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December 8, 2023ANTI OBESOGENIC
December 8, 2023- GSK3 inhibitors: development and therapeutic potential
- The conundrum of GSK3 inhibitors: is it the dawn of a new beginning?
- Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes
- GSK3 inhibitors and disease
- GSK3 inhibitors show benefits in an Alzheimer’s disease (AD) model of neurodegeneration but adverse effects in control animals
- GSK3 inhibitors in the therapeutic development of diabetes, cancer and neurodegeneration: past, present and future
- Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor
- The development of potent and selective bisarylmaleimide GSK3 inhibitors
- Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors
- Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes
- Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes
- A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice
- The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of …
- GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling
- Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation
- Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels
- GSK3 inhibitor-induced dentinogenesis using a hydrogel
- QSAR, docking, and CoMFA studies of GSK3 inhibitors
- GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs)
- GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis
- GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells
- Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127
- From on‐target to off‐target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti‐Trypanosoma brucei drug …
- Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation
- Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania
- GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients
- GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells
- EGF and a GSK3 inhibitor deplete junctional E-cadherin and stimulate proliferation in the mature mammalian ear
- Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock
- Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells
- The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells
- Stable generation of serum‐and feeder‐free embryonic stem cell‐derived mice with full germline‐competency by using a GSK3 specific inhibitor
- The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype
- Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells
- GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation
- Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline‐competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability
- A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells
- GSK3 inhibitor AR-A014418 promotes osteogenic differentiation of human adipose-derived stem cells via ERK and mTORC2/Akt signaling pathway
- The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in …
- Docking and quantitative structure–activity relationship of oxadiazole derivates as inhibitors of GSK3
- Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor
- GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells
- Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals
- Tacrine, an oral acetylcholinesterase inhibitor, induced hepatic oxidative damage, which was blocked by liquiritigenin through GSK3-beta inhibition
- Derivation of Mouse Embryonic Stem (ES) Cell Lines Using Small-Molecule Inhibitors of Erk and Gsk3 Signaling (2i).
- Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta
- GSK3 inhibitor enhances gemtuzumab ozogamicin‐induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance
- The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL …
- Glucose dependence of glycogen synthase activity regulation by GSK3 and MEK/ERK inhibitors and angiotensin-(1–7) action on these pathways in cultured human …
- Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
- Differential effects of glycogen synthase kinase 3 (GSK3) inhibition by lithium or selective inhibitors in the central nervous system
- In vitro and in vivo antitumor and anti-inflammatory capabilities of the novel GSK3 and CDK9 inhibitor ABC1183
- From simple quinoxalines to potent oxazolo [5, 4-f] quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)
- Novel optimization of valmerins (tetrahydropyrido [1, 2-a] isoindolones) as potent dual CDK5/GSK3 inhibitors
- Glycogen synthase kinase 3 (GSK3): its role and inhibitors
- Glycogen synthase kinase 3 (GSK3)-inhibitor SB216763 promotes the conversion of human umbilical cord mesenchymal stem cells into neural precursors in adherent …
- A phase I dose-escalation, pharmacokinetic (PK), and pharmacodynamic (PD) evaluation of intravenous LY2090314 a GSK3 inhibitor administered in combination …
- Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
- Synergistic effects of GSK3 and p38 MAPK inhibitors on growth of Plasmodium falciparum ex vivo.
- Evaluation of in vivo lithium chloride effects as a GSK3-β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an …
- Phosphorylation of the inhibitor-2 of protein phosphatase-1 by cdc2-cyclin B and GSK3
- Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors
- The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 …
- Different concentrations of GSK3 inhibitor fail to suppress interleukin-6 in stimulated THP-1 macrophage
- Supplementation of freezing/thawing media with GSK3 inhibitor alsterpaullone does not bypass the harmful effect of cryopreservation on boar spermatozoa
- Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment
- Identification of a first in class GSK3-alpha selective inhibitor as a new differentiation therapy for AML
- 195 Effects of Gsk3 Inhibitor on the Pluripotency Maintenance of Buffalo Embryonic Stem-Cell-Like Cells
- Targeting BRCA2 deficiency with GSK3 inhibitors
- Evaluation of Lithium chloride effects as a GSK3-β inhibitor on human Adipose Derived Stem cells differentiation into oligodendrocytes and re-myelination in animal …
- GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells
- Assessment of the regenerative ability of two GSK3 inhibitors (Tideglusib & CHIR99021) on the Wnt/beta catenin pathway activation, the proliferative capacity, and the …
- Evaluation of hepatic activity of immunomodulatory compounds and GSK3 inhibitors
- Effect of Kenpaullone, a Specific Inhibitor of GSK3, on Melanin Synthesis in B16 Melanoma and Human Melanocytes
- Preferential Selectivity of Inhibitors with Human Tau Protein Kinase Gsk3 Elucidates Their Potential Roles for Off-Target Alzheimer’s Therapy
- THE EFFECT OF GLYCOGEN SYNTHASE KINASE3 (GSK3) INHIBITOR ON PROLIFERATION OF NEURAL STEM CELLS
- Back Cover: From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti …
- … of AtherosclerosisPart II: The Role of RNase L in Lipopolysaccharide-Induced Lung InflammationPart III: Development of LC-MS/MS Assay for GSK3 Inhibitors …
- BIO (6-bromoindirubin-3′-oxime) GSK3 inhibitor induces dopaminergic differentiation of human immortalized RenVm cells
- GSK3 plays a crucial role in determining cell response to mTOR inhibitors
- Combination of GSK3 and HDAC inhibitors increases gene expression efficiency to the hypoxia/neuron-specific system: an optimal experimental scheme in treating …
- Targeting GSK3 from Ustilago maydis: Type-II kinase inhibitors as potential antifungals
- Computational analysis of conformational changes in GSK3-β/CDK2 kinases for understanding inhibitor selectivity
- Glycogen synthase kinase 3 (GSK3) inhibitor 6-bromoindirubin-3′-oxime (BIO) promotes the proliferation of mouse male germline stem cells (mGSCs) under serum …
- Effects of GSK3-β Inhibitors on Wnt Signaling in Zebrafish Fin Regeneration: Chemical Biology
- Abstract B33: Transient upregulation of Myc with GSK3-β inhibitors in B-cell lymphomas enhances p53-independent apoptotic responses to chemotherapy
- Treatment with the autophagy inhibitor 3-Methyladenine sensitizes pancreatic cancer cells to GSK3 inhibition-induced apoptosis
- Thiadiazolidinone-8, a GSK3 beta inhibitor, ameliorates aldosterone-induced cardiac inflammation and fibrosis by regulating autophagy
- Glycogen Synthase Kinase 3-Beta (GSK3-β) inhibitors decrease protein degradation in L6 myotubes
