacy in hepatocellular carcinoma
- insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTor/ATF4 axis
- Tissue-specific responses of IGF-1/insulin and mTor signaling in calorie restricted rats
- Improved insulin sensitivity by rapamycin is associated with reduction of mTor and S6K1 activities in L6 myotubes
- Scutellarin, a modulator of mTor, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP‐1c suppression
- Rumen-Protected Glucose Stimulates the insulin-Like Growth Factor System and mTor/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows
- Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTor and MAPK pathways in K562 cells
- Intranasal insulin increases synaptic protein expression and prevents anesthesia-induced cognitive deficits through mTor-eEF2 pathway
- insulin increases sestrin 2 content by reducing Its degradation through the PI3K/mTor signaling pathway
- … acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTor activation and mitochondrial …
- Rosemary Extract Activates AMPK, Inhibits mTor and Attenuates the High Glucose and High insulin-Induced Muscle Cell insulin Resistance
- … Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTor/CREB signaling pathway
- Adipocyte-specific DKO of Lkb1 and mTor protects mice against HFD-induced obesity, but results in insulin resistance
- Impaired overload-induced hypertrophy is associated with diminished mTor signaling in insulin-resistant skeletal muscle of the obese Zucker rat
- The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTor-P70S6K pathway
- … the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTor
- insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo‐2 cells by upregulating SR‐BI via a PI3K, AKT, and mTor …
- mTor partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine307 residues after burn
- mTor inhibition: reduced insulin secretion and sensitivity in a rat model of metabolic syndrome
- insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTor signaling
- Effect of electrical stimulation combined with diet therapy on insulin resistance via mTor signaling
- insulin-stimulated mTor activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of …
- … of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTor and p70 S6K
- 4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTor signaling
- PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTor signaling pathways
- … , methionine, threonine, and other amino acids on insulin and glucagon concentrations, mammalian target of rapamycin (mTor) signaling, and lactational …
- Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTor signaling pathway
- Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRβ1–Akt–mTor pathway in the pancreas
- insulin inhibition of apolipoprotein B mRNA translation is mediated via the PI-3 kinase/mTor signaling cascade but does not involve internal ribosomal entry site …
- Exercise improves skeletal muscle insulin resistance without reduced basal mTor/S6K1 signaling in rats fed a high-fat diet
- Essential amino acids improve insulin activation of AKT/mTor signaling in soleus muscle of aged rats
- Reduction of insulin signalling pathway IRS‐1/IRS‐2/AKT/mTor and decrease of epithelial cell proliferation in the prostate of glucocorticoid‐treated rats
- Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTor axis
- Attenuation of insulin resistance in rats by agmatine: role of SREBP-1c, mTor and GLUT-2
- insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTor …
- Medium-chain triacylglycerol suppresses the decrease of plasma albumin level through the insulin-Akt-mTor pathway in the livers of malnourished rats
- Amino acid-sensing mTor signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
- insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTor pathway
- Melanocortin-4 receptor activation promotes insulin-stimulated mTor signaling
- insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTor/S6K1
- … and autophagy of articular chondrocytes via modulating the phosphoinositide 3‐kinase/protein kinase B‐mTor pathway by targeting insulin‐like growth factor‐1
- Crosstalk with insulin and dependence on PI3K/Akt/mTor rather than MAPK pathways in upregulation of basal growth following long-term oestrogen …
- Effects of resveratrol, lovastatin and the mTor-inhibitor RAD-001 on insulin-induced genomic damage in vitro
- Eicosapentaenoic acid abolishes inhibition of insulin-induced mTor phosphorylation by LPS via PTP1B downregulation in skeletal muscle
- insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTor) signalling is impaired …
- The effects of amino acids on glucose metabolism of isolated rat skeletal muscle are independent of insulin and the mTor/S6K pathway
- Combination of the mammalian target of rapamycin (mTor) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: A …
- miR-155-5p alleviates ethanol-induced myocardial insulin resistance in H9C2 cells via regulating the mTor signalling pathway
- Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTor signaling, β cell growth, and insulin secretion
- Preoperative oral carbohydrate improved postoperative insulin resistance in Rats through the PI3K/AKT/mTor pathway
- insulin-induced mTor activity exhibits anti-hepatitis C virus activity
- In human endothelial cells amino acids inhibit insulin-induced Akt and ERK1/2 phosphorylation by an mTor-dependent mechanism
- miR‐483 is d ownregulated in pre‐eclampsia via targeting insulin‐like growth factor 1 (IGF1) and regulates the PI3K/Akt/mTor pathway of endothelial progenitor cells
- 1, 25 (OH) 2D3 protects trophoblasts against insulin resistance and inflammation via suppressing mTor signaling
- Inhibition of PI-3 kinase/Akt/mTor, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in …
- insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTor pathway in prostate cancer
- Effect of AMPK/mTor/S6K1 pathways and the insulin-sensitizing effect for adiponectin in endometrial cancer cells
- Modeling the effects of insulin and amino acids on the phosphorylation of mTor, Akt, and 4EBP1 in mammary cells
- Correction: insulin and mTor pathway regulate HDAC3-mediated deacetylation and activation of PGK1
- Bromodomain-containing protein 2 induces insulin resistance via the mTor/Akt signaling pathway and an inflammatory response in adipose tissue
- Involvement of mTor in type 2 CRF receptor inhibition of insulin signaling in muscle cells
- … pathway leads to phosphorylation of IRS-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mTor insulin biosynthetic pathway in RIN …
- Anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody cixutumumab (cix) plus mTor inhibitor temsirolimus (tem) in metastatic castration-resistant …
- Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTor pathway
- Branched-Chain α-Ketoacids Regulate insulin and mTor Signalling in Skeletal and Cardiac Muscle
- 2313-PUB: Alterations in Basal State of insulin and mTor-Dependent Signalings Closely Related to Impaired Incretin Profile and Type 2 Diabetes in Subcutaneous …
- SDC3 acts as a timekeeper of myogenic differentiation by regulating the insulin/AKT/mTor axis in muscle stem cell progeny
- insulin promotes the expression of the gluconeogenic rate-limiting enzymes phosphoenolpyruvate carboxykinase (Pepck) and glucose 6-phosphatase …
- Forskolin attenuates the action of insulin on the Akt–mTor pathway in human skeletal muscle
- Anti-insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody cixutumumab plus mammalian target of rapamycin (mTor) inhibitor temsirolimus in metastatic …
- The relationship between mTor/S6K1 signaling pathway and insulin resistance and the study of aerobic exercise on this pathway
- Bifurcation analysis of insulin regulated mTor signalling pathway in cancer cells
- Effects of insulin on Milk Fat Synthesis by Regulating the Expressions of SREBP1 and mTor in Bovine Mammary Epithelial Cells.
- … Holstein male calves accelerated by branched-chain volatile fatty acids addition with up-regulated hepatic mTor expression via insulin and insulin-like growth factor …
- … Acid-and insulin-Induced Activation of Mechanistic Target of Rapamycin Complex 1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTor …
- insulin Stimulation of Protein Synthesis and mTor Signaling in Chick Myotube Cultures
- Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRb1–Akt–mTor pathway in the pancreas
- Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTor activation. Diabetes 2015; 64: 1555 …
- insulin Confers Neuroprotection Against Hyperglycemic Stress-Induced Apoptosis Through PI3K/Akt/mTor/Nrf2/GCL/Redox Signaling.
- Molecular mechanism of insulin resistance: role of mTor signaling pathways
- Activation of the PI3K/Akt/mTor Pathway by insulin Is Crucial for Amplification of FSH-Induced Differentiation, but Not Proliferation, of Ovarian Granulosa Cells.
- Analysis of Integrated insulin–mTor Signalling Network-Diabetes Perspective
- The ageing process: insulin signalling and mTor signalling
- Fish Oil and Cardiac Akt/mTor-Mediated insulin Resistance in Infants with Maternal Diabetes
- … carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTor signal transduction pathways in …
- Effects of α-ketoglutarate on Plasma Concentrations of insulin and Amino Acids and mTor Signal Transduction in Gastrocnemius of Piglets Challenged by …
- The Effect of insulin-like Growth Factor 1 (IGF-1) and Exercise on the Protein Expression of Mammalian Target of Rapamycin (mTor) and Androgen Receptor (AR) in …
- Agpat1 Decreases insulin Signaling by Activating the mTor Pathway.
- The insulin/IGF-1, the sirtuin and the mTor pathway. How alterations of these pathways could affect age-related diseases and lifespan.
- … giant cell tumor with benign histologic features, treated with SCH 717–454, an insulin growth factor receptor inhibitor, in combination with everolimus, an mTor …
- insulin Stimulates mTor Phosphorylation via Protein Klnase B
- Evaluation of combined insulin-like growth factor type 1 (IGF1R) and mTor pathway blockade in sarcoma xenograft models
- Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTor, and p70S6K protein kinases in lymphocytes of …
- Calcium/calmodulin-dependent Protein Kinase IV Limits ER stress and insulin Resistance through Inhibition of Autophagy in Adipocytes by mTor/CREB Signaling
- Research progress of inhibitors in mTor and insulin/IGF-1 signaling pathway and age-related diseases
- Retraction: insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTor Signaling
- mTor kinase activity is required by the myocardium for basal level and insulin‐induced mTor‐mediated signals
- Actions of insulin As a Survival and Growth Factor: Akt, mTor, and Regulation of Translation
- Hypothalamic mTor pathway mediates neuronal actions of insulin
- … -Protein Diet in Utero Demonstrate Changes in mTor Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and insulin Expression and a …
- A high fat diet induces insulin resistance and insulin-independent activation of the mTor-S6 kinase pathway in mouse liver
- Insights into insulin-mediated regulation of CYP2E1: miR 132/212 targeting of CYP2E1 and role of PI3-K, Akt, mTor signaling in regulating miR132/212 and miR 122 …
- The effect of mTor/S6K1 signaling pathway on the development of high fat diet-induced mouse insulin resistance
- insulin-mediated regulation of the miR132/212 cluster and miR 122/181a expression through PI3K, Akt, mTor signaling in primary cultured rat hepatocytes.
- A Dual PI3K-mTor Inhibitor Induced Hyperglycemia and Increased insulin Signals in the Heart
- mTor Signaling Pathway Regulates insulin-Induced Redistribution and Degradation of IRS-1 in 3T3-L1 Adipocytes
- Targeting the insulin-like growth factor 1 (IGF1R) and insulin (IR) receptor with a dual IGF1R/IR inhibitor, OSI-906, to potentiate mTor inhibitor effects in experimental …
- insulin-Mediated Down-Regulation of the Anti-Angiogenic Protein PEDF is mTor Dependent.
- Hepatic Overexpression of Dominant Negative Form of mTor Enhances Akt Phosphorylation and Restores insulin Resistance in K/KAy Mice.
- The regulation of skeletal muscle insulin‐stimulated signaling by the MEK‐REDD1‐mTor axis
- Abstract A56: A dual PI3K-mTor inhibitor induced cardiac hypertrophy in mice: Role of the insulin signaling
- The role of PRAS40 in insulin action: at the intersection of protein kinase B (PKB/Akt) and mamalian target of rapamyein (mTor)
- Human postprandial blood concentrations of leucine and insulin increase phosphorylation of mTor in C2C12 myoblasts
- insulin stimulates muscle protein synthesis in neonates during endotoxemia despite suppression of insulin-stimulated mTor-dependent translation initiation
- Role of PRAS40 in mammalian target of rapamycin (mTor) modulation in cancer and insulin resistance
- PI3K-mTor Axis is a Critical Node for Hypothalamic insulin Receptor Signaling and Sympathetic Activation Induced by insulin
- insulin Resistance Suppresses Cardiac Autophagy Through the AMPK/mTor Pathway in Type 2 Diabetes
- Towards a mechanistic explanation of insulin resistance, which incorporates mTor, autophagy, and mitochondrial dysfunction
- A study on the relationship of mTor/S6K1 signaling pathway and aerobic exercises attenuating insulin resistance induced by high fat diet in mice
- … of heavy resistance exercise in combination with orally administered branched-chain amino acids or leucine on insulin signaling and Akt/mTor pathway activity in …
- # 11 insulin-like growth factor-I promotes myogenesis via both mTor-dependent and-independent pathways
- … derived from hR1, a humanized anti-insulin-like growth factor receptor-I monoclonal antibody, are enhanced in renal cell carcinoma and synergistic with an mTor …
- Supplemental Data Inappropriate Activation of the TSC/Rheb/mTor/S6K Cassette Induces IRS1/2 Depletion, insulin Resistance, and Cell Survival Deficiencies
- Activity of insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with metastatic refractory …
- Abstract P5-11-06: Combination of insulin-like growth factor 1 receptor and PI3K/mTor inhibition in triple-negative breast cancers
- PO-063 Exercise alleviates insulin resistance by regulating MG53 and IR/IRS/AKT/mTor signaling in db/db mice skeletal muscle
- … Michael McDaniel, Ph. D., professor of pathology and immunology, wants to use this ability to makes cells divide and maintain enough insulin-making beta cells …
- insulin-like Growth Factor-I Suppresses Bone Morphogenetic Protein Signaling through a Phosphatidylinositol 3-Kinase, Akt and mTor-Dependant Mechanism
- insulin-Like Growth Factor Binding Protein (IGFBP) 3 Suppresses HIF1a Expression in Cancer Cells through Reactivating mTor/Tln Pathway
- Fasting and refeeding regulate in different manner SNAT 2, SREBP‐1 and 2, mTor, serum insulin in animals fed different types of protein
- … tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor (TAE226) leads to apoptosis in esophageal cancer by inhibiting AKT-mTor …
- Abstract LB-124: insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTor inhibitor temsirolimus in patients with refractory Ewing’s …
- EFFECTS OF DISRUPTING insulin-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R) SIGNAL TRANSDUCTION PATHWAYS WITH INHIBITORS OF IGF-1R …
- Impact of obesity on MMTV-Wnt-1 mammary cancer: role of the insulin-like growth factor-1 (IGF-1)/Akt/mTor pathway
- PI 3-Kinase and mTor Are Required for insulin Induced Phosphorylation of Eukaryotic Initiation Factor 4E Binding Protein 1 (4E-BP1) in Proximal Tubular Epithelial …
- Correction: Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTor signaling, β cell growth, and insulin secretion.
- Impact of Obesity on MMTV-Wnt-1 Mammary Cancer: Role of The insulin-Like Growth Factor-1 (IGF-1)/Akt/mTor Pathway
- … 3900: Resveratrol suppresses insulin-like growth factor-1 promoted colon cancer cell growth via activation of p53/AMPK/TSC-2 and suppression of IGF-1R/Akt/mTor …
