ATGL
December 8, 2023REVERSES AND PREVENTS FATTY LIVER
December 21, 2023- Sirtuin functions in health and disease
- Sirtuin chemical mechanisms
- Sirtuin activators
- From sirtuin biology to human diseases: an update
- Sirtuin activators and inhibitors
- Sirtuin catalysis and regulation
- Biological and potential therapeutic roles of sirtuin deacetylases
- Structural basis for sirtuin function: what we know and what we don’t
- Sirtuin deacetylases in neurodegenerative diseases of aging
- The Sirtuin family: therapeutic targets to treat diseases of aging
- Sirtuin inhibitors
- Sirtuin 1 in lipid metabolism and obesity
- Sirtuin regulation in aging and injury
- A molecular mechanism for direct sirtuin activation by resveratrol
- Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
- The sirtuin family’s role in aging and age-associated pathologies
- Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation
- Emerging role of sirtuin 2 in the regulation of mammalian metabolism
- SIRTUIN 1: regulating the regulator
- Sirtuin activators mimic caloric restriction and delay ageing in metazoans
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
- Sirtuin deacylases: a molecular link between metabolism and immunity
- Sirtuin-1 regulation of mammalian metabolism
- Sirtuin and metabolic kidney disease
- Structural basis for sirtuin activity and inhibition
- Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
- Redox Regulation of Sirtuin-1 by S-Glutathiolation
- Sirtuin inhibitors as anticancer agents
- Sirtuin 6: a review of biological effects and potential therapeutic properties
- The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
- Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
- Altered sirtuin expression is associated with node-positive breast cancer
- The sirtuin SIRT6 regulates lifespan in male mice
- Sirtuin 1 in malignant transformation: friend or foe?
- Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
- Regulation of sirtuin function by posttranslational modifications
- Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
- Sirtuin-1 and HIV-1: an overview
- The human sirtuin family: evolutionary divergences and functions
- Targeting sirtuin 1 to improve metabolism: all you need is NAD+?
- The diversity of histone versus nonhistone sirtuin substrates
- A novel continuous assay for the deacylase sirtuin 5 and other deacetylases
- Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
- The life span-prolonging effect of sirtuin-1 is mediated by autophagy
- Sirtuin 1 regulation of developmental genes during differentiation of stem cells
- Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson’s disease
- Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury
- Sirtuin 1: a target for kidney diseases
- Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
- Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
- Sirtuin 1 in immune regulation and autoimmunity
- Renal protective effect of sirtuin 1
- Role of Sirtuin 1 in metabolic regulation
- Neuroprotective Sirtuin ratio reversed by ApoE4
- Vitamin B3 and sirtuin function
- The Structural Basis of Sirtuin Substrate Affinity,
- Sirtuin-7 inhibits the activity of hypoxia-inducible factors
- Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
- Sirtuin 1 (SIRT1) the misunderstood HDAC
- Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes
- The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension
- The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
- Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
- Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
- Structure-based development of novel sirtuin inhibitors
- Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
- Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
- Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer
- Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
- Aging genes: the sirtuin story unravels
- Mechanism of sirtuin inhibition by nicotinamide: altering the NAD+ cosubstrate specificity of a Sir2 enzyme
- Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer
- Sirtuin modulators: an updated patent review (2012–2014)
- Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
- Sirtuin function in aging heart and vessels
- Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity
- Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins
- Distinct patterns of sirtuin expression during progression of Alzheimer’s disease
- Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
- An in silico approach to discovering novel inhibitors of human sirtuin type 2
- Sirtuin functions in female fertility: possible role in oxidative stress and aging
- Sirtuin‐dependent epigenetic regulation in the maintenance of genome integrity
- Crosstalk between poly (ADP-ribose) polymerase and sirtuin enzymes
- The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models
- Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors
- A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.
- Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
- MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
- Sirtuin‐6–dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
- Rapid temporal control of Foxp3 protein degradation by sirtuin-1
- Sirtuin 1 signaling and alcoholic fatty liver disease
- The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
- Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1
- Silent information regulator, Sirtuin 1, and age‐related diseases
- Sirtuin 6 protects the heart from hypoxic damage
- Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
- Medicinal chemistry of sirtuin inhibitors
- The sirtuin system: the holy grail of resveratrol?
- Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis
- Differential expression of sirtuin family members in the developing, adult, and aged rat brain
- The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
- Altered sirtuin deacetylase gene expression in patients with a mood disorder
- Identification of tri‐and tetracyclic pyrimidinediones as sirtuin inhibitors
- Downregulation of miR-199a derepresses hypoxia-inducible factor-1α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
- Sirtuin activators: designing molecules to extend life span
- The role of sirtuin proteins in obesity
- A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: Part 2.
- The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients
- Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis
- Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans
- Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction
- Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!
- Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
- Sirtuin modulators
- Nicotinamide restores cognition in Alzheimer’s disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
- Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis
- Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications
- The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases
- Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
- Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival
- Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone
- Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients
- Sirtuin-1 is a nutrient-dependent modulator of inflammation
- Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
- Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell tolerance
- SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
- Sirtuin-dependent clock control: new advances in metabolism, aging and cancer
- Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease
- Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
- Plasmodium falciparum Sir2: an Unusual Sirtuin with Dual Histone Deacetylase and ADP-Ribosyltransferase Activity
- Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells
- Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth
- The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
- Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
- Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway
- Sirtuin 1 and aging theory for chronic obstructive pulmonary disease
- Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke
- The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5)
- Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease
- Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues
- Sirtuin-3 (SIRT3) and the Hallmarks of Cancer
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
- Anti‐aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway
- Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide
- Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese
- Sirtuin deacetylases: a new target for melanoma management
- Sirtuin biology and relevance to diabetes treatment
- Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
- Inhibition of the human deacylase Sirtuin 5 by the indole GW5074
- New assays and approaches for discovery and design of Sirtuin modulators
- Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
- Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme
- NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response
- Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
- A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo
- Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen‐induced arthritis
- Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free‐energy calculations, and biological testing
- Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1
- Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine
- Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors
- An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms
- Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells
- The NAD‐dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation
- Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
- A patent review of sirtuin activators: an update
- Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation
- Sirtuin modulators: mechanisms and potential clinical implications
- Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition
- A mini-review on Sirtuin activity assays
- Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
- Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
- A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase
- NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway
- Sirtuin regulation in calorie restriction
- Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia
- The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells
- Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
- Sirtuin deacetylases as therapeutic targets in the nervous system
- A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington’s disease
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson’s disease but not amyotrophic lateral sclerosis and cerebral ischemia
- A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer
- Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes
- Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for …
- Altered sirtuin 7 expression is associated with early stage breast cancer
- The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
- Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia
- Non-sirtuin histone deacetylases in the control of cardiac aging
- Sirtuin 1 activator SRT 2104 protects Huntington’s disease mice
- The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism
- Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through …
- Sirtuin 1–mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
- Urea cycle regulation by mitochondrial sirtuin, SIRT5
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
- Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF‐κB‐dependent transcriptional activity
- Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
- Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
- Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
- Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep‐deprived rats
- Genome-wide analysis of functional sirtuin chromatin targets in yeast
- Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
- Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes
- A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
- Potential role of sirtuin as a therapeutic target for neurodegenerative diseases
- Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin‐induced mouse model of asthma
- Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease
- Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies
- The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism
- Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1
- Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection
- Fungus-specific sirtuin HstD coordinates secondary metabolism and development through control of LaeA
- Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
- Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site
- Catalysis and mechanistic insights on Sirtuin activation
- Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer
- Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
- The protein–protein interaction network of the human Sirtuin family
- Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress
- Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pathway
- Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform
- Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target
- Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells
- Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 …
- Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations
- Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
- SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients
- The contentious history of sirtuin debates
- Identification and characterization of novel sirtuin inhibitor scaffolds
- Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia
- Hydrolase controls cellular NAD, sirtuin, and secondary metabolites
- Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism
- Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
- Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction
- Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence
- SIRT7 an emerging sirtuin: deciphering newer roles
- Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma
- Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach
- Plant defence suppression is mediated by a fungal sirtuin during rice infection by Magnaporthe oryzae
- Therapeutic potential of sirtuin-activating compounds in Alzheimer’s disease.
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
- Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque
- Epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors
- Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective
- Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury
- Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor
- Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia
- Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response
- Novel thiourea-based sirtuin inhibitory warheads
- Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence
- Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
- Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi
- Free [NADH]/[NAD+] regulates sirtuin expression
- Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway
- Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
- Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response
- Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
- Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide‐based inhibitors
- Vascular Smooth Muscle Sirtuin‐1 Protects Against Aortic Dissection During Angiotensin II–Induced Hypertension
- Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin
- Molecular cloning and characterization of porcine sirtuin genes.
- Sirtuin-3 (SIRT3) protein attenuates doxorubicin-induced oxidative stress and improves mitochondrial respiration in H9c2 cardiomyocytes
- trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington …
- Mechanical stress‐activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells
- Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains
- Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus
- Sirtuin 1 participates in the process of age-related retinal degeneration
- Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1
- Disruption of sirtuin 1–mediated control of circadian molecular clock and inflammation in chronic obstructive pulmonary disease
- Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
- Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3
- A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
- Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages
- Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D
- Regulation of histone H2A. Z expression is mediated by sirtuin 1 in prostate cancer
- Selectivity hot-spots of sirtuin catalytic cores
- Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes
- Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia–ischemia
- The Sirtuin Inhibitor Nicotinamide Enhances Neuronal Cell Survival During Acute Anoxic Injury Through AKT, BAD, PARP, and Mitochondrial Associated
- Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction
- Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
- The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites
- Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3
- Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1
- Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression
- Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer
- Sirtuin 6 Is Essential for Sodium Sulfide-mediated Cytoprotective Effect in Ischemia/Reperfusion–Stimulated Brain Endothelial Cells
- Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities
- Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
- Discovering inhibitors of human sirtuin type 2: novel structural scaffolds
- Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner
- Cyclic AMP mimics the anti-ageing effects of calorie restriction by up-regulating sirtuin
- Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation
- Hepatoprotection of Berberine Against Hydrogen Peroxide‐induced Apoptosis by Upregulation of Sirtuin 1
- A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity
- Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
- The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
- Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells
- Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer’s disease in two independent European samples
- The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
- Sirtuin 3 interacts with Lon protease and regulates its acetylation status
- Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma
- Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation
- Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity
- Neurons from senescence‐accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
- The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis
- Regulation of cerebral vascular function by sirtuin 1
- Sirtuin 1 regulates dendritic cell activation and autophagy during respiratory syncytial virus–induced immune responses
- Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene
- Sirtuin family: a link to metabolic signaling and senescence
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
- A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer
- Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling
- Apo-10′-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice
- Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
- Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia
- Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion
- Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation
- Expression patterns of sirtuin genes in porcine preimplantation embryos and effects of sirtuin inhibitors on in vitro embryonic development after parthenogenetic …
- Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
- Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway
- Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity
- Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
- Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3
- Sirtuin deacetylation mechanism and catalytic role of the dynamic cofactor binding loop
- The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor β signaling
- Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback
- Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
- Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
- Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation
- Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties
- Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways
- Finding a sirtuin truth in Huntington’s disease
- Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
- Targeting sirtuin-1 in Huntington’s disease: rationale and current status
- Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol
- Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells
- Sirtuin mechanism and inhibition: explored with Nε-acetyl-lysine analogs
- Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia
- Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
- The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
- Comparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families
- Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
- Nephroprotective action of sirtuin 1 (SIRT1)
- Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells
- The selective sirtuin 1 activator SRT2104 reduces endotoxin-induced cytokine release and coagulation activation in humans
- Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3
- Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
- Light–dark condition regulates sirtuin mRNA levels in the retina
- Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss
- miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1–Lipin-1 signaling
- Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway
- Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
- Insulin receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia
- In Bacillus subtilis, the Sirtuin Protein Deacetylase, Encoded by the srtN Gene (Formerly yhdZ), and Functions Encoded by the acuABC Genes Control the Activity of …
- Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway
- Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism
- Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites
- Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway
- Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein
- Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging …
- Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer
- Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells
- Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6
- Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent …
- Innovative cosmeceuticals: sirtuin activators and anti-glycation compounds
- Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer
- Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate α-ENaC transcription in collecting duct
- Side chain specificity of ADP‐ribosylation by a sirtuin
- Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
- Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation
- Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy
- Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion
- A dual role for sirtuin 1 in tumorigenesis
- Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay
- Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity
- Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration
- Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
- Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters
- Effects of sirtuin 1 activation on nicotine and lipopolysaccharide‐induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts
- The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1
- … induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling …
- Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol
- Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?
- High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
- Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with …
- Cross regulation of sirtuin 1, AMPK, and PPARγ in conjugated linoleic acid treated adipocytes
- Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone …
- Docking and binding free energy calculations of sirtuin inhibitors
- Role of sirtuin proteins in life extension by caloric restriction
- Sirtuin 6 promotes transforming growth factor‐β1/H2O2/HOCl‐mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular …
- Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors
- #VALUE!
- Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension
- Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
- Influence of age and physical exercise on sirtuin activity in humans.
- Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index
- #VALUE!
- Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
- Mitochondrial Matrix Ca2+ Accumulation Regulates Cytosolic NAD+/NADH Metabolism, Protein Acetylation, and Sirtuin Expression
- Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol …
- Surprising sirtuin crosstalk in the heart
- Zebrafish as a model organism to evaluate drugs potentially able to modulate sirtuin expression
- Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic …
- D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection
- Activation of Kaposi’s sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life …
- Aging: a sirtuin shake-up?
- Sirtuin 1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes
- Porcine sirtuin 1 gene clone, expression pattern, and regulation by resveratrol
- In Salmonella enterica, the sirtuin‐dependent protein acylation/deacylation system (SDPADS) maintains energy homeostasis during growth on low concentrations of …
- Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells
- Simvastatin inhibits cysteine‐rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin‐1/FoxO3a signaling
- Mechanism-based modulator discovery for sirtuin-catalyzed deacetylation reaction
- Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats: a role in impaired regeneration?
- Sirtuin-3 modulates Bak-and Bax-dependent apoptosis
- Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
- Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway
- Advanced glycation end‐products impair Na+/K+‐ATPase activity in diabetic cardiomyopathy: Role of the adenosine monophosphate‐activated protein kinase/sirtuin …
- Intersections between mitochondrial sirtuin signaling and tumor cell metabolism
- Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
- A sirtuin link between metabolism and heart disease
- Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses
- Serum sirtuin 1 levels in patients with polycystic ovary syndrome
- Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors
- The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction
- RETRACTED: Sirtuin-4 modulates sensitivity to induction of the mitochondrial permeability transition pore
- Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and …
- Capillary electrophoresis-based sirtuin assay using non-peptide substrates
- Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans
- Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts
- Chroman-4-one-and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells
- The deacetylase sirtuin 1 regulates human papillomavirus replication by modulating histone acetylation and recruitment of DNA damage factors NBS1 and …
- Sirtuin inhibition adversely affects porcine oocyte meiosis
- An integrated on‐chip sirtuin assay
- Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach
- Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
- Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death
- Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain
- Sirtuin 3: a major control point for obesity-related metabolic diseases?
- Electrophoretically mediated microanalysis assay for sirtuin enzymes
- Virtual screening approach of sirtuin inhibitors results in two new scaffolds
- Advances in label-free screening approaches for studying sirtuin-mediated deacetylation
- … Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective …
- Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
- Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans
- Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle
- Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus)
- Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis
- … -initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
- Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1
- Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK …
- FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2)
- Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose
- Sirtuin modulators: targets for metabolic diseases and beyond
- Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway
- Development of a capillary electrophoresis‐based assay of sirtuin enzymes
- Evidence of a sirtuin gene family in grapevine (Vitis vinifera L.)
- Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis
- Sirtuin 1 activator SRT1720 protects against lung injury via reduction of type II alveolar epithelial cells apoptosis in emphysema
- Receptor‐interacting protein (RIP) and Sirtuin‐3 (SIRT3) are on opposite sides of anoikis and tumorigenesis
- Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding
- Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
- Breed difference and regulation of the porcine Sirtuin 1 by insulin
- Sirtuin type 1 mediates the retinal protective effect of hydrogen-rich saline against light-induced damage in rats
- The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis
- Changes in human sirtuin 6 gene promoter methylation during aging
- Sirtuin inhibitor sirtinol is an intracellular iron chelator
- Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …
- Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy‐induced stress
- The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells
- Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis
- A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)
- Cyclin-dependent kinase 5–mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis
- Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control
- Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity
- Discovery of potent, proteolytically stable, and cell permeable human sirtuin peptidomimetic inhibitors containing Nε-thioacetyl-lysine
- The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function
- Biologically Active Isoforms of CobB Sirtuin Deacetylase in Salmonella enterica and Erwinia amylovora
- Structural analysis of trypanosomal sirtuin: an insight for selective drug design
- Structure Function Analysis of Leishmania Sirtuin: An Ensemble of In Silico and Biochemical Studies
- Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin …
- Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH …
- Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
- Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation
- Genetic association of sirtuin genes and Parkinson’s disease
- Sulfated and Glucuronated trans-Resveratrol Metabolites Regulate Chemokines and Sirtuin-1 Expression in U-937 Macrophages
- Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis
- Sirtuin 6 modulates hypoxia-induced apoptosis in osteoblasts via inhibition of glycolysis: implication for pathogenesis of periapical lesions
- Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Muğla province
- Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse
- Interplay between intravitreal RvD1 and local endogenous sirtuin-1 in the protection from endotoxin-induced uveitis in rats
- Cre-Mediated Stress Affects Sirtuin Expression Levels, Peroxisome Biogenesis and Metabolism, Antioxidant and Proinflammatory Signaling Pathways
- Icariin inhibits hydrogen peroxide‐mediated cytotoxicity by up‐regulating sirtuin type 1‐dependent catalase and peroxiredoxin
- Correction: Corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans
- Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the …
- MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1
- Potent sirtuin inhibition bestowed by l-2-amino-7-carboxamidoheptanoic acid (l-ACAH), a N ε-acetyl-lysine analog
- Differential prooxidative effects of the green tea polyphenol,(–)‐epigallocatechin‐3‐gallate, in normal and oral cancer cells are related to differences in sirtuin 3 …
- Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α
- Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
- Insight the C-site pocket conformational changes responsible for sirtuin 2 activity using molecular dynamics simulations
- E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans
- Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1
- 75‐kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes
- Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
- Will the real aging Sirtuin please stand up?
- Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat‐mediated long terminal repeat transactivation
- Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis
- Radiation-induced alteration of the brain proteome: understanding the role of the sirtuin 2 deacetylase in a murine model
- Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration
- Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
- The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity
- Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
- Study of 1, 4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors
- c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver
- Genomewide Screen for Negative Regulators of Sirtuin Activity in Saccharomyces cerevisiae Reveals 40 Loci and Links to Metabolism
- The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
- Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis
- #VALUE!
- Over-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal
- STAT3‐dependent effects of IL‐22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
- Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study
- Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice
- Upregulation of long non-coding RNA HIF 1α-anti-sense 1 induced by transforming growth factor-β-mediated targeting of sirtuin 1 promotes osteoblastic …
- Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance
- Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease
- N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases
- Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies
- Evaluation of benzoic acid derivatives as sirtuin inhibitors
- Sirtuin/uncoupling protein gene variants and carotid plaque area and morphology
- Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure–activity relationship analysis and molecular dynamics simulations
- Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet
- Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells
- Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway
- Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome
- Sirtuin 4 identification in normal human epidermal keratinocytes and its relation to sirtuin 3 and energy metabolism under normal conditions and UVB‐induced stress
- Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100β secretion by regulating sirtuin 1 in C6 rat glioma cells
- Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation …
- A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5
- Up-regulation of the Sirtuin 1 (Sirt1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
- Design, synthesis and structure–activity relationship studies of novel Sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton
- Effect of Resveratrol on Leptin and Sirtuin 2 Expression in the Kidneys in Streptozotocin-induced Diabetic Rats.
- Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study
- Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation
- Insight into the mechanism of intramolecular inhibition of the catalytic activity of sirtuin 2 (SIRT2)
- Sirtuin 1 is upregulated in young obese Zucker rat cerebral arteries
- Novel role of resveratrol: suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury
- Cyclooxygenase-2–Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1–Dependent-Manner
- … quinine on ultraviolet A irradiation‑induced human dermal fibroblast senescence in vitro proceeds via the anti‑apoptotic sirtuin 1/nuclear factor‑derived …
- Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human
- Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue
- RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
- Sirtuin to the rescue: SIRT 2 extends life span of B ub R 1 mice
- Characterization and differential expression analysis of complete coding sequences of Vitis vinifera L. sirtuin genes
- Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C …
- Sirtuin on a high-fat diet
- Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
- A neuroprotective role for sirtuin 1
- Age-related decrease of Sirtuin 2 protein in human peripheral blood mononuclear cells
- … slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs–but the sirtuin hypothesis is now …
- Effects of resveratrol and trans-3, 5, 4′-trimethoxystilbene on glutamate-induced cytotoxicity, heme oxygenase-1, and sirtuin 1 in HT22 neuronal cells
- Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery
- Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration‐dependent modulation of multiple nuclear receptor‐mediated pathways in androgen …
- Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
- Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks.
- The role of microRNAs in modulating sirtuin 1 expression
- Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo
- K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation
- Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes
- Acetyltransferase SAS2 and sirtuin SIR2, respectively, control flocculation and biofilm formation in wine yeast
- A new nonpeptide substrate of human sirtuin in a capillary electrophoresis‐based assay. Investigation of the binding mode by docking experiments
- Pharmacophore modeling and molecular dynamics simulation to identify the critical chemical features against human sirtuin 2 inhibitors
- Discovery of a potent and highly fluorescent sirtuin inhibitor
- The effects of resveratrol on cyclooxygenase-1 and-2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of …
- The sirtuin family: regulators that connect metabolism, aging, and longevity
- #VALUE!
- Plasma membrane redox and control of sirtuin
- Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena
- Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis
- MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1
- Novel sirtuin inhibitory warheads derived from the N ε-acetyl-lysine analog l-2-amino-7-carboxamidoheptanoic acid
- 9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes
- Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity
- Sirtuin 1 agonist minimizes injury and improves the immune response following traumatic shock
- Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness
- Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica
- Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
- Circadian measurements of sirtuin biology
- Entamoeba histolytica sirtuin EhSir2a deacetylates tubulin and regulates the number of microtubular assemblies during the cell cycle
- Sirtuin inhibitor Ex‐527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos
- Sirtuin 3 in acute kidney injury
- Effects of maternal aging on expression of sirtuin genes in ovulated oocyte and cumulus cells
- Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced …
- Poly (ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion
- Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases
- Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells
- N,N’-Bisbenzylidenebenzene-1,4-diamines and N,N’-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
- Sirtuin activation: a role for plasma membrane in the cell growth puzzle
- Viral genome silencing by neuronal sirtuin 1
- Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection
- Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse
- Apelin gene therapy increases autophagy via activation of Sirtuin 3 in diabetic heart
- … monophosphate–activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside treatment increases the sirtuin 1 protein expression in …
- … disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin …
- MicroRNA‑34a induces apoptosis in PC12 cells by reducing B‑cell lymphoma 2 and sirtuin‑1 expression
- Impact of angiotensin II on skeletal muscle metabolism and function in mice: contribution of IGF-1, Sirtuin-1 and PGC-1α
- Renal protective effect of sirtuin 1
- Food for thought: linking caloric intake to behavior via sirtuin activity
- 3-(N-arylsulfamoyl) benzamides, inhibitors of human Sirtuin type 2 (SIRT2)
- Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures
- Sirtuin functions in the brain: From physiological to pathological aspects
- Small molecule modulators of sirtuin activity
- Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse
- Sirtuin 3—a master regulator of mitochondrial integrity in AKI
- Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells
- Functionalized tetrahydro-1H-pyrido [4, 3-b] indoles: a novel chemotype with Sirtuin 2 inhibitory activity
- Emerging drug target in pancreatic cancer: placing sirtuin 1 on the canvas
- Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake
- Interleukin 6 increases dysfunction of organs in sepsis rats through sirtuin 1
- Sirtuin 1 as a key player of ‘metabolic memory’
- … 7-alkylidene-7, 12-dihydroindolo [3, 2-d] benzazepine-6-(5 H)-ones (7-alkylidene-paullones) by N-cyclization–oxidative Heck cascade and characterization as sirtuin …
- Complex roles of Sirtuin 1 in cancer and aging
- In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity
- Sirtuin 3 is down-regulated in Apolipoprotein E4 carriers with Alzheimer’s disease (P5. 011)
- Carbohydrate-responsive element-binding protein, Sirtuin 1, and ethanol metabolism: a complicated network in alcohol-induced hepatic steatosis.
- A pro-apoptotic role for sirtuin 3
- Correction: discovery of a potent and highly fluorescent sirtuin inhibitor
- Development of a nuclear-localized fluorescent probe for hydrogen peroxide and applications to the study of sirtuin-mediated oxidative stress responses in …
- SIRT3 deacetylase: the Jekyll and Hyde sirtuin
- A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
- The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity
- Identification of a new nicotinamide binding site in a sirtuin: a reassessment
- Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model
- Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process
- Relationship between sirtuin and mitochondrial uncoupling protein genes and carotid artery stiffness
- Influence of Olmesartan on Sirtuin 1 mRNA expression in 5/6 Nephrectomized spontaneously hypertensive rats
- Still un-sirtuin
- … -indazol-6-amines and indoles: a greener approach to the synthesis of exo-1, 6, 7, 7a, 12, 12a-hexahydroindolo [3, 2-c] pyrazolo [3, 4-f] quinolines as potential sirtuin …
- Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3
- Detecting Sirtuin-Catalyzed Deacylation Reactions Using 32P-Labeled NAD and Thin-Layer Chromatography
- Cloning, chromosomal characterization and FISH mapping of the NAD+-dependent histone deacetylase gene sirtuin 5 in the mouse
- Cell size control is sirtuin (ly) exciting
- #VALUE!
- Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
- Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and …
- Salermide down-regulates sirtuin proteins to induce human cancer cell apoptosis
- Sirtuin expression is decreased in malignant breast tissue and is associated with patient outcome.
- Emerging Roles of the Sirtuin Family
- Up-regulation of Fas ligand expression by sirtuin 1 in both flow-restricted vessels and serum-stimulated vascular smooth muscle cells
- Sirtuin, an oxidant sensitive deacetylase, is post‐translationally modified and degraded by the proteasome in response to cigarette smoke in lung epithelial cells
- Effects of the sirtuin inhibitor, salermide, on exercise‐induced changes in endothelial function
- Response to Comment on Balestrieri et al. Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment. Diabetes …
- Role of Sirtuin 6 in the Initiation and Progression of Calcific Aortic Valve Disease
- Effect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thickness
- Sirtuin function in longevity
- Preliminary observations on the role of sirtuin genes in grapevine (Vitis vinifera L.) physiology
- Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload
- Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1
- Correction: mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies
- C. elegans sirtuin SIR-2.4 and its mammalian homolog SIRT6 in stress response
- Targeting Sirtuin to Modulate Human Inflammation
- 59 Endothelial colony forming cells (ECFC) are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels
- Overexpression of the Sirtuin Sirt1 Increases Insulin Sensitivity in Aging Mice.
- Generating Mammalian Sirtuin Tools for Protein-Interaction Analysis
- Melatonin drives beneficial Sirtuin 1 expression in leptin-deficient mice liver through MT1 receptor
- The research development of deacetylase (Sirtuin)
- Impact of aging on the angiogenic potential of the myocardium: implications for angiogenic therapies with emphasis on sirtuin agonists
- Characterization of Sirtuin Proteins using RasMol‐RP and Three Dimensional Modeling
- 22 Sirtuin and Resveratrol
- Studying the Role of Sirtuin-1 Gene in the Maintenance of Mouse Intestinal Epithelium
- Examination of the cytoprotective role of Sirtuin-1 in the renal medulla
- Sirtuin expression is downregulated in non‐small cell lung cancer
- Relation of Sirtuin 1 Gene Polymorphisms with Lipid Profile in Hemodialysis Patients
- Aging and Non-sirtuin Histone Modifications
- Synergy between metformin and leucine in sirtuin signaling and fat oxidation in vitro, and in reducing lipid accumulation in diet-induced obese mice
- Back nonhomologous end-joining is the target of sirtuin inhibitor
- Resveratrol: A sirtuin activator and the fountain of youth
- Sirtuin 1 Maitains Survival via PKB Signaling in Degenerative Human Disc Nucleus Pulposus Cells [J]
- Sirtuin; Molecular Target for Antiaging
- The role of sirtuin 3 in the differential pro‐oxidant effects of (‐)‐epigallocatechin‐3‐gallate in oral cells (261.4)
- The mitochondrial sirtuin SIRT3 promotes survival of human melanoma cells in vitro
- Role of sirtuin 3 on mitochondrial dynamics in Huntington’s disease striatal cells
- Cloning and characterization of NAD-dependent deacetylase sirtuin 2 homolog from the silkworm, Bombyx mori
- Association Between A Sirtuin 5 SNP (rs SIRT5 SNP, rs9382222) And Three Functional Markers Of Brain Health
- Sirtuin-induced protein deacetylation affects the heat shock response in blue mussel congeners (Mytilus)
- Sirtuin‐1 gain of function increases endothelium‐dependent vasorelaxation of murine femoral arteries
- Increased Pulmonary Vascular and Systemic Response to Chronic Hypoxia in Sirtuin 1 Mutant Mice: a Role for Hypoxia-inducible Factor-3α?
- PROGRESS IN FUNCTIONS AND REGULATION OF SIRTUIN
- Investigations of sirtuin metabolism
- Sirtuin Inhibition in Combination with Histone Deacetylase (HDAC) Inhibition Is Effective Therapy for Aggressive B-Cell Lymphomas in Both Pre-Clinical and Clinical …
- Sirtuin polymorphisms and methods of use thereof
- Hdac6 and Sirtuin Inhibitors Protect Against Tachypacing-Induced Contractile Dysfunction in in vitro and in vivo Models for Atrial Fibrillation.
- The differential effects of Sirtuin-3 in cardio-protection
- Breed difference of porcine Sirtuin 1, adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL)
- Role of sirtuin genes in longevity
- Modulating Sirtuin Activity
- … -1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 …
- Withdrawal: Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a …
- Steroid boost for sirtuin research
- Un-sirtuin effects of natural products
- Comment on “Renal Protective Effect of Sirtuin 1”
- Emerging Roles of the Sirtuin Family in Cancer
- The Chemistry and Biology of Sirtuin Enzymes
- A sirtuin switch in the brain
- Sirtuin on a high-fat diet
- Sirtuin 6 expression in breast cancer
- Nutrition, Aging, and Sirtuin
- Mechanism-based sirtuin enzyme activation
- The Flavoring Agent Dihydrocoumarin Is An Epigenetic Toxicant That Inhibits Sirtuin Deacetylases
- Expression of sirtuin in hepatocellular carcinoma and its clinical significance
- Studying sirtuin inhibitors with in silico and in vitro approaches
- Studies Towards Biochemical Characterization Of A Novel Activity For Sirtuin 6
- Antitumor Effects of a Sirtuin Inhibitor
- Modulating Sirtuin Activity-Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
- INFLUENCE OF AGE AND PHYSICAL EXERCISE ON SIRTUIN ACTIVITY IN HUMANS
- Radiation-induced autophagy is dependent on Sirtuin 3.
- Sort-term sirtuin inhibition does not affect survival of CHO and xrs6 cells
- Sirtuin protein linked to longevity in mammals
- Application of computer-based methods to guide the development of novel sirtuin inhibitors-[kumulative Dissertation]
- Sirtuin 1 in Steatotic and Non Steatotic Liver Graft Preservation: Differential Aspects.: Abstract# C1664
- Sirtuin-mediated mechanisms of homeostasis and aging in metazoans
- Novel Cambinol Analogs as Sirtuin Inibitors: Synthesis and Biological Evaluation.
- Perspectives on pharmacological and clinical benefits from sirtuin 1 activators in oxidative damage
- Skeletal muscle regeneration and the role of Sirtuin 1
- Structure-based Development of a Sirtuin 2 Affinity Probe
- Quantitation of sirtuin activity with a one-step luminescent assay
- Effect of caloric restriction on the expression of the Sirtuin Proteins
- Role Of Sirtuin 6 In Macrophage Polarization In Diabetes
- Novel assays for Sirtuin and PARP families utilizing unmodified substrates
- A Review of the Sirtuin System, its Clinical Implications, and the Potential Role of Dietary Activators like Res…
- Resveratrol and Synthetic Sirtuin Activators
- Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats
- Preliminary observations on the role of sirtuin genes in grapevine physiology.
- Structural and Biochemical Studies of Histone Acetyltransferases and Sirtuin Enzymes
- Sirtuin 6 localization at cortical brain level of young diabetic mice
- Selective Targeting of Sirtuin Isoforms for Cancer Therapeutics
- Identification and characterization of novel sirtuin inhibitors against aging-related diseases
- Understanding the Role of Sirtuin 3 in a Cell Model of Parkinson’s Disease
- Late-breaking abstract: Decreased sirtuin expression in squamous cell carcinoma compared to adenocarcinoma
- SIRT5 Mutants Reveal Insights into Sirtuin Regulation
- Sirtuin 2 in hypothalamus: an emerging target in insulin resistance?
- Light-dark Condition Regulates Sirtuin Genes in the Retina
- Regulation of Mitochondrial Functions by Sirtuin Proteins in Heart Failure
- Targeting sirtuin-1 improves murine renal allograft survival and function (TRAN3P. 901)
- CHARACTERIZATION AND STUDY OF VITIS VINIFERA L. SIRTUIN GENES
- Protection against age-related neuronal frailty by sirtuin 1 enhancement
- Weight loss with preserved glucose homeostasis during chronic treatment of obese mice with 3-iodothyronamine (T1AM): role of the sirtuin family
- The Role of Sirtuin-2 in Tubular Forming Activity of Human Umbilical Vein Endothelial Cells
- The Angiogenic Defect in Diabetes is Reversed by the Activation of Sirtuin 1
- THE ACTIVITY OF SIRTUIN 1 IN MCF-7 BREAST CANCER CELL LINE: THE EFFECTS OF VISFATIN
- To sirtuin with love: caloric restrictions and the genes of the aging brain
- Role of Sirtuin 6 in Macrophage Polarization and Cardiac Repair in Diabetes
- Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells
- Sirtuin 1 and angiotensin II as inflammatory modulators in the development of diabetes
- Characterization of Sirtuin family protein expression in human trabecular meshwork cells
- Molecular Mechanisms and Biological Functions of the NAD +-dependent Deacylase Sirtuin-6
- Sirtuin 1 Modulates Cardiac Sodium Channels in vivo
- Characterization of the NAD-Dependent Human Histone Deacetylases Gene Sirtuin 1 and Its Implications on Aging and the Development of Malignant Disease.
- Sirtuin 1 reduction causes activation of Wnt/b catenin signalling
- AB0610 No changes in sirtuin-1 (hdac 3) activity from pbmc of patients with osteoporosis
- Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does
- Exploring the role of sirtuin deacetylases in regulating megakaryocyte and erythrocyte differentiation
- Sirtuin 2 expression in uveal melanoma correlates with metastasis in an animal model
- Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
- Increased sirtuin expression in patient with lung squamous cell carcinoma co-morbid with COPD
- Mechanism-Based Peptidic and Peptidomimetic Human Sirtuin Inhibitors
- Sirtuin inhibition increases the rate of DNA double strand break repair in xrs6 cells
- AB0019 Change in MRNA Expression of Sirtuin-2 and Sirtuin-3 in Rheumatoid Arthritis
- The role of MnSOD and sirtuin 3 in thymocyte responses to radiation and lymphomagenesis
- Sirtuin 1 is a key regulator of the IL-12 p70/IL-23 balance in human dendritic cells
- Novel cambinol analogues as potential anticancer agents: an improved understanding of sirtuin isoform selectivity
- Role of Sirtuin 3 on Doxorubicin-induced Toxicity on H9c2 Cardiomyoblasts
- Roles for the Human Sirtuin SIRT7 in Chromatin Regulation and Cancer
- Development of sirtuin and calmodulin-dependent protein kinase inhibitors as anti-cancer therapeutics
- EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in …
- Mitochondrial Complex II is a Source of the Reserve Respiratory Capacity that is Regulated by Metabolic Sensors via Sirtuin 3
- Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells
- Leucine and Resveratrol: Experimental Model of Sirtuin Pathway Activation
- Anti-Inflammatory Role for Sirtuin-1 Activators in a Peptide-Induced B10riii Model of Experimental Autoimmune Uveitis
- Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation
- Exercise-Induced Sirtuin Expression in Blood Vessels and Skeletal Muscles of Rats
- Decreased persistence of {gamma} H2AX foci in x-irradiated xrs6 cells treated with sirtuin inhibitor
- Sirtuin 1 is a key regulator of the IL-12 p70/IL-23 balance in human dendritic cells (DC)
- Sirtuin 1 induces autophagy to suppress liver ischemia/reperfusion injury in mice (1115.1)
- Regulation of energy homeostasis by hypothalamic Sirtuin 1 and endoplasmic reticulum stress
- Activation of Sirtuin 3 Protects the Heart From Ischemia-Reperfusion Injury by Increased Cellular Antioxidant Defenses
- Assessing the Cytoprotective Properties and Central Nervous System Expression Profile of Mammalian Sirtuin SIRT3
- Abstract A73: Altered expression of sirtuin 1 and Deleted in Breast Cancer 1 and its functional impact on pancreatic carcinogenesis.
- Ethanol intoxication increases hepatic mitochondrial protein acetylation but not through sirtuin inhibition
- A proteomics view of SIRT6 functions and the anti-viral roles of sirtuin proteins
- Sirtuin 1 mediates acidosis-induced metabolic reprogramming of tumor cells
- Sirtuin 1 mediates acidosis-induced metabolic reprogramming of tumor cells
- Emerging Role of Sirtuin 1 in Rat Orthotopic Liver Transplantation Using IGL-1 Preservation Solution.: Abstract# C1656
- Structural and biochemical insights into the mechanism of sirtuin catalysis and regulation by nicotinamide and small molecule inhibitors
- Upregulated sirtuin 5 gene expression in frontal cortex of serotonin 1b receptor knock out mice
- Comment on Balestrieri et al. Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment. Diabetes 2015; 64: 1395 …
- Virtual screening and binding free energy calculations of sirtuin inhibitors
- Sirtuin-3 (SIRT3), a novel potential therapeutic target for head and neck cancer
- Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
- Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation
- Correction: Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies
- Hypoxia-Induced Decrease In Cardiac Stem Cell Proliferation Is Associated With Downregulation Of Sirtuin 1
- Sirtuin-1 Activation Has no Effect on Aortic Root Dilatation in Marfan Mice
- The sirtuin activating compound resveratrol decreases GH transcription
- SIRTUIN 1 REGULATES AMYLOID BETA OLIGOMER METABOLISM IN HEP G2 CELLS WITH RELEVANCE TO DIET AND ALZHEIMER’S DISEASE
- AMP-activated protein kinase, Sirtuin 1, and p53 interactions in HEPG2 cells
- Regulation of sirtuin 6 protein expression by cyclic AMP signaling system in non-small cell lung cancer cells
- TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
- Sirtuin 2 mediated-deacetylation regulates cellular iron homeostasis
- Sirtuin regulation of lysine acylation targets diverse metabolic networks in hepatic mitochondria (981.3)
- Sirtuin 1 enzyme activity and autophagy proteins are increased in the kidney during murine sepsis
- Sirtuin-1 Induced Reduction Of Pulmonary Artery Smooth Muscle Cell Proliferation And Hypertrophy
- #VALUE!
- Shear Stress Increases Sirtuin‐1 Expression to Mediate Shear‐Induced Autophagy in Endothelial Cells
- Sirtuin-3 is Essential for Glucagon-like Peptide-1-mediated Restoration of Diabetic Cardiomyopathy
- Hypoxia-Induced Downregulation of Sirtuin 1 Impairs Cardiac Stem Cell Proliferation
- Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells (MUC2P. 818)
- SAT0323 Resveratrol, a Sirtuin-1 (HDAC 3) Activator, Increases IL-6 Production by PBMC of Patients with Knee Osteoarthritis.
- Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
- Sirtuin 1 (Sirt1) regulates the HSF1-dependent pro-survival mechanism in neurons
- The Role of Sirtuin 1 and Ceramide in t10c12 Conjugated Linoleic Acid Induced Delipidation in 3T3-L1 Adipocytes
- A novel sirtuin inhibitor, AS4. 064, enhances apoptosis and acetylation of targets in hematological lines in combination with the novel HDACi, SelSA-1.
- Annexin-A1 Biomimetic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury via Increased Sirtuin-3
- The Sirtuin SIRT3 Blocks Doxorubicin-induced Cardiac Hypertrophic Response of Mice
- Acute doxorubicin treatment induces proteome lysine deacetylation, with no change in sirtuin expression, in the heart and liver of fasted animals
- … Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly …
- Structural Basis for Enzyme Promiscuity and Specificty-Insights from Human Cytosolic sulfotransferase (SULT) and Sirtuin (SIRT) Families
- Role of myelin-associated NAD⁺-dependent deacetylase Sirtuin 2 in modifying axonal degeneration
- SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy
- Alzheimer research forum live discussion: Meet new players, histone deacetylase and sirtuin-Will they help the cell cycle, DNA repair, and gene expression break into …
- Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by Targeting Sirtuin 1
- #VALUE!
- A targeted knockdown of sirtuin histone deacetylase Sirt1 imparts significant growth inhibitory effects in human prostate cancer cells.
- Sirtuin‐1‐dependent COX2 Induction is an Essential Survival Mechanism in Renal Medullary Interstitial Cells against Oxidative Stress
- The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells
- Sirtuin 3 inhibited HBV replication by deacetylating HBV cccDNA-bound histone H3 and antagonized the oxidative stress induced by HBV infection
- Ionizing Radiation-induced Apoptosis of Cerebral Microvascular Endothelium Occurs with Mitochondrial Mediated Sirtuin, p53, and Grp75 Expression
- Sirtuin (Sirt1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
- Resveratrol-Sirtuin 1 Pathway: Beneficial Effects of White Wine and Resveratrol Intake on Lung Function in the General Population.
- MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells
- Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback Part A Molecular & integrative physiology
- Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures1, 2
- The [NAD+ over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
- Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
- The sirtuin activator represses glucokinase expression via the combined action of FoxO1 and HNF-4
- Reversible Protein Acetylation in the Mitochondria: Cellular and Molecular Function of the NAD+ Dependent Deacetylase Sirtuin 3
- Abstract LB-209: SIRT3, a mitochondrial sirtuin deacetylase, promotes survival of human melanoma cells.
- Chemical biology studies on 5-nitrofurans and sirtuin inhibitors
- Receptor interacting protein (RIP) and Sirtuin-3 (SIRT3) on opposite sides of anoikis resistance and promotes tumorigenesis
- Effects of sirtuin 6/nuclear factor κB signaling pathway in delaying hematopoietic stem cell and progenitor cell senescence with ginsenoside R1 during serial …
- Modulations of sirtuin 1 protein levels by nicotine and β‐cryptoxanthin can be mediated by miR‐34a in A/J mice lung cancer model
- OP0192 Sirtuin Deacetylase 2 Inhibition Suppresses Inflammatory Activation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and IFN-Γ–Differentiated …
- #VALUE!
- Water soluble cinnamon extract reverses the hydrogen peroxide‐induced down regulation of S100 β secretion and sirtuin protein expression in C6 rat glioma cells
- Synergistic Effects of Leucine and β‐Hydroxy‐β‐Methyl‐Butyrate (HMB) with Phosphodiesterase (PDE) Inhibitors on Sirtuin Activation
- The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap …
- The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
- The novel Sirtuin inhibitor AS4. 064 induces apoptosis in lymphoid malignancy lines and regulates transcription of spliceosome components and the metabolic …
- Carcinogenic Compounds, 2-nitrofluorene and Clonidine Can Modulate the Level of Sirtuin mRNAs Expression in Human Adipose Tissue-derived Stem Cells
- 2 Light–dark condition regulates sirtuin mRNA levels in the retina
- Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
- Mitochondrial Sirtuin 3 and Sirtuin 5 in granulosa and cumulus cells and their contribution to the altered follicular environment in women with either reduced ovarian …
- B27 VIRAL INFECTION AND PEDIATRIC ASTHMA: Resveratrol, A Sirtuin-1 Agonist, Inhibits Respiratory Syncytial Virus Infection By Decreasing Viral Replication …
- 12 Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation
- SIN‐1 cause downregulation of sirtuin expression in mouse astrocytes
- 774: Placental visfatin/NAMPT and sirtuin-1 expression in pre-eclampsia
- Mitofusin 2 mediates Sirtuin 1 induced autophagy to suppress liver ischemia/reperfusion injury
- … ACUTE EFFECTS OF INTENSE CARDIORESPIRATORY EXERCISE ON HUMAN TELOMERASE REVERSE TRANSCRIPTASE AND SIRTUIN 6 EXPRESSION IN …
- Tetrahymena Histone Deacetylase 14, a Stress-Responsive Class I Sirtuin That Changes Localization and Expression in Response to Genotoxic and Metabolic Stress
- 0273: Role of Sirtuin 3 in cardioprotection–evolution with aging
- 128. A ROLE FOR SIRTUIN 3 IN THE DEVELOPING MAMMALIAN EMBRYO
- Effect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thickness
- Serum and Glucocorticoid-Inducible Kinase 1 Regulates Sirtuin 3, the Mitochondrial Deacetylase via Phosphorylation and Sumoylation Mechanisms in Rat Aortic …
- #VALUE!
- 2Chapter 2 Sirtuin and Resveratrol
- P3. 40 Potential role of sirtuin-1 as druggable target in muscular dystrophy: effect of a chronic resveratrol treatment on in vivo and ex vivo pathological signs of …
- Sirtuin functions and modulation: from chemistry to the clinic
- Mechanisms and disease implications of sirtuin-mediated autophagic regulation
- Sirtuin activators and inhibitors: promises, achievements, and challenges
- Sirtuin signaling in cellular senescence and aging
- Role of sirtuin-1 in diabetic nephropathy
- The sirtuin family in cancer
- Sirtuin inhibition: strategies, inhibitors, and therapeutic potential
- Natural polyphenols as sirtuin 6 modulators
- Sirtuin 1 and Alzheimer’s disease: an up-to-date review
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- The roles of sirtuin family proteins in cancer progression
- Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology
- Decreased serum sirtuin-1 in COPD
- Role of Sirtuin 1 in the pathogenesis of ocular disease
- Structural basis of sirtuin 6 activation by synthetic small molecules
- Mitochondrial sirtuin 3 and renal diseases
- Sirtuin 3 deregulation promotes pulmonary fibrosis
- Structure‐Based Development of an Affinity Probe for Sirtuin 2
- Hippocampal sirtuin 1 signaling mediates depression-like behavior
- Sirtuin 1 and oral cancer
- Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
- High-throughput screening of Sirtuin family of genes in breast cancer
- Emerging roles of Sirtuin 6 in Alzheimer’s disease
- Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors
- Mechanism‐based inhibitors of the human sirtuin 5 deacylase: structure–activity relationship, biostructural, and kinetic insight
- A continuous, fluorogenic sirtuin 2 deacylase assay: substrate screening and inhibitor evaluation
- Sirtuin 6, a possible therapeutic target for type 2 diabetes
- Finding reactive configurations: a machine learning approach for estimating energy barriers applied to Sirtuin 5
- Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
- The role of sirtuin 1 and its activator, resveratrol in osteoarthritis
- Quercetin based derivatives as sirtuin inhibitors
- Advances in cellular characterization of the sirtuin isoform, SIRT7
- Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging
- Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization
- Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury
- Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium
- The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
- Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
- Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis
- Loss of sirtuin 1 alters the secretome of breast cancer cells by impairing lysosomal integrity
- Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury
- Investigating the sensitivity of NAD+-dependent sirtuin deacylation activities to NADH
- Sirtuin 5 is required for mouse survival in response to cardiac pressure overload
- Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
- Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition
- State of the art–sirtuin 1 in kidney pathology–clinical relevance
- Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression
- Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers
- Potent and selective inhibitors of human sirtuin 5
- Regulation of sirtuin-mediated protein deacetylation by cardioprotective phytochemicals
- The future of genomic medicine involves the maintenance of sirtuin 1 in global populations
- Structural basis of sirtuin 6 inhibition by the hydroxamate trichostatin A: implications for protein deacylase drug development
- Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
- Sirtuin 7: a new marker of aggressiveness in prostate cancer
- Suppression of endothelial-to-mesenchymal transition by SIRT (Sirtuin) 3 alleviated the development of hypertensive renal injury
- Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide
- Role of hydrogen sulfide in NRF2-and sirtuin-dependent maintenance of cellular redox balance
- Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
- Vascular smooth muscle sirtuin-1 protects against diet-induced aortic stiffness
- Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy
- Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner
- A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
- Sirtuin 3: A Janus face in cancer
- Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats
- Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease
- Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1
- Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm
- Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration
- Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration
- Sirtuin 2 enhances allergic asthmatic inflammation
- Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel
- Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis
- Myricanol rescues dexamethasone‐induced muscle dysfunction via a sirtuin 1‐dependent mechanism
- Sirtuin lipoamidase activity is conserved in bacteria as a regulator of metabolic enzyme complexes
- Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis
- Targeting Sirtuin-1 prolongs murine renal allograft survival and function
- Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
- Nicotinamide mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1–dependent manner
- Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation
- Sirtuin 3 deficiency does not impede digit regeneration in mice
- Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity
- Amyloid-β increases tau by mediating sirtuin 3 in Alzheimer’s disease
- Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance
- Regulatory effects of NAD+ metabolic pathways on sirtuin activity
- Sirtuin-1 activation controls tumor growth by impeding Th17 differentiation via STAT3 deacetylation
- The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
- Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
- Suppression of Sirtuin-1 increases IL-6 expression by activation of the Akt pathway during allergic asthma
- Sirtuin‐1 in immunotherapy: A Janus‐headed target
- Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
- Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer
- Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells
- Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI
- Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells
- Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury
- A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma
- Could sirtuin activities modify ALS onset and progression?
- Sirtuin 2 regulates microvascular inflammation during sepsis
- Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
- Yeast sirtuin family members maintain transcription homeostasis to ensure genome stability
- Serum Sirtuin 1, 3 and 6 levels in acute myocardial infarction patients
- A prospective compound screening contest identified broader inhibitors for sirtuin 1
- Aging promotes sirtuin 3–dependent cartilage superoxide dismutase 2 acetylation and osteoarthritis
- Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway
- Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegeneration
- Sirtuin inhibitors are broadly antiviral against arboviruses
- Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles
- Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
- The mechanism of diabetic retinopathy pathogenesis unifying key lipid regulators, sirtuin 1 and liver X receptor
- Management of diabetic nephropathy: the role of sirtuin-1
- Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
- Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota
- Sirtuin 2 deficiency increases bacterial phagocytosis by macrophages and protects from chronic staphylococcal infection
- Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
- Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension
- Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/reperfusion: from mouse to human
- Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-KB and p38 …
- Activation of sirtuin 1 attenuates high glucose-induced neuronal apoptosis by deacetylating p53
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Phenotype of vascular smooth muscle cells (VSMCs) is regulated by miR-29b by targeting sirtuin 1
- Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1
- Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism
- MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4
- Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells
- Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars
- Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy
- Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
- Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons
- Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity
- Pro-proliferative function of mitochondrial sirtuin deacetylase SIRT3 in human melanoma
- Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1
- Fine‐tuning of sirtuin 1 expression is essential to protect the liver from cholestatic liver disease
- Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients
- Deep vein thrombosis is modulated by inflammation regulated via sirtuin 1/NF-κB signalling pathway in a rat model
- Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells
- KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin‐1‐mediated chromatin silencing
- Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll‐like receptor 4 signaling pathway
- Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis
- A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model
- Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation
- Thienopyrimidinone based sirtuin-2 (SIRT2)-selective inhibitors bind in the ligand induced selectivity pocket
- Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
- Nicotinamide N‑methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
- Sirtuin 2 mutations in human cancers impair its function in genome maintenance
- Proposed tandem effect of physical activity and sirtuin 1 and 3 activation in regulating glucose homeostasis
- Mitochondrial sirtuin 4 resolves immune tolerance in monocytes by rebalancing glycolysis and glucose oxidation homeostasis
- Melatonin modulates the microenvironment of glioblastoma multiforme by targeting sirtuin 1
- Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and-independent mechanisms
- Role of beta-adrenergic receptors and sirtuin signaling in the heart during aging, heart failure, and adaptation to stress
- Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy
- Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3
- Mitochondrial dynamics is linked to longevity and protects from end-organ injury: the emerging role of sirtuin 3
- Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium
- Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells
- The emerging role of sirtuin 1 in cellular metabolism, diabetes mellitus, diabetic kidney disease and hypertension
- Exogenous hydrogen sulfide supplement attenuates isoproterenol-induced myocardial hypertrophy in a sirtuin 3-dependent manner
- Age-related changes in sirtuin 7 expression in calorie-restricted and refed rats
- … of peptide-based sirtuin defatty-acylase inhibitors identified by the fluorescence probe, SFP3, that can efficiently measure defatty-acylase activity of sirtuin
- Mitochondrial function, metabolic regulation, and human disease viewed through the prism of sirtuin 4 (SIRT4) functions
- Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
- … heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse …
- Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia
- Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma
- Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A …
- Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation
- A novel sirtuin-3 inhibitor, LC-0296, inhibits cell survival and proliferation, and promotes apoptosis of head and neck cancer cells
- Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ
- Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer’s disease
- Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
- Sirtuin A regulates secondary metabolite production by Aspergillus nidulans
- Adherence to the mediterranean diet and circulating levels of sirtuin 4 in obese patients: a novel association
- Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration
- Cysteine cathepsins control hepatic NF-κ B-dependent inflammation via sirtuin-1 regulation
- Myeloid sirtuin 6 deficiency causes insulin resistance in high-fat diet–fed mice by eliciting macrophage polarization toward an M1 phenotype
- Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1
- Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1‐dependent mitochondrial oxidative damage
- Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples
- Heme oxygenase‐1 regulates sirtuin‐1–autophagy pathway in liver transplantation: From mouse to human
- Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response
- Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
- Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis
- Sirtuin 5 is anti-apoptotic and anti-oxidative in cultured SH-EP neuroblastoma cells
- Hepatocyte‐specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up‐regulation of Bach1, an Nrf2 repressor
- Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
- AMP-activated protein kinase and sirtuin 1 coregulation of cortactin contributes to endothelial function
- The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling
- Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue
- High glucose‐induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects
- Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression
- Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells
- Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions
- Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons
- Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis
- A conserved mechanism of sirtuin signalling through steroid hormone receptors
- Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice
- Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway
- Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
- Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,“selectivity pocket” and NAD+-binding site
- Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells
- Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation
- Aromatase acetylation patterns and altered activity in response to sirtuin inhibition
- Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function
- Comparison of sirtuin 3 levels in ALS and Huntington’s disease—differential effects in human tissue samples vs. transgenic mouse models
- Novel lysine-based thioureas as mechanism-based inhibitors of Sirtuin 2 (SIRT2) with anticancer activity in a colorectal cancer murine model
- Sirtuin 1 activation reduces transforming growth factor-β1–induced fibrogenesis and affords organ protection in a model of progressive, experimental kidney …
- Heterogeneous nuclear ribonucleoprotein F stimulates sirtuin-1 gene expression and attenuates nephropathy progression in diabetic mice
- Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway
- miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
- Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death
- SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis
- Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats
- miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
- Sirtuin 2 inhibition improves cognitive performance and acts on amyloid-β protein precursor processing in two Alzheimer’s disease mouse models
- Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway
- MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs
- Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3
- Sirtuin 6 in preosteoclasts suppresses age-and estrogen deficiency-related bone loss by stabilizing estrogen receptor α
- Sirtuin 2 isoform 1 enhances hepatitis B virus RNA transcription and DNA synthesis through the AKT/GSK-3β/β-catenin signaling pathway
- Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR‐α/sirtuin 1/PGC‐1α pathway
- Aging-related correlation between serum sirtuin 1 activities and basal metabolic rate in women, but not in men
- Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes
- SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION
- Sirtuin‐1/mitochondrial ribosomal protein S5 axis enhances the metabolic flexibility of liver cancer stem cells
- Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation
- Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma
- Activation of sirtuin 3 and maintenance of mitochondrial integrity by N-acetylcysteine protects against bisphenol A-induced kidney and liver toxicity in rats
- Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury
- Inhibition of mitochondrial oxidative damage improves reendothelialization capacity of endothelial progenitor cells via SIRT3 (Sirtuin 3)-enhanced SOD2 (Superoxide …
- Inhibition of Sirtuin 6 induces neuroblastoma differentiation
- Activators of sirtuin-1 and their involvement in cardioprotection
- X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells
- Sirtuin 1 stimulation attenuates ischemic liver injury and enhances mitochondrial recovery and autophagy
- Sirtuin 1 (Sirt1) overexpression in BaF3 cells contributes to cell proliferation promotion, apoptosis resistance and pro-inflammatory cytokine production
- Resveratrol inhibits doxorubicin‑induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes
- Sirtuin 1 represses PKC‐ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
- Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice
- Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer
- Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy
- Peroxynitrite-mediated SIRT (Sirtuin)-1 inactivation contributes to nicotine-induced arterial stiffness in mice
- microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma
- Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections
- Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway
- Melatonin modulation of sirtuin-1 attenuates liver injury in a hypercholesterolemic mouse model
- MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death
- Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner
- MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
- Comparison of calorie-restricted diet and resveratrol supplementation on anthropometric indices, metabolic parameters, and serum sirtuin-1 levels in patients with …
- Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism
- The prognostic and Clinicopathological roles of Sirtuin-3 in various cancers
- Mitochondrial metabolism regulates microtubule acetylome and autophagy trough sirtuin-2: impact for Parkinson’s disease
- NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65
- Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind …
- Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway
- Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy
- Sirtuin 1 regulates mitochondrial biogenesis and provides an endogenous neuroprotective mechanism against seizure-induced neuronal cell death in the …
- Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis
- Neuroprotective effect of salidroside against central nervous system inflammation‐induced cognitive deficits: a pivotal role of sirtuin 1‐dependent N rf‐2/HO‐1/NF‐κ B …
- Melatonin reverses H2O2‐induced senescence in SH‐SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF‐κB
- Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells
- Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection
- The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1‐bone morphogenic protein 2 longevity axis
- Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells
- Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
- Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)
- Fibrogenic secretome of sirtuin 1-deficient endothelial cells: Wnt, notch and glycocalyx rheostat
- Sirtuin inhibitors: An overview from medicinal chemistry perspective
- Development of substrate‐derived sirtuin inhibitors with potential anticancer activity
- Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway
- Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
- Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3
- Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages
- Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy
- Contrasting sirtuin and poly (ADP‐ribose) polymerase activities of selected 2, 4, 6‐trisubstituted benzimidazoles
- Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
- Hyperacetylation of cardiac mitochondrial proteins is associated with metabolic impairment and sirtuin downregulation after chronic total body irradiation of ApoE …
- Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor‐β1/Smad2 and nuclear factor‐κB signaling pathways in human fetal lung …
- Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study
- Cross-talk between sirtuin 1 and the proinflammatory mediator high-mobility group box-1 in the regulation of blood-retinal barrier breakdown in diabetic retinopathy
- Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway
- KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis
- MicroRNA 199a is downregulated in patients after coronary artery bypass graft surgery and is associated with increased levels of sirtuin 1 (SIRT 1) protein and …
- Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage
- Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin‐3 down‐regulation
- … factor serves a pivotal role in the regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway
- Nicotinic ACh receptor α7 inhibits PDGF‐induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3
- Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism
- Diisononyl phthalate differentially affects sirtuin expression in the HepG2 cell line
- Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response
- Highly Efficient Synthesis of Spirooxindole, Spiroacenaphthylene and Bisbenzo [b] pyran Derivatives and Evaluation of Their Inhibitory Activity against Sirtuin 2
- Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway
- Heat shock gene Sirtuin 1 regulates post-prandial lipid metabolism with relevance to nutrition and appetite regulation in diabetes
- Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice
- Mitochondrial intermediate peptidase is a novel regulator of sirtuin‐3 activation by caloric restriction
- Visualization of sirtuin 4 distribution between mitochondria and the nucleus, based on bimolecular fluorescence self-complementation
- Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis
- Hydroxytyrosol attenuates LPS-induced acute lung injury in mice by regulating autophagy and sirtuin expression
- Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis
- Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
- Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage
- Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation
- Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
- Sirtuin 1 and autophagy attenuate cisplatin-induced hair cell death in the mouse cochlea and zebrafish lateral line
- Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia
- Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling
- A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase
- Sirtuin 1 promotes deacetylation of Oct4 and maintenance of naive pluripotency
- Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study
- Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis
- A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons
- Identification of bichalcones as sirtuin inhibitors by virtual screening and in vitro testing
- Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1)
- Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of …
- Association between sirtuin 1 gene rs10997870 polymorphism and suicide behaviors in bipolar disorder
- Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)
- Alterations in fatty acid metabolism and sirtuin signaling characterize early type‐2 diabetic hearts of fructose‐fed rats
- Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells
- Sirtuin 1 inhibits TNF-α-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation
- A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease
- New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
- Identification of diketopiperazine-containing 2-anilinobenzamides as potent sirtuin 2 (SIRT2)-Selective inhibitors targeting the “selectivity pocket”, substrate-binding …
- Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase …
- Sirtuin 3 mediates tau deacetylation
- MicroRNA-519d inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting Sirtuin 7
- Resveratrol directly affects ovarian cell sirtuin, proliferation, apoptosis, hormone release and response to follicle-stimulating hormone (FSH) and insulin-like growth …
- Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity
- Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine‐Monophosphate–Activated Protein Kinase Alpha/Mammalian …
- Nicotinamide phosphoribosyltransferase regulates cocaine reward through Sirtuin 1
- Sirtuin-1 controls poly (I: C)–dependent matrix metalloproteinase 9 activation in primary human nasal epithelial cells
- Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction
- Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells
- The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway
- Betalain-and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A …
- Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors
- The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line
- Three‐Component Aminoalkylations Yielding Dihydronaphthoxazine‐Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side‐Chains
- Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway
- Shelterin telomere protection protein 1 reduction causes telomere attrition and cellular senescence via sirtuin 1 deacetylase in chronic obstructive pulmonary disease
- Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4
- Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking
- Sirtuin‑1 protects hair follicle stem cells from TNFα-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway
- Structure‐based discovery of new selective small‐molecule sirtuin 5 inhibitors
- Simple Nε-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition
- Enzymatic and biological characterization of novel sirtuin modulators against cancer
- Sirtuin 6 Modulates Hypoxia-Induced Autophagy in Nasal Polyp Fibroblasts via Inhibition of Glycolysis
- Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer
- Chemical probes in sirtuin research
- Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway
- A low-salt diet increases the expression of renal sirtuin 1 through activation of the ghrelin receptor in rats
- A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One‐Step Cleavage of the Dabcyl Quencher
- Peroxisome proliferator-activated receptor-γ coactivator-1α inhibits vascular calcification through sirtuin 3-mediated reduction of mitochondrial oxidative stress
- Protective effect of tyrosol and S-adenosylmethionine against ethanol-induced oxidative stress of Hepg2 cells involves sirtuin 1, P53 and Erk1/2 signaling
- miRNA regulation of Sirtuin‑1 expression in human astrocytoma
- Sirtuin 1 mediates the actions of peroxisome proliferator-activated receptor δ on the oxidized low-density lipoprotein–triggered migration and proliferation of vascular …
- … attenuates lipopolysaccharide-induced depressive-like behavior through the brain-derived neurotrophic factor/tropomyosin-related kinase B and sirtuin type 1/nuclear …
- Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3
- The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study …
- Reduced sirtuin 1/adenosine monophosphate‐activated protein kinase in amyotrophic lateral sclerosis patient‐derived mesenchymal stem cells can be restored by …
- Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa
- The preconditioning of berberine suppresses hydrogen peroxide-induced premature senescence via regulation of sirtuin 1
- Autophagy in ischemic livers: a critical role of sirtuin 1/mitofusin 2 axis in autophagy induction
- Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans
- Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence
- Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma
- Resveratrol protects against cadmium chloride‐induced hippocampal neurotoxicity by inhibiting ER stress and GAAD 153 and activating sirtuin 1/AMPK/Akt
- Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH
- … Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent …
- Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability
- … and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
- Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors
- Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 …
- Catching Sirtuin-2 intermediates one structure at the time
- Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1‐mediated deacetylation of high‐mobility group box 1 in rats
- Sinomenine induces G1-phase cell cycle arrest and apoptosis in malignant glioma cells via downregulation of sirtuin 1 and induction of p53 acetylation
- A label-free Sirtuin 1 assay based on droplet-electrospray ionization mass spectrometry
- Induction of nuclear enlargement and senescence by sirtuin inhibitors in glioblastoma cells
- Erythromycin regulates cigarette smoke-induced proinflammatory mediator release through Sirtuin 1-nuclear factor κB axis in macrophages and mice lungs
- CD36/sirtuin 1 axis impairment contributes to hepatic steatosis in ACE2-deficient mice
- Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair
- A one-step specific assay for continuous detection of sirtuin 2 activity
- Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels
- Sirtuin inhibition leads to autophagy and apoptosis in porcine preimplantation blastocysts
- Gene expression of sirtuin-1 and endogenous secretory receptor for advanced glycation end products in healthy and slightly overweight subjects after caloric …
- Loss of sirtuin 4 leads to elevated glucose-and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic …
- Sirtuin 1 activator Srt1720 protects against organ injury induced by intestinal ischemia-reperfusion
- Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding
- Regulation of sirtuin 3-mediated deacetylation of cyclophilin D attenuated cognitive dysfunction induced by sepsis-associated encephalopathy in mice
- Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway
- Structure of the sirtuin‐linked macrodomain SAV0325 from Staphylococcus aureus
- Sirtuin 1-chromatin-binding dynamics points to a common mechanism regulating inflammatory targets in SIV infection and in the aging brain
- Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
- Saccharomyces cerevisiae TORC1 controls histone acetylation by signaling through the Sit4/PP6 phosphatase to regulate sirtuin deacetylase nuclear accumulation
- Sirtuin 3 (SIRT3) regulates α-smooth muscle actin (α-SMA) production through the succinate dehydrogenase-G protein-coupled receptor 91 (GPR91) pathway in …
- Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma
- MicroRNA-195 regulates metabolism in failing myocardium via alterations in sirtuin 3 expression and mitochondrial protein acetylation
- Sirtuin 1 mediates hydrogen sulfide-induced cytoprotection effects in neonatal mouse cardiomyocytes
- Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells
- Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism
- Sirtuin 4 regulates lipopolysaccharide mediated Leydig cell dysfunction
- Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population
- Sirtuin 6 suppresses hypoxia‐induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis—A therapeutic …
- Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia
- Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-κB signaling pathway
- Serum Sirtuin 1, 3 and 6 levels in acute myocardial infarction patients
- Retracted: Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and …
- Mechanism of osteogenic and adipogenic differentiation of tendon stem cells induced by sirtuin 1
- Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer’s disease
- Tip60-and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
- γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis
- Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2–AS1
- Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line
- Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators
- Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway
- Resveratrol reduced liver damage after liver resection in a rat model by upregulating sirtuin 1 (SIRT1) and inhibiting the acetylation of high mobility group box …
- Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction
- Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses
- Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis
- Constitutive activation of NAD-dependent sirtuin 3 plays an important role in tumorigenesis of chromium (VI)-transformed cells
- Effects of Sirtuin 1 on microglia in spinal cord injury: Involvement of Wnt/β-catenin signaling pathway
- p53 inhibits the upregulation of sirtuin 1 expression induced by c‑Myc
- 4′‐Bromo‐resveratrol, a dual Sirtuin‐1 and Sirtuin‐3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming
- Peroxisome proliferator-activated receptor α facilitates osteogenic differentiation in MC3T3-E1 cells via the sirtuin 1-dependent signaling pathway
- Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor–κB in …
- Sirtuin 3 promotes microglia migration by upregulating CX3CR1
- Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells
- Exploration of the fluorescent properties and the modulated activities against sirtuin fluorogenic assays of chromenone-derived natural products
- MicroRNA-506 is involved in regulation of the occurrence of lipopolysaccharides (LPS)-induced pulpitis by sirtuin 1 (SIRT1)
- The NAD-dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator runt-related transcription factor 2 (Runx2) and production of …
- Sirtuin‑7 knockdown inhibits the growth of endometrial cancer cells by inducing apoptosis via the NF‑κB signaling pathway
- Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system
- … protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal pathway
- Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death
- Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction
- Studies of the binding of modest modulators of the human enzyme, sirtuin 6, by STD NMR
- Identification of the binding site of chroman-4-one-based sirtuin 2-selective inhibitors using photoaffinity labeling in combination with tandem mass spectrometry
- Resveratrol relieves Angiostrongylus cantonensis–Induced meningoencephalitis by activating sirtuin-1
- The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line
- Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cells
- Expression profile of diabetes-related genes associated with leukocyte sirtuin 1 overexpression in gestational diabetes
- Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1
- Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway
- Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes
- Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice
- Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes
- Ginsenoside Rg1 attenuates isoflurane/surgery-induced cognitive disorders and sirtuin 3 dysfunction
- Cannabinoid‐1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin‐1/Mechanistic Target of Rapamycin Complex 2 …
- A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs
- The fungal metabolite eurochevalierine, a sequiterpene alkaloid, displays anti-cancer properties through selective sirtuin 1/2 inhibition
- The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats
- Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin
- The role of Sirtuin 2 in the regulation of myogenesis
- Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18-and sirtuin-1-independent pathways
- Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort
- MicroRNA‐506 upregulation contributes to sirtuin 1 inhibition of osteoclastogenesis in bone marrow stromal cells induced by TNF‐α treatment
- Sirtuin 6 mitigated LPS‐induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2‐related factor 2
- Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
- Screening the impact of sirtuin inhibitors on inflammatory and innate immune responses of macrophages and in a mouse model of endotoxic shock
- Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind …
- Structural Modifications of Benzimidazoles via Multi‐Step Synthesis and Their Impact on Sirtuin‐Inhibitory Activity
- Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla
- The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration
- Treatment with the neurotoxic Aβ (25–35) peptide modulates the expression of neuroprotective factors Pin1, Sirtuin 1, and brain-derived neurotrophic factor in SH …
- Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C‐peptide, sirtuin 1–liver kinase B1–adenosine monophosphate …
- Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent
- Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
- Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide …
- Exosomal microRNA‐155‐5p from PDLSCs regulated Th17/Treg balance by targeting sirtuin‐1 in chronic periodontitis
- QSAR studies on the human sirtuin 2 inhibition by non-covalent 7, 5, 2-anilinobenzamide derivatives
- Update on the role of Sirtuin 3 in cell differentiation: A major metabolic target that can be pharmacologically controlled
- Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway
- Sirtuin 6 mediated stem cell cardiomyogenesis on protein coated nanofibrous scaffolds
- An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM
- High basolateral glucose increases sodium-glucose cotransporter 2 and reduces sirtuin-1 in renal tubules through glucose transporter-2 detection
- De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment
- Sirtuin 6 attenuates Kaposi’s sarcoma-associated herpesvirus reactivation by suppressing ori-Lyt activity and expression of RTA
- Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
- MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1
- … mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin …
- Sirtuin 6 (SIRT6) activity assays
- A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases
- Mono-(2-ethylhexyl) phthalate aggravates inflammatory response via Sirtuin regulation and Inflammasome activation in RAW 264.7 cells
- Edible Bird’s Nest prevents menopause-related memory and cognitive decline in rats via increased hippocampal Sirtuin-1 expression
- Sirtuin 1 independent effects of resveratrol in INS-1E β-cells
- Development of 1, 2, 4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure–activity relationship, X-ray crystal structure, and …
- Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs
- Sirtuin-3 is expressed by enteric neurons but it does not play a major role in their regulation of oxidative stress
- MicroRNA‐590‐3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin‐1 and deacetylation of p53
- Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
- Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase
- Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling
- Staphylococcus aureus modulates the activity of acetyl‐Coenzyme A synthetase (Acs) by sirtuin‐dependent reversible lysine acetylation
- Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans
- MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma
- 2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy
- Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1.
- Lack of association between sirtuin gene variants and endometrial cancer
- Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice
- Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells
- Intrathecal injection of resveratrol attenuates burn injury pain by activating spinal sirtuin 1
- Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells
- Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells
- Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells
- Effect of sirtuin-1 on synaptic plasticity in nucleus accumbens in a rat model of heroin addiction
- Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization
- Sirtuin 7 is involved in the consolidation of fear memory in mice
- … high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in …
- Metabolic reprogramming by 3-iodothyronamine (T1AM): a new perspective to reverse obesity through co-regulation of sirtuin 4 and 6 expression
- Epigallocatechin-3-gallate-rich green tea extract ameliorates fatty liver and weight gain in mice fed a high fat diet by activating the sirtuin 1 and AMP activating protein …
- Potent sirtuin inhibition with 1, 2, 5-trisubstituted benzimidazoles
- Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
- Sirtuin modulation as novel neuroprotective strategy for Alzheimer’s disease
- Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3–Forkhead box O3a axis in human small‐cell lung cancer
- Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model
- Sirtuin activation as a therapeutic approach against inborn errors of metabolism
- MicroRNA-320 enhances radiosensitivity of glioma through down-regulation of sirtuin type 1 by directly targeting forkhead box protein M1
- Sirtuin-activating compounds (STACs) alleviate D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: involvement of sirtuin 1 and heme …
- Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients
- BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil
- MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and sirtuin‐6
- Sirtuin Inhibitors and Activators
- Characterizing sirtuin 3 deacetylase affinity for aldehyde dehydrogenase 2
- MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1
- Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner
- Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study
- Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1
- Carnosic acid protects normal mouse hepatocytes against H2O2‐induced cytotoxicity via sirtuin 1‐mediated signaling
- Sirtuin 1 steers anti-inflammatory effects in vascular smooth muscle cells: protection without burden?
- Sirtuin 1 levels in recurrent implantation failure
- Sirtuin 1 promotes hyperoxia-induced lung epithelial cell death independent of NF-E2–related factor 2 activation
- MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3
- Neohesperidin exerts lipid-regulating effects in vitro and in vivo via fibroblast growth factor 21 and AMP-activated protein kinase/sirtuin type 1/peroxisome proliferator …
- Phencynonate mediates antidepressant response by activating sirtuin 6-SOD2/Prdx6 pathway
- MicroRNA‑217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1
- MicroRNA106a regulates matrix metalloprotease 9 in a sirtuin‐1 dependent mechanism
- A silver lining for 24-hydroxycholesterol in Alzheimer’s disease: the involvement of the neuroprotective enzyme sirtuin 1
- Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease
- Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice
- Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress
- Discovery of 2-((4, 6-dimethylpyrimidin-2-yl) thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors
- Carbohydrate metabolism and gene expression of sirtuin 1 in healthy subjects after Sacha inchi oil supplementation: a randomized trial
- MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3
- Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases
- Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1
- The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level
- A novel screening test for esophageal squamous cell carcinoma: sirtuin-3
- Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer
- Differences in sirtuin regulation in response to calorie restriction in Cryptococcus neoformans
- Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species
- Poly (ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
- Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1
- The effect of Ramadan fasting on sirtuin and visfatin levels
- Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives
- The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver …
- Receptor‐interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes
- Involvement of flavonoids from the leaves of carya cathayensis sarg. In sirtuin 1 expression in HUVEC senescence
- Scalable and purification-free synthesis of a myristoylated fluorogenic sirtuin substrate
- Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1a pathway
- Sirtuin 1 and adenosine in brain disorder therapy
- Dehomocysteinylation is catalysed by the sirtuin‐2‐like bacterial lysine deacetylase CobB
- Impacts on sirtuin function and bioavailability of the dietary bioactive compound dihydrocoumarin
- Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus
- Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala
- Effect of eight weeks aerobic and combined training on serum levels of sirtuin 1 and PGC-1α in coronary artery bypass graft patients
- Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis
- Sirtuin activation by small molecules
- The mimics of Nε-acyl-lysine derived from cysteine as sirtuin inhibitors
- β-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner
- Hypothermic machine perfusion ameliorates inflammation during ischemia‑reperfusion injury via sirtuin‑1‑mediated deacetylation of nuclear factor‑κB p65 in …
- Involvement of resveratrol and ω-3 polyunsaturated fatty acids on sirtuin 1 gene expression in THP1 cells
- Metal-binding effects of sirtuin inhibitor sirtinol
- Structure-based design and computational studies of sirtuin inhibitors
- Browning of adipose tissue and sirtuin involvement
- Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without …
- Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs
- Downregulation of angiotensin type 1 receptor and nuclear factor-κB by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction
- Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract–induced heme oxygenase-1 by cleaving sirtuin 1
- … , 3, 3′-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the …
- 5-((3-Amidobenzyl) oxy) nicotinamides as Sirtuin 2 Inhibitors
- Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education
- Adipocyte differentiation is regulated by mitochondrial trifunctional protein α-subunit via sirtuin 1
- MiR-30a-5p accelerates adipogenesis by negatively regulating Sirtuin 1
- Mitochondrial respiration in intact peripheral blood mononuclear cells and sirtuin 3 activity in patients with movement disorders
- A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae
- A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells
- Differential expression of human n-alpha-acetyltransferase 40 (hnaa40), nicotinamide phosphoribosyltransferase (nampt) and sirtuin-1 (sirt-1) pathway in …
- Differential expression of sirtuin 2 and adipocyte maturation restriction: an adaptation process during hypoxia in fish
- MicroRNA‑3666 inhibits breast cancer cell proliferation by targeting sirtuin 7
- miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide …
- High-mobility group nucleosome-binding protein 1 as endogenous ligand induces innate immune tolerance in a TLR4-Sirtuin-1 dependent manner in human …
- Aberrant caspase activation in laminin-α2-deficient human myogenic cells is mediated by p53 and sirtuin activity
- Sirtuin 1/soluble guanylyl cyclase: a nitric oxide-independent pathway to rescue ageing-induced vascular dysfunction
- Sirtuin 6 promotes cell aging of myeloma cell line KM-HM_ (31) by via Hippo signal pathway
- MicroRNA‑378b regulates α‑1‑type 1 collagen expression via sirtuin 6 interference
- Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1
- Cooperative binding of cinnamon polyphenols as activators of Sirtuin‐1 protein in the insulin signaling pathway
- Hydrogen attenuated oxidized low‑density lipoprotein‑induced inflammation through the stimulation of autophagy via sirtuin 1
- Cross-talk between Sirtuin 1 and high-mobility box 1 in steatotic liver graft preservation
- Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPARγ Receptor Activators
- Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia‐induced chemokine (C‐C motif) ligand 2 production in osteoblasts
- Age-related changes in the content of sirtuin 1 in fibroblasts of human dermis
- Effects of Berberine on Hepatic Sirtuin 1-uncoupling Protein 2 Pathway in Non-alcoholic Fatty Liver Disease Rats Induced by High-fat Diet
- Sirtuin 6 builds a wall against inflammation, trumping diabetes
- Effect of metformin on Sirtuin-1 disorders associated with diabetes in male rats
- Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer
- Evaluation of Sirtuin-3 probe quality and co-expressed genes using literature cohesion
- Sirtuin 1 evaluation with a novel immunoassay approach based on TiO2–Au label and hyperbranched polymer hybrid
- Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia
- Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences
- Sirtuin activator and inhibitor affect early Dictyostelium development upon starvation
- … of D-Glucose, Extends the Lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling D-Allose Extends Nematode Lifespan via Sirtuin and Insulin Signaling
- 5-Methylmellein is a novel inhibitor of fungal sirtuin and modulates fungal secondary metabolite production
- Corrigendum to “Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from …
- Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1
- The key role of microRNA-34a in the reduction of sirtuin-1 in COPD
- MicroRNA‑506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1
- Small-Molecules Targeting Sirtuin 1: A Patent Review (2012-2015)
- The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation
- #VALUE!
- Apelin and Sirtuin 1 dysregulation induce endocrine and metabolic disorders in chronic disease
- Sirtuin 1 activation and cardioprotective role: thy eternal summer shall not fade
- Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1
- Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
- Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium …
- Cyclic Peptide-Based Sirtuin Substrates
- Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast …
- Peripheral levels of BDNF and sirtuin 1 in migraine
- Sirtuin 5 promotes ischemia/reperfusion-induced blood-brain barrier damage after stroke
- #VALUE!
- Effects of 10 weeks of high intensity interval training and green tea supplementation on serum levels of Sirtuin-1 and peroxisome proliferator-activated receptor …
- Detection of Sirtuin-1 protein expression in peripheral blood leukocytes in dogs
- Immunohistochemical examination of osteopontin and sirtuin-1 expression in cattle tuberculosis
- Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease
- Intracellular localization of sirtuin and cell length analysis of Lactobacillus paracasei suggest possible role of sirtuin in cell division and cell shape regulation
- Identification of sirtuin and its target as the ribosomal protein S4 in Lactobacillus paracasei
- Significant association of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) rs3846662 and sirtuin 1 (SIRT1) rs7895833 and apolipoprotein E (APOE) …
- Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 …
- Sirtuin 1: A New Potential Therapeutic Target for Rhinosinusitis? Who “Nose”?
- The Potential Impact of Sirtuin 1 Protein on Premature Ovarian Insufficiency
- Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats
- Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients
- Age-Related Changes in the Content of Sirtuin 1 in Human Dermal Fibroblasts
- Sirtuin 1 gene rs2273773 C> T single nucleotide polymorphism and protein oxidation markers in asthmatic patients
- The effects of 10 weeks of high-intensity interval training and green tea supplementation on serum levels of sirtuin 1 and catalase in overweight women
- The pathophysiological importance and therapeutic potential of NAD’biosynthesis and mitochondrial sirtuin SIRT3 in age-associated diseases.
- Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
- Toxicarioside H induces drug-resistant mitophagy via promoting expression of sirtuin-3 in lung cancer cells
- Discovery of (5-phenylfuran-2-yl) methanamine derivatives as new human Sirtuin 2 inhibitors
- Fission yeast sirtuin Hst4 functions in preserving genomic integrity by regulating replisome component Mcl1
- Possible role of Sirtuin in neuronal mitochondrial energy cascade for memory cognition
- MicroRNA‑448 modulates the progression of neuropathic pain by targeting sirtuin 1
- Deficiency of Sirtuin 3 Accentuates Angiotensin II‐Induced Arterial/Myocardial Stiffness and Hypertension
- Adiponectin receptor 1-mediated micro RNA-323-3p regulates functions of the MIN6 cell line via the AMP-activated protein kinase/sirtuin-1 pathway
- SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
- 1819-P: Growth Hormone Receptor (GHR) in AgRP Neurons Modulates Energy Balance and Metabolic Adaptation to Fasting via Sirtuin 1 (SIRT1)
- The Nicotinamide Adenine Dinucleotide (NAD)-dependent deacetylase Sirtuin-1 regulates chondrocyte energy metabolism through the modulation of …
- MicroRNA‑29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression
- Impact of NAD-dependent deacetylase Sirtuin-1 in the osteophyte formation and the degradation of articular cartilage in osteoarthritis (OA)
- Therapeutic Potential of Sirtuin Inhibitors in Cancer
- Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 [alpha] pathway
- Mitophagy induced by endoplasmic reticulum stress in heart is modulated by the sirtuin 1
- P2624 The contribution of Sirtuin-1 to the obesity-related endothelial dysfunction
- Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1
- L-arginine, an active component of salmon milt nucleoprotein, promotes thermotolerance via Sirtuin in Caenorhabditis elegans
- Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo
- Regulation of human sirtuin deacylase activity by cellular oxidants
- NAD+ as a Pharmacological Tool to Boost Sirtuin Activity
- The protective effect of Egb 761 against 3-nitropropionic acid-induced hearing loss: the role of sirtuin 1
- Effects of Sirtuin 2 on Hepatitis B Virus Replication
- Sirtuin Modulators and Brain Aging
- Effects of LPA2R, LPA3R, or EP4R agonists on luteal or endometrial function in vivo or in vitro and sirtuin or EP1R, EP2R, EP3R or EP4R agonists on endometrial …
- Sirtuin-2 is Regulated by Serum Response Factor and p49/STRAP genes
- Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
- microRNA-802 is involved in palmitate-induced damage to pancreatic β cells through repression of sirtuin 6
- 2182 Sirtuin 5 regulates arterial thrombosis by modulating endothelial plasminogen activator inhibitor-1
- PC200 A Deacetylase Enzyme, Sirtuin 3, Plays a Major Role in Macrophage Inflammation and Wound Healing
- Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7)
- The nuclear sirtuin SIRT6 promotes epithelial-mesenchymal transition in human melanoma cells
- Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet
- Molecular responses to whole-body dehydration in a sequenced vertebrate, Xenopus laevis: Regulation of antioxidants and metabolism by the Sirtuin protein …
- … , interleukin-1B downregulates chondrocyte energy metabolism through the modulation of adenosine monophosphate-activated protein kinase and sirtuin 1 in OA
- Azologization of a hetero-stilbene based c-RAF kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors
- Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
- Triiodothyronine improves age-induced glucose intolerance and increases the expression of sirtuin-1 and glucose transporter-4 in skeletal muscle of aged rats.
- Sirtuin 1 regulation of mitophagy and function in hindlimb muscles of aging mice
- … , poly (ADP-ribose) polymerase-1 (PARP1) expression in intra-testicular blood vessels, and stage-dependent expression of PARP1 and Sirtuin 1 in the rat …
- Relationship of fibroblast growth factor 21, sirtuin 1, visfatin, and regulators in children with short stature
- Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases
- Regulation of Sirtuin-dependent skin cell Senescence by dermatology-associated compounds
- Mitochondrial function and sirtuin expression in hippocampus of young and old high-and low-capacity runner rats
- Effects of Pilates Training and Turmeric Supplementation on Sirtuin 1 Level and Body Composition in Postmenopausal Females with Sedentary Overweight: A …
- Association of sirtuin 1 gene single nucleotide polymorphisms with type 2 diabetes mellitus in essential hypertension patients
- Sirtuin‐1 deacetylation of p53 plays a role in shear stress‐induced autophagy in endothelial cells
- Chromone-3-aldehyde derivatives–sirtuin 2 inhibitors for correction of muscular dysfunction
- RNA-binding protein HuR inhibits the expression of sirtuin-1 in patients with COPD
- Sirtuin 1 as a potential therapeutic target in pulmonary artery hypertension
- Deregulation of selective autophagy & sirtuin 3 expression in lung aging and pulmonary fibrosis
- Beyond longevity: novel roles of Sirtuin-3 in thrombosis
- Association of variable number tandem repeat polymorphism of Intron 5 of the Sirtuin-3 Gene with the risk of breast cancer
- Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling
- Sirtuin 3 ablation exacerbates cerebral injury after experimental cardiac surgery via inflammasome activation
- P5381 Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
- … Prevention of Cigarette Smoke-Induced Inflammatory Lung Lesions Independent of Carotenoid Cleavage Enzymes and Mechanistic Understanding of Sirtuin 1 …
- Sirtuin 3 Expression and Acetylation of Three Downstream Targets in Painted Turtle Liver and Brain During Anoxia
- Sirtuin Inhibitor as a Novel Cell Cycle Checkpoint and Regulator of the TP53-MDM2 Pathway in Uveal Melanoma
- Influence of treatment of periodontal disease on sirtuin 1 and mannose-binding lectin in individuals with coronary artery disease
- AB0044 PHARMACOLOGICAL MANIPULATION OF SIRTUIN 1 ACTIVITY IN EXPERIMENTALLY INDUCED ARTHRITIS
- Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
- GW27-e1067 Resveratrol Protects against TNF-α-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and …
- SIRTUIN 3 REGULATES THE ENDOTHELIAL-TO-MESENCHYMAL TRANSITION BY IMPROVING AUTOPHAGIC DEGRADATION PYRUVATE KINASE M2
- Determining the Conservation and Metabolic Role of Sirtuin Lipoamidase Activity
- A6645 Sirtuin 3-mediated glycolysis enhancing during Angiotension II-induced endothelial-to-mesenchymal transition
- Sirtuin-regulated lipoylation is an evolutionarily conserved mediator of metabolic health and disease
- The Sirtuin SIRT6 Represses Expression of Cachexia‐Associated Cytokine Myostatin by Blocking its NF‐kB‐Dependent Gene Transcription
- A6555 Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
- Exploring the role of sirtuin 2 in lipid homeostasis
- #VALUE!
- Decreased serum sirtuin-1 in chronic obstructive pulmonary disease
- Investigating Sirtuin-3 in Host Defense Against HCMV Infection
- Effect of 1.2-epoxy-3 [3-3 [3.4-dimetoxyi-phenil]-4h-1-benzopiran-4-on] Propane (epi) on Sirtuin-1 and Nuclear Factor-κB Expression of DMBA induced …
- Sirtuin 2 Promotes Collagen II Synthesis Through Deacetylating p65-NF-κB in Human Intervertebral Disc Cartilage Endplate Cells
- Sex-Specific Behavioural Traits of the Sirtuin-3 Knockout Mouse Model
- Roles of Sirtuin family in non-small cell lung cancer
- Role of Sirtuin 3 in the differentiation of 3T3-L1 preadipocytes
- Epigenetic regulation of sirtuin 1‐induced skeletal muscle mass: exercise and heart disease
- Neuron survival modulated by 24-hydroxycholesterol: the role of sirtuin pathway in Alzheimer’s Disease.
- Characterizing a novel bacterial sirtuin protein in an intact protein system
- The role of sirtuin in the growth and encystation of Acanthamoeba
- Myeloid Sirtuin 6 Deficiency Accelerates Experimental and Human Rheumatoid Arthritis by Enhancing Macrophage Activation and Infiltration into Synovium
- Unraveling the Role of Sirtuin 2 in Metabolic Homeostasis
- Validation of Sirtuin 3 as a Neuroprotective and Neurorestorative Target in the Mutant Human A53T α-synuclein Rat Model of Parkinson’s Disease
- The Role of Sirtuin-2 in Ischaemic Stroke-Induced Neuronal Cell Death
- Insights into the role of sirtuin 2 in obesity and insulin resistance
- Role of Sirtuin 6 in Mouse Pancreatic Beta Cell Development and Homeostasis
- The Role of Sirtuin 6 in Maintaining Vascular Integrity
- The Role of Sirtuin 3 in Ovarian Cancer Metastasis
- Investigating the Role of Sirtuin 1 in the Pulmonary Vascular Response to Chronic Hypoxia-Induced Pulmonary Hypertension
- Sirtuin 6 (SIRT6) overexpression regulates antioxidant status and redox signaling in human chondrocytes
- Identification of bichalcones as natural product sirtuin inhibitors by virtual screening and in vitro testing
- Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19)
- Diagnosis and Management of Immunological Diseases requires Sirtuin 1 as a Diagnostic protein marker
- Serum sirtuin-1 is reduced in COPD
- Sirtuin-1 and MMP-2 levels in patients with advanced coronary artery disease: A combined index for incidence of myocardial infarction
- Transcriptional Dysregulation of Sirtuin 1 is Relevant to Diabetes and Global Chronic Disease
- Inhibition of Profibrotic Signaling in Primary Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis (IPF) by Sirtuin-1/-2-Inhibitor Sirtinol
- Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological Modulation
- The sirtuin family of proteins: the role in the aging processes and regulation of cell metabolism.
- THU0099 Myeloid sirtuin 6 deficiency accelerates experimental and human arthritis by increasing macrophage infiltration into synovium
- Ligand Binding and Catalysis in Selected Sirtuin Isozymes
- The effects of Sirtuin 6 inhibition on autophagy-related pathways in melanoma
- OP0291 ACTIVATION OF THE DEACETYLASE SIRTUIN-1 COUNTERACTS THE ACTIVATED AND PROANGIOGENIC PROFILE OF ENDOTHELIAL CELLS …
- Inter-individual responses to high intensity interval training: interactions with the sirtuin system
- Expression and significance of Sirtuin 1 in human colorectal cancer
- Investigating Human Mitochondrial Sirtuin 3 and its Anti-Viral Functions
- #VALUE!
- Effects of sirtuin 1 on arterial stiffening in a model of diet-induced obesity
- Examining the Effect of Oxidative Stress on Tetrahymena Thermophila Sirtuin, THD17
- Corrigendum to ‘Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury'[Int. J. Cardiol. 260 (2018) 148–155]
- A prospective compound screening contest identified broader inhibitors for Sirtuin
- A synthetic non-histone substrate provides insight into substrate targeting by the Gcn5 HAT and sirtuin HDACs
- Sirtuin 1 (SIRT1) and activated caspase 3 expression on rat spinal cord in acute phase after Sciatic nerve injury
- Investigating the Impact of Oxidative Stress on Tetrahymena Thermophila Sirtuin, THD 18
- SAT0029 Impact of glucocorticoids on sirtuin 1 expression and proinflammatory cytokine production in rats with adjuvant-induced arthritis
- Potential Involvement and Significance of Histone Deacetylase Sirtuin-6 in Melanoma
- Effects of liraglutide on the biological behavior of human endothelial colony forming cell induced by high glucose via regulating sirtuin expression
- Metformin regulates sirtuin expression in airway epithelial cells
- Computational approach towards sirtuin inhibitors: application of molecular docking methods
- Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
- Small solute carrier and sirtuin genes are potential prognostic biomarkers for renal cell carcinoma
- EFFECTS OF PERSPECTIVE SIRTUIN-1 ACTIVATOR ON ENERGY HOMEOSTASIS CONSTITUENTS IN RATS WITH E XPERIMENTAL T YPE 2 DIABETES …
- THE ROLE OF SIRTUIN-2 IN ISCHAEMIC STROKE-INDUCED NEURONAL CELL DEATH
- Tissue Specific Reductions in Sirtuin-6 Expression Affect Calcium Burden and Pro-osteogenic Signaling in the Aortic Valve
- The Nuclear Sirtuin, Sirt6 Mitigates Muscle Atrophy Associated With Cancer
- DEFINING THE FUNCTIONS OF HUMAN SIRTUIN 2 IN CELLULAR HOUSEKEEPING AND DURING VIRAL INFECTION
- Cardiovascular effects of the sirtuin and urocortin systems in humans
- In silico-driven strategies for the identification of novel sirtuin modulators
- Morphological characterization of a dietary challenged Sirtuin 1 heterozygous mice
- PROLONGATION OF HUMAN LIFESPAN BY IMMATURE PEAR EXTRACT MEDIATED SIRTUIN-RELATED GENE EXPRESSION
- Frontispiece: Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight
- The NAD+-Dependent Histone Deacetylase Sirtuin-2 is Upregulated during Myogenesis and Promotes the Differentiation of C2C12 Myoblasts
- P5329Gene expression of sirtuin-1 and receptor for advanced glycation end products in healthy and slightly overweight subjects after caloric restriction and resveratrol …
- Regulation of acetyl-CoA metabolism in plants: Role of acetyl-CoA synthetase and sirtuin proteins
- 1765-P: Adipose Sirtuin 6 Drives Macrophage Polarization Toward M2 through IL-4 Production and Maintains Systemic Insulin Sensitivity in Mice and Human
- The Investigation of Sirtuin Activities on Short-Chained Mono-Acylated Histone H3 Tetramers and Nucleosomes
- Front Cover: Development of Substrate‐Derived Sirtuin Inhibitors with Potential Anticancer Activity (ChemMedChem 20/2017)
- Sirtuin 3‐and Diet‐Mediated Regulation of Mitochondrial Function During Aging
- The thrifty phenotype hypothesis: is sirtuin 6 the solution to the enigma?
- Sirtuin-1 Signaling Regulates Organismal Growth by Altering Feeding Behavior and Stem Cell Differentiation in Planarians.
- Evidence for the interplay between post‐translational modifications in regulating mycobacterial sirtuin activity
- Sirtuin-3 modulates Bak-and Bax-dependent apoptosis
- Vascular Smooth Muscle Sirtuin-1 Regulates Tgf-b1 Signaling Pathway in Angiotensin II-induced Aortic Aneurysm and Dissection
- BIOINFORMATIC ANALYSES OF METALLOME AND STRUCTURAL ANALYSIS OF SIRTUIN FROM Glaciozyma antarctica PI12
- Sirtuin 1 Prevents Age-associated Aortic Valve Calcification in vivo
- #VALUE!
- In vitro study of in silico designed sirtuin 1 and bromodomain 4 inhibitors on human neuroblastoma SH-SY5Y and acute myeloid leukemia U937 cells
- Sirtuin-cAMP crosstalk in metabolic diseases: nucleus versus mitochondria
- #VALUE!
- #VALUE!
- A12686 The sirtuin 6 attenuates myocardial injury and dysfunction by regulating ADAM17/ACE2 pathway in hypertensive rats
- Expression Grade Sirtuin-1 (SIRT-1) in Tumor Tissue in Women with Breast Cancer: A New Biomarker Prognosis?
- Modulation of Sirtuin NAD+‐dependent Deacylase Activity by Cysteine Oxidation
- Effects of Resveratrol Postconditioning on Cerebral Ischemia in mice: Role of the Sirtuin-1 (SIRT1) Pathway
- Amiodarone induces autophagy/mitophagy by activating sirtuin-3 in acute myelocytic leukemia
- Effects of vitamin D supplementation on sirtuin-1, Angiogenesis fac-tors and Matrix metalloproteinases enzmes in Obese subjects with Vitamin D Insufficiency …
- The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration
- Retraction notice to-Sirtuin-4 modulates sensitivity to induction of the mitochondrial permeability transition pore
- Re: Sirtuin 3 Suppresses the Formation of Renal Calcium Oxalate Crystals through Promoting M2 Polarization of Macrophages
- MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the …
- Exploring the Functions of Cytoplasmic Sirtuin 2 during Herpesvirus Infection
- Hypomethylated CG islands of sirtuin promoters in gilthead sea bream (Sparus aurata)
- Roles of Sirtuin 1 Activity and Tomato Carotenoids in the Development of Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
- Functional Role of Sirtuin 3 in the Regulation of Pancreatic Beta-Cell Function in Type 2 Diabetes
- SHEAR STRESS INCREASES SIRTUIN 3 EXPRESSION AND PROMOTES MITOCHONDRIAL FUNCTIONS IN ENDOTHELIAL CELLS
- Regulation of histone H2A. Z expression is mediated by sirtuin 1 in prostate cancer
- Absence of Functional Sirtuin 3 Alters Fatty Acid and Glucose Metabolism Following 4-OH-PCB11 Exposure
- Melatonin fails to protect cardiac mitochondria in sirtuin 1 heterozygous mice placed on a high-fat diet
- The Role of Sirtuin 1 in the Regulation of Autophagy and Respiratory Syncytial Virus-induced Immune Responses
- Sirtuin 1 Downregulation Exacerbates Fibrosis and Inflammation in Obese Mice Liver
- Post-translational lysine-acetylation of Ran and its regulation by Sirtuin deacetylases
- The Sirtuin Inhibitor Tenovin-6 as a Novel Regulator of the TP53-MDM2 Signaling Pathway in Uveal Melanoma
- NAD~+ de novo synthesis from tryptophan metabolism sustains Sirtuin 1 dependent Immune Tolerance
- Vascular smooth muscle Sirtuin-1 protects against aortic dissection during angiotensin II-induced hypertension
- Sirtuin 4 controls leucine metabolism and insulin secretion by reversing effects of reactive metabolites
- Unripe pear fruit extract induces the transcriptional activity of sirtuin-related genes to extend the chronological lifespan of Saccharomyces cerevisiae
- Expression of Concern: Sirtuin-3 modulates Bak-and Bax-dependent apoptosis. Manish Verma, Nataly Shulga, John G. Pastorino. J Cell Sci
- microRNA-138-5p Participates in Psoriasis Progress Through Regulating the Growth of Keratinocytes and Inflammatory Responses by Targeting Sirtuin 1
- Hydrogen sulfide protects mitochondrial function during myocardial hypertrophy via sirtuin 3
- Sirtuin 7 Is Associated With Pulmonary Fibrosis And Attenuates Collagen Expression In Lung Fibroblasts
- The effect of aerobic training with Citrus aurantium L. on Sirtuin 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha gene expression …
- MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes
- Sirtuin 3 is a Novel Regulator of Mitochondrial Ceramide Metabolism in Stroke
- Sirtuin-1 Inhibition by Peroxynitrite Contributes to Nicotine-induced Arterial Stiffness in Mice
- Effects of muscle-specific UCP1 overexpression on spermatogenesis and mitochondrial sirtuin expression in the testis
- Elevation of Cardiac NAD+ Levels Improves Mitochondrial Function in Mice Lacking Sirtuin 3
- Translational Research in Acute Lung Injury and Pulmonary Fibrosis: Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung …
- Retraction notice to:” Role of Mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes” MCE Volume 382, Issue 1, 25 …
- Long-term therapy with elamipretide normalizes sirtuin-3 protein levels in isolated mitochondria of left ventricular myocardium of dogs with chronic heart failure
- Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,” selectivity pocket” and NAD+-binding site
- Increased Deacetylation of Proteins in Sensory Neurons by Sirtuin 1 Protein Overexpression Reverses T2D Peripheral Neuropathy
- Muscle‐Specific Over‐Expression of the NAD+‐Dependent Nuclear Sirtuin SIRT6, Suppresses Cancer‐Associated Cachexia
- Comparison of resveratrol supplementation and calorie restricted diet on nutritional status, metabolic and oxidative parameters, serum sirtuin-1 and fibroblast growth …
- The relationship between renalase together with catecholamines and anti-aging factors-sirtuin 1 and αKlotho in hemodialysis patients.
- Myeloid sirtuin 6 deletion delays wound healing in mice by modulating inflammation and macrophage phenotype
- Effect of hypoxic preconditioning on sirtuin 1 and sirtuin 3 expressions in alpha7 nicotinic receptor deficient mice brain at chronic cerebral hypoperfusion
- Sirtuin 1 (SIRT1) Content and Angiotensin II Receptor Type I (AT1) Expression in Human Umbilical Vein Endothelial Cells (HUVECs) in Response to Resveratrol …
- NeuroprotectinD1 (NPD1) mediates Sirtuin signaling in cell survival under-uncompensated oxidative stress in Retinal Pigment Epithelial (RPE) cells
- PM2. 5 Activates Sirtuin‐SREBP1‐PIR Axis to Induce Pulmonary Fibroblast Inflammation: A Molecular Mechanism Model of Environmental Factor Induced Lung …
- Resveratrol Can Improve Chronic Hypoxia Induced Pulmonary Hypertension Only In Absence Of Sirtuin 1 Catalytic Activity
- Mechanisms of Sirtuin-2 (SIRT2) enhancement of mitochondrial function and axon regeneration in control and diabetic adult sensory neurons
- Sex-Specific Cardioprotective Effects of Annexin A1 Peptide Mimetic Involve the Sirtuin 3 Signaling Pathway
- Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
- Dichloroacetate Fails to Improve Exaggerated Chronic-Hypoxia Induced Pulmonary Hypertension in Sirtuin 1 Mutant Mice
- Corrigendum to” Sirtuin 3 Rescues Neurons Through the Stabilisation of Mitochondrial Biogenetics in the Virally-Expressing Mutant α-synuclein Rat Model of …
- Secretome released from adipose mesenchymal stem cells protects SH-SY5Y cells from oxidative stress and increases sirtuin 3 expression
- 2026-P: Myeloid Sirtuin 6 Is a Molecular Switch of White Adipose Tissue Browning
- Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
- … Kinase With Dichloroacetate in Pulmonary Arterial Hypertension: A Variable Clinical Response Driven by Genetic Polymorphisms in Sirtuin-3 and Uncoupling Protein …
- Abstract C11: Linoleic acid elevates sirtuin 6 expression and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like …
- Expression of Concern: Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3. Nataly Shulga …
- Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John …
- NAD-dependent deacetylase Sirtuin-1 down-regulates expressions of osteogenic transcription facter RUNX2 and matrix metaprotinase (MMP)-13 in osteoarthritic …
- Resveratrol induces apoptosis of bovine adipocytes through activiate of sirtuin type 1/adenosine monophosphate activated protein kinase signaling pathway.
- Abstract P180: Deficiency of Sirtuin 3 Sensitizes Angiotensin II-Induced Cardiac Pericyte-Fibroblast Transition and Diastolic Dysfunction via Iron Overloading
- The NAD-dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator Runt-related transcription factor 2 (Runx2) and production of …
- … : BREATHLESS IN SAN FRANCISCO: Resveratrol Can Improve Chronic Hypoxia Induced Pulmonary Hypertension Only In Absence Of Sirtuin 1 Catalytic Activity
- The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 regulates chondrocyte energy metabolism through the modulation of adenosine …
- … and NAD+-Dependent (Ie Sirtuins) Histone Deacetylases (HDACS) on Innate Immune Responses: Lessons from the Usage of HDAC Inhibitors and Sirtuin …
- Genetic Deletion of Sirtuin 3 (SIRT3) in the Mitochondria of the Proximal Tubules Aggravates Angiotensin II-Induced Hypertension by Impairing the Pressure …
- PSXIII-3 Maternal eicosapentaenoic acid feeding decreases placental and fetal lipid deposition and improves antioxidant capacity through a Sirtuin-1 independent
- Analysis of caspase-1 regulated transcriptome in various tissues lead to identification of novel IL-1β, IL-18 and sirtuin-1 intendent pathways
- … PROTECTS AGAINST TNF-α-INDUCED INJURY IN HUMAN UMBILICAL ENDOTHELIAL CELLS THROUGH PROMOTING SIRTUIN-1-INDUCED REPRESSION OF …
- The insulin/IGF-1, the sirtuin and the mTOR pathway. How alterations of these pathways could affect age-related diseases and lifespan.
- Nicotinamide riboside affects toll‐like receptor 4‐NF‐κB pathway via sirtuin‐dependent and–independent ways in AML12 hepatocytes
- The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients
- 0433: Sirtuin 3: does cardiomyocyte care?
- P002: MicroRNA-378b represses the expression of α-1-type 1 collagen through interference with sirtuin 6
- The silver lining of cerebrosterol in Alzheimer’s disease: the involvement of sirtuin 1 in neuroprotection
- Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1
- DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells
- The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients
- Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
- Mechanism of activation for the sirtuin 6 protein deacylase
- Host sirtuin 2 as an immunotherapeutic target against tuberculosis
- Emerging role of sirtuin 2 in Parkinson’s disease
- Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
- Sirtuin 6: A potential therapeutic target for cardiovascular diseases
- The versatility of sirtuin-1 in endocrinology and immunology
- Sirtuin 1 and endothelial glycocalyx
- The sirtuin 6: An overture in skin cancer
- A Molecular Perspective on Sirtuin Activity
- Sirtuin-1 and its relevance in vascular calcification
- Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
- Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery
- Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control
- Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review
- Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
- Sirtuin 2 regulates protein lactoylLys modifications
- Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities
- Post-translational modification crosstalk and hotspots in sirtuin interactors implicated in cardiovascular diseases
- Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells
- Sirtuin 1: a dilemma in transplantation
- Antioxidant modulation of mTOR and sirtuin pathways in age-related neurodegenerative diseases
- The role of Sirtuin-1 in the vasculature: focus on aortic aneurysm
- Sirtuin 6: linking longevity with genome and epigenome stability
- Sirtuin activation targets IDH-mutant tumors
- Molecular mechanisms of doxorubicin-induced cardiotoxicity: Novel roles of sirtuin 1-mediated signaling pathways
- RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer’s disease mouse model
- Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model
- Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system
- Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
- Five days periodic fasting elevates levels of longevity related christensenella and sirtuin expression in humans
- Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice
- Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model
- Hypertension and mitochondrial oxidative stress revisited: sirtuin 3, the improved “antioxidant”
- Sirtuin 1 inhibiting thiocyanates (S1th)—a new class of isotype selective inhibitors of NAD+ dependent lysine deacetylases
- Legionella pneumophila infection rewires the Acanthamoeba castellanii transcriptome, highlighting a class of sirtuin genes
- Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
- Sirtuin 3 is essential for hypertension‐induced cardiac fibrosis via mediating pericyte transition
- Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance
- Impact of neural stem cell‐derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer’s disease
- The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders
- Targeting Sirtuin 1 signaling pathway by ginsenosides
- Structural basis for activation of human Sirtuin 6 by fluvastatin
- Cardioprotective effects of sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (sodium-glucose cotransporter 2) …
- Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
- Dual role of sirtuin 1 in inflammatory bowel disease
- Sustained activation of AMPK enhances differentiation of human iPSC-derived cardiomyocytes via sirtuin activation
- The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression
- Lactate increases renal cell carcinoma aggressiveness through sirtuin 1-dependent epithelial mesenchymal transition axis regulation
- Endothelial sirtuin 3 dictates glucose transport to cardiomyocyte and sensitizes pressure overload‐induced heart failure
- Impact of sirtuin enzymes on the altered metabolic phenotype of malignantly transformed cells
- Fucoxanthin mitigates subarachnoid hemorrhage-induced oxidative damage via sirtuin 1-dependent pathway
- Concerted action of AMPK and Sirtuin-1 induces mitochondrial fragmentation upon inhibition of Ca2+ transfer to mitochondria
- Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner
- Nimbolide abrogates cerulein-induced chronic pancreatitis by modulating β-catenin/Smad in a sirtuin-dependent way
- Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer
- Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy
- Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)
- Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway
- Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation
- Development of a mitochondrial sirtuin 4 FRET assay based on its activity for removing 3-hydroxy-3-methylglutaryl (HMG) modification
- Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines
- Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death
- Sirtuin acetylation and deacetylation: a complex paradigm in neurodegenerative disease
- Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice
- Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co …
- Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA‐3666
- Berberine increases glucose uptake and intracellular ROS levels by promoting Sirtuin 3 ubiquitination
- Histone acetyltransferase p300 inhibitor improves coronary flow reserve in SIRT3 (sirtuin 3) knockout mice
- Parasitic sirtuin 2 as an opportunity in drug discovery
- Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons
- Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner
- Sirtuin 2 inhibition attenuates sevoflurane-induced learning and memory deficits in developing rats via modulating microglial activation
- The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic …
- Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency
- Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and lacto-ovo vegetarians
- DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation
- Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1
- Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis
- Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
- Sirtuin inhibits M. tuberculosis-induced apoptosis in macrophage through glycogen synthase kinase-3β
- Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double …
- Sirtuin 6 attenuates epithelial–mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and c-Jun in asthma models
- Ethanol exposure attenuates immune response in sepsis via sirtuin 2 expression
- The cAMP pathway promotes sirtuin-1 expression in human granulosa-lutein cells
- Sirtuins and the circadian clock interplay in cardioprotection: Focus on sirtuin 1
- Sirtuin 3 is required for the protective effect of Resveratrol on Manganese‐induced disruption of mitochondrial biogenesis in primary cultured neurons
- Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential
- Cardiomyocyte Sirt (Sirtuin) 7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA4
- A new vision of mitochondrial unfolded protein response to the sirtuin family
- Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase …
- Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians
- Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells
- Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway
- Sirtuin 3 inhibits airway epithelial mitochondrial oxidative stress in cigarette smoke-induced COPD
- An alternatively spliced sirtuin 2 isoform 5 inhibits hepatitis B virus replication from cccDNA by repressing epigenetic modifications made by histone lysine …
- Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
- Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of Candida albicans
- Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight …
- Sirtuin 3 alleviates diabetic cardiomyopathy by regulating TIGAR and cardiomyocyte metabolism
- Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease
- Sirtuin 3 activation by honokiol decreases unilateral ureteral obstruction-induced renal inflammation and fibrosis via regulation of mitochondrial dynamics and the …
- Development of Fluorogenic Probes for Rapid High‐Contrast Imaging of Transient Nuclear Localization of Sirtuin 3
- Melatonin prevents deterioration of erectile function in streptozotocin‐induced diabetic rats via sirtuin‐1 expression
- A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors
- Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition
- Sirtuin-1 expression and activity is diminished in aged liver grafts
- Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis
- SIRT3 (sirtuin-3) prevents Ang II (angiotensin II)–induced macrophage metabolic switch improving perivascular adipose tissue function
- Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
- Progranulin modulates cartilage-specific gene expression via sirtuin 1–mediated deacetylation of the transcription factors SOX9 and P65
- Aging-related overactivity of the angiotensin/AT1 axis decreases sirtuin 3 levels in the substantia nigra, which induces vulnerability to oxidative stress and …
- Baicalin protects against 17α-ethinylestradiol-induced cholestasis via the sirtuin 1/hepatic nuclear receptor-1α/farnesoid X receptor pathway
- Deficiency of sirtuin 1 impedes endometrial decidualization in recurrent implantation failure patients
- Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders
- Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
- Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 …
- Proteomics analysis reveals the effect of Aeromonas hydrophila sirtuin CobB on biological functions
- Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia
- Is nuclear sirtuin SIRT6 a master regulator of immune function?
- Aqueous extract of Whitmania Pigra Whitman alleviates thrombus burden via sirtuin 1/NF-κB pathway
- Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury
- Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus
- Sirtuin 2 Dysregulates Autophagy in High-Fat-Exposed Immune-Tolerant Macrophages
- Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts
- Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
- Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling
- Sirtuin 1-dependent regulation of high mobility box 1 in hypoxia–reoxygenated brain microvascular endothelial cells: roles in neuronal amyloidogenesis
- … lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF‐κB/NLRP3 inflammasome and sirtuin 1/autophagy axis
- Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients
- Sirtuin 6 and renal injury: another link in the β-catenin chain?
- The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line
- Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle
- Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma
- Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay
- Low expression of sirtuin 1 in the dairy cows with mild fatty liver alters hepatic lipid metabolism
- The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection
- The role of sirtuin 1 on the induction of trained immunity
- Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence
- Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses
- Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway
- Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
- Role of N-terminus in function and dynamics of sirtuin 7: an in silico study
- The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus
- Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers
- Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications
- Pancreatic Sirtuin 3 deficiency promotes hepatic steatosis by enhancing 5-hydroxytryptamine synthesis in diet-induced obese mice
- Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression
- Sirtuin-1 Inhibits Endothelin-2 Expression in Human Granulosa-Lutein Cells via HIF1A and Epigenetic Modifications
- Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women
- Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates
- A fungal sirtuin modulates development and virulence in the insect pathogen, Beauveria bassiana
- Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models
- Sirtuin 3‐mediated deacetylation of acyl‐CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease
- The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase
- Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
- Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway
- Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)
- Hypothalamic NAD+-Sirtuin Axis: Function and Regulation
- Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype
- Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy
- Modulation of the bacterial CobB sirtuin deacylase activity by N-terminal acetylation
- The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress–induced mice
- Sirtuin (Sirt) 3 overexpression prevents retinopathy in streptozotocin-induced diabetic rats
- Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis
- Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation
- Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease
- Long noncoding RNA‐GAS5 attenuates progression of glioma by eliminating microRNA‐10b and Sirtuin 1 in U251 and A172 cells
- Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All …
- The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
- BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT116 colorectal cancer cells
- A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis
- Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease
- Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′-deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an …
- Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling
- … -pituitary ovarian axis (HPO) in female mammals: role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)
- E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation
- Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis
- … of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric measurements and the serum levels of VEGF, NO, sirtuin-1, and PGC1-α in …
- Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
- Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
- Aβ-induced damage memory in hCMEC/D3 cells mediated by Sirtuin-1
- … ‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 …
- Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy
- Grape seed proanthocyanidins improves mitochondrial function and reduces oxidative stress through an increase in sirtuin 3 expression in EA. hy926 cells in high …
- Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-κB Pathways
- A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway
- … of Cell Senescence in CD34+ CD38− Leukemia Stem Cells Derived from KG1α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous …
- Phylogenetic diversification of sirtuin genes with a description of a new family member
- Natural Sirtuin Modulators in Drug Discovery: A Review (2010-2020)
- DeepSIRT: A deep neural network for identification of sirtuin targets and their subcellular localizations
- Understanding the Potential Role of Sirtuin 2 on Aging: Consequences of SIRT2. 3 Overexpression in Senescence
- Terminating rice innate immunity induction requires a network of antagonistic and redox‐responsive E3 ubiquitin ligases targeting a fungal sirtuin
- Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose‐binding lectin
- Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive
- Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression
- β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice
- Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors
- Pancreatic sirtuin 3 deficiency promotes hepatic steatosis by enhancing 5-Hydroxytryptamine synthesis in mice with diet-induced obesity
- Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Giα proteins and hyperproliferation of vascular smooth muscle cells
- Aging exaggerates acute‐on‐chronic alcohol‐induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1‐C/EBPα‐miRNA‐223 axis
- A scaffold replacement approach towards new sirtuin 2 inhibitors
- Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma
- Sirtuin-dependent recovery from aerial heat shock: The effects of food ration, thermal history, and sirtuin inhibition on clearance rates and valve gape activity of the …
- Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling
- Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span
- Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
- Effects of androgens and estrogens on sirtuin 1 gene expression in human aortic endothelial cells
- Blood Pressure-Lowering Effect of Wine Lees Phenolic Compounds Is Mediated by Endothelial-Derived Factors: Role of Sirtuin 1
- Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus
- The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
- The Sirtuin‐1 relied antioxidant and antiaging activity of 5, 5′‐diferulic acid glucoside esters derived from corn bran by enzymatic method
- Kumiss supplementation reduces oxidative stress and activates sirtuin deacetylases by regulating antioxidant system
- Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages
- Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells
- Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells
- Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
- Activation of sirtuin 2 inhibitors employing photoswitchable geometry and aqueous solubility
- Sirtuin GdSir2.4 participates in the regulation of rRNA transcription in the Giardia duodenalis parasite
- Sirtuin-dependent reversible lysine acetylation controls the activity of acetyl-Coenzyme A synthetase in Campylobacter jejuni
- FSH, oxytocin and IGF-I regulate the expression of sirtuin 1 in porcine ovarian granulosa cells
- Plasma levels of sirtuin-1 in patients with cerebrovascular stroke
- Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery …
- Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis
- Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis
- … ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide+/Sirtuin-1 pathway in mice
- Annexin A1 tripeptide mimetic increases sirtuin-3 and augments mitochondrial function to limit ischemic kidney injury
- … II-Induced Cardiac Fibroblast Proliferation and Transverse Aortic Constriction-Induced Myocardial Fibrosis through Oxidative Stress Inhibition via Sirtuin 3
- Sirtuin signaling in hematologic malignancies
- Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach
- Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma …
- Mechanisms and neuroprotective activities of stigmasterol against oxidative stress-induced neuronal cell death via sirtuin family
- A sex-specific role of endothelial Sirtuin 3 on blood pressure and diastolic dysfunction in female mice
- MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels
- Sirtuin SirD is involved in α-amylase activity and citric acid production in Aspergillus luchuensis mut. kawachii during a solid-state fermentation process
- Ginsenoside Rg1 performs anti-aging functions by suppressing mitochondrial pathway-mediated apoptosis and activating sirtuin 3 (SIRT3)/superoxide …
- Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
- The lifespan extension ability of nicotinic acid depends on whether the intracellular NAD+ level is lower than the sirtuin-saturating concentrations
- Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology
- … , MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity
- Energy intake focused analysis of sexual dimorphism in biological aging and hypothesized sex-specificity in sirtuin dependency
- Skeletal muscle‐specific over‐expression of the nuclear sirtuin SIRT6 blocks cancer‐associated cachexia by regulating multiple targets
- Protective Effects of N1-Methylnicotinamide Against High-Fat Diet-and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein
- Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats
- Smooth Muscle Sirtuin 1 Blocks Thoracic Aortic Aneurysm/Dissection Development in Mice
- The possible role of sirtuin 5 in the pathogenesis of apical periodontitis
- … phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 …
- Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway
- Sirtuin 1 inhibitor EX527 suppresses morphine-induced behavioral sensitization
- NAD+/sirtuin metabolism is enhanced in response to cold‐induced changes in lipid metabolism in mouse liver
- Inter‐individual variation in postprandial glycaemic responses in women co‐ingesting green leafy vegetables with a carbohydrate meal: interactions with the sirtuin …
- Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice
- Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-κB and NLRP3 Signaling Pathways
- Sirtuin 6 attenuates angiotensin II-induced vascular adventitial aging in rat aortae by suppressing the NF-κB pathway
- Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells
- Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet …
- Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling …
- Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy
- Sirtuin 3 therapy attenuates aging expression, oxidative stress parameters, and neointimal hyperplasia formation in vein grafts
- Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3
- Muscle‐specific sirtuin 3 overexpression does not attenuate the pathological effects of high‐fat/high‐sucrose feeding but does enhance cardiac SERCA2a activity
- Stereoisomer-specific ginsenoside 20 (S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
- Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer
- Finding the gas pedal on a slow sirtuin
- Molecular characterization and expression of sirtuin 2, sirtuin 3, and sirtuin 5 in the Wuchang bream (Megalobrama amblycephala) in response to acute temperature …
- Sirtuin 6 supra‐physiological overexpression in hypothalamic pro‐opiomelanocortin neurons promotes obesity via the hypothalamus‐adipose axis
- MicroRNA‐199a‐5p aggravates angiotensin II–induced vascular smooth muscle cell senescence by targeting Sirtuin‐1 in abdominal aortic aneurysm
- Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B‑cell lymphoma 2
- Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis
- Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation
- Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2. 5) on all-cause mortality: a longitudinal cohort study in China
- Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion
- In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein
- Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease
- A Theacrine-Based Supplement Increases Cellular NAD+ Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro
- Saccharomyces boulardii modulates necrotizing enterocolitis in neonatal mice by regulating the sirtuin 1/NF‑κB pathway and the intestinal microbiota
- Litopenaeus vannamei sirtuin 6 homolog (LvSIRT6) is involved in immune response by modulating hemocytes ROS production and apoptosis
- Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage …
- Sirtuin 1 Expression in the Rat Ventromedial and Dorsomedial Hypothalamic Nuclei during Ageing
- Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury
- Serum levels of visfatin, sirtuin-1, and interleukin-6 in stable and acute exacerbation of chronic obstructive pulmonary disease
- Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses
- The Protective Effect of 1, 25 (OH) 2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism
- Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome
- Dethioacylation by sirtuins 1–3: considerations for drug design using mechanism-based sirtuin inhibition
- Serum Levels of Sirtuin-1 in Patients with Lung Cancer and its Association with Karnofsky Performance Status
- … prevents cadmium‐induced disorder of testicular lactic acid metabolism in rats by activating 5′ AMP‐activated protein kinase (AMPK)/sirtuin 1 (SIRT1) signaling …
- Genomics of aging: The role of sirtuin and metabolic health
- The effect of trans-palmitoleic acid on cell viability and sirtuin 1 gene expression in hepatocytes and the activity of peroxisome-proliferator-activated receptor …
- Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients
- Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice
- Sirtuin 3 Restores Synthesis and Secretion of Very Low-Density Lipoproteins in Cow Hepatocytes Challenged with Nonesterified Fatty Acids In Vitro
- Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3
- Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4 …
- 1, 4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1
- Sirtuin-7 as a Novel Therapeutic Target in Vascular Smooth Muscle Cell Proliferation and Remodeling
- Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model
- Sirtuin 6 is Reduced in Alzheimer’s Disease (5101)
- From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas?
- Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis
- DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
- The long noncoding RNA MALAT1 suppresses miR‐211 to confer protection from ultraviolet‐mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1*
- Sirtuin 1: endocan and sestrin 2 in different biological samples in patients with asthma. Does severity make the difference?
- Sirtuin 5, vascular endothelium and fibrinolysis: a deadly embrace?
- Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma
- The clinical value of serum sirtuin-1 in the diagnosis of rheumatoid arthritis: a pilot study
- Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease
- Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer
- Fasting and fasting mimetic supplementation address sirtuin expression, miRNA and microbiota composition
- Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk
- Expression of sirtuin type 3 in locus ceruleus is associated with long-term intermittent hypoxia-induced neurocognitive impairment in mice
- Apocynin protects retina cells from ultraviolet radiation damage via inducing sirtuin 1
- Sirtuin 1 activated by SRT1460 protects against myocardial ischemia/reperfusion injury
- Role of forkhead box protein O1 and insulin on cell proliferation mediated by sirtuin 1 in goose primary hepatocytes
- MicroRNA-874-5p regulates autophagy and proliferation in pulmonary artery smooth muscle cells by targeting Sirtuin 3
- Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1
- Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices
- Comparison of sirtuin 1 level and related blood factors in diabetic and healthy subjects.
- Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer
- … upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)
- The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice
- Histone Deacetylase Sirtuin 2 Enhances Viability of Trophoblasts Through p65-Mediated MicroRNA-146a/ACKR2 Axis
- Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins
- Sirtuin 6 protects human retinal pigment epithelium cells from LPS-induced inflammation and apoptosis partly by regulating autophagy
- Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity
- Value of serum and follicular fluid sirtuin (SIRT) 1 and SIRT2 protein levels in predicting the outcome of assisted reproduction
- Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis
- Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes
- Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis
- Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction
- Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
- Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis
- Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial …
- Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis
- Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis
- Single clove garlic extract increase sirtuin 6 mRNA expression in PBMC culture
- Gene expression and prognosis of sirtuin family members in ovarian cancer
- Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness
- Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells
- Discovery of Dihydro-1, 4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1
- Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism
- The interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis
- Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes
- MicroRNA‑217 inhibits the proliferation and invasion, and promotes apoptosis of non‑small cell lung cancer cells by targeting sirtuin 1
- SIRTUIN 1, a novel approach in the treatment of type 2 diabetes mellitus
- Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway
- Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization
- Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
- Sirtuin regulation of NLRP3
- Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat …
- Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of Sirtuin 1
- The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension
- Sirtuin Deacetylases: Linking Mycobacterial Infection and Host Metabolism
- MicroRNA‑132 promotes oxidative stress‑induced pyroptosis by targeting sirtuin 1 in myocardial ischaemia‑reperfusion injury
- Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1
- MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling
- Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease
- Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery
- Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like …
- … (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis …
- MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3
- Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism
- Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy
- 14-3-3 protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2
- Exploring the Sirtuin Functionality in Ageing Through Human Protein Interaction Networks
- TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents
- Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling
- Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1
- Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
- Metabolism, Oxidative Stress and Cell Signaling: Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b …
- Overlapping tumor‐specific expression of p53, p16INK4a, and sirtuin 1 in Bowen’s disease: A case report
- Astaxanthin inhibits alcohol-induced inflammation and oxidative stress by mediating the sirtuin 1 and histone deacetylase 4 axis in macrophages
- MO084 THE INFLUENCE OF INTRAVENOUS CORTICOSTEROIDS ON PLASMA SIRTUIN-1 AND SCLEROSTIN LEVELS IN PATIENTS WITH PRIMARY …
- Sirtuin-6 in Hepatic Fibrosis: Does Cell Type Matter?
- Role of SIRTUIN 6 in vascular smooth muscle cells in atherosclerosis
- Integrated Omics Analysis Reveals Sirtuin Signaling is Central to Hepatic Response to a High Fructose Diet
- Role of Exercise and Natural Protective Substances on Sirtuin Activation
- Resveratrol suppresses interleukin‐6 expression through activation of sirtuin 1 in hypertrophied H9c2 cardiomyoblasts
- In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
- … Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt …
- Increased Sirtuin expression, senescence regulating miRNAs, mtDNA, and bifidobacteria correlate with wellbeing and skin appearance after Sirtuin-activating drink
- Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma
- Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1 …
- Senescence associated long non-coding RNA 1 regulates cigarette smoke-induced senescence of type II alveolar epithelial cells through sirtuin-1 signaling
- Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
- Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating Nuclear factor-like 2 and Sirtuin 2 signaling pathways
- Recent Trends on Telomerase Activators, Sirtuin Activators, and Senolytics as a Potential Anti-aging Agent
- A Review of Sirtuin Inhibitors in Therapeutics, Pharmaceutics, and Plant Research
- Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma
- Electroacupuncture Regulates Inguinal White Adipose Tissue Browning by Promoting Sirtuin-1-Dependent PPARγ Deacetylation and Mitochondrial …
- Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe
- Resveratrol Pretreatment Ameliorates Concanavalin A-Induced Advanced Renal Glomerulosclerosis in Aged Mice through Upregulation of Sirtuin 1-Mediated Klotho …
- miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1
- Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds
- Developmental programming: intrauterine caloric restriction promotes upregulation of mitochondrial sirtuin with mild effects on oxidative parameters in the ovaries and …
- At the Interface between Metabolism and Redox Regulation: Sirtuin 1 as Checkpoint for Neurogenesis and Longevity
- … -23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor …
- Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease
- Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
- … Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated …
- Sirtuin 5 promotes arterial thrombosis through endothelial plasminogen activator inhibitor-1
- Inhibition of miR-383 suppresses oxidative stress and improves endothelial function by increasing sirtuin 1
- #VALUE!
- Activation of Sirtuin 1 by Ellagic Acid Ameliorates Cisplatin-Induced Apoptosis, Oxidative Stress and Nephrotoxicity
- Global query on bacterial sirtuin CobB interactants reveals crosstalk with PRPP synthase Prs
- Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B …
- Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1α)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress …
- Transcription box‑3 protects human umbilical vein endothelial cells in a high‑glucose environment through sirtuin 1/AKT signaling
- Mitochondria dynamics in postmitotic cells drives neurogenesis through Sirtuin-dependent chromatin remodeling
- The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1
- Buyang Huanwu Decoction Alleviates Cerebral Ischemia-Reperfusion Injury via Sirtuin 1/Autophagy Pathway
- 9-Hydroxy-6, 7-dimethoxydalbergiquinol suppresses hydrogen peroxide-induced senescence in human dermal fibroblasts through induction of sirtuin-1 …
- The Effects of NAD-Boosting Therapies on Sirtuin Activity and DNA Repair Capacity
- Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
- Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
- The effects of taurine supplementation on serum levels of adiponectin, irisin, fibroblast growth factor-21, sirtuin-1, metabolic parameters, oxidative/inflammatory …
- The Effect of Sirtuin 2 (Sirt2) Overexpressing Bone Marrow Mesenchymal Stem Cells on the Growth of Human Epidermal Growth Factor Receptor 2 (Her-2) Breast …
- Cilostazol improves hyperglycemia-induced impaired vasculo-angiogenesis through stimulating adiponectin/adiponectin receptor 1/Sirtuin 1 signaling pathway
- The in vivo roles of Sirtuin 1 and 3 in age and obesity-related decline in female fertility
- Analysis of Coding RNA and LncRNA Expression Profile of Stem Cells from the Apical Papilla After Depletion of Sirtuin 7
- Sirtuin 4 contributes to heart failure development by increasing mitochondrial oxidative stress
- Post-transcriptional Regulation of Lysosomal Function by the Lysine Deacylase Sirtuin 1
- The Role of Sirtuin 1 in Palmitic-acid-induced Endoplasmic-reticulum Stress in Cardiac Myoblasts
- Postprandial adropin responses in women co-ingesting green leafy vegetables with a carbohydrate meal: interactions with the sirtuin system
- Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1
- Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells
- NAD+: a crucial regulator of sirtuin activity in aging
- Role of Sirtuin-1 in the pathogenesis of hypertension in spontaneously hypertensive rats: molecular mechanisms
- Evaluation of serum levels of Sirtuin-1 in lung cancer patients
- Expression of Sirtuin 4 in Oral Squamous Cell Carcinoma and it’s Correlation with Clinicopathological Parameters
- Withdrawal: Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV …
- Change in plasma sirtuin 1 level by injection into uterus of resveratrol in Korean cattle
- Decreased expression and Activity of the desacetylase Sirtuin-1 contribute to the activated and proangiogenic profile of endothelial cells in rheumatoid arthritis and …
- Regulation of Sirtuin NAD+-dependent Deacylase Activity by Cellular Oxidants
- The Effects of a Theacrine-based Supplement on mRNAs Related to Various Metabolic Processes and Sirtuin Activity in vitro
- Fat and Carbohydrate Distribution in Maternal Diet Programs Liver Sirtuin-1 Expression and Fatty acid Profile in Offspring
- The Effect of Two-month Concurrent Training with and without Calorie Restriction on Sirtuin-1 Activity and Content in the Peripheral Blood Mononuclear Cells of …
- Fat and Carbohydrate Distribution in Maternal Diet Programs Liver Sirtuin-1 Expression and Fatty Acid Profile in Mice Offspring
- The Effect of Eight Weeks High Intensity Interval Training on Serum Levels of Telomerase Enzyme and Sirtuin 6 Protein in Aged Men
- SERUM ANTI-AGING PROTEIN-SIRTUIN 1 CONCENTRATION CORRELATES WITH IMPAIRED KIDNEY FUNCTION
- Corrigendum to” MicroRNA-128-3p Aggravates Doxorubicin-Induced Liver Injury by Promoting Oxidative Stress via Targeting Sirtuin-1″[Pharmacol. Res. 146 (2019) …
- Association of hyperuricemia-induced renal damage with sirtuin 1 and endothelial nitric oxide synthase in rats
- Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells
- Exploring SIRT6 modulators and an indirect approach to regulate sirtuin activity
- MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
- Identification of small molecule sirtuin-1 inhibitors for treating acute myeloid leukemia based on molecular docking, quantitative structure-activity relationships and …
- Role of vascular smooth muscle sirtuin-1 in the development of aortic aneurysm
- Developmental Regulation of Sirtuin Genes in Broiler Chicks
- Abstract MP55: Endothelial Sirtuin-1 Deficiency Promotes the Rupture of Intracranial Aneurysm
- The role of Sirtuin in respiratory disease
- Virtual screening and molecular modeling studies applied to discover novel sirtuin modulators and cholinesterase inhibitors:[kumulative Dissertation]
- Sirtuin Correlation with p-value
- Effects of 8 weeks of moderate continuous and intensive interval training on the expression of Sirtuin-1 and long-chain Acyl-CoA dehydrogenase gene in the heart …
- Pharmacological Analysis and Molecular Docking of Laurus nobilis (Bay Leaf) for Lung Cancer with Reference to Sirtuin Drug Targets
- Brown Adipose Tissue Promotes Exercise Capacity Through Sirtuin-3
- Transcriptional Regulation of Fatty Acid Transport by Sirtuin 2
- Front Cover: Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology …
- Characterizing the Evolution and Function of a Sirtuin Deacetylase in the Pathogenic Yeast Candida parapsilosis
- Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) …
- Confirmation of Allosteric Switches in Human Sirtuin 1 Using a Sirtuin Activating Compound
- BET Bromodomain Inhibition Results in the Conserved Upregulation of Sirtuin 1
- Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and
- … for A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of The Sirtuin 3-NLRP3 Pathway
- The nuclear sirtuin SIRT6 protects mice from polymicrobial sepsis by suppressing the host immune response
- The nuclear sirtuin SIRT6 plays a role in regulating cardiac branched‐chain amino acid catabolism
- P021: Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
- … -four-component synthesis of 5-(4-hydroxy-2-oxo-1, 2-dihydropyridin-3-yl)-substituted 5H-chromeno [2, 3-b] pyridines and estimation of its affinity to sirtuin 2
- Quinacrine ameliorated Cisplatin‐induced renal toxicity via modulation of Sirtuin‐1 and its downstream inflammatory and apoptosis pathways
- Evaluation of phthalates exposition in sirtuin transcription in HepG2 cells and its toxicity in human hematopoietic stem cells
- Molecular Cloning and Characterization of Sirtuin 1 and Its Potential Regulation of Lipid Metabolism and Antioxidant Response in Largemouth Bass …
- Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease but does not impact sirtuin activity
- … Differences in Angiotensin II‐induced Hypertensive and Natriuretic Responses in Mice with Proximal Tubule‐Specific Deletion of Mitochondrial Protein Sirtuin 3 in The …
- Activation of Sirtuin 1 (SIRT1) Signaling by Resveratrol Increases Human Beta‐Defensins‐2 and‐3 (HBD2, HBD3) Production in Response to Lipopolysaccharide …
- 4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome
- PE-060: An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone …
- Resveratrol Attenuates Incidence of Aortic Aneurysm by Decreasing Reversible Oxidation of Sirtuin-1 and Inhibiting Excessive Tgf-b1 in a Mouse Model of Marfan’s …
- 1553: THE EFFECT OF SIRTUIN 1 ON MITOCHONDRIAL INJURY IN A RAT MODEL OF CARDIAC ARREST
- Cytochrome P450‐Derived Epoxy Lipids of N‐3 PUFAs Protect the Heart From Ischemia‐Reperfusion Injury by Regulating Mitochondrial Sirtuin 3
