PPARα
May 21, 2024DYSLIPIDEMIA OBESITY
May 21, 2024- The central MELANOCORTIN system as a treatment target for OBESITY and diabetes: A brief overview
- OBESITY and Stress: The MELANOCORTIN Connection
- Loss‐of‐function mutations in the MELANOCORTIN‐3 receptor gene confer risk for human OBESITY: A systematic review and meta‐analysis
- A unique metalolic sysdrone causes OBESITY in the MELANOCORTIN-3 receptor-deficient mouse
- The MELANOCORTIN-4 receptor as target for OBESITY treatment: a systematic review of emerging pharmacological therapeutic options
- The MELANOCORTIN pathway and energy homeostasis: From discovery to OBESITY therapy
- Clinical spectrum of OBESITY and mutations in the MELANOCORTIN 4 receptor gene
- The central MELANOCORTIN system and human OBESITY
- OBESITY in the mouse model of pro-opioMELANOCORTIN deficiency responds to peripheral MELANOCORTIN
- MELANOCORTIN-4 receptor in energy homeostasis and OBESITY pathogenesis
- MELANOCORTIN-4 receptor signalling: importance for weight regulation and OBESITY treatment
- Pro-opioMELANOCORTIN processing in the hypothalamus: impact on MELANOCORTIN signalling and OBESITY
- Targeted disruption of the MELANOCORTIN-4 receptor results in OBESITY in mice
- Neural MELANOCORTIN receptors in OBESITY and related metabolic disorders
- MELANOCORTIN signalling and the regulation of blood pressure in human OBESITY
- The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced MELANOCORTIN OBESITY and the contribution of hypothalamic …
- MELANOCORTIN‐4 receptor complexity in energy homeostasis, OBESITY and drug development strategies
- MELANOCORTIN-4 receptor mutations are a frequent and heterogeneous cause of morbid OBESITY
- Dominant and recessive inheritance of morbid OBESITY associated with MELANOCORTIN 4 receptor deficiency
- Effect of interactions of polymorphisms in the MELANOCORTIN‐4 receptor gene with dietary factors on the risk of OBESITY and Type 2 diabetes: a systematic review
- The MELANOCORTIN‐4 receptor pathway and the emergence of precision medicine in OBESITY management
- A metabolic defect promotes OBESITY in mice lacking MELANOCORTIN-4 receptors
- MELANOCORTIN-4 receptor gene variant I103 is negatively associated with OBESITY
- Mutations in ligands and receptors of the leptin–MELANOCORTIN pathway that lead to OBESITY
- OBESITY-Associated GNAS Mutations and the MELANOCORTIN Pathway
- Mutations in MELANOCORTIN‐4 receptor and human OBESITY
- MELANOCORTIN receptor accessory proteins in adrenal disease and OBESITY
- MELANOCORTIN‐4 receptor mutations in OBESITY
- Molecular mechanisms of the neural MELANOCORTIN receptor dysfunction in severe early onset OBESITY
- Effects of acute and chronic administration of the MELANOCORTIN agonist MTII in mice with diet-induced OBESITY
- Understanding MELANOCORTIN-4 receptor control of neuronal circuits: toward novel therapeutics for OBESITY syndrome
- OBESITY-associated mutations in the MELANOCORTIN 4 receptor provide novel insights into its function
- Synaptic input organization of the MELANOCORTIN system predicts diet-induced hypothalamic reactive gliosis and OBESITY
- Functional characterization of MELANOCORTIN-4 receptor mutations associated with childhood OBESITY
- OBESITY treatment effect in Danish children and adolescents carrying MELANOCORTIN-4 Receptor mutations
- Loss of function of the MELANOCORTIN 2 receptor accessory protein 2 is associated with mammalian OBESITY
- The role of MELANOCORTIN 3 receptor gene in childhood OBESITY
- A Novel MELANOCORTIN 3 Receptor Gene (MC3R) Mutation Associated with Severe OBESITY
- Diet-induced OBESITY causes severe but reversible leptin resistance in arcuate MELANOCORTIN neurons
- MELANOCORTIN-4 receptor–deficient mice are not hypertensive or salt-sensitive despite OBESITY, hyperinsulinemia, and hyperleptinemia
- Effect of setmelanotide, a MELANOCORTIN‐4 receptor agonist, on OBESITY in Bardet‐Biedl syndrome
- Gain‐of‐function variants in the MELANOCORTIN 4 receptor gene confer susceptibility to binge eating disorder in subjects with OBESITY: a systematic review and meta …
- Tracing the effect of the MELANOCORTIN-4 receptor pathway in OBESITY: study design and methodology of the TEMPO registry
- MELANOCORTIN 4 receptor pathway dysfunction in OBESITY: patient stratification aimed at MC4R agonist treatment
- The interaction between dietary patterns and MELANOCORTIN-4 receptor polymorphisms in relation to OBESITY phenotypes
- OBESITY-associated mutations in the human MELANOCORTIN-4 receptor gene
- Peroxisome proliferation–associated control of reactive oxygen species sets MELANOCORTIN tone and feeding in diet-induced OBESITY
- Mutations in the human MELANOCORTIN-4 receptor gene associated with severe familial OBESITY disrupts receptor function through multiple molecular mechanisms
- Functional characterization of mutations in MELANOCORTIN-4 receptor associated with human OBESITY
- Mutations in MELANOCORTIN-3 receptor gene and human OBESITY
- Feeding response to MELANOCORTIN agonist predicts preference for and OBESITY from a high-fat diet
- Investigation of a genome wide association signal for OBESITY: synthetic association and haplotype analyses at the MELANOCORTIN 4 receptor gene locus
- Non-synonymous polymorphisms in MELANOCORTIN-4 receptor protect against OBESITY: the two facets of a Janus OBESITY gene
- Functional characterization and structural modeling of OBESITY associated mutations in the MELANOCORTIN 4 receptor
- Pro‐opioMELANOCORTIN (POMC) neurones, POMC‐derived peptides, MELANOCORTIN receptors and OBESITY: how understanding of this system has changed over the last …
- Polymorphisms and mutations in the MELANOCORTIN-3 receptor and their relation to human OBESITY
- Several mutations in the MELANOCORTIN-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited OBESITY in humans
- Lateral septum as a MELANOCORTIN downstream site in OBESITY development
- The MELANOCORTIN 4 receptor p. Ile269Asn mutation is associated with childhood and adult OBESITY in Mexicans
- The brain MELANOCORTIN system, sympathetic control, and OBESITY hypertension
- OBESITY due to MELANOCORTIN 4 receptor (MC4R) deficiency is associated with delayed gastric emptying
- MELANOCORTIN-4 receptor modulators for the treatment of OBESITY: a patent analysis (2008–2014)
- Rapid communication: a novel MELANOCORTIN 4 receptor (MC4R) gene mutation associated with morbid OBESITY
- OBESITY as a neuroendocrine disease: lessons to be learned from proopioMELANOCORTIN and MELANOCORTIN receptor mutations in mice and men
- Patients with OBESITY caused by MELANOCORTIN-4 receptor mutations can be treated with a glucagon-like peptide-1 receptor agonist
- Rare MELANOCORTIN-3 receptor mutations with in vitro functional consequences are associated with human OBESITY
- Linkage and association studies between the MELANOCORTIN receptors 4 and 5 genes and OBESITY-related phenotypes in the Quebec Family Study
- Hyperphagia, not hypometabolism, causes early onset OBESITY in MELANOCORTIN-4 receptor knockout mice
- Implication of heterozygous variants in genes of the leptin–MELANOCORTIN pathway in severe OBESITY
- High cortisol response to adrenocorticotrophic hormone identifies ewes with reduced MELANOCORTIN signalling and increased propensity to OBESITY
- MELANOCORTIN-4-receptor autoantibodies: a new player in OBESITY
- MELANOCORTIN 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset OBESITY: genetic and clinical characteristics
- Association of functionally significant MELANOCORTIN-4 but not MELANOCORTIN-3 receptor mutations with severe adult OBESITY in a large North American case–control study
- Immunoglobulin G modulation of the MELANOCORTIN 4 receptor signaling in OBESITY and eating disorders
- Association of MELANOCORTIN-4 receptor gene polymorphisms with OBESITY-related parameters in Malaysian Malays
- Phenotypes in three pedigrees with autosomal dominant OBESITY caused by haploinsufficiency mutations in the MELANOCORTIN-4 receptor gene
- MELANOCORTIN-3-receptor gene variants in morbid OBESITY
- Poor cell surface expression of human MELANOCORTIN-4 receptor mutations associated with OBESITY
- Prevalence of mutations and functional analyses of MELANOCORTIN 4 receptor variants identified among 750 men with juvenile-onset OBESITY
- MELANOCORTIN-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene …
- Homozygous null mutation of the MELANOCORTIN-4 receptor and severe early-onset OBESITY
- OBESITY‐associated mutant MELANOCORTIN‐4 receptors with normal Gαs coupling frequently exhibit other discoverable pharmacological and biochemical defects
- OBESITY-associated MELANOCORTIN-4 receptor mutations are associated with changes in the brain response to food cues
- Defective MELANOCORTIN 4 receptors in hyperphagia and morbid OBESITY
- Pharmacological chaperones for the misfolded MELANOCORTIN-4 receptor associated with human OBESITY
- Impact of OBESITY on renal structure and function in the presence and absence of hypertension: evidence from MELANOCORTIN-4 receptor-deficient mice
- MELANOCORTIN receptors as targets in the treatment of OBESITY
- Mutations in the MELANOCORTIN-3 receptor (MC3R) gene: Impact on human OBESITY or adiposity.
- OBESITY due to MELANOCORTIN 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely …
- MELANOCORTIN receptor-mediated effects on OBESITY are distributed over specific hypothalamic regions
- Early childhood BMI trajectories in monogenic OBESITY due to leptin, leptin receptor, and MELANOCORTIN 4 receptor deficiency
- MELANOCORTIN-4 receptor (MC4R) agonists for the treatment of OBESITY
- Hypothalamic MELANOCORTIN signaling and leptin resistance—Perspective of therapeutic application for OBESITY-diabetes syndrome
- Altered hypothalamic leptin, insulin, and MELANOCORTIN binding associated with moderate-fat diet and predisposition to OBESITY
- … genetic variants in autosomal recessive genes of the leptin-MELANOCORTIN signalling pathway are associated with the development of childhood OBESITY
- Autosomal-dominant mode of inheritance of a MELANOCORTIN-4 receptor mutation in a patient with severe early-onset OBESITY is due to a dominant-negative effect …
- Defect in MAPK signaling as a cause for monogenic OBESITY caused by inactivating mutations in the MELANOCORTIN-4 receptor gene
- OBESITY-induced inflammation in white adipose tissue is attenuated by loss of MELANOCORTIN-3 receptor signaling
- Subdiaphragmatic vagotomy with pyloroplasty ameliorates the OBESITY caused by genetic deletion of the MELANOCORTIN 4 receptor in the mouse
- Effect of the MELANOCORTIN-3 receptor C17A and G241A variants on weight loss in childhood OBESITY
- A Novel Homozygous Missense Mutation of MELANOCORTIN-4 Receptor (MC4R) in a Japanese Woman With Severe OBESITY
- Polymorphisms in genes involved in the leptin-MELANOCORTIN pathway are associated with OBESITY-related cardiometabolic alterations in a Southern Chilean population
- MELANOCORTIN 4 receptor sequence variations are seldom a cause of human OBESITY: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
- High prevalence of leptin and MELANOCORTIN-4 receptor gene mutations in children with severe OBESITY from Pakistani consanguineous families
- Association of MELANOCORTIN 4 Receptor Gene Single Nucleotide Polymorphism [Rs17782313] In Young OBESITY
- MELANOCORTIN-4 receptor gene variants in Chilean families: association with childhood OBESITY and eating behavior
- A unique MELANOCORTIN-4-receptor signaling profile for OBESITY-associated constitutively active variants
- Low frequency of MELANOCORTIN-4 receptor (MC4R) mutations in a Mediterranean population with early-onset OBESITY
- Molecular screening of the human MELANOCORTIN-4 receptor gene: identification of a missense variant showing no association with OBESITY, plasma glucose, or insulin
- Signal pathway analysis of selected OBESITY-associated MELANOCORTIN-4 receptor class V mutants
- MELANOCORTIN-4 receptor agonists for the treatment of OBESITY
- A missense mutation in the human MELANOCORTIN-4 receptor gene in relation to abdominal OBESITY and salivary cortisol
- Backbone cyclic peptidomimetic MELANOCORTIN-4 receptor agonist as a novel orally administrated drug lead for treating OBESITY
- The MELANOCORTIN system and its role in OBESITY and cachexia
- Mutationally induced disulfide bond formation within the third extracellular loop causes MELANOCORTIN 4 receptor inactivation in patients with OBESITY
- MELANOCORTIN 4 receptor gene variation is associated with severe OBESITY in Pima Indians
- Novel MELANOCORTIN-3 and-4 receptor functional variants in Asian children with severe OBESITY
- A novel loss of function MELANOCORTIN-4-receptor mutation (MC4R-F313Sfs* 29) in morbid OBESITY
- A novel nonsense mutation in the MELANOCORTIN-4 receptor associated with OBESITY in a Spanish population
- Deletion of the feeding-induced hepatokine TSK ameliorates the MELANOCORTIN OBESITY syndrome
- Several mutations in the MELANOCORTIN 4 receptor gene are associated with OBESITY in Chinese children and adolescents
- Voluntary exercise delays monogenetic OBESITY and overcomes reproductive dysfunction of the MELANOCORTIN-4 receptor knockout mouse
- Are Common MELANOCORTIN-3 Receptor Polymorphisms Associated with an Increased Risk of OBESITY in Childhood?
- A variant in the fat mass and OBESITY-associated gene (FTO) and variants near the MELANOCORTIN-4 receptor gene (MC4R) do not influence dietary intake
- SAT027 Novel OBESITY-Associated MELANOCORTIN 4 Receptor Variants Modulate Signaling Differently
- Genetic predisposition to OBESITY in bulimia nervosa: a mutation screen of the MELANOCORTIN-4 receptor gene
- OBESITY-linked variants of MELANOCORTIN-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone
- Inactivation and intracellular retention of the human I183N mutated MELANOCORTIN 3 receptor associated with OBESITY
- Understanding gut structure and function associated with MELANOCORTIN OBESITY
- Double deletion of MELANOCORTIN 4 receptors and SAPAP3 corrects compulsive behavior and OBESITY in mice
- Central role for MELANOCORTIN-4 receptors in offspring hypertension arising from maternal OBESITY
- Unravelling the mysterious roles of MELANOCORTIN-3 receptors in metabolic homeostasis and OBESITY using mouse genetics
- MELANOCORTIN-4 receptor polymorphism rs17782313: Association with OBESITY and eating in the absence of hunger in Chilean children
- Long-acting neurotensin synergizes with liraglutide to reverse OBESITY through a MELANOCORTIN-dependent pathway
- A novel MELANOCORTIN-4 receptor gene mutation in a female patient with severe childhood OBESITY
- Early leptin response to a palatable diet predicts dietary OBESITY in rats: key role of MELANOCORTIN‐4 receptors in the ventromedial hypothalamic nucleus
- Monogenic and complex forms of OBESITY: insights from genetics reveal the leptin-MELANOCORTIN signaling pathway as a common player
- Leptin infusion and OBESITY in mouse cause alterations in the hypothalamic MELANOCORTIN system
- MELANOCORTIN‐4 receptor and proopioMELANOCORTIN: Candidate genes for OBESITY in domestic shorthair cats
- Association study of MELANOCORTIN-4 Receptor (rs17782313) and PKHD1 (rs2784243) variations and early incidence of OBESITY at the age of maturity
- Role of the MELANOCORTIN-4 receptor mutations in human OBESITY
- Replication of Association Between a Common Variant Near MELANOCORTIN‐4 Receptor Gene and OBESITY‐related Traits in Asian Sikhs
- Physical activity and sedentary behaviors modify the association between MELANOCORTIN 4 receptor gene variant and OBESITY in Chinese children and …
- Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme OBESITY, and reduced MELANOCORTIN 4 receptor function
- … of Single nucleotide polymorphism rs17782313 in MELANOCORTIN 4 Receptor Gene with anthropometric indices in normal and OBESITY primary school children in Hanoi
- MELANOCORTIN-3 receptor gene variants: association with childhood OBESITY and eating behavior in Chilean families
- Feeding responses to a MELANOCORTIN agonist and antagonist in OBESITY induced by a palatable high-fat diet
- Monogenic human OBESITY: role of the leptin-MELANOCORTIN system in the regulation of food intake and body weight in humans
- Point mutations in the MELANOCORTIN-4 receptor cause variable OBESITY in mice
- Molecular therapy of MELANOCORTIN-4-receptor OBESITY by an autoregulatory BDNF vector
- Successful methylphenidate treatment of early onset extreme OBESITY in a child with a MELANOCORTIN-4 receptor gene mutation and attention deficit/hyperactivity …
- Agouti/MELANOCORTIN interactions with leptin pathways in OBESITY
- Neural Programmatic Role of Leptin, TNFα, MELANOCORTIN, and Glutamate in Blood Pressure Regulation vs OBESITY-Related Hypertension in Male C57BL/6 Mice
- … -mediated knockdown of MELANOCORTIN-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and OBESITY
- Variants in genes of the leptin/MELANOCORTIN pathway are involved in 3% of cases of early-onset severe OBESITY
- OBESITY due to MELANOCORTIN 4 Receptor (MC4R) Deficiency Is Associated with Increased Linear Growth and Final Height…
- Exacerbation of autoimmune uveitis by OBESITY occurs through the MELANOCORTIN 5 receptor
- Does OBESITY induce resistance to the long-term cardiovascular and metabolic actions of MELANOCORTIN 3/4 receptor activation?
- MELANOCORTIN-3 receptor gene variants in a Maori kindred with OBESITY and early onset type 2 diabetes
- Chronic blockade of the MELANOCORTIN 4 receptor subtype leads to OBESITY independently of neuropeptide Y action, with no adverse effects on the gonadotropic and …
- Mechanisms underlying hypertension and OBESITY: a MELANOCORTIN linkage in the brain
- Anti-MELANOCORTIN-4 receptor autoantibodies in OBESITY
- In silico approach to identify non-synonymous SNPs in human OBESITY related gene, MC3R (MELANOCORTIN-3-receptor)
- Lean rats with hypothalamic pro-opioMELANOCORTIN overexpression exhibit greater diet-induced OBESITY and impaired central MELANOCORTIN responsiveness
- Allelic variants of MELANOCORTIN 3 receptor gene (MC3R) and weight loss in OBESITY: a randomised trial of hypo-energetic high-versus low-fat diets
- A novel MELANOCORTIN-4 receptor mutation MC4R-P272L associated with severe OBESITY has increased propensity to be ubiquitinated in the ER in the face of …
- CX3CL1 action on microglia protects from diet-induced OBESITY by restoring POMC neuronal excitability and MELANOCORTIN system activity impaired by high-fat …
- A Two-Base Deletion–439delGC in the MELANOCORTIN-4 Receptor Promoter Associated with Early-Onset OBESITY
- Molecular genetic studies of MELANOCORTIN receptors in morbid OBESITY
- MELANOCORTIN-4 receptor and lipocalin 2 gene variants in Spanish children with abdominal OBESITY: effects on BMI-SDS after a lifestyle intervention
- Pharmacological Treatment of a Patient with Life-long OBESITY and Heterozygous Complete loss-of-function MELANOCORTIN 4 Receptor Mutation
- Targeting MELANOCORTIN receptors for the treatment of OBESITY
- Relationship between a near MELANOCORTIN-4 receptor gene variant and puberty timing in children is vague unlike OBESITY
- Daisaikoto improves fatty liver and OBESITY in MELANOCORTIN-4 receptor gene-deficient mice via the activation of brown adipose tissue
- … in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and OBESITY-associated (FTO), and the MELANOCORTIN-4 receptor (MC4R) …
- Regulation of PPARγ and OBESITY by agouti/MELANOCORTIN signaling in adipocytes
- Counterintuitive effects of double-heterozygous null MELANOCORTIN-4 receptor and leptin genes on diet-induced OBESITY and insulin resistance in C57BL/6J mice
- A novel non-synonymous mutation in the MELANOCORTIN-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme OBESITY
- Understanding the Role of MELANOCORTIN Stimulating Hormone Peptides in Regulation of OBESITY
- MELANOCORTIN 1 Receptors in the Hypothalamus of Mice within the Norm and in Diet-Induced OBESITY
- Developmental programming of OBESITY and liver metabolism by maternal perinatal nutrition involves the MELANOCORTIN system
- Chronic MELANOCORTIN 4 receptor blockage causes OBESITY without influencing sexual behavior in male rats
- MELANOCORTIN-4 receptor agonists for the treatment of OBESITY.
- GLP-1 receptor agonist treatment in morbid OBESITY and type 2 diabetes due to pathogenic homozygous MELANOCORTIN-4 receptor mutation: a case report
- Common MELANOCORTIN-3 receptor variants are not associated with OBESITY, although rs3746619 does influence weight in obese individuals
- Enhanced blood pressure and appetite responses to chronic central MELANOCORTIN-3/4 receptor blockade in dietary-induced OBESITY
- A phase 3 trial in participants with OBESITY due to Bardet-Biedl syndrome or Alström syndrome: efficacy and safety of the MELANOCORTIN 4 receptor agonist setmelanotide
- Promising strategies for OBESITY pharmacotherapy: MELANOCORTIN-4 (MC-4) receptor agonists and melanin concentrating hormone (MCH) receptor-1 antagonists
- Late onset OBESITY in mice with targeted deletion of potassium inward rectifier Kir7. 1 from cells expressing the MELANOCORTIN‐4 receptor
- Functional characterization of a new human MELANOCORTIN-4 receptor homozygous mutation (N72K) that is associated with early-onset OBESITY
- The CNS MELANOCORTIN system: A biological weapon against the threat of OBESITY
- Repeating of emotional stress prevents development of MELANOCORTIN OBESITY and type 2 diabetes in the mice with the Agouti yellow mutation
- Leptin‐MELANOCORTIN pathway variants and gastric emptying in patients with OBESITY
- Effects of Diet-Induced and MELANOCORTIN OBESITY on the Expression of Tryptophan Hydroxylase 2 in Midbrain and Hypothalamus Neurons in Mice
- … mechanism of setmelanotide (RM-493) as a potent and first-in-class MELANOCORTIN-4 receptor (MC4R) agonist to treat rare genetic disorders of OBESITY through an in …
- The genetics of OBESITY: the role of the MELANOCORTIN 4 receptor
- Association of leptin–MELANOCORTIN gene polymorphisms with the risk of OBESITY in northwest Indian population
- The effect of diet-induced and MELANOCORTIN OBESITY on expression of tryptophan hydroxylase 2 in the dorsal raphe nucleus and ventral tegmental area in mice
- Predictive Analysis of the Leptin-MELANOCORTIN and Adiponectin Signaling Pathways in OBESITY through In Silico Techniques
- Reduced anorexigenic efficacy of leptin, but not of the MELANOCORTIN receptor agonist melanotan-II, predicts diet-induced OBESITY in rats
- Leptin-MELANOCORTIN system, body weight regulation and OBESITY
- Polymorphisms of leptin-MELANOCORTIN system genes associated with OBESITY in an adult population from Barranquilla
- … Cyclic Peptides for Human MELANOCORTIN-4 Receptor (MC-4 R): Design, Synthesis, Bioactive Conformation, and Pharmacological Evaluation as an Anti-OBESITY Agent
- Nutritional regulation of central fat mass and OBESITY-associated (FTO) expression, and its association with the central MELANOCORTIN signaling in the regulation …
- Association between MELANOCORTIN 4 receptor gene polymorphisms and OBESITY
- Intracellular retention of human MELANOCORTIN-4 receptor: a molecular mechanism underlying early-onset OBESITY in F261S pedigree of Chinese
- Variation analysis of β3‐adrenergic receptor and MELANOCORTIN‐4 receptor genes in childhood OBESITY
- OBESITY caused by MELANOCORTIN-4 receptor mutations
- S1651 Association of Leptin-MELANOCORTIN Pathway Genetic Variants and OBESITY-Related Phenotypic Traits
- Changes of lipid-carbohydrate metabolism during development of MELANOCORTIN OBESITY in the mice with the Agouti yellow mutation
- Drugs, exercise, and the MELANOCORTIN-4 receptor—Different means, same ends: Treating OBESITY
- Inhibitory effect of the MELANOCORTIN receptor agonist melanotan-II (MTII) on feeding depends on dietary fat content and not OBESITY in rats on free-choice diets
- OBESITY-related mutations of leptin and MELANOCORTIN receptors
- The Effects of Mutations in MELANOCORTIN-4 Receptors and Ligand Melanocyte-Stimulating Hormone that Cause Inherited OBESITY in Humans
- CRTC1 deficiency, specifically in MELANOCORTIN‐4 receptor‐expressing cells, induces hyperphagia, OBESITY, and insulin resistance
- Two SNPs associated with type 2 diabetes and OBESITY at MELANOCORTIN-4 receptor gene loci exhibited high Fst values and natural selection
- Leptin-MELANOCORTIN Pathway and childhood OBESITY
- Leptin-MELANOCORTIN Pathway Mutations and Cardiovascular Morbidity in Patients with OBESITY
- Inactivating MELANOCORTIN 4 Receptor Mutations and Human OBESITY
- The effect of high-dose metformin on the metabolic parameters and functional state of the liver of agouti-mice with the MELANOCORTIN OBESITY.
- CHRONIC CARDIOVASCULAR AND DIETARY RESPONSES TO ACTIVATION OF MELANOCORTIN 3/4 RECEPTORS IN A MODEL OF DIET-INDUCED OBESITY: P …
- Optimized High-Yield Purification of OBESITY-Associated MELANOCORTIN 4 Receptor
- Pro-opio-MELANOCORTIN deficiency OBESITY–what has it taught us?
- Implication of heterozygous variants in genes of the leptin-MELANOCORTIN pathway in severe OBESITY
- Functional analysis of MELANOCORTIN-4 receptor variants linked to OBESITY
- An Evidence-based Framework to Evaluate MELANOCORTIN-4 Receptor (MC4R) Pathway Relevance for OBESITY-associated Genes
- Effect of High-Dose Metformin on the Metabolic Parameters and Functional State of the Liver of Agouti Mice with MELANOCORTIN OBESITY
- MELANOCORTIN-4 Receptor Mutation and OBESITY
- Peripheral MELANOCORTIN 3 Receptor (MC3R) Regulates Hepatic Autophagy in OBESITY
- OBESITY due to mutations in the anorexigenic MELANOCORTIN pathway: a paradigm for OBESITY in Prader-Willi syndrome?
- Genetics of OBESITY in Hong Kong Chinese: a candidate gene approach focusing on the MELANOCORTIN-4 receptor andadiponectin
- ROLE OF MUTATIONS IN THE MELANOCORTIN-4 RECEPTOR GENE IN CHILDHOOD OBESITY
- Bariatric Surgery Improves Glycemia But Not OBESITY in a Family with Inactive MELANOCORTIN 4 Receptor Signaling
- Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus MELANOCORTIN circuit to treat diet-induced OBESITY
- Rare heterozygous variants in genes of the leptin-MELANOCORTIN satiety pathway contribute to childhood OBESITY
- Differential contribution of brain‐region‐specific MELANOCORTIN 5 receptor to physical activity levels in lean vs. OBESITY‐prone rats
- Molecular genetic analysis of genes from the leptin-MELANOCORTIN pathway in the pathogenesis of OBESITY
- … Variants in MELANOCORTIN 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of OBESITY in …
- Motivational and Physiological Dysregulation Due to Development and Onset of OBESITY via MELANOCORTIN 4 Receptor+/-Haploinsufficiency
- Role Of Endogenous Brain MELANOCORTIN-4 Receptor Activation In Regulating Blood Pressure And Metabolic Function In Offspring Of Parents With OBESITY
- Targeting MELANOCORTIN‐4 receptor (MC4R) agonists to the endoplasmic reticulum (ER) as a potential approach to OBESITY therapy
- Clinical and Functional Characterization of MELANOCORTIN 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset OBESITY
- OBESITY, Diabetes and Energy Homeostasis: Control of appetite, blood glucose, and blood pressure during MELANOCORTIN-4 receptor activation in …
- Activation of leptin receptors in the NTS contributes to the elevated blood pressure in OBESITY via inhibiting NTS MELANOCORTIN signaling
- … 3 gene-targeted deletion reduces fat deposition and total body weight in MELANOCORTIN 4 receptor (MC4R)-null mice: A model of hypothalamic-driven late-onset OBESITY …
- A novel MELANOCORTIN-4 receptor mutation MC4R-P272L associated with severe OBESITY has increased propensity to be ubiquitinated in the ER in the face of correct …
- OBESITY, Diabetes and Energy Homeostasis: Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic MELANOCORTIN …
- MELANOCORTIN 4 receptors in the paraventricular nucleus of the hypothalamus do not mediate chronic metabolic or cardiovascular effects of leptin after established …
- Role of MELANOCORTIN receptor-4 in energy regulation and OBESITY
- Erratum: Peroxisome proliferation-associated control of reactive oxygen species sets MELANOCORTIN tone and feeding in diet-induced OBESITY (Nature Medicine (2011) …
- Association analysis of Leptin MELANOCORTIN signaling pathway genes with diabetes and OBESITY
- Investigations of MELANOCORTIN-receptor genes in patients with severe childhood OBESITY
- A Phase 2 Trial of the MELANOCORTIN-4 Receptor Agonist Setmelanotide in OBESITY Due to SRC1 Insufficiency: Body Weight, Body Mass Index Z Score, and Safety …
- MELANOCORTIN 4 receptor and children OBESITY
- … -targeted deletion reduces fat deposition and total body weight in MELANOCORTIN 4 receptor (MC4R)-null mice: A model of hypothalamic-driven late-onset OBESITY …
- 193 ACUTE HIGH FAT DIET ACTIVATES CENTRAL MELANOCORTIN PATHWAYS CONTRIBUTING TO OBESITY RELATED HYPERTENSION.
- The role of MELANOCORTIN 3 receptor gene in childhood OBESITY.
- Understanding MELANOCORTIN-4 receptor control of neuronal circuits: toward novel therapeutics for OBESITY syndrome.
- MELANOCORTIN 4 receptor genetics in defining the morbid OBESITY in general population: common polymorphisms vs mutations
- Mutational Analysis of the MELANOCORTIN-4 Receptor Gene in Chinese Children with OBESITY
- MELANOCORTIN reverses OBESITY in POMC-deficient mice
- Association of MELANOCORTIN-4 receptor gene polymorphisms with OBESITY-related parameters in Malaysian Malays.
- Morphological characteristics of liver and white adipose tissue during development of MELANOCORTIN OBESITY in C57Bl/6J Agouti yellow mutant mice
- Role of MELANOCORTIN 4 Receptor (Mc4R) in OBESITY
- MELANOCORTIN receptors mediate renal sympathetic activation to leptin in OBESITY
- OBESITY-associated MELANOCORTIN-4 receptor mutations are associated with changes in the brain response to food cues.
- Relationship between MELANOCORTIN 4 receptor (MC4R) gene polymorphism, diet, physical activity and OBESITY in children
- 389 PATHOPHYSIOLOGY OF OBESITY AND HYPERTENSION: ROLE OF CNS LEPTIN-MELANOCORTIN SYSTEM
- Impact of OBESITY on Renal Structure and Function in The Absence of Hypertension: Evidence From MELANOCORTIN‐4 Receptor (MC4R) Deficient Mice
- … of peripheral [alpha]-MELANOCORTIN stimulating hormone ([alpha]-MSH) in childhood craniopharyngioma patients in comparison with other forms of childhood OBESITY
- [OM3-1]: Hypothalamic MELANOCORTIN receptor 4 signaling in control of OBESITY
- PD. 05. Evidence of early life programming of the MELANOCORTIN-4 receptor in leptin induced hypertension arising from maternal OBESITY
